Obtención empírica del límite frecuencial entre las bandas de baja y altra frecuencia en análisis de variabilidad del ritmo cardíaco: aplicación en ratas y humanos

Se propone un nuevo método para la determinación empírica de los límites entre las bandas de baja frecuencia y alta frecuencia del espectro de potencia de las series RR en los estudios de variabilidad del ritmo cardíaco. El método se ha aplicado a series RR obtenidas en humanos y ratas Sprague-Dawley. Para humanos el límite coincide con la recomendación de 0,15 Hz mientras que para ratas Sprague-Dawley la metodología empleada sugiere un límite de 0,75 Hz.Postprint (published version

Obtención empírica del límite frecuencial entre las bandas de baja y altra frecuencia en análisis de variabilidad del ritmo cardíaco: aplicación en ratas y humanos

Se propone un nuevo método para la determinación empírica de los límites entre las bandas de baja frecuencia y alta frecuencia del espectro de potencia de las series RR en los estudios de variabilidad del ritmo cardíaco. El método se ha aplicado a series RR obtenidas en humanos y ratas Sprague-Dawley. Para humanos el límite coincide con la recomendación de 0,15 Hz mientras que para ratas Sprague-Dawley la metodología empleada sugiere un límite de 0,75 Hz

Voluntary Exercise Promotes Beneficial Anti-aging Mechanisms in SAMP8 Female Brain

Regular physical exercise mediates health and longevity promotion involving Sirtuin 1 (SIRT1)-regulated pathways. The anti-aging activity of SIRT1 is achieved, at least in part, by means of fine-tuning the adenosine monophosphate (AMP)-activated protein kinase (AMPK) pathway by preventing the transition of an originally pro-survival program into a pro-aging mechanism. Additionally, SIRT1 promotes mitochondrial function and reduces the production of reactive oxygen species (ROS) through regulating peroxisome proliferator-activated receptor γ coactivator 1α (PGC-1α), the master controller of mitochondrial biogenesis. Here, by using senescence-accelerated mice prone 8 (SAMP8) as a model for aging, we determined the effect of wheel-running as a paradigm for long-term voluntary exercise on SIRT1-AMPK pathway and mitochondrial functionality measured by oxidative phosphorylation (OXPHOS) complex content in the hippocampus and cortex. We found differential activation of SIRT1 in both tissues and hippocampal-specific activation of AMPK. These findings correlated well with significant changes in OXPHOS in the hippocampal, but not in the cerebral cortex, area. Collectively, the results revealed greater benefits of the exercise in the wheel-running intervention in a murine model of senescence, which was directly related with mitochondrial function and which was mediated through the modulation of SIRT1 and AMPK pathways. © 2014 Springer Science+Business Media New York

New indices for quantification of the power spectrum of heart rate variability time series without the need of any frequency band definition

This paper presents a new family of indices for the frequency domain analysis of heart rate variability time series that do not need any frequency band definition. After proper detrending of the time series, a cumulated power spectrum is obtained and frequencies that contain a certain percentage of the power below them are identified, so median frequency, bandwidth and a measure of the power spectrum asymmetry are proposed to complement or improve the classical spectral indices as the ratio of the powers of LF and HF bands (LF/HF). In normal conditions the median frequency provides similar information as the classical indices, while the bandwidth and asymmetry can be complementary measures of the physiological state of the tested subject. The proposed indices seem to be a good choice for tracking changes in the power spectrum in exercise stress, and they can guide in the determination of frequency band limits in other animal species.Peer Reviewe