Etch Rate and Dimensional Accuracy of Machinable Glass Ceramics in Chemical Etching

Machinable glass ceramic (MGC) is well known in the micro-electromechanical system and semiconductor industry. Chemical etching is used in this experiment to study the performance of MGC. The etching rate of MGC and its accuracy by indentation method is studied. The categoric parameter applied here is the type of chemical etchant used: hydrochloric (HCl), hydrophosphoric (H3PO4) and hydrobromic (HBr) acids; and, numerical parameters are etching temperature and etching solution. The experimental investigation that was carried out is governed by design of experiment (DoE)

Application of design of experiment for modelling of etching of ceramics

These instructions give you guidelines for preparing papers for EnCon 2008. Use this document as a template if you are using Microsoft Word 6.0 or later. Otherwise, use this document as an instruction set. Define all symbols used in the abstract. Do not cite references in the abstract. Do not delete the blank line immediately above the abstract; it sets the footnote at the bottom of this column. The abstract text should be formatted using 9 point Times (or Times Roman, or Times New Roman). The abstract follows the addresses and should give readers concise information about the content of the article and indicate the main results obtained and conclusions drawn. It should be self-contained with no reference to figures, tables, equations or bibliographic references and should not normally exceed 200 words

Prediction of Etching Rate of Alumino-Silicate Glass by RSM and ANN

920-924In this study, response surface methodology (RSM) andartificial neural network (ANN) were applied to predict material removal rate in chemical etching process of alumino-silicate glass (SiO2 57/Al2O3 36/CaO/MgO/BaO). 2k Factorial design was performed to evaluate linearity condition among process parameters. Analysis of variance (ANOVA) was performed and quadratic model was found most significant for data values of process parameters. New models were able to predict etching rate of alumino-silicate glass, with a great confidence. Input parameters analyzed were temperature, etching period and type of setup with and without condensation

Mechanistic insights into the pathogenesis of microtubule‐targeting agent‐induced peripheral neuropathy from pharmacogenetic and functional studies

Chemotherapy-induced peripheral neuropathy (CIPN) is a common dose-limiting toxicity that affects 30%-40% of patients undergoing cancer treatment. Although multiple mechanisms of chemotherapy-induced neurotoxicity have been described in preclinical models, these have not been translated into widely effective strategies for the prevention or treatment of CIPN. Predictive biomarkers to inform therapeutic approaches are also lacking. Recent studies have examined genetic risk factors associated with CIPN susceptibility. This review provides an overview of the clinical and pathologic features of CIPN and summarizes efforts to identify target pathways through genetic and functional studies. Structurally and mechanistically diverse chemotherapeutics are associated with CIPN; however, the current review is focused on microtubule-targeting agents since these are the focus of most pharmacogenetic association and functional studies of CIPN. Genome-wide pharmacogenetic association studies are useful tools to identify not only causative genes and genetic variants but also genetic networks implicated in drug response or toxicity and have been increasingly applied to investigations of CIPN. Induced pluripotent stem cell-derived models of human sensory neurons are especially useful to understand the mechanistic significance of genomic findings. Combined genetic and functional genomic efforts to understand CIPN hold great promise for developing therapeutic approaches for its prevention and treatment.Fil: Chua, Katherina C.. University of California; Estados UnidosFil: El Haj, Nura. University of California; Estados UnidosFil: Priotti, Josefina. University of California; Estados Unidos. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario. Instituto de Química Rosario. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Instituto de Química Rosario; ArgentinaFil: Kroetz, Deanna L.. University of California; Estados Unido

Probiotication of Punica granatum (pomegranate) juice by lactobacillus plantarum

Fruit juice enriched with probiotics is increasingly accepted nowadays, mainly due to its health benefit for digestive system. In particular, probioticated fruit juice is the good choice for those who are having lactose intolerant problem from milk based drinks. In the present study, the whole fruit of Punica granatum (pomegranate) has been probioticated with Lactobacillus plantarum at different fermentation temperatures (22ºC, 30ºC and 35ºC). The growth rate of L. plantarum has been monitored based on the optical density and acidity of the broth culture at 24 hours of time interval for 72 hours. The bacterial growth in the pomegranate juice was predicted by measuring absorbance at 600 nm spectrophotometrically and pH value by a pH meter. There was an increasing trend in the bacterial growth of L. plantarumincubated at 35ºC compared to other temperatures at 22ºC and 30ºC. The results also indicated there was no significant changes on pH during the fermentation as the bacterial strain was in adaptation process with the new medium and conditions. Meanwhile, the antioxidant assay showed that probiotication of pomegranate juice by L. plantarum significantly increased the radical scavenging activity. The pomegranate juice was shown to be a suitable substrate for L. plantarum cultivation at 35ºC

Effects of agitation speed and kinetic studies on probiotication of pomegranate juice with Lactobacillus casei

The issues of lactose intolerance and vegetarianism have encouraged the introduction of non-dairy fermented food into the market. Therefore, this study aims to evaluate the effect of agitation speed on the bioactive compounds and functional characteristics of probioticated pomegranate juice. Pomegranate juice was fermented with Lactobacillus casei at different agitation speeds ranging from 0 (microaerophilic) to 150 rpm at 37 °C. The functional properties of probioticated pomegranate juice were evaluated in terms of growth (biomass), lactic acid production, antioxidant activity, total phenolic content, and key metabolites using LC-MS/MS. The growth kinetics of fermentation was monitored at the optimal condition using one factor at a time method. High cell growth (3.58 × 1010 cfu/mL or 7.9 gL-1) was observed for L. casei probioticated pomegranate juice agitated at 0 rpm. The findings of this study reveal the potential of pomegranate juice as a medium for L. casei cultivation without nutrient supplementation. The improvement of antioxidant activity in the probioticated juice could be due to the increment of quercetin-3-glucoside. Therefore, L. casei grew well in pomegranate juice with a high cell viability and antioxidant activity at a non-agitated condition. Probioticated pomegranate juice is a potentially functional drink

Optical properties of zinc borotellurite glass system doped with erbium and erbium nanoparticles for photonic applications

Comparative analysis on optical properties between two glass series (a—ordinary glass, b—glass with nanoparticles) have been estimated. The two glass series (a—ordinary glass, b—glass with nanoparticles) with compositions {[(TeO2)0.70 (B2O3)0.30]0.70 (ZnO)0.30}1−y (Er2O3/Er2O3 nanoparticles)y; y = 0.005, 0.01, 0.02, 0.03, 0.04, 0.05 mol% were successfully prepared by using melt-quenching method. The TEM, EDX and XRD have been used to confirm the existence of nanoparticles and all elements in the glass system. The density of b—glass with nanoparticles are found greater than a—ordinary glass. The optical properties of the glass series were characterized by using Ellipsometer and UV–Vis spectrophotometer. There is a linear increasing trend in refractive index of the glass series along with concentration of erbium and erbium nanoparticles oxide. The refractive index of b—glass with nanoparticles is greater than a—ordinary glass. Moreover, the absorption peaks of a—ordinary glass are more intense than b—glass with nanoparticles. The glass with nanoparticles will offer a potential materials for nanophotonic devices

Performance evaluation of a waste-heat driven adsorption system for automotive air-conditioning: Part II - Performance optimization under different real driving conditions

[EN] In this part, Part 11, of a two-part study, the validated model of part I is integrated into a general vehicle model in order to predict the performance of the system under real driving conditions. The overall model takes into account all the system components to simulate the dynamic performance of the entire system and predict the cabin temperature at the available waste heat. The system was implemented in a Fiat Grande Punto vehicle and the experimental tests were performed at the Centro Ricerche Fiat (CRF), Italy laboratories. Different design configurations were investigated to explore further improvements of the performance. Results showed that the model was able to well predict the transient performance of the system under different start-up and ambient conditions as well as the normal operating conditions. Using two radiators instead of one radiator increases the cooling capacity by 7.0% and decreases the cabin temperature by 9.1%. At the warming up period, the adsorption system faces serious difficulties to start producing the required cooling. Possible strategies to avoid this problem were studied and compared. In general, it has been proved that the amount of engine waste heat available is sufficient to produce enough cooling to keep reasonably comfortable temperatures in the cabin. (C) 2016 Elsevier Ltd. All rights reserved.This work has been partially supported by the Thermally Operated Mobile Air Conditioning Systems (TOPMACS). The authors are very grateful to the Energy Research Center of Netherlands (ECN) for their support with the experimental work.This work has been partially supported by the Thermally Operated Mobile Air Conditioning Systems (TOPMACS). The authors are very grateful to the Energy Research Center of Netherlands (ECN) for their support in the experimental work.Verde Trindade, M.; Harby Mohamed Abd Alaal, K.; De Boer, R.; Corberán, JM. (2016). Performance evaluation of a waste-heat driven adsorption system for automotive air-conditioning: Part II - Performance optimization under different real driving conditions. Energy. 115:996-1009. doi:10.1016/j.energy.2016.09.086S996100911

Factors affecting interprofessional teamwork in emergency department care of polytrauma patients : results of an exploratory study

Considering that traumatic injuries are the leading cause of death among young adults across the globe, emergency department care of polytrauma patients is a crucial aspect of optimized care and premature death prevention. Unfortunately, many studies have highlighted important gaps in collaboration among different trauma team professionals, posing a major quality of care challenge. Using the conceptual framework for interprofessional teamwork (IPT) of Reeves, Lewin, Espin, and Zwarenstein (2010), the aim of this qualitative descriptive exploratory study was to better understand IPT from the perspective of health professionals in emergency department care of polytrauma patients, specifically by identifying factors that facilitate and impede IPT. Data was collected from a sample of seven health professionals involved in the care of polytrauma patients, through individual interviews and a focus group. In a second phase, two structured observations of polytrauma patient care were conducted. Following a thematic analysis, results show multiple factors affecting IPT, which can be divided into five broad categories: individual, relational, processual, organizational and contextual. Individual factors, a category that is not part of the conceptual framework of Reeves et al. (2010), also emerged as playing a major part in IPT

Grey and white matter correlates of recent and remote autobiographical memory retrieval:Insights from the dementias

The capacity to remember self-referential past events relies on the integrity of a distributed neural network. Controversy exists, however, regarding the involvement of specific brain structures for the retrieval of recently experienced versus more distant events. Here, we explored how characteristic patterns of atrophy in neurodegenerative disorders differentially disrupt remote versus recent autobiographical memory. Eleven behavioural-variant frontotemporal dementia, 10 semantic dementia, 15 Alzheimer's disease patients and 14 healthy older Controls completed the Autobiographical Interview. All patient groups displayed significant remote memory impairments relative to Controls. Similarly, recent period retrieval was significantly compromised in behavioural-variant frontotemporal dementia and Alzheimer's disease, yet semantic dementia patients scored in line with Controls. Voxel-based morphometry and diffusion tensor imaging analyses, for all participants combined, were conducted to investigate grey and white matter correlates of remote and recent autobiographical memory retrieval. Neural correlates common to both recent and remote time periods were identified, including the hippocampus, medial prefrontal, and frontopolar cortices, and the forceps minor and left hippocampal portion of the cingulum bundle. Regions exclusively implicated in each time period were also identified. The integrity of the anterior temporal cortices was related to the retrieval of remote memories, whereas the posterior cingulate cortex emerged as a structure significantly associated with recent autobiographical memory retrieval. This study represents the first investigation of the grey and white matter correlates of remote and recent autobiographical memory retrieval in neurodegenerative disorders. Our findings demonstrate the importance of core brain structures, including the medial prefrontal cortex and hippocampus, irrespective of time period, and point towards the contribution of discrete regions in mediating successful retrieval of distant versus recently experienced events