453 research outputs found
Unique and predictive relationships between components of cognitive vulnerability and symptoms of depression
Unique and predictive relationships between components of cognitive vulnerability and symptoms of depression
Dielectronic Recombination in He+ Ions
This research was sponsored by the National Science Foundation Grant NSF PHY-931478
Small BGK waves and nonlinear Landau damping
Consider 1D Vlasov-poisson system with a fixed ion background and periodic
condition on the space variable. First, we show that for general homogeneous
equilibria, within any small neighborhood in the Sobolev space W^{s,p}
(p>1,s<1+(1/p)) of the steady distribution function, there exist nontrivial
travelling wave solutions (BGK waves) with arbitrary minimal period and
traveling speed. This implies that nonlinear Landau damping is not true in
W^{s,p}(s<1+(1/p)) space for any homogeneous equilibria and any spatial period.
Indeed, in W^{s,p} (s<1+(1/p)) neighborhood of any homogeneous state, the long
time dynamics is very rich, including travelling BGK waves, unstable
homogeneous states and their possible invariant manifolds. Second, it is shown
that for homogeneous equilibria satisfying Penrose's linear stability
condition, there exist no nontrivial travelling BGK waves and unstable
homogeneous states in some W^{s,p} (p>1,s>1+(1/p)) neighborhood. Furthermore,
when p=2,we prove that there exist no nontrivial invariant structures in the
H^{s} (s>(3/2)) neighborhood of stable homogeneous states. These results
suggest the long time dynamics in the W^{s,p} (s>1+(1/p)) and particularly, in
the H^{s} (s>(3/2)) neighborhoods of a stable homogeneous state might be
relatively simple. We also demonstrate that linear damping holds for initial
perturbations in very rough spaces, for linearly stable homogeneous state. This
suggests that the contrasting dynamics in W^{s,p} spaces with the critical
power s=1+(1/p) is a trully nonlinear phenomena which can not be traced back to
the linear level
Race, ethnicity and risk of second primary contralateral breast cancer in the United States
Breast cancer survivors have a high risk of a second primary contralateral breast cancer (CBC), but there are few studies of CBC risk in racial/ethnic minority populations. We examined whether the incidence and risk factors for CBC differed by race/ethnicity in the United States. Women with a first invasive Stage I-IIB breast cancer diagnosis at ages 20-74 years between 2000 and 2015 in the Surveillance, Epidemiology, and End Results Program (SEER) 18 registries were followed through 2016 for a diagnosis of invasive CBC ≥1 year after the first breast cancer diagnosis. We used cause-specific Cox proportional hazards models to test the association between race/ethnicity and CBC, adjusting for age, hormone receptor status, radiation therapy, chemotherapy and stage at first diagnosis, and evaluated the impact of contralateral prophylactic mastectomy, socioeconomic status, and insurance status on the association. After a median follow-up of 5.9 years, 9247 women (2.0%) were diagnosed with CBC. Relative to non-Hispanic (NH) White women, CBC risk was increased in NH Black women (hazard ratio = 1.44, 95% CI 1.35-1.54) and Hispanic women (1.11, 95% CI 1.02-1.20), with the largest differences among women diagnosed at younger ages. Adjustment for contralateral prophylactic mastectomy, socioeconomic status and health insurance did not explain the associations. Therefore, non-Hispanic Black and Hispanic women have an increased risk of CBC that is not explained by clinical or socioeconomic factors collected in SEER. Large studies of diverse breast cancer survivors with detailed data on treatment delivery and adherence are needed to inform interventions to reduce this disparity
Deterministic and stochastic descriptions of gene expression dynamics
A key goal of systems biology is the predictive mathematical description of
gene regulatory circuits. Different approaches are used such as deterministic
and stochastic models, models that describe cell growth and division explicitly
or implicitly etc. Here we consider simple systems of unregulated
(constitutive) gene expression and compare different mathematical descriptions
systematically to obtain insight into the errors that are introduced by various
common approximations such as describing cell growth and division by an
effective protein degradation term. In particular, we show that the population
average of protein content of a cell exhibits a subtle dependence on the
dynamics of growth and division, the specific model for volume growth and the
age structure of the population. Nevertheless, the error made by models with
implicit cell growth and division is quite small. Furthermore, we compare
various models that are partially stochastic to investigate the impact of
different sources of (intrinsic) noise. This comparison indicates that
different sources of noise (protein synthesis, partitioning in cell division)
contribute comparable amounts of noise if protein synthesis is not or only
weakly bursty. If protein synthesis is very bursty, the burstiness is the
dominant noise source, independent of other details of the model. Finally, we
discuss two sources of extrinsic noise: cell-to-cell variations in protein
content due to cells being at different stages in the division cycles, which we
show to be small (for the protein concentration and, surprisingly, also for the
protein copy number per cell) and fluctuations in the growth rate, which can
have a significant impact.Comment: 23 pages, 5 figures; Journal of Statistical physics (2012
Attentive Learning of Sequential Handwriting Movements: A Neural Network Model
Defense Advanced research Projects Agency and the Office of Naval Research (N00014-95-1-0409, N00014-92-J-1309); National Science Foundation (IRI-97-20333); National Institutes of Health (I-R29-DC02952-01)
On the verge of Umdeutung in Minnesota: Van Vleck and the correspondence principle (Part One)
In October 1924, the Physical Review, a relatively minor journal at the time,
published a remarkable two-part paper by John H. Van Vleck, working in virtual
isolation at the University of Minnesota. Van Vleck combined advanced
techniques of classical mechanics with Bohr's correspondence principle and
Einstein's quantum theory of radiation to find quantum analogues of classical
expressions for the emission, absorption, and dispersion of radiation. For
modern readers Van Vleck's paper is much easier to follow than the famous paper
by Kramers and Heisenberg on dispersion theory, which covers similar terrain
and is widely credited to have led directly to Heisenberg's "Umdeutung" paper.
This makes Van Vleck's paper extremely valuable for the reconstruction of the
genesis of matrix mechanics. It also makes it tempting to ask why Van Vleck did
not take the next step and develop matrix mechanics himself.Comment: 82 page
Mutation update for the SATB2 gene
SATB2-associated syndrome (SAS) is an autosomal dominant neurodevelopmental disorder caused by alterations in the SATB2 gene. Here we present a review of published pathogenic variants in the SATB2 gene to date and report 38 novel alterations found in 57 additional previously unreported individuals. Overall, we present a compilation of 120 unique variants identified in 155 unrelated families ranging from single nucleotide coding variants to genomic rearrangements distributed throughout the entire coding region of SATB2. Single nucleotide variants predicted to result in the occurrence of a premature stop codon were the most commonly seen (51/120=42.5%) followed by missense variants (31/120=25.8%). We review the rather limited functional characterization of pathogenic variants and discuss current understanding of the consequences of the different molecular alterations. We present an expansive phenotypic review along with novel genotype-phenotype correlations. Lastly, we discuss current knowledge on animal models and present future prospects. This review should help provide better guidance for the care of individuals diagnosed with SAS
Narrative Exposure Therapy for Posttraumatic Stress Disorder associated with repeated interpersonal trauma in patients with Severe Mental Illness: a mixed methods design
Background: In the Netherlands, most patients with severe mental illness (SMI) receive flexible assertive community treatment (FACT) provided by multidisciplinary community mental health teams. SMI patients with comorbid posttraumatic stress disorder (PTSD) are sometimes offered evidence-based trauma-focused treatment like eye movement desensitization reprocessing or prolonged exposure. There is a large amount of evidence for the effectiveness of narrative exposure therapy (NET) within various vulnerable patient groups with repeated interpersonal trauma. Some FACT-teams provide NET for patients with comorbid PTSD, which is promising, but has not been specifically studied in SMI patients.
Objectives: The primary aim is to evaluate NET in SMI patients with comorbid PTSD associated with repeated interpersonal trauma to get insight into whether (1) PTSD and dissociative symptoms changes and (2) changes occur in the present SMI symptoms, care needs, quality of life, global functioning, and care consumption. The second aim is to gain insight into patients’ experiences with NET and to identify influencing factors on treatment results.
Methods: This study will have a mixed methods convergent design consisting of quantitative repeated measures and qualitative semi-structured in-depth interviews based on Grounded Theory. The study population will include adult SMI outpatients (n=25) with comorbid PTSD and receiving NET. The quantitative study parameters will be existence and severity of PTSD, dissociative, and SMI symptoms; care needs; quality of life; global functioning; and care consumption. In a longitudinal analysis, outcomes will be analyzed using mixed models to estimate the difference in means between baseline and repeated measurements. The qualitative study parameters will be experiences with NET and perceived factors for success or failure. Integration of quantitative and qualitative results will be focused on interpreting how qualitative results enhance the understanding of quantitative outcomes.
Discussion: The results of this study will provide more insight into influencing factors for clinical changes in this population
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