Cross Section Measurements of Charged Pion Photoproduction in Hydrogen and Deuterium from 1.1 to 5.5 GeV

The differential cross section for the gamma +n --> pi- + p and the gamma + p --> pi+ n processes were measured at Jefferson Lab. The photon energies ranged from 1.1 to 5.5 GeV, corresponding to center-of-mass energies from 1.7 to 3.4 GeV. The pion center-of-mass angles varied from 50 degree to 110 degree. The pi- and pi+ photoproduction data both exhibit a global scaling behavior at high energies and high transverse momenta, consistent with the constituent counting rule prediction and the existing pi+ data. The data suggest possible substructure of the scaling behavior, which might be oscillations around the scaling value. The data show an enhancement in the scaled cross section at center-of-mass energy near 2.2 GeV. The differential cross section ratios at high energies and high transverse momenta can be described by calculations based on one-hard-gluon-exchange diagrams.Comment: 18 pages, 19 figure

Signatures for short-range correlations in {16}O, observed in the reaction {16}O(e,e'pp){14}C.

The reaction O-16(e,e'pp)C-14 has been studied at a transferred four-momentum (omega,\q\) = (210 MeV, 300 MeV/c). The differential cross sections for the transitions to the ground state and the lowest excited states in C-14 were determined as a function of the momentum of the recoiling C-14 nucleus and the angle between the momentum of the proton emitted in the forward direction and the momentum transfer q. A comparison of the data to the results of calculations, performed with a microscopic model, shows clear signatures for short-range correlations in the O-16 ground state

Deep exclusive π+\pi^+ electroproduction off the proton at CLAS

The exclusive electroproduction of $\pi^+$ above the resonance region was studied using the $\rm{CEBAF}$ Large Acceptance Spectrometer ($\rm{CLAS}$) at Jefferson Laboratory by scattering a 6 GeV continuous electron beam off a hydrogen target. The large acceptance and good resolution of $\rm{CLAS}$, together with the high luminosity, allowed us to measure the cross section for the $\gamma^* p \to n \pi^+$ process in 140 ($Q^2$, $x_B$, $t$) bins: $0.16<x_B<0.58$, 1.6 GeV$^2<$$Q^2$$<4.5$ GeV$^2$ and 0.1 GeV$^2<$$-t$$<5.3$ GeV$^2$. For most bins, the statistical accuracy is on the order of a few percent. Differential cross sections are compared to two theoretical models, based either on hadronic (Regge phenomenology) or on partonic (handbag diagram) degrees of freedom. Both can describe the gross features of the data reasonably well, but differ strongly in their ingredients. If the handbag approach can be validated in this kinematical region, our data contain the interesting potential to experimentally access transversity Generalized Parton Distributions.Comment: 18pages, 21figures,2table

An Integrated TCGA Pan-Cancer Clinical Data Resource to Drive High-Quality Survival Outcome Analytics

For a decade, The Cancer Genome Atlas (TCGA) program collected clinicopathologic annotation data along with multi-platform molecular profiles of more than 11,000 human tumors across 33 different cancer types. TCGA clinical data contain key features representing the democratized nature of the data collection process. To ensure proper use of this large clinical dataset associated with genomic features, we developed a standardized dataset named the TCGA Pan-Cancer Clinical Data Resource (TCGA-CDR), which includes four major clinical outcome endpoints. In addition to detailing major challenges and statistical limitations encountered during the effort of integrating the acquired clinical data, we present a summary that includes endpoint usage recommendations for each cancer type. These TCGA-CDR findings appear to be consistent with cancer genomics studies independent of the TCGA effort and provide opportunities for investigating cancer biology using clinical correlates at an unprecedented scale. Analysis of clinicopathologic annotations for over 11,000 cancer patients in the TCGA program leads to the generation of TCGA Clinical Data Resource, which provides recommendations of clinical outcome endpoint usage for 33 cancer types

Nuclear transparency with the γn⃗π-p process in 4He

We have measured the nuclear transparency of the fundamental process γn⃗π-p in 4He. These measurements were performed at Jefferson Lab in the photon energy range of 1.6–4.5 GeV and at θcmπ=70° and 90°. These measurements are the first of their kind in the study of nuclear transparency in photoreactions. They also provide a benchmark test of Glauber calculations based on traditional models of nuclear physics. The transparency results suggest deviations from the traditional nuclear physics picture. The momentum transfer dependence of the measured nuclear transparency is consistent with Glauber calculations that include the quantum chromodynamics phenomenon of color transparency

Asymptotic stability of solitary waves

We show that the family of solitary waves (1-solitons) of the Korteweg-de Vries equation is asymptotically stable. Our methods also apply for the solitary waves of a class of generalized Korteweg-de Vries equations, In particular, we study the case where f(u)=u p+1 / (p+1) , p =1, 2, 3 (and 30, with f ∈ C 4 ). The same asymptotic stability result for KdV is also proved for the case p =2 (the modified Korteweg-de Vries equation). We also prove asymptotic stability for the family of solitary waves for all but a finite number of values of p between 3 and 4. (The solitary waves are known to undergo a transition from stability to instability as the parameter p increases beyond the critical value p =4.) The solution is decomposed into a modulating solitary wave, with time-varying speed c(t) and phase γ( t ) ( bound state part ), and an infinite dimensional perturbation ( radiating part ). The perturbation is shown to decay exponentially in time, in a local sense relative to a frame moving with the solitary wave. As p →4 − , the local decay or radiation rate decreases due to the presence of a resonance pole associated with the linearized evolution equation for solitary wave perturbations.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/46489/1/220_2005_Article_BF02101705.pd

Driver Fusions and Their Implications in the Development and Treatment of Human Cancers.

Gene fusions represent an important class of somatic alterations in cancer. We systematically investigated fusions in 9,624 tumors across 33 cancer types using multiple fusion calling tools. We identified a total of 25,664 fusions, with a 63% validation rate. Integration of gene expression, copy number, and fusion annotation data revealed that fusions involving oncogenes tend to exhibit increased expression, whereas fusions involving tumor suppressors have the opposite effect. For fusions involving kinases, we found 1,275 with an intact kinase domain, the proportion of which varied significantly across cancer types. Our study suggests that fusions drive the development of 16.5% of cancer cases and function as the sole driver in more than 1% of them. Finally, we identified druggable fusions involving genes such as TMPRSS2, RET, FGFR3, ALK, and ESR1 in 6.0% of cases, and we predicted immunogenic peptides, suggesting that fusions may provide leads for targeted drug and immune therapy

All-sky search for long-duration gravitational wave transients with initial LIGO

We present the results of a search for long-duration gravitational wave transients in two sets of data collected by the LIGO Hanford and LIGO Livingston detectors between November 5, 2005 and September 30, 2007, and July 7, 2009 and October 20, 2010, with a total observational time of 283.0 days and 132.9 days, respectively. The search targets gravitational wave transients of duration 10-500 s in a frequency band of 40-1000 Hz, with minimal assumptions about the signal waveform, polarization, source direction, or time of occurrence. All candidate triggers were consistent with the expected background; as a result we set 90% confidence upper limits on the rate of long-duration gravitational wave transients for different types of gravitational wave signals. For signals from black hole accretion disk instabilities, we set upper limits on the source rate density between 3.4×10-5 and 9.4×10-4 Mpc-3 yr-1 at 90% confidence. These are the first results from an all-sky search for unmodeled long-duration transient gravitational waves. © 2016 American Physical Society