CONFRONTING MASCULINITY: THE GEN X NOVEL (1984-2000) AND THE SENTIMENTAL MAN

Experimental novels written from 1984-2000 by authors associated with Generation X collectively struggle with common sense notions of masculinity in their various decades at the end of the twentieth century. Relying on confessional, first-person narration, first novels written by white men stage a critical engagement of outdated patriarchal norms in an effort to produce a more progressive masculinity based on sentimentality. In the 1980s, McInerney and Ellis novels, Bright Lights, Big City and Less Than Zero chronicle the struggles of empty, yuppie men who cannot make connections with their peers due to their emotionally devoid lives. By the 1990s, Douglas Coupland proposes a new, sentimental masculinity with his protagonist Andy who narrates Generation X: Tales for an Accelerated Culture. Andy creates sympathetic connections with his peers through the act of confessional storytelling. Chuck Palahniuk’s Fight Club does similar cultural work as Coupland’s novel by creating an anti-sentimental, nameless narrator so bereft of emotion that he creates a hypermasculine alter-ego and violent groups to avoid the emotional emptiness of his life. Finally, Dave Eggers’s A Heartbreaking Work of Staggering Genius (2000) produces the most progressive, evolved masculine narrator, Dave, who spends the entire novel coming to terms with the death of his parents while raising his brother as a son. The novels, in both content and form, become more complex and richer reflecting the development of their protagonists and their philosophical arguments for progressing into sentimental men

Towards a Reference Architecture of Intent for Information Systems Strategic Alignment

Enterprise architecture enables strategic alignment through creation of a unified business and IS view of the target state of the business. Using a design science approach, this paper proposes an intent-based technique as an extension to existing modeling techniques for strategic alignment. The proposed approach defines a reference architecture of enterprise intent that includes vocabulary, rules, and structure for development of purposefully aligned strategic-level enterprise architecture. The proposed approach results in interacting hierarchies that can be analyzed through network science approaches

Improving the Alignment Between IT Projects and Strategic Initiatives: The Target State Specfic Outcome (TSSO) Method

There is little direct evidence that information systems (IS) deliver measurable value at the organizational level. This inability to measure IS value is often caused by an inability to directly allocate beneficial financial outcomes to IS. Therefore, an alternative approach to determining IS value is required. This paper builds on Kaplan and Norton’s third-generation balanced score card to measure IS value. The authors propose a causal Target State Specific Outcome (TSSO) model to achieve the required IS alignment with strategic initiative objectives and measures

Physiological and driving behaviour changes associated to different road intersections

Road traffic injuries claim more than 1.2 million lives each year in the world and have a huge impact on health and development. It is commonly acknowledged that the human factor and the interaction between the human factor and the road environment are among the most common causes of road accidents. Intersections are among the most complex road environments: their geometric and traffic characteristics weigh the driver workload, affecting the driving behaviour and consequently the risk of accident. This study intends therefore to contribute for a better understanding of the relationship between different types of intersection and the human factor. The ultimate aim is to understand how at grade intersections affect the driving behaviour by comparing the drivers’ stress level for roundabouts and standard intersections. Electrodermal activity can provide a real-time assessment of the driver's stress level. Electrodermal activity was therefore collected continuously during a driving study which took place on a test environment based at Cranfield University and surrounding roads. Twenty participants were involved within the study. The analysis focused on four crossing manoeuvres on three at grade intersections (two T-junctions and a roundabout) situated on the study location. Results showed that the number of SCR peaks as well as the amplitude of the peaks are overall higher for the two manoeuvres on the roundabout. The stress level induced by each type of intersection was evaluated through an Electrodermal Impact Index which takes into account both the number and the amplitude of SCR peaks. Results suggested that the stress level induced by roundabouts is more than double that induced by standard intersections

Cyclic Adenosine Monophosphate Accumulation and beta-Adrenergic Binding in Unweighted and Denervated Rat Soleus Muscle

Unweighting, but not denervation, of muscle reportedly "spares" insulin receptors, increasing insulin sensitivity. Unweighting also increases beta-adrenergic responses of carbohydrate metabolism. These differential characteristics were studied further by comparing cyclic adenosine monophosphate (cAMP) accumulation and beta-adrenergic binding in normal and 3-day unweighted or denervated soleus muscle. Submaximal amounts of isoproterenol, a p-agonist, increased cAMP accumulation in vitro and in vivo (by intramuscular (IM) injection) to a greater degree (P less than .05) in unweighted muscles. Forskolin or maximal isoproterenol had similar in vitro effects in all muscles, suggesting increased beta-adrenergic sensitivity following unweighting. Increased sensitivity was confirmed by a greater receptor density (B(sub max)) for iodo-125(-)-pindolol in particulate preparations of unweighted (420 x 10(exp -18) mol/mg muscle) than of control or denervated muscles (285 x 10(exp-18) mol/mg muscle). The three dissociation constant (Kd) values were similar (20.3 to 25.8 pmol/L). Total binding capacity (11.4 fmol/muscle) did not change during 3 days of unweighting, but diminished by 30% with denervation. This result illustrates the "sparing" and loss of receptors, respectively, in these two atrophy models. In diabetic animals, IM injection of insulin diminished CAMP accumulation in the presence of theophylline in unweighted muscle (-66% +/- 2%) more than in controls (-42% +'- 6%, P less than .001). These results show that insulin affects CAMP formation in muscle, and support a greater in vivo insulin response following unweighting atrophy. These various data support a role for lysosomal proteolysis in denervation, but not in unweighting, atrophy

Constraints on aerosol nitrate photolysis as a potential source of HONO and NOx, Environmental Science and Technology

The concentration of nitrogen oxides (NOx) plays a central role in controlling air quality. On a global scale, the primary sink of NOx is oxidation to form HNO3. Gas-phase HNO3 photolyses slowly with a lifetime in the troposphere of 10 days or more. However, several recent studies examining HONO chemistry have proposed that particle-phase HNO3 undergoes photolysis 10–300 times more rapidly than gas-phase HNO3. We present here constraints on the rate of particle-phase HNO3 photolysis based on observations of NOx and HNO3 collected over the Yellow Sea during the KORUS-AQ study in summer 2016. The fastest proposed photolysis rates are inconsistent with the observed NOx to HNO3 ratios. Negligible to moderate enhancements of the HNO3 photolysis rate in particles, 1–30 times faster than in the gas phase, are most consistent with the observations. Small or moderate enhancement of particle-phase HNO3 photolysis would not significantly affect the HNO3 budget but could help explain observations of HONO and NOx in highly aged air

Emerging therapies of hemangioblastomas

Hemangioblastoma are benign, vascularized cranial tumors caused by autosomal dominant inherited von Hippel-Lindau disease or can appear sporadically. This review will investigate current and emerging treatments for cerebral tumors. It will focus on the current and, more importantly, developing hemangioblastoma treatments. Surgical resectioning and radiotherapy are effective treatment options for cerebral tumors, whereas chemotherapies are not commonly used due to their limited ability to penetrate the blood-brain barrier. Recent chemotherapies have shown promise, but further research is needed to determine the efficacy as a treatment for hemangioblastomas. New advances in brachytherapy and immunotherapy are considered promising treatment options for hemangioblastoma. This review aims to offer valuable insights into the latest developments in hemangioblastoma treatments

Effective suckling in relation to naked maternal-infant body contact in the first hour of life: an observation study

Background Best practice guidelines to promote breastfeeding suggest that (i) mothers hold their babies in naked body contact immediately after birth, (ii) babies remain undisturbed for at least one hour and (iii) breastfeeding assistance be offered during this period. Few studies have closely observed the implementation of these guidelines in practice. We sought to evaluate these practices on suckling achievement within the first hour after birth. Methods Observations of seventy-eight mother-baby dyads recorded newborn feeding behaviours, the help received by mothers and birthing room practices each minute, for sixty minutes. Results Duration of naked body contact between mothers and their newborn babies varied widely from 1 to 60 minutes, as did commencement of suckling (range = 10 to 60 minutes). Naked maternal-infant body contact immediately after birth, uninterrupted for at least thirty minutes did not predict effective suckling within the first hour of birth. Newborns were four times more likely to sustain deep rhythmical suckling when their chin made contact with their mother’s breast as they approached the nipple (OR 3.8; CI 1.03 - 14) and if their mothers had given birth previously (OR 6.7; CI 1.35 - 33). Infants who had any naso-oropharyngeal suctioning administered at birth were six times less likely to suckle effectively (OR .176; CI .04 - .9). Conclusion Effective suckling within the first hour of life was associated with a collection of practices including infants positioned so their chin can instinctively nudge the underside of their mother’s breast as they approach to grasp the nipple and attach to suckle. The best type of assistance provided in the birthing room that enables newborns to sustain an effective latch was paying attention to newborn feeding behaviours and not administering naso-oropharyngeal suction routinely