TO THE QUESTION ABOUT «DESIGN MANAGEMENT» AS AN INNOVATIVE DIRECTION IN PREPARING STUDENT DESIGNERS

This article discusses the issue of a new conceptual direction of training specialists in the field of design - “design management”, since a modern designer should not only have professional knowledge and skills, create a holistic harmonious image in accordance with the task, create new promising image projects, on based on modern information technology, predict future design trends, but also own business tools, be market oriented and end-user people helping organizations make design decisions.В данной статье рассматривается вопрос о новом концептуальном направлении подготовки специалистов в сфере дизайна – «дизайн-менеджмент», поскольку современный дизайнер должен не только обладать профессиональными знаниями и навыками, формировать целостный гармоничный образ в соответствии с поставленной задачей, создавать новые перспективные имиджевые проект на основе современных информационных технологий, прогнозировать будущие тенденции дизайна, но и владеть инструментами бизнеса, быть ориентированным на рынок и конечного потребителя, помогать организациям принимать решения по вопросам дизайна

Hyperpolarized 83Kr magnetic resonance imaging of alveolar degradation in a rat model of emphysema

Hyperpolarized 83Kr surface quadrupolar relaxation (SQUARE) generates MRI contrast that was previously shown to correlate to surface to volume ratios in porous model surface systems. The underlying physics of SQUARE contrast is conceptually different from any other current MRI methodology as the method utilizes the nuclear electric properties of the spin I = 9/2 isotope 83Kr. To explore the usage of this non-radioactive isotope for pulmonary pathophysiology, MRI SQUARE contrast was acquired in excised rat lungs obtained from an elastase induced model of emphysema. A significant 83Kr T1 relaxation time increase in the SQUARE contrast was found in the elastase treated lungs compared to the baseline data from control lungs. The SQUARE contrast suggests a reduction in pulmonary surface to volume ratio in the emphysema model that was validated by histology. The finding supports usage of 83Kr SQUARE as new biomarker for surface to volume ratio changes in emphysema

The relationship between challenging behaviour, burnout and cognitive variables in staff working with people who have intellectual disabilities

Introduction There is evidence to suggest a relationship between the way in which staff perceive challenging behaviour and burnout in staff working with people with intellectual disabilities and challenging behaviour. However the evidence of a direct link is equivocal and it is possible that a number of different variables mediate this relationship. The aim of the study is to confirm whether there is a relationship between challenging behaviour and staff burnout, and in addition, to test whether staff perceptions about challenging behaviour mediate this relationship. Method Seventy-eight staff completed measures of burnout, challenging behaviour and perceptions about challenging behaviour. The perceptions explored included beliefs about the timeline of behaviour, staff’s perception of whether they themselves have control over the behaviour, beliefs about clients’ ability to control the behaviour and staff’s negative emotional responses. Results Significant positive correlations were found between challenging behaviour and burnout, challenging behaviour and cognitive variables, and cognitive variables and burnout. Regression analyses demonstrated that negative emotions mediate the relationship between challenging behaviour and burnout. Conclusion The results show evidence that there is a relationship between challenging behaviour and burnout which is mediated by negative emotion, namely the fear of potential assault.EThOS - Electronic Theses Online ServiceGBUnited Kingdo

System Approach to the Development of Intelligent Complexes of Oncological Diagnostics

The system approach to the development of intellectual complexes in cancer diagnosis are discussed in the article. Distinctive features of this approach: the participation of pathologist at the stage of description of recognizable images (the description is based on traditional assessments of quality informative features of tumors); the set of the most similar probabilistic diagnoses is forming on the classification stage of recognition; final histological diagnosis is made by pathologist. The proposed approach has been successfully tested in clinical practice. Keywords: image processing, image description, image classification, pattern recognition, qualitative attributes of tumor images, interactive recognition, cancer diagnosis, decision support syste

Statistics of highly heterogeneous flow fields confined to three-dimensional random porous media

We present a strong relationship between the microstructural characteristics of, and the fluid velocity fields confined to, three-dimensional random porous materials. The relationship is revealed through simultaneously extracting correlation functions R-uu (r) of the spatial (Eulerian) velocity fields and microstructural two-point correlation functions S-2(r) of the random porous heterogeneous materials. This demonstrates that the effective physical transport properties depend on the characteristics of complex pore structure owing to the relationship between R-uu (r) and S-2(r) revealed in this study. Further, the mean excess plot was used to investigate the right tail of the streamwise velocity component that was found to obey light-tail distributions. Based on the mean excess plot, a generalized Pareto distribution can be used to approximate the positive streamwise velocity distribution

Taxonomic structure of bacterial communities in sourdoughs of spontaneous fermentation

The article is devoted to the study of the microbiome of spontaneously fermented sourdoughs. The aim of the work was to study the influence of the technological parameters of sourdough propagations on the taxonomic structure of the microbiome of spontaneously fermented sourdoughs. Two spontaneously fermented sourdoughs were studied: dense rye sourdough and liquid rye sourdough, both prepared using the same batch of peeled rye flour. To study the taxonomic structure of the sourdough microbiome in dynamics, the method of high-throughput sequencing of 16S rRNA gene fragments of microorganisms was used. It was shown that the technological parameters of sourdough (humidity, temperature) do not affect the taxonomic composition of the microbiome of dense rye or liquid rye sourdough at the phylum/class/genus level. It was found that during the first three days of propagations, bacteria from the phyla Proteobacteria and Firmicutes dominated in the microbial community. In the phylum Proteobacteria, microorganisms from the order Enterobacterales took a large share, which persisted for three days of backslopping. The phylum Firmicutes was represented by lactic acid bacteria of the genera Weissella, Lactobacillus, Leuconostoc, Pediococcus, Lactococcus. It was established by classical microbiological methods that after a day of fermentation, the number of lactic acid bacteria cells was significantly higher in liquid rye sourdough compared to dense one. However, with further propagation of sourdoughs, the number of cells was comparable, while significant changes occurred at the level of genera and species. It was shown that as the relative number of lactic acid bacteria of the genus Lactobacillus increased, a gradual displacement of the coccal forms of Lactococcus, Leuconostoc, Weissella, Pediococcus happened. With further propagation of sourdough after 10 days, the position of the dominant groups of bacteria was occupied by representatives of the phylum Firmicutes, lactic acid bacteria of the genus Lactobacillus. The influence of the mode and parameters of the sourdough on the species composition of lactobacilli, which demonstrated a low bacterial diversity, is shown. In the first three days of propagations, lactobacilli L. curvatus, L. brevis, and Lactiplantibacillus sp. dominated in both sourdoughs. After a month of backslopping, Fructilactobacillus sanfranciscensis and Companilactobacillus sp. dominated in dense rye sourdough, and L. pontis dominated in liquid rye sourdough

ИСПОЛЬЗОВАНИЕ КОМПЬЮТЕРИЗИРОВАННОГО МЕТОДА ИССЛЕДОВАНИЯ СКОРОСТИ РЕАКЦИИ И ТОЧНОСТИ МОТОРИКИ РУК У ПАЦИЕНТОВ С АРТЕРИАЛЬНОЙ ГИПЕРТЕНЗИЕЙ

The results of examination of the motility accuracy and speed in patients with arterial hypertension depending of the arterial hypertension level and cognitive disorders are shown.Приведены результаты оценки скорости реакции и точности моторики рук у пациентов с артериальной гипертензией в зависимости от степени заболевания и наличия когнитивного снижения

Hyperpolarised xenon MRI and time-resolved X-ray computed tomography studies of structure-transport relationships in hierarchical porous media

© 2020 Elsevier B.V. Catalysed diesel particulate filter (DPF) monoliths are hierarchical porous solids, as demonstrated by mercury porosimetry. Establishing structure-transport relationships, including assessing the general accessibility of the catalyst, is challenging, and, thus, a comprehensive approach is necessary. Contributions, from each porosity level, to transport have been established using hyperpolarised (hp) xenon-129 magnetic resonance imaging (MRI) of gas dispersion within DPF monoliths at variable water saturation, since X-ray Computerised-Tomography, and 1H and 2H NMR methods, have shown that porosity levels dry out progressively. At high saturation, hp 129Xe MRI showed gas transport between the channels of the monolith is predominantly taking place at channel wall intersections with high macroporosity. The walls themselves make a relatively small contribution to through transport due to the distribution of the micro-/meso-porous washcoat layer away from intersections. Only at low saturation, when the smallest pores are opened, do hp 129Xe MR images became strongly affected by relaxation. This observation indicates accessibility of paramagnetic (catalytic) centres for gases arises only once the smallest pores are open

Трансформированный вариант диффузной В-клеточной крупноклеточной лимфомы желудка у пациентки с сочетанием болезни Шегрена и системной склеродермии (описание случая и обзор литературы)

This article describes a case of a transformed diffuse large B-cell lymphoma of the stomach in a patient with Sjogren’s disease (SjD) and systemic sclerosis (SSc), as well as a brief review of the literature on lymphoproliferative diseases in SjD and SSc.Представлены описание случая трансформированного варианта диффузной В-клеточной крупноклеточной лимфомы желудка у пациентки с болезнью Шегрена (БШ) и лимитированной системной склеродермией (ССД), а также краткий обзор литературы, посвященной лимфопролиферативным заболеваниям при БШ и ССД. Обсуждаются связи между указанными состояниями

Формирование сложных радиационных дефектов в облучаемых материалах

The principles of formation of the complex vacancy defects (V-clusters), their ensembles and patterns of formation of superlattices of the V-clusters are determined. The inclusion of the drift component of the elementary defects into the field of elastic stresses of the V-cluster in the analysis allowed describing its genesis and development adequately. The mechanisms of motion of the V-clusters in the material are described in detail, considering their interaction with each other. The authors have developed the original physical and mathematical formalism within which it has become possible to describe the order-disorder phase transition when an ensemble of clusters chaotically distributed in the irradiated solid transforms into an ordered coherent superlattice. The critical point of the phase transition and the parameters of the defect lattice itself are determined. They are confirmed by the experimental results. The ordering process in this system is understood as the motion of the undamped wave of order parameter through the material, while other configuration states of the V-cluster ensemble constitute rapidly damping fluctuations. The article also shows the mechanism of linking the symmetry of the V-cluster superlattice to the symmetry of the initial crystal.Установлены принципы образования сложных вакансионных дефектов (V-кластеров), их ансамблей и закономерности формирования сверхрешеток V-кластеров. Учет дрейфовой составляющей элементарных дефектов в поле упругих напряжений V-кластера позволил адекватно описать его зарождение и развитие. Детально описаны механизмы движения V-кластеров в материале с учетом их взаимодействия друг с другом. Предложен оригинальный физико-математический формализм, в рамках которого оказалось возможным описать фазовый переход беспорядок–порядок, когда ансамбль хаотически распределенных в облучаемом твердом теле V-кластеров переходит в упорядоченное когерентное состояние – сверхрешетку. Строго определена критическая точка фазового перехода и параметры самой решетки дефектов, которые подтверждаются результатами эксперимента. Процесс упорядочения в данной системе представляется движением по материалу незатухающей волны параметра порядка, в то время как другие конфигурационные варианты состояния ансамбля V-кластеров являются быстрозатухающими флуктуациями. Показан механизм связи симметрии сверхрешетки V-кластеров и симметрии исходного кристалла