Prevalence of metabolic syndrome in baluch women in Chabahar

Epidemiological studies have shown the importance of the metabolic syndrome. With estimation of the metabolic syndrome, it may predict cardiovascular disease, sudden death and the presence of some other cardiovascular risk factors. The aim of this study was to assess the metabolic syndrome among Baluch women. Our study consisted of 120 Baluch women. Baseline data of Baluch women, prevalence of metabolic syndrome and its components and distribution of body mass index were determined. The mean Body Mass Index (BMI), waist circumference, systolic blood pressure, triglyceride, High Density Lipoprotein-Cholesterol (HDL-Chol.) and fasting blood glucose levels were significantly higher in the subjects with metabolic syndrome. The prevalence of HDL-cholesterol, high triglyceride, high fasting glucose levels, high waist circumference and high blood pressure were shown to be 33.3, 20.8, 12.5, 11.8 and 2.5, respectively. HDL-cholesterol (33.3) and high triglyceride levels (20.8) were the most frequent characteristics of metabolic components. The prevalence of subject with normal weight, overweight and obese BMIs were 77.5, 15 and 7.5, respectively. About 9.17, 4.17 and 4.17 of Baluch women had three, four and five criteria of metabolic syndrome components, respectively. This study reveals that there is a significant difference in the metabolic syndrome components in patients with and without metabolic syndrome. The prevalence of HDL-cholesterol and high triglyceride in Baluch women was highest. Definition of metabolic syndrome may help physicians to estimate, decrease and prevent coronary heart disease and cardiovascular morbidity and mortality in subjects with metabolic syndrome. © 2015 Asian Network for Scientific Information

Hydrology and hydrobiology of Chaloos River

The Chaloos River originates from Alborz Mountain and enters into the Caspian Sea in Chaloos city. Five stations were chosen in different areas for the study during 1371 to 1372 (1992-93). Total variation range of hardness decreased 1 to 5 station, but measure NH4 and NO3 increased. 45 genera belongs to 4 phyla of phytoplankton as follows: Chrysophyta, Chlorophyta, Euglenophyta and Cyanophyta. Zooplankton existing in this river belong to animal classes, which had more abundance in Sarcodina and Monogononta. The benthos river establish Insecta larvae of Ephemeroptera, Coleoptera, Diptera, Plecoptera and Odonata (Orders). Chaloos fishes included to 4 families, 10 genera and 12 species. Cyprinidac consisted 66.7% of total fish and had maximum diversity at the various stations

A tile model of circuit topology for self-entangled biopolymers

Building on the theory of circuit topology for intra-chain contacts in entangled proteins, we introduce tiles as a way to rigorously model local entanglements which are held in place by molecular forces. We develop operations that combine tiles so that entangled chains can be represented by algebraic expressions. Then we use our model to show that the only knot types that such entangled chains can have are 3(1), 4(1), 5(1), 5(2), 6(1), 6(2), 6(3), 7(7), 8(12) and connected sums of these knots. This includes all proteins knots that have thus far been identified.Pharmacolog

Random forest and live single‐cell metabolomics reveal metabolic profiles of human macrophages upon polarization

Human macrophages are innate immune cells with diverse, functionally distinct phenotypes, namely, pro-inflammatory M1 and anti-inflammatory M2 macrophages. Both are involved in multiple physiological and pathological processes, including would healing, infection, and cancer. However, the metabolic differences between these phenotypes are largely unexplored at single-cell resolution. To address this knowledge gap, an untargeted live single-cell mass spectrometry-based metabolomic profiling coupled with a machine-learning data analysis approach was developed to investigate the metabolic profile of each phenotype at the single-cell level. Results show that M1 and M2 macrophages have distinct metabolic profiles, with differential levels of fatty acyls, glycerophospholipids, and sterol lipids, which are important components of plasma membrane and involved in multiple biological processes. Furthermore, we could discern several putatively annotated molecules that contribute to inflammatory response of macrophages. The combination of random forest and live single-cell metabolomics provided an in-depth profile of the metabolome of primary human M1 and M2 macrophages at the single-cell level for the first time, which will pave the way for future studies targeting the differentiation of other immune cells.Pharmacolog

In Vitro and in Vivo Effectiveness of Carvacrol, Thymol and Linalool against Leishmania infantum

Background: One of the most important causative agents of visceral leishmaniasis (VL) is Leishmania infantum, which is mainly spread by Phlebotomus and Lutzomyia sandflies in the Old and New World, respectively. Novel and effective drugs to manage this neglected vector-borne disease are urgently required. In this study, we evaluated the toxicity of carvacrol, thymol and linalool, three common essential oil constituents, on amastigotes and promastigotes of L. infantum. Methods: in vitro experiments were performed by 24 h MTT assay. Carvacrol, thymol and linalool at concentrations ranging from 1.3 to 10 µg/mL were tested on promastigotes of L. infantum. For in vivo test, two groups of hamsters (Mesocricetus auratus) received 100 mg/kg of body weight/day of carvacrol and thymol as intraperitoneal injection on day 7 post-infection, followed by a 48 h later injection. The third group was treated with the glucantime as standard drug (500 mg/kg) and the last group (control) just received normal saline. On the 16th day, the number of parasites and histopathological changes in liver and spleen were investigated. Results: 24 h MTT assay showed promising antileishmanial activity of thymol and carvacrol, with IC50 values of 7.2 (48 µM) and 9.8 µg/mL (65 µM), respectively. Linalool at all concentrations did not affect L. infantum promastigote viability. In vivo toxicity data of carvacrol and thymol showed that the former at 100 mg/kg was the safest and most effective treatment with little side effects on the liver. Conclusions: Overall, thymol and carvacrol are highly promising candidates for the development of effective and safe drugs in the fight against VL

Rainfall trend analysis and geospatial mapping of the Kelantan River Basin

Trend analysis was widely used as a tool to detect changes in climatic and hydrologic time series data such as rainfall. Fourteen rainfall stations in the Kelantan River Basin were used to detect trends for each of the sub-basin areas. Two objectives of the study are (i) to quantify the changing trends of rainfall of Kelantan River using statistical tests (i.e., Mann-Kendall test and Sen’s slope test) based on monthly, seasonal, and annual time series, and secondly, (ii) to map rainfall trend according to Mann-Kendall test result. Analysis for these two tests revealed that several stations indicated significant increasing and decreasing trends for monthly, seasonal, and annual rainfall time series. The study found that rainfall varies in different months, seasons, and annually as evidenced by the graph and trend maps. Therefore, this information will benefit especially for flood preparation and responses in Kelantan River Basin which annually experiences monsoon flooding

Study of penculture of the common carp (Cyprinus carpio L.) fingerlings at the Gorgan Bay to the maturity stage (broodstock management)

The aim of present project is study on the possibilities of brood stock production from fingerlings in the penculture condition and the effect of density on it .this project was done during three years with two different treatment and three repetitions in the Gorgan Bay. First treatment with two fingerlings per square meter and the 2nd with four fingerlings per square meter in each pen.To carry out the project at first fingerlings were brought from breeding and recruitment centre –Sijeval (Kolmeh) and the stocked at the earthen pound with concentrated food .After that they were adaptated with brakish water between 7-10 days and transferred to Gorgan Bay for cultivation with average weight of 93.78±32.66 grams and 20.53±2.37 cm in length. It should be noted that 6 pens (which surrounded by nets in the water) were fixed using mast with 15-20 cm in diameter and 5.5 meter in length , Net mesh size was 16 mm with string number 33 of kapron.Feeding was done according to the program two times by giving concentrated food at the period of cultivation Physic -o -chemical factors were measured. biometery was done monthly at each pen and other fishes (unwanted) were observed at the same time. results indicate that in the 1st and 2nd treatments average survival rate was 52.3 and 41 percent respectively with average weight of 410±64.98 grams and 390±52.8 and 28.3±1.79 cm and 27.66±1.57in length. SPSS used to analysethe data such as average length and weight of fish in the treatments and in different months with ANOVA method (p≤ 0.05) . results show that there is no significant difference between treatments. Autopsy observation also showed that fishes (female and male) are mature and histological studies showed that most of observed eggs are entirely mature with 800-1200 micron diameter gonad ( male) were mature at the pen in the Gorgan Bay condition .The male and female hormones were evaluated. 17-B- Estradiol and 11-keto testosterone hormones for adult fish (female and male) parents respectively are similar in dense with those adult fish before injection to use at the artificial breeding. Maturation were verified by autopsy, histology and hormone studies

Impact of maternal education on response to lifestyle interventions to reduce gestational weight gain: Individual participant data meta-Analysis

Objectives To identify if maternal educational attainment is a prognostic factor for gestational weight gain (GWG), and to determine the differential effects of lifestyle interventions (diet based, physical activity based or mixed approach) on GWG, stratified by educational attainment. Design Individual participant data meta-Analysis using the previously established International Weight Management in Pregnancy (i-WIP) Collaborative Group database (https://iwipgroup.wixsite.com/collaboration). Preferred Reporting Items for Systematic reviews and Meta-Analysis of Individual Participant Data Statement guidelines were followed. Data sources Major electronic databases, from inception to February 2017. Eligibility criteria Randomised controlled trials on diet and physical activity-based interventions in pregnancy. Maternal educational attainment was required for inclusion and was categorised as higher education ( 65tertiary) or lower education ( 64secondary). Risk of bias Cochrane risk of bias tool was used. Data synthesis Principle measures of effect were OR and regression coefficient. Results Of the 36 randomised controlled trials in the i-WIP database, 21 trials and 5183 pregnant women were included. Women with lower educational attainment had an increased risk of excessive (OR 1.182; 95% CI 1.008 to 1.385, p =0.039) and inadequate weight gain (OR 1.284; 95% CI 1.045 to 1.577, p =0.017). Among women with lower education, diet basedinterventions reduced risk of excessive weight gain (OR 0.515; 95% CI 0.339 to 0.785, p = 0.002) and inadequate weight gain (OR 0.504; 95% CI 0.288 to 0.884, p=0.017), and reduced kg/week gain (B-0.055; 95% CI-0.098 to-0.012, p=0.012). Mixed interventions reduced risk of excessive weight gain for women with lower education (OR 0.735; 95% CI 0.561 to 0.963, p=0.026). Among women with high education, diet based interventions reduced risk of excessive weight gain (OR 0.609; 95% CI 0.437 to 0.849, p=0.003), and mixed interventions reduced kg/week gain (B-0.053; 95% CI-0.069 to-0.037,p<0.001). Physical activity based interventions did not impact GWG when stratified by education. Conclusions Pregnant women with lower education are at an increased risk of excessive and inadequate GWG. Diet based interventions seem the most appropriate choice for these women, and additional support through mixed interventions may also be beneficial

Mortality from gastrointestinal congenital anomalies at 264 hospitals in 74 low-income, middle-income, and high-income countries: a multicentre, international, prospective cohort study

Background: Congenital anomalies are the fifth leading cause of mortality in children younger than 5 years globally. Many gastrointestinal congenital anomalies are fatal without timely access to neonatal surgical care, but few studies have been done on these conditions in low-income and middle-income countries (LMICs). We compared outcomes of the seven most common gastrointestinal congenital anomalies in low-income, middle-income, and high-income countries globally, and identified factors associated with mortality. // Methods: We did a multicentre, international prospective cohort study of patients younger than 16 years, presenting to hospital for the first time with oesophageal atresia, congenital diaphragmatic hernia, intestinal atresia, gastroschisis, exomphalos, anorectal malformation, and Hirschsprung's disease. Recruitment was of consecutive patients for a minimum of 1 month between October, 2018, and April, 2019. We collected data on patient demographics, clinical status, interventions, and outcomes using the REDCap platform. Patients were followed up for 30 days after primary intervention, or 30 days after admission if they did not receive an intervention. The primary outcome was all-cause, in-hospital mortality for all conditions combined and each condition individually, stratified by country income status. We did a complete case analysis. // Findings: We included 3849 patients with 3975 study conditions (560 with oesophageal atresia, 448 with congenital diaphragmatic hernia, 681 with intestinal atresia, 453 with gastroschisis, 325 with exomphalos, 991 with anorectal malformation, and 517 with Hirschsprung's disease) from 264 hospitals (89 in high-income countries, 166 in middle-income countries, and nine in low-income countries) in 74 countries. Of the 3849 patients, 2231 (58·0%) were male. Median gestational age at birth was 38 weeks (IQR 36–39) and median bodyweight at presentation was 2·8 kg (2·3–3·3). Mortality among all patients was 37 (39·8%) of 93 in low-income countries, 583 (20·4%) of 2860 in middle-income countries, and 50 (5·6%) of 896 in high-income countries (p<0·0001 between all country income groups). Gastroschisis had the greatest difference in mortality between country income strata (nine [90·0%] of ten in low-income countries, 97 [31·9%] of 304 in middle-income countries, and two [1·4%] of 139 in high-income countries; p≤0·0001 between all country income groups). Factors significantly associated with higher mortality for all patients combined included country income status (low-income vs high-income countries, risk ratio 2·78 [95% CI 1·88–4·11], p<0·0001; middle-income vs high-income countries, 2·11 [1·59–2·79], p<0·0001), sepsis at presentation (1·20 [1·04–1·40], p=0·016), higher American Society of Anesthesiologists (ASA) score at primary intervention (ASA 4–5 vs ASA 1–2, 1·82 [1·40–2·35], p<0·0001; ASA 3 vs ASA 1–2, 1·58, [1·30–1·92], p<0·0001]), surgical safety checklist not used (1·39 [1·02–1·90], p=0·035), and ventilation or parenteral nutrition unavailable when needed (ventilation 1·96, [1·41–2·71], p=0·0001; parenteral nutrition 1·35, [1·05–1·74], p=0·018). Administration of parenteral nutrition (0·61, [0·47–0·79], p=0·0002) and use of a peripherally inserted central catheter (0·65 [0·50–0·86], p=0·0024) or percutaneous central line (0·69 [0·48–1·00], p=0·049) were associated with lower mortality. // Interpretation: Unacceptable differences in mortality exist for gastrointestinal congenital anomalies between low-income, middle-income, and high-income countries. Improving access to quality neonatal surgical care in LMICs will be vital to achieve Sustainable Development Goal 3.2 of ending preventable deaths in neonates and children younger than 5 years by 2030