Mayonesas y aderezos adicionados con extracto de jamaica (Hibiscus sabdariffa L.)

La jamaica (Hibiscus sabdariffa L.) es una especie vegetal que destaca por sus propiedades medicinales como reducir el colesterol y disminuir la presión arterial. En México se cosechan 18 mil hectáreas de jamaica con un rendimiento promedio de 265 kg/ha. Posee una gran cantidad de antioxidantes, principalmente antocianinas. El objetivo de este trabajo fue emplear el extracto de Jamaica para la elaboración de mayonesas y aderezos con un valor agregado. Se elaboraron tres formulaciones: MCtrl (73% de aceite y 0% de extracto), MJ1 (64.15% de aceite y 20% de extracto) y ADJ2 (54.15% de aceite y 30% de extracto) a las cuales se les midió el tamaño de partícula, y para las formulaciones MJ1 y ADJ2 se realizó una descripción organoléptica. Los resultados de tamaño de partícula indicaron que la formulación ADJ2 es la más estable. En la prueba hedónica el 66.67% de los jueces dijo que les disgustaba ligeramente las formulación MJ1, y el 33.33% que le gustaba ligeramente. Por lo que en base a estos resultados hay que disminuir el sabor ácido que aporta el extracto de jamaica a las formulaciones empleando algún saborizante

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ABSTRACT. The tumor necrosis factor-alpha (TNF-α) gene plays an important role in cell proliferation, differentiation, apoptosis, lipid metabolism, coagulation, insulin resistance, and endothelial function. Polymorphisms of TNF-α have been associated with cancer. We examined the role of the -308G>A polymorphism in this gene by comparing the genotypes of 294 healthy Mexican women with those of 465 Mexican women with breast cancer. The observed genotype frequencies for controls and breast cancer patients were 1 and 14% for AA, 13 and 21% for GA, and 86 and 65% for GG, respectively. We found that the odds ratio (OR) for AA genotype was 2.4, with a 95% confidence interval (95%CI) of 5.9-101.1 (P = 0.0001). The association was also evident when comparing the distribution of the AA-GA genotype in patients in the following categories: 1) premenopause and obesity I (OR = 3.5, 95%CI = 1.3-9.3, P = 0.008), 2) Her-2 neu and tumor stage I-II (OR = 2.5, 95%CI = 1.31-4.8, P = 0.004), 3) premenopause and tumor stage III-IV (OR = 1.7, 95%CI = 1.0-2.9, P = 0.034), 4) chemotherapy non-response and abnormal hematocrit (OR = 2.4, 95%CI = 1.2-4.8, P = 0.015), 5) body mass index and Her-2 neu and III-IV tumor stage (OR = 2.8, 95%CI = 1.2-6.6, P = 0.016), and 6) nodule metastasis and K-I67 (OR = 4.0, 95%CI = 1.01-15.7, P = 0.038). We concluded that the genotypes AA-GA of the -308G>A polymorphism in TNF-α significantly contribute to breast cancer susceptibility in the analyzed sample from the Mexican population

Tissue culture of ornamental cacti

Cacti species are plants that are well adapted to growing in arid and semiarid regions where the main problem is water availability. Cacti have developed a series of adaptations to cope with water scarcity, such as reduced leaf surface via morphological modifications including spines, cereous cuticles, extended root systems and stem tissue modifications to increase water storage, and crassulacean acid metabolism to reduce transpiration and water loss. Furthermore, seeds of these plants very often exhibit dormancy, a phenomenon that helps to prevent germination when the availability of water is reduced. In general, cactus species exhibit a low growth rate that makes their rapid propagation difficult. Cacti are much appreciated as ornamental plants due to their great variety and diversity of forms and their beautiful short-life flowers; however, due to difficulties in propagating them rapidly to meet market demand, they are very often over-collected in their natural habitats, which leads to numerous species being threatened, endangered or becoming extinct. Therefore, plant tissue culture techniques may facilitate their propagation over a shorter time period than conventional techniques used for commercial purposes; or may help to recover populations of endangered or threatened species for their re-introduction in the wild; or may also be of value to the preservation and conservation of the genetic resources of this important family. Herein we present the state-of-the-art of tissue culture techniques used for ornamental cacti and selected suggestions for solving a number of the problems faced by members of the Cactaceae family

Results of the COVID-19 mental health international for the general population (COMET-G) study.

INTRODUCTION: There are few published empirical data on the effects of COVID-19 on mental health, and until now, there is no large international study. MATERIAL AND METHODS: During the COVID-19 pandemic, an online questionnaire gathered data from 55,589 participants from 40 countries (64.85% females aged 35.80 ± 13.61; 34.05% males aged 34.90±13.29 and 1.10% other aged 31.64±13.15). Distress and probable depression were identified with the use of a previously developed cut-off and algorithm respectively. STATISTICAL ANALYSIS: Descriptive statistics were calculated. Chi-square tests, multiple forward stepwise linear regression analyses and Factorial Analysis of Variance (ANOVA) tested relations among variables. RESULTS: Probable depression was detected in 17.80% and distress in 16.71%. A significant percentage reported a deterioration in mental state, family dynamics and everyday lifestyle. Persons with a history of mental disorders had higher rates of current depression (31.82% vs. 13.07%). At least half of participants were accepting (at least to a moderate degree) a non-bizarre conspiracy. The highest Relative Risk (RR) to develop depression was associated with history of Bipolar disorder and self-harm/attempts (RR = 5.88). Suicidality was not increased in persons without a history of any mental disorder. Based on these results a model was developed. CONCLUSIONS: The final model revealed multiple vulnerabilities and an interplay leading from simple anxiety to probable depression and suicidality through distress. This could be of practical utility since many of these factors are modifiable. Future research and interventions should specifically focus on them

Familial hypercholesterolaemia in children and adolescents from 48 countries: a cross-sectional study

Background: Approximately 450 000 children are born with familial hypercholesterolaemia worldwide every year, yet only 2·1% of adults with familial hypercholesterolaemia were diagnosed before age 18 years via current diagnostic approaches, which are derived from observations in adults. We aimed to characterise children and adolescents with heterozygous familial hypercholesterolaemia (HeFH) and understand current approaches to the identification and management of familial hypercholesterolaemia to inform future public health strategies. Methods: For this cross-sectional study, we assessed children and adolescents younger than 18 years with a clinical or genetic diagnosis of HeFH at the time of entry into the Familial Hypercholesterolaemia Studies Collaboration (FHSC) registry between Oct 1, 2015, and Jan 31, 2021. Data in the registry were collected from 55 regional or national registries in 48 countries. Diagnoses relying on self-reported history of familial hypercholesterolaemia and suspected secondary hypercholesterolaemia were excluded from the registry; people with untreated LDL cholesterol (LDL-C) of at least 13·0 mmol/L were excluded from this study. Data were assessed overall and by WHO region, World Bank country income status, age, diagnostic criteria, and index-case status. The main outcome of this study was to assess current identification and management of children and adolescents with familial hypercholesterolaemia. Findings: Of 63 093 individuals in the FHSC registry, 11 848 (18·8%) were children or adolescents younger than 18 years with HeFH and were included in this study; 5756 (50·2%) of 11 476 included individuals were female and 5720 (49·8%) were male. Sex data were missing for 372 (3·1%) of 11 848 individuals. Median age at registry entry was 9·6 years (IQR 5·8-13·2). 10 099 (89·9%) of 11 235 included individuals had a final genetically confirmed diagnosis of familial hypercholesterolaemia and 1136 (10·1%) had a clinical diagnosis. Genetically confirmed diagnosis data or clinical diagnosis data were missing for 613 (5·2%) of 11 848 individuals. Genetic diagnosis was more common in children and adolescents from high-income countries (9427 [92·4%] of 10 202) than in children and adolescents from non-high-income countries (199 [48·0%] of 415). 3414 (31·6%) of 10 804 children or adolescents were index cases. Familial-hypercholesterolaemia-related physical signs, cardiovascular risk factors, and cardiovascular disease were uncommon, but were more common in non-high-income countries. 7557 (72·4%) of 10 428 included children or adolescents were not taking lipid-lowering medication (LLM) and had a median LDL-C of 5·00 mmol/L (IQR 4·05-6·08). Compared with genetic diagnosis, the use of unadapted clinical criteria intended for use in adults and reliant on more extreme phenotypes could result in 50-75% of children and adolescents with familial hypercholesterolaemia not being identified. Interpretation: Clinical characteristics observed in adults with familial hypercholesterolaemia are uncommon in children and adolescents with familial hypercholesterolaemia, hence detection in this age group relies on measurement of LDL-C and genetic confirmation. Where genetic testing is unavailable, increased availability and use of LDL-C measurements in the first few years of life could help reduce the current gap between prevalence and detection, enabling increased use of combination LLM to reach recommended LDL-C targets early in life

Study of the pull-in voltage for MEMS parallel plate capacitor actuators

This paper provides new investigation for the static and dynamic behavior of a MEMS parallel plate capacitor derived by analytical and numerical design modeling programs developed in Matlab. One significant finding is about the role, which has so far overlooked in many analyses, of a dielectric layer normally placed on top of the ground electrode to avoid short circuiting risks. It is demonstrated in this paper that this layer produces an increased force between electrodes that in turns decreases the well-known pull-in voltage, V pi, as compared to the one calculated when this dielectric layer is not considered on the system's static analysis. Expressions for the static V pi and its corresponding maximum stable electrode swing x pi are derived to take the above effect into account. The system dynamic analysis is done with a user-friendly Simulink interface constructed to allow easy introduction of capacitor design dimensions, material parameter values and voltage signal stimuli. The impact of any combination of these parameters on the electro-mechanical system behavior, that is, the voltage-electrode position dependence data can be easily extracted and become of help for design decision making on the early design stages of this type of structures. This modeling tool interface is based on solving the full differential equation that describes the free electrode displacement without relying on linearizing the inverse quadratic electrode separation dependence of the electro-static force term. This approach intrinsically takes into account the voltage dependant k-spring softening effect derived precisely from a linearizing simplification. Finally, by applying a saw-tooth voltage waveform, the dynamic pull-in voltage and the maximum stable electrode travel range are observed to go well beyond the predicted static pull-in voltage and travel range values

Study of the pull-in voltage for MEMS parallel plate capacitor actuators

This paper provides new investigation for the static and dynamic behavior of a MEMS parallel plate capacitor derived by analytical and numerical design modeling programs developed in Matlab. One significant finding is about the role, which has so far overlooked in many analyses, of a dielectric layer normally placed on top of the ground electrode to avoid short circuiting risks. It is demonstrated in this paper that this layer produces an increased force between electrodes that in turns decreases the well-known pull-in voltage, V pi, as compared to the one calculated when this dielectric layer is not considered on the system's static analysis. Expressions for the static V pi and its corresponding maximum stable electrode swing x pi are derived to take the above effect into account. The system dynamic analysis is done with a user-friendly Simulink interface constructed to allow easy introduction of capacitor design dimensions, material parameter values and voltage signal stimuli. The impact of any combination of these parameters on the electro-mechanical system behavior, that is, the voltage-electrode position dependence data can be easily extracted and become of help for design decision making on the early design stages of this type of structures. This modeling tool interface is based on solving the full differential equation that describes the free electrode displacement without relying on linearizing the inverse quadratic electrode separation dependence of the electro-static force term. This approach intrinsically takes into account the voltage dependant k-spring softening effect derived precisely from a linearizing simplification. Finally, by applying a saw-tooth voltage waveform, the dynamic pull-in voltage and the maximum stable electrode travel range are observed to go well beyond the predicted static pull-in voltage and travel range values