CORRELATION OF ASPARTATE AMINOTRANSFERASE TO PLATELET RATIO INDEX (APRI) WITH THE DEGREE OF SEVERITY LIVER ORGAN IN CIRRHOSIS HEPATIC PATIENTS

Background: Cirrhosis hepatic is a chronic liver disease characterized by the replacement of liver tissue into scar tissue resulting in decreased liver function. The patient's diagnosis is gold standard for cirrhosis hepatic by invasive assessment cause tissue damage. The development of the way of diagnosis with secondary markers is APRI score was considered quite good in determining cirrhosis hepatic. On the other to, there is a method for assessing the severity of the liver organ in patients with cirrhosis hepatic using the Child-Pugh score. APRI scores and Child-Pugh scores are based on the calculation of secondary markers caused by hepatocyte cell fungtional damage. This is very useful in the early diagnosis of cirrhosis hepatic patients using simple markers and predicting the severity of the liver organ to assess further prognosis and management. Objective: To knowing the correlation of APRI index with the degree of severity liver organ in cirrhosis hepatic patients in RSUD Prof. dr. Margono Soekarjo. Specifically, it aims to determine the APRI score and Child-Pugh score in patients with cirrhosis hepatic. Methods: This study used a cross sectional design with a sample of 31 patients with a diagnosis of cirrhosis hepatic which was selected using a consecutive sampling technique. Primary data were obtained from a one-time blood sampling calculation and secondary data were obtained from medical records from patients with a diagnosis of liver cirrhosis from the physician in charge. Hypothesis analysis using Pearson correlation test. Resuls: Pearson test results showed a significant difference p = 0.024 (p <0.05) with the strength of the relationship r = 0.404 and the direction of a positive relationship on the correlation of APRI scores and Child-Pugh scores. Conclusions: There is a significant correlation between APRI scores with the degree of severity liver organ in cirrhosis hepatic patients in RSUD Prof. dr. Margono Soekarjo. The average APRI score in patients cirrhosis hepatic is 3, 107. The Child-Pugh score for the degree of severity liver organ is 8 or in the category of Child-Pugh B or moderate category

Philanthropism in Charles Dickens's a Christmas Carol: a Genetic Structuralism Analysis

Artikel ini menganalisis tentang pandangan dunia Charles Dickens yang terdapat dalam karyanya yang berjudul A Christmas Carol. Tujuan artikel ini adalah untuk menjelaskan pandangan dunia yang dimiliki oleh Charles Dickens serta tujuan Charles Dickens memasukkan pandangan dunianya tersebut ke dalam karyanya. Selain itu, tujuan dari penelitian ini yaitu untuk menjelaskan faktor-faktor apa yang menyebabkan Charles Dickens memiliki pandangan dunia tersebut. Penelitian ini menggunakan teori Lucien Goldmann tentang Strukturalisme Genetik. Penelitian ini menggunakan metode penelitian kualitatif. Dalam melakukan penelitian ini, dilakukan beberapa tahapan. Tahapan pertama yaitu mengumpulkan data yang berkaitan dengan topik bahasan. Tahapan yang ke dua adalah mengklasifikasi data yang telah dikumpulkan sesuai dengan topik bahasan dan teori strukturalisme genetik. Tahapan yang ketiga yaitu menganalisis data yang telah terklasifikasi tersebut dengan menggunakan teori strukturalisme genetik. Dari analisis tersebut dihasilkan kesimpulan yang menunjukkan bahwa Charles Dickens memiliki pandangan dunia pilantropisme. Pandangan dunia yang terdapat dalam karyanya tersebut muncul karena masa kecil Charles Dickens yang menyedihkan, keadaan orang-orang miskin di Inggris yang sangat memprihatinkan serta agama yang dianutnya. Tujuannya menciptakan novela ini adalah untuk mengembalikan keseimbangan antara dirinya dengan lingkungannya. Ttujuan dimasukkannya pandangan dunia ini dalam karyanya adalah untuk menyadarkan para kaum atas akan pentingnya berbagi dan cinta sesama sehingga tidak ada jarak antara mereka dan orang-orang miskin. Selain itu, Dickens ingin mengembalikan moral manusia yang mengalami kemunduran akibat kapitalisme

Proofs for the Automated Inversion of Attribute Mappings in Bidirectional Model Transformations

Bidirectional model transformations create or update a target model according to a base model and vice versa using a single transformation specification for both directions. Triple graph grammars, for example, define which model elements shall exist and how they should reference each other without repeating information for both directions. They can also copy values of simple-typed attributes, such as enumerations, strings, or numbers. But currently only the identity operator can be easily specified in bidirectional transformation languages: Other attribute mappings either have to be specified for both directions or with a special constraint language. In this technical report, we present proofs for an approach that inverts attribute transformation expressions that can be written in a simple Java-like syntax by extending the original paper [KR16]. We also present an initial library of 30 operator-specific inverters that result in well-behaved view-update round-trips (GetPut) for all changes. For changes for which well-behaved update-view round-trips (PutGet) are impossible, we chose inversions that sustain as much information as possible. We realized our inversion approach for a prototypical transformation language that generates Java code. An evaluation using all 103 transformations of the ATL zoo shows that 26% of the LLOC of all non-trivial attribute transformation expressions could be inverted with our initial inverters. This may indicate that many transformation tasks could involve non-trivial attribute transformations that can easily be specified and inverted with our approach

Automated Inversion of Attribute Mappings in Bidirectional Model Transformations

Bidirectional model transformations create or update a target model according to a base model and vice versa using a single transformation specification for both directions. Triple graph grammars, for example, define which model elements shall exist and how they should reference each other without repeating information for both directions. They can also copy values of simple-typed attributes, such as enumerations, strings, or numbers. But currently only the identity operator can be easily specified in bidirectional transformation languages: Other attribute mappings either have to be specified for both directions or with a special constraint language. In this paper, we present an approach that inverts attribute transformation expressions that can be written in a simple Java-like syntax. We also present an initial library of 30 operator-specific inverters that result in well-behaved view-update round-trips (GetPut) for all changes. For changes for which well-behaved update-view round-trips (PutGet) are impossible, we chose inversions that sustain as much information as possible. We realized our inversion approach for a prototypical transformation language that generates Java code. An evaluation using all 103 transformations of the ATL zoo shows that 26% of the LLOC of all non-trivial attribute transformation expressions could be inverted with our initial inverters. This may indicate that many transformation tasks could involve non-trivial attribute transformations that can easily be specified and inverted with our approach

Development of Neh2-Luciferase Reporter and Its Application for High Throughput Screening and Real-Time Monitoring of Nrf2 Activators

SummaryThe NF-E2-related factor 2 (Nrf2) is a key transcriptional regulator of antioxidant defense and detoxification. To directly monitor stabilization of Nrf2, we fused its Neh2 domain, responsible for the interaction with its nucleocytoplasmic regulator, Keap1, to firefly luciferase (Neh2-luciferase). We show that Neh2 domain is sufficient for recognition, ubiquitination, and proteasomal degradation of Neh2-luciferase fusion protein. The Neh2-luc reporter system allows direct monitoring of the adaptive response to redox stress and classification of drugs based on the time course of reporter activation. The reporter was used to screen the Spectrum library of 2000 biologically active compounds to identify activators of Nrf2. The most robust and yet nontoxic Nrf2 activators found—nordihydroguaiaretic acid, fisetin, and gedunin—induced astrocyte-dependent neuroprotection from oxidative stress via an Nrf2-dependent mechanism

Electroexcitation of the Δ+(1232)\Delta^{+}(1232) at low momentum transfer

We report on new p$(e,e^\prime p)\pi^\circ$ measurements at the $\Delta^{+}(1232)$ resonance at the low momentum transfer region. The mesonic cloud dynamics is predicted to be dominant and rapidly changing in this kinematic region offering a test bed for chiral effective field theory calculations. The new data explore the low $Q^2$ dependence of the resonant quadrupole amplitudes while extending the measurements of the Coulomb quadrupole amplitude to the lowest momentum transfer ever reached. The results disagree with predictions of constituent quark models and are in reasonable agreement with dynamical calculations that include pion cloud effects, chiral effective field theory and lattice calculations. The reported measurements suggest that improvement is required to the theoretical calculations and provide valuable input that will allow their refinements

Single Spin Asymmetries of Inclusive Hadrons Produced in Electron Scattering from a Transversely Polarized 3^3He Target

We report the first measurement of target single-spin asymmetries (A$_N$) in the inclusive hadron production reaction, $e~$+$~^3\text{He}^{\uparrow}\rightarrow h+X$, using a transversely polarized $^3$He target. The experiment was conducted at Jefferson Lab in Hall A using a 5.9-GeV electron beam. Three types of hadrons ($\pi^{\pm}$, $\text{K}^{\pm}$ and proton) were detected in the transverse hadron momentum range 0.54 $<p_T<$ 0.74 GeV/c. The range of $x_F$ for pions was -0.29 $<x_F<$ -0.23 and for kaons -0.25 $<x_F<$-0.18. The observed asymmetry strongly depends on the type of hadron. A positive asymmetry is observed for $\pi^+$ and $\text{K}^+$. A negative asymmetry is observed for $\pi^{-}$. The magnitudes of the asymmetries follow $|A^{\pi^-}| < |A^{\pi^+}| < |A^{K^+}|$. The K$^{-}$ and proton asymmetries are consistent with zero within the experimental uncertainties. The $\pi^{+}$ and $\pi^{-}$ asymmetries measured for the $^3$He target and extracted for neutrons are opposite in sign with a small increase observed as a function of $p_T$.Comment: Updated version, submitted to Phys. Rev.