State measures of family economic support as parental labour precarization reducing factors

В статье рассматриваются меры государственной экономической поддержки семей с детьми, направленные на снижение прекаризации родительского труда: государственные пособия семьям с детьми, материнский капитал, обеспечение жильём, доступность детских дошкольных учреждений. Тем не менее, такие меры могут обеспечить только краткосрочные потребности семей. С целью обеспечения качества человеческого капитала в долгосрочной перспективе необходимо учитывать результаты родительского труда в пенсионной системе РФ.The article reviews state measures of family economic support that aim to reduce parental labour precarization: state allowances to families with children, maternal capital, provision of housing, kindergartens. However, these measures can provide only short-term family needs. In order to ensure the quality of human capital in the-long term, it is necessary to take into account the results of the parental labour in the pension system of the Russian Federation.Исследование выполнено при финансовой поддержке РГНФ (проект «Интеграция результатов родительского труда в пенсионную систему РФ», № 16-32-00020)

Factors predicting chronic pain after open inguinal hernia repair : a regression analysis of randomized trial comparing three different meshes with three fixation methods (FinnMesh Study)

Correction: Volume: 22 Issue: 5 Pages: 819-819 DOI: 10.1007/s10029-018-1788-y WOS:000446065400016Chronic pain after inguinal hernioplasty is the foremost side-effect up to 10-30% of patients. Mesh fixation may influence on the incidence of chronic pain after open anterior mesh repairs. Some 625 patients who underwent open anterior mesh repairs were randomized to receive one of the three meshes and fixations: cyanoacrylate glue with low-weight polypropylene mesh (n = 216), non-absorbable sutures with partially absorbable mesh (n = 207) or self-gripping polyesther mesh (n = 202). Factors related to chronic pain (visual analogue scores; VAS ae 30, range 0-100) at 1 year postoperatively were analyzed using logistic regression method. A second analysis using telephone interview and patient records was performed 2 years after the index surgery. At index operation, all patient characteristics were similar in the three study groups. After 1 year, chronic inguinal pain was found in 52 patients and after 2 years in only 16 patients with no difference between the study groups. During 2 years' follow-up, three (0.48%) patients with recurrences and five (0.8%) patients with chronic pain were re-operated. Multivariate regression analysis indicated that only new recurrent hernias and high pain scores at day 7 were predictive factors for longstanding groin pain (p = 0.001). Type of mesh or fixation, gender, pre-operative VAS, age, body mass index or duration of operation did not predict chronic pain. Only the presence of recurrent hernia and early severe pain after index operation seemed to predict longstanding inguinal pain.Peer reviewe

Efficient model for modular multi-level converter simulation

Detailed models of modular multi-level converters (MMCs) are cumbersome for electromagnetic transient simulation programs because of their high number of components which involve large simulation times. In this work, the modeling of an MMC is addressed with the objective of reducing the simulation time. First, the MMC structure is presented, including the modulation technique, the voltage balancing algorithm and the circulating current control used to validate the model. Next, an efficient simplified model is proposed. This is formed by just one variable voltage source, one variable capacitor and one variable resistor per arm, regardless of the number of submodules. This simplified model allows the simulation time to be reduced while keeping the dynamics of the MMC. The comparison through several PSCAD simulations with a detailed 5-level MMC model proves its validity during both steady-state and transient conditions (ac and dc short-circuits).The authors acknowledge the financial support of the Spanish Ministry of Economy and EU FEDER Funds under Grant DPI2014-53245-R and the Universitat Jaume I under Grants P1.1B2013-51 and E-2014-24.Vidal-Albalate, R.; Belenguer, E.; Beltrán, H.; Blasco Gimenez, R. (2015). Efficient model for modular multi-level converter simulation. Mathematics and Computers in Simulation. 99(1):1-15. https://doi.org/10.1016/j.matcom.2015.10.001S11599

Digital Technologies in Jewelry design: Present and Future

В статье поднимаются вопросы виртуализации культуры и искусства на примере анализа возможностей проектирования и производства ювелирных украшений в эпоху цифровизации. Показано изменение роли дизайнера ювелирных украшений в связи с вовлечением в процесс разработки дизайна конечного потребителя. Описано влияние аддитивных технологий на дизайн ювелирных украшений и возможность получения украшений принципиально новой конструкции.The paper is devoted to the study of culture and art virtualization by analyzing the possibilities of jewelry designing and manufacturing in the digital era. The jewelry designer role is changed because the end user is involved in the design process more and more. The influence of additive technologies on the jewelry design and the possibility of obtaining fundamentally new design jewelry are described

Cryo-EM structure of a helicase loading intermediate containing ORC-Cdc6-Cdt1-MCM2-7 bound to DNA

In eukaryotes, the Cdt1-bound replicative helicase core MCM2-7 is loaded onto DNA by the ORC-Cdc6 ATPase to form a prereplicative complex (pre-RC) with an MCM2-7 double hexamer encircling DNA. Using purified components in the presence of ATP-γS, we have captured in vitro an intermediate in pre-RC assembly that contains a complex between the ORC-Cdc6 and Cdt1-MCM2-7 heteroheptamers called the OCCM. Cryo-EM studies of this 14-subunit complex reveal that the two separate heptameric complexes are engaged extensively, with the ORC-Cdc6 N-terminal AAA+ domains latching onto the C-terminal AAA+ motor domains of the MCM2-7 hexamer. The conformation of ORC-Cdc6 undergoes a concerted change into a right-handed spiral with helical symmetry that is identical to that of the DNA double helix. The resulting ORC-Cdc6 helicase loader shows a notable structural similarity to the replication factor C clamp loader, suggesting a conserved mechanism of action

The Possibility of Using a Ferrosulfate Dosimeter to Measure the Effectiveness of Radiomodification

In this paper the application of the ferrosulfate dosimeter on URT-1 accelerator was investigated. The optimal settings of accelerator’s operating mode and irradiation setup of the dosimeter were found. The results show the prospects of using the ferrosulfate dosimeter on URT-1 accelerator

PRODUCTION AND EXPLORING PROPERTIES OF NANOPOWDER OF GADOLINIUM OXIDE

Applying the method of pulse electron beam produced gadolinium oxide nanoparticles, promising in diagnosis and therapy. Exploring their properties

ОСОБЕННОСТИ РАЗВИТИЯ НЕЙРОДЕГЕНЕРАЦИИ ТАЛАМУСА У БОЛЬНЫХ РАССЕЯННЫМ СКЛЕРОЗОМ

Currently the role of CNS structures atrophy in disability development in patients with multiple sclerosis (MS) is undisputed. Particular attention is paid to the atrophy of the thalamus, which is associated with a lot of passing through pathways and determine its sensitivity to changes in various parts of the central nervous system. The causes and sequence of the neurodegenerative processes development in MS are still the subject of scientific debates. The aim of our study was to determine the characteristics of neurodegenerative changes in the thalamus in cohort of MS patients with different severity of disability. The study involved 117 patients with clinically isolated syndrome of probable demyelination and multiple sclerosis, according to McDonald criteria (2010) at the age of 18 to 64 and disease duration varied from 1 to 30 years (6,57+7,18). Examination program included a clinical test and MRI, as well as single-voxel proton magnetic resonance spectroscopy (1H-MRS), performed in 34 patients and 5 healthy volunteers. The results of our study showed that the thalamus atrophy plays an important role in development of disability in patients with multiple sclerosis. It is also reached significance in patients with a more than three points of disability score according to EDSS scale. In carrying out the correlation and analysis of variance data1H-MRS statistically significant results were obtained only for the correlation analysis of NAA concentration and severity of disability in the left thalamus, which showed a direct correlation. NAA levels in the right thalamus depending on the severity of the disease were not significantly changed. Comparison of the results of morphometric analysis and1H-MRS data leaded to conclusion that a decrease of the thalamus volume is mainly due to structural damage of the pathways, with relative preservation of gray matter. The findings may contribute to the formation of therapeutic approaches aimed at preventing the development of disability in patients with MS.В настоящее время считается неоспоримой роль атрофии структур ЦНС в развитии инвалидизации больных рассеянным склерозом (РС). Особое внимание уделяется атрофии таламуса, что связано с большим количеством проходящих через него проводящих путей и определяет его чувствительность к происходящим изменениям в различных отделах ЦНС. Причины и последовательность развития нейродегенеративных процессов при РС до сих пор остаются предметом научных споров. Целью исследования являлось определение особенностей нейродегенеративных изменений таламуса в группах больных РС с различной тяжестью инвалидизации. Обследованы 117 пациентов с клинически изолированным синдромом вероятной демиелинизации и рассеянным склерозом, определенным согласно критериям Мак-Дональда 2010 года в возрасте от 18 до 64 лет с длительностью заболевания от 1 до 30 лет (6,57+7,18). Программа обследования включала клиническое и МРТ-исследование, а также одновоксельную протонную магнитно-резонансную спектроскопию (1Н-МРС), выполненную 34 пациентам и 5 здоровым добровольцам. Результаты исследования показали, что в развитии инвалидизации больных рассеянным склерозом важную роль играет атрофия таламуса, которая достигает значимости у больных с инвалидизацией больше трех баллов по шкале EDSS. При проведении корреляционного и дисперсионного анализа данных1Н-МРС статистически значимые результаты получены только при корреляционном анализе концентрации NAA и тяжести инвалидизации в левом таламусе - прямая корреляция, в правом таламусе уровень NAA в зависимости от тяжести заболевания значимо не изменяется. Сопоставление результатов морфометрического анализа и данных1Н-МРС позволило сделать вывод, что уменьшение объема таламуса происходит преимущественно за счет структурного разрушения проводящих путей, при относительной сохранности серого вещества. Полученные данные могут способствовать формированию лечебных подходов, направленных на предотвращение развития инвалидизации больных РС