Light-Trap: A SiPM Upgrade for Very High Energy Astronomy and Beyond

With the development of the Imaging Atmospheric Cherenkov Technique (IACT), Gamma-ray astronomy has become one of the most interesting and productive fields of astrophysics. Current IACT telescope arrays (MAGIC, H.E.S.S, VERITAS) use photomultiplier tubes (PMTs) to detect the optical/near-UV Cherenkov radiation emitted due to the interaction of gamma rays with the atmosphere. For the next generation of IACT experiments, the possibility of replacing the PMTs with Silicon photomultipliers (SiPMs) is being studied. Among the main drawbacks of SiPMs are their limited active area (leading to an increase in the cost and complexity of the camera readout) and their sensitivity to unwanted wavelengths. Here we propose a novel method to build a relatively low-cost pixel consisting of a SiPM attached to a PMMA disc doped with a wavelength shifter. This pixel collects light over a much larger area than a single standard SiPM and improves sensitivity to near-UV light while simultaneously rejecting background. We describe the design of a detector that could also have applications in other fields where detection area and cost are crucial. We present results of simulations and laboratory measurements of a pixel prototype and from field tests performed with a 7-pixel cluster installed in a MAGIC telescope camera.Comment: Proceedings of the 35th International Cosmic Ray Conference (ICRC 2017), Bexco, Busan, Korea. Id:81

A Cross-National Investigation of Hallucination-Like Experiences in 10 Countries: The E-CLECTIC Study

Hallucination-like experiences (HLEs) are typically defined as sensory perceptions in the absence of external stimuli. Multidimensional tools, able to assess different facets of HLEs, are helpful for a better characterization of hallucination proneness and to investigate the cross-national variation in the frequencies of HLEs. The current study set out to establish the validity, factor structure, and measurement invariance of the Launay-Slade Hallucinations Scale-Extended (LSHS-E), a tool to assess HLEs. A total of 4419 respondents from 10 countries were enrolled. Network analyses between the LSHS-E and the 3 dimensions of the Community Assessment of Psychic Experiences (CAPE) were performed to assess convergent and divergent validity of the LSHS-E. Confirmatory factor analysis was used to test its measurement invariance. The best fit was a 4-factor model, which proved invariant by country and clinical status, indicating cross-national stability of the hallucination-proneness construct. Among the different components of hallucination-proneness, auditory-visual HLEs had the strongest association with the positive dimension of the CAPE, compared with the depression and negative dimensions. Participants who reported a diagnosis of a mental disorder scored higher on the 4 LSHS-E factors. Small effect size differences by country were found in the scores of the 4 LSHS-E factors even after taking into account the role of socio-demographic and clinical variables. Due to its good psychometric properties, the LSHS-E is a strong candidate tool for large investigations of HLEs

Belief Revision and Delusions: How Do Patients with Schizophrenia Take Advice?

The dominant cognitive model that accounts for the persistence of delusional beliefs in schizophrenia postulates that patients suffer from a general deficit in belief revision. It is generally assumed that this deficit is a consequence of impaired reasoning skills. However, the possibility that such inflexibility affects the entire system of a patient's beliefs has rarely been empirically tested. Using delusion-neutral material in a well-documented advice-taking task, the present study reports that patients with schizophrenia: 1) revise their beliefs, 2) take into account socially provided information to do so, 3) are not overconfident about their judgments, and 4) show less egocentric advice-discounting than controls. This study thus shows that delusional patients' difficulty in revising beliefs is more selective than had been previously assumed. The specificities of the task and the implications for a theory of delusion formation are discussed

Evidence for Sub-Haplogroup H5 of Mitochondrial DNA as a Risk Factor for Late Onset Alzheimer's Disease

BACKGROUND: Alzheimer's Disease (AD) is the most common neurodegenerative disease and the leading cause of dementia among senile subjects. It has been proposed that AD can be caused by defects in mitochondrial oxidative phosphorylation. Given the fundamental contribution of the mitochondrial genome (mtDNA) for the respiratory chain, there have been a number of studies investigating the association between mtDNA inherited variants and multifactorial diseases, however no general consensus has been reached yet on the correlation between mtDNA haplogroups and AD. METHODOLOGY/PRINCIPAL FINDINGS: We applied for the first time a high resolution analysis (sequencing of displacement loop and restriction analysis of specific markers in the coding region of mtDNA) to investigate the possible association between mtDNA-inherited sequence variation and AD in 936 AD patients and 776 cognitively assessed normal controls from central and northern Italy. Among over 40 mtDNA sub-haplogroups analysed, we found that sub-haplogroup H5 is a risk factor for AD (OR=1.85, 95% CI:1.04-3.23) in particular for females (OR=2.19, 95% CI:1.06-4.51) and independently from the APOE genotype. Multivariate logistic regression revealed an interaction between H5 and age. When the whole sample is considered, the H5a subgroup of molecules, harboring the 4336 transition in the tRNAGln gene, already associated to AD in early studies, was about threefold more represented in AD patients than in controls (2.0% vs 0.8%; p=0.031), and it might account for the increased frequency of H5 in AD patients (4.2% vs 2.3%). The complete re-sequencing of the 56 mtDNAs belonging to H5 revealed that AD patients showed a trend towards a higher number (p=0.052) of sporadic mutations in tRNA and rRNA genes when compared with controls. CONCLUSIONS: Our results indicate that high resolution analysis of inherited mtDNA sequence variation can help in identifying both ancient polymorphisms defining sub-haplogroups and the accumulation of sporadic mutations associated with complex traits such as AD

Design concepts for the Cherenkov Telescope Array CTA: an advanced facility for ground-based high-energy gamma-ray astronomy

Ground-based gamma-ray astronomy has had a major breakthrough with the impressive results obtained using systems of imaging atmospheric Cherenkov telescopes. Ground-based gamma-ray astronomy has a huge potential in astrophysics, particle physics and cosmology. CTA is an international initiative to build the next generation instrument, with a factor of 5-10 improvement in sensitivity in the 100 GeV-10 TeV range and the extension to energies well below 100 GeV and above 100 TeV. CTA will consist of two arrays (one in the north, one in the south) for full sky coverage and will be operated as open observatory. The design of CTA is based on currently available technology. This document reports on the status and presents the major design concepts of CTA

Iron, Inflammation, Dialysis Adequacy, Nutritional Status, and Hyperparathyroidism Modify Erythropoietic Response

Background and objectives: The erythropoietic response in hemodialysis patients depends on several physiologic factors. Most epidemiologic studies include the effect of these factors by representing them as confounders. This study tested the hypothesis that iron stores, inflammation, dialysis adequacy, nutritional status, and hyperparathyroidism act as nonlinear effect modifiers of the erythropoietic response and quantified the magnitude of those effects over clinically relevant ranges

Zachwaszczenie pszenicy ozimej w zależności od przedplonu i systemu uprawy roli

In-crop weed infestation is affected by both habitat conditions and agronomic practices, including the forecrop and tillage treatments used. This study evaluated the effect of the forecrop and the tillage system on species composition, number and dry weight of weeds in a winter wheat ‘Astoria’. A field study was carried out over the period 2014–2017 at the Uhrusk Experimental Farm (SE Poland), on a mixed rendzina soil with a grain-size distribution of sandy loam. Wheat was grown in a four-course crop rotation: soybean – winter wheat – rapeseed – winter wheat. The experimental factors were as follows: a forecrop of winter wheat (soybean and winter rapeseed) and a tillage system (ploughing and no-tillage). Avena fatua was the most frequently occurring weed in the wheat crop sown after soybean, whereas after winter rapeseed it was Viola arvensis. Viola arvensis was the dominant weed under both tillage systems. In all experimental treatments, the species Viola arvensis and Cirsium arvense were characterized by the highest constancy (Constancy Class V and IV), and also Veronica arvensis after the previous winter rapeseed crop. In the wheat crop sown after winter rapeseed, the number of weeds was found to be higher by 62.1% and the weed dry weight higher by 27.3% compared to these parameters after the previous soybean crop. A richer floristic composition of weeds was also observed in the stand after winter rapeseed. Under conventional tillage conditions, compared to no-tillage, the number of weeds was found to be lower by 39.7% and their dry weight by 50.0%. An increase in the numbers of the dominant weed species was also noted in the untilled plots.Zachwaszczenie łanu roślin uprawnych kształtują zarówno czynniki siedliska, jak i zabiegi agrotechniczne, w tym zastosowany przedplon i zabiegi uprawowe. W pracy oceniano wpływ przedplonu i sytemu uprawy roli na skład gatunkowy, liczbę oraz powietrznie suchą masę chwa- stów w łanie pszenicy ozimej (Triticum aestivum‘Astoria’). Badania polowe przeprowadzono w Gospodarstwie Doświadczalnym w Uhrusku w latach 2014–2017, na rędzinie mieszanej o składzie granulometrycznym gliny piaszczystej. Pszenica uprawiana była w czteropolowym płodozmianie: soja – pszenica ozima – rzepak – pszenica ozima. Czynnikami badawczym były: przedplon pszenicy ozimej (soja i rzepak ozimy) oraz system uprawy roli (płużny i bezpłużny). W łanie pszenicy wysiewanej po soi najliczniej występującym chwastem był Avena fatua , natomiast po rzepaku ozimym Viola arvensis. W obu systemach uprawy dominującym gatunkiem chwastów był Viola arvensis. Na wszystkich obiektach doświadczenia największą stałością występowania (V i IV stopień stałości fitosocjologicznej) charakteryzowały się gatunki Viola arvensis i Cirsium arvense, a po przedplonie rzepaku ozimym również Veronica arvensis . W łanie pszenicy wysiewanej po rzepaku ozimym stwierdzono większą o 62,1% liczebność i o 27,3% powietrznie suchą masę chwastów w porównaniu do występujących po przedplonie soi. W stanowisku po rzepaku ozimym zaobserwowano również bogatszy skład florystyczny chwastów. W warunkach tradycyjnej uprawy płużnej względem obiektu z uprawą bezpłużną stwierdzono mniejszą o 39,7% liczebność chwastów i o 50,0% ich powietrznie suchą masę. Na poletkach z uprawą bezorkową zanotowano również wzrost liczebności dominujących gatunków chwastów