Propagation properties and limitations on the attainable entanglement in a driven harmonic chain

The limitations on the production and profitability of entanglement in a harmonic chain under strong driving are considered. We report on the limits of attainable entanglement for a given set of squeezings of the eigenmodes, showing that the higher the entanglement the more oscillatory and thus less easy to profit from. We also comment on propagation properties of entanglement, discussing the role of fast rotating terms and illustrating several issues with the example of a sudden switch of the coupling.Comment: 9 pages, 5 figure

Optimal nonequilibrium entanglement of nanomechanical oscillators

We investigate nonequilibrium entanglement generation in a chain of harmonic oscillators with time-dependent linear coupling. We use optimal control theory to determine the coupling modulation that leads to maximum logarithmic negativity for a pair of opposite oscillators and show that it corresponds to a synchronization of the eigenmodes of the chain. We further analytically relate the maximum attainable entanglement to the irreversible work done to produce it, thus bridging nonequilibrium entanglement production and nonequilibrium thermodynamics.Comment: 4 pages, 3 figure

Creation and manipulation of entanglement in spin chains far from equilibrium

We investigate creation, manipulation, and steering of entanglement in spin chains from the viewpoint of quantum communication between distant parties. We demonstrate how global parametric driving of the spin-spin coupling and/or local time-dependent Zeeman fields produce a large amount of entanglement between the first and the last spin of the chain. This occurs whenever the driving frequency meets a resonance condition, identified as "entanglement resonance". Our approach marks a promising step towards an efficient quantum state transfer or teleportation in solid state system. Following the reasoning of Zueco et al. [1], we propose generation and routing of multipartite entangled states by use of symmetric tree-like structures of spin chains. Furthermore, we study the effect of decoherence on the resulting spin entanglement between the corresponding terminal spins.Comment: 10 pages, 8 figure

The Physical Basis for Long-lived Electronic Coherence in Photosynthetic Light Harvesting Systems

The physical basis for observed long-lived electronic coherence in photosynthetic light-harvesting systems is identified using an analytically soluble model. Three physical features are found to be responsible for their long coherence lifetimes: i) the small energy gap between excitonic states, ii) the small ratio of the energy gap to the coupling between excitonic states, and iii) the fact that the molecular characteristics place the system in an effective low temperature regime, even at ambient conditions. Using this approach, we obtain decoherence times for a dimer model with FMO parameters of $\approx$ 160 fs at 77 K and $\approx$ 80 fs at 277 K. As such, significant oscillations are found to persist for 600 fs and 300 fs, respectively, in accord with the experiment and with previous computations. Similar good agreement is found for PC645 at room temperature, with oscillations persisting for 400 fs. The analytic expressions obtained provide direct insight into the parameter dependence of the decoherence time scales.Comment: 5 figures; J. Phys. Chem. Lett. (2011

Linking coastal and seafloor morphological features along the eastern side of the Maltese archipelago

The integration of detailed geomorphological information from the present subaerial exposures of the Maltese archipelago, with morphobathymetric data obtained from the adjacent continental margin may serve in understanding processes active in shaping the archipelago since the Last Glacial Maximum. In perspective, this appears also to be of fundamental importance to better define the kinematics of active gravitational processes occurring along the coastlines. Preliminary results reveal the existence of submerged morphologies comparable to subaerial analogous. A case in point is circular depressions at shallow depth interpreted as inundated former karst features like sinkholes on-land. This is probably the case also of fractured plateaus surrounded by detached blocks identified offshore, which are comparable to terrestrial landforms formed by lateral spreading. Other relevant features identified on the continental margin and easily correlatable with morphologies on land include meandering river valleys.peer-reviewe

Images from a drowned prehistoric landscape : the eastern side of the maltese archipelago

Offshore research carried out to map the seafloor on the north-eastern Maltese margin resulted in the first acquisition of multibeam bathymetric data imaging with detail the seascape. The surveys were conducted during cruises MEDCOR and DECORS in December 2009 and August 2011 respectively onboard R/V Urania. These missions mapped the north-eastern Maltese continental margin from off north Gozo to the southern tip of Malta. These data have been integrated by further high-resolution multibeam records acquired during cruise RICS 2010 onboard R/V Hercules on the shallow eastern margin between southern Gozo and north Malta.peer-reviewe

Activation of Type 1 Cannabinoid Receptor (CB1R) promotes neurogenesis in murine subventricular zone cell cultures

The endocannabinoid system has been implicated in the modulation of adult neurogenesis. Here, we describe the effect of type 1 cannabinoid receptor (CB1R) activation on self-renewal, proliferation and neuronal differentiation in mouse neonatal subventricular zone (SVZ) stem/progenitor cell cultures. Expression of CB1R was detected in SVZ-derived immature cells (Nestin-positive), neurons and astrocytes. Stimulation of the CB1R by (R)-(+)-Methanandamide (R-m-AEA) increased self-renewal of SVZ cells, as assessed by counting the number of secondary neurospheres and the number of Sox2+/+ cell pairs, an effect blocked by Notch pathway inhibition. Moreover, R-m-AEA treatment for 48 h, increased proliferation as assessed by BrdU incorporation assay, an effect mediated by activation of MAPK-ERK and AKT pathways. Surprisingly, stimulation of CB1R by R-m-AEA also promoted neuronal differentiation (without affecting glial differentiation), at 7 days, as shown by counting the number of NeuN-positive neurons in the cultures. Moreover, by monitoring intracellular calcium concentrations ([Ca2+](i)) in single cells following KCl and histamine stimuli, a method that allows the functional evaluation of neuronal differentiation, we observed an increase in neuronal-like cells. This proneurogenic effect was blocked when SVZ cells were co-incubated with R-m-AEA and the CB1R antagonist AM 251, for 7 days, thus indicating that this effect involves CB1R activation. In accordance with an effect on neuronal differentiation and maturation, R-m-AEA also increased neurite growth, as evaluated by quantifying and measuring the number of MAP2-positive processes. Taken together, these results demonstrate that CB1R activation induces proliferation, self-renewal and neuronal differentiation from mouse neonatal SVZ cell cultures.Fundacao para a Ciencia e a Tecnologia - Portugal [POCTI/SAU-NEU/68465/2006, PTDC/SAU-NEU/104415/2008, PTDC/SAU-NEU/101783/2008, POCTI/SAU-NEU/110838/2009]; Fundacao Calouste Gulbenkian [96542]; Fundacao para a Ciencia e Tecnologiainfo:eu-repo/semantics/publishedVersio

Portable magnetic resonance imaging of patients indoors, outdoors and at home

Mobile medical imaging devices are invaluable for clinical diagnostic purposes both in and outside healthcare institutions. Among the various imaging modalities, only a few are readily portable. Magnetic resonance imaging (MRI), the gold standard for numerous healthcare conditions, does not traditionally belong to this group. Recently, low-field MRI start-up companies have demonstrated the first decisive steps towards portability within medical facilities, but these are so far incompatible with more demanding use cases such as in remote and developing regions, sports facilities and events, medical and military camps, or home healthcare. Here we present in vivo images taken with a light, home-made, low-field extremity MRI scanner outside the controlled environment provided by medical facilities. To demonstrate the true portability of the system and benchmark its performance in various relevant scenarios, we have acquired images of a volunteer's knee in: i) an MRI physics laboratory; ii) an office room; iii) outside a campus building, connected to a nearby power outlet; iv) in open air, powered from a small fuel-based generator; and v) at the volunteer's home. All images have been acquired within clinically viable times, and signal-to-noise ratios (SNR) and tissue contrast suffice for 2D and 3D reconstructions with diagnostic value, with comparable overall image quality across all five situations. Furthermore, the volunteer carries a fixation metallic implant screwed to the femur, which leads to strong artifacts in standard clinical systems but appears sharp in our low-field acquisitions. Altogether, this work opens a path towards highly accessible MRI under circumstances previously unrealistic.Comment: 17 pages, 4 figures, comments welcom

Control of a hippocampal recurrent excitatory circuit by cannabinoid receptor-interacting protein Gap43

The type-1 cannabinoid receptor (CB1R) is widely expressed in excitatory and inhibitory nerve terminals, and by suppressing neurotransmitter release, its activation modulates neural circuits and brain function. While the interaction of CB1R with various intracellular proteins is thought to alter receptor signaling, the identity and role of these proteins are poorly understood.Using a highthroughput proteomic analysis complemented with an array of in vitro and in vivo approaches in the mouse brain, we report that the C-terminal, intracellular domain of CB1R interacts specifically with growth-associated protein of 43 kDa (GAP43). The CB1R-GAP43 interaction occurs selectively at mossy cell axon boutons, which establish excitatory synapses with dentate granule cells in the hippocampus. This interaction impairs CB1R-mediated suppression of mossy cell to granule cell transmission, thereby inhibiting cannabinoidmediated anti-convulsant activity inmice. Thus, GAP43 acts as a synapse typespecific regulatory partner of CB1R that hampers CB1R-mediated effects on hippocampal circuit function