AINUR: Atlas of Images of NUclear Rings

We present the most complete atlas of nuclear rings to date. We include 113 rings found in 107 galaxies, six of which are elliptical galaxies, five are highly inclined disc galaxies, 18 are unbarred disc galaxies, and 78 are barred disc galaxies. Star-forming nuclear rings occur in 20% of disc galaxies with types between T=-3 and T=7. We aim to explore possible relationships between the size and morphology of the rings and various galactic parameters. We produce colour index and structure maps, as well as Halpha and Paalpha continuum-subtracted images from HST archival data. We derive ellipticity profiles from H-band 2MASS images in order to detect bars and find their metric parameters. We measure the non-axisymmetric torque parameter, Qg, and search for correlations between bar, ring metric parameters, and Qg. Our atlas of nuclear rings includes star-forming and dust rings. Nuclear rings span a range from a few tens of parsecs to a few kiloparsecs in radius. Star-forming nuclear rings can be found in a wide range of morphological types, from S0 to Sd, with a peak in the distribution between Sab and Sb, and without strong preference for barred galaxies. Dust nuclear rings are found in elliptical and S0 galaxies. For barred galaxies, the maximum radius that a nuclear ring can reach is a quarter of the bar radius. We found a nearly random distribution of PA offsets between nuclear rings and bars. There is some evidence that nuclear ring ellipticity is limited by bar ellipticity. We confirm that the maximum relative size of a star-forming nuclear ring is inversely proportional to the non-axisymmetric torque parameter, Qg, and that the origin of nuclear rings, even the ones in non-barred hosts, are closely linked to the existence of dynamical resonances.Comment: Accepted for publication in MNRAS. A full resolution version of the manuscript with high resolution figures can be found at http://www.iac.es/folleto/research/preprints

The Tissue-Specific Rep8/UBXD6 Tethers p97 to the Endoplasmic Reticulum Membrane for Degradation of Misfolded Proteins

The protein known as p97 or VCP in mammals and Cdc48 in yeast is a versatile ATPase complex involved in several biological functions including membrane fusion, protein folding, and activation of membrane-bound transcription factors. In addition, p97 plays a central role in degradation of misfolded secretory proteins via the ER-associated degradation pathway. This functional diversity of p97 depends on its association with various cofactors, and to further our understanding of p97 function it is important that these cofactors are identified and analyzed. Here, we isolate and characterize the human protein named Rep8 or Ubxd6 as a new cofactor of p97. Mouse Rep8 is highly tissue-specific and abundant in gonads. In testes, Rep8 is expressed in post-meiotic round spermatids, whereas in ovaries Rep8 is expressed in granulosa cells. Rep8 associates directly with p97 via its UBX domain. We show that Rep8 is a transmembrane protein that localizes to the ER membrane with its UBX domain facing the cytoplasm. Knock-down of Rep8 expression in human cells leads to a decreased association of p97 with the ER membrane and concomitantly a retarded degradation of misfolded ER-derived proteasome substrates. Thus, Rep8 tethers p97 to the ER membrane for efficient ER-associated degradation

EPIdemiology of Surgery-Associated Acute Kidney Injury (EPIS-AKI) : Study protocol for a multicentre, observational trial

More than 300 million surgical procedures are performed each year. Acute kidney injury (AKI) is a common complication after major surgery and is associated with adverse short-term and long-term outcomes. However, there is a large variation in the incidence of reported AKI rates. The establishment of an accurate epidemiology of surgery-associated AKI is important for healthcare policy, quality initiatives, clinical trials, as well as for improving guidelines. The objective of the Epidemiology of Surgery-associated Acute Kidney Injury (EPIS-AKI) trial is to prospectively evaluate the epidemiology of AKI after major surgery using the latest Kidney Disease: Improving Global Outcomes (KDIGO) consensus definition of AKI. EPIS-AKI is an international prospective, observational, multicentre cohort study including 10 000 patients undergoing major surgery who are subsequently admitted to the ICU or a similar high dependency unit. The primary endpoint is the incidence of AKI within 72 hours after surgery according to the KDIGO criteria. Secondary endpoints include use of renal replacement therapy (RRT), mortality during ICU and hospital stay, length of ICU and hospital stay and major adverse kidney events (combined endpoint consisting of persistent renal dysfunction, RRT and mortality) at day 90. Further, we will evaluate preoperative and intraoperative risk factors affecting the incidence of postoperative AKI. In an add-on analysis, we will assess urinary biomarkers for early detection of AKI. EPIS-AKI has been approved by the leading Ethics Committee of the Medical Council North Rhine-Westphalia, of the Westphalian Wilhelms-University Münster and the corresponding Ethics Committee at each participating site. Results will be disseminated widely and published in peer-reviewed journals, presented at conferences and used to design further AKI-related trials. Trial registration number NCT04165369