Summary of DSN (Deep Space Network) reimbursable launch support

The Deep Space Network is providing ground support to space agencies of foreign governments as well as to NASA and other agencies of the Federal government which are involved in space activities. DSN funding for support of missions other than NASA are on either a cooperative or a reimbursable basis. Cooperative funding and support are accomplished in the same manner as NASA sponsored missions. Reimbursable launch funding and support methods are described

Method of establishing breast cancer brain metastases affects brain uptake and efficacy of targeted, therapeutic nanoparticles

HER2‐targeted therapies effectively control systemic disease, but their efficacy against brain metastases is hindered by their low penetration of the blood‐brain and blood‐tumor barriers (BBB and BTB). We investigate brain uptake and antitumor efficacy of transferrin receptor (TfR)‐targeted, therapeutic nanoparticles designed to transcytose the BBB/BTB in three murine models. Two known models involving intracranial (IC) or intracardiac (ICD) injection of human breast cancer cells were employed, as was a third model developed here involving intravenous (IV) injection of the cells to form whole‐body tumors that eventually metastasize to the brain. We show the method of establishing brain metastases significantly affects therapeutic BBB/BTB penetration. Free drug accumulates and delays growth in IC‐ and ICD‐formed brain tumors, while non‐targeted nanoparticles show uptake and inhibition only in IC‐established metastases. TfR‐targeted nanoparticles accumulate and significantly delay growth in all three models, suggesting the IV model maintains a more intact BBB/BTB than the other models

A causal look into the quantum Talbot effect

A well-known phenomenon in both optics and quantum mechanics is the so-called Talbot effect. This near field interference effect arises when infinitely periodic diffracting structures or gratings are illuminated by highly coherent light or particle beams. Typical diffraction patterns known as quantum carpets are then observed. Here the authors provide an insightful picture of this nonlocal phenomenon as well as its classical limit in terms of Bohmian mechanics, also showing the causal reasons and conditions that explain its appearance. As an illustration, theoretical results obtained from diffraction of thermal He atoms by both N-slit arrays and weak corrugated surfaces are analyzed and discussed. Moreover, the authors also explain in terms of what they call the Talbot-Beeby effect how realistic interaction potentials induce shifts and distortions in the corresponding quantum carpets.Comment: 12 pages, 6 figure

Multi-Epoch Observations of HD69830: High Resolution Spectroscopy and Limits to Variability

The main-sequence solar-type star HD69830 has an unusually large amount of dusty debris orbiting close to three planets found via the radial velocity technique. In order to explore the dynamical interaction between the dust and planets, we have performed multi-epoch photometry and spectroscopy of the system over several orbits of the outer dust. We find no evidence for changes in either the dust amount or its composition, with upper limits of 5-7% (1 $\sigma$ per spectral element) on the variability of the {\it dust spectrum} over 1 year, 3.3% (1 $\sigma$) on the broad-band disk emission over 4 years, and 33% (1 $\sigma$) on the broad-band disk emission over 24 years. Detailed modeling of the spectrum of the emitting dust indicates that the dust is located outside of the orbits of the three planets and has a composition similar to main-belt, C-type asteroids asteroids in our solar system. Additionally, we find no evidence for a wide variety of gas species associated with the dust. Our new higher SNR spectra do not confirm our previously claimed detection of H$_2$O ice leading to a firm conclusion that the debris can be associated with the break-up of one or more C-type asteroids formed in the dry, inner regions of the protoplanetary disk of the HD69830 system. The modeling of the spectral energy distribution and high spatial resolution observations in the mid-infrared are consistent with a $\sim$ 1 AU location for the emitting material

Performance Analysis of Satellite Payload Architectures for Mobile Services

YesThis paper is concerned with the effects on the network performance of moving parts of what is considered traditionally to belong to the ground segment to on board the satellite. Initially, an overview of geostationary satellite communication systems and payload technology is presented, followed by a description of the network architecture and protocols that are the basis of the simulation models. The results obtained from this testbed are presented before concluding with a discussion of the results obtained