23 research outputs found
Oxidative and antioxidative properties of medicinal flora of the Chechen Republic
The oxidative and antioxidative properties of medicinal infusions of Chamomile (Matricaria chamomilla) and Wormwood (ArtemΓsia absΓnthium) were studied on luminescent strains of Escherichia coli. The studied plants grow in the mountains of the Nozhai-Yurt and Shatoi regions of the Chechen Republic. Various concentrations of infusions showed a pronounced bactericidal effect. Wormwood suspension reduced the level of oxidative stress caused by hydrogen peroxide. Concentrations of chamomile (0.0625, 0.125 and 0.25 g/10 ml) together with hydrogen peroxide on the pKatG-lux strain increased oxidative stress within acceptable limits. However, all concentrations of chamomile had an antioxidant effect
Blood Chemistry Value Assesment in Hypodermatosis of Cattle in the Chechen Republic
This article is devoted to the problem of cattle hypodermatosis caused by Hypoderma bovis De Geer and Hypoderma lineatum De Villers hypoderma flies. The results of studies of blood chemistry value of cattle diseased with hypodermatosis in the Chechen Republic are revealed in the article. The examination of ten blood samples taken from cattle diseased with animals hypodermatosis showed an increase in the activity of creatinine parameters above normal by 60 % or more, a significant decrease in carotene indicators (within 50 % or more), a relative decrease in crude protein, a decrease in glucose levels, an increase in alkaline phosphatase and alanine-aminotransferase, reduction of the studied reserve alkalinity index vol. % CO2 from 2 to 5 units (12 %) is lower, in six samples an increase in the activity of immunoglobulin IgA. All this is connected with the complex of pathomorphological changes expressed in the mechanical impact β traumatization, intoxication and hypersusceptibility of the organism of the infested animal with the development of inflammatory and dystrophic manifestations associated with injuries of muscle cells and tissues, intoxication, and an acid-alkali balance of the body shift in the acidic side (acidosis), pathological liver abnormality or diseases, with the defeat of organs and body systems, edema in different parts of the body, defect of immunoreaction and homeostasis in the body. Information obtained from biochemical screen provide an opportunity to conduct a deeper assessment of homeostasis and the bodyβs ability to self-regulate, promptly and comprehensively diagnosing diseases, study the dynamics of the development of pathological processes and conditions in the body, determine the clinical course and justifiably prescribe a complex of effective household and medical-preventive activities aimed at reducing the economic damage to livestock [8, 10]
Scaling up business plans in Tajikistan: a qualitative study of the history, barriers, facilitators and lessons learnt
BACKGROUND: To improve health planning at primary health care (PHC) level, Business Plans were introduced in Tajikistan by the Enhancing Primary Health Care (EPHC) Services Project. OBJECTIVE: To describe the history and process of implementation of Business Plans and to identify barriers, facilitators and lessons learnt from scaling up Business Plans. METHODS: Set in a qualitative research design, we conducted a desk review of project and official documents and seventeen semi-structured interviews with key stakeholders at national and sub-national levels between May and July 2020. We used an interview guide informed by the ExpandNet/WHO framework and analyzed the data following a content analysis approach facilitated by MAXQDA. RESULTS: With the participation of various user organizations and resource teams and through a variety of strategic scale-up choices, Business Plans have been scaled up from a vertical pilot project to institutionalized health management tools covering 45% of Tajikistan's PHC facilities. The most prominent facilitators for scaling up Business Plans were the institutionalization and integration of the tool into the Tajik health system, the close collaboration with Community Health Teams (CHTs), the high acceptance of the tool among the users, the advocacy through champions and policy-makers and the large dissemination network. The most outstanding barriers to scaling up Business Plans were insufficient financial or human resources, general weaknesses in health governance, the lack of a strategic scale-up plan and strategic decisions, the lack of motivation or overall vision to implement Business Plans at a large scale and difficulties in donor coordination. CONCLUSION: To ensure the continuity of scaling up Business Plans, developing a scale-up strategy, strengthening cross-sectoral collaboration and participation during scaling up, and capacitating the user organizations of Business Plans are important next steps to ensure the sustainability and effectiveness of Business Plans in the future
Solid dispersion complex triclabendazole preparations with succinic acid and their fasciolocidal activity
The purpose of the research is to test the efficacy of triclafascid and two solid dispersion complex preparations based on the triclabendazole substance against fasciolosis in cattle and sheep. Materials and methods. Complex preparations of triclabendazole (TCB) formulations: Succinic Acid (SA): Polyvinylpyrrolidone (PVP) (1: 1 : 8) and TCB: SA: Arabinogalactan (AG) (1: 1 : 8) were obtained by combined solid-stategrinding of the components in a fiber drum on an LE-101 ball mill at a roll rotation speed of 60 rpm with a process module of 1: 17 for 1 to 6 hours with sampling for analysis (HPLC) for changes in the TCB solubility. A comparative test of the efficacy of triclafascid and new solid dispersions (SD) of TCB complexes with SA against fascioliasis of sheep and cattle was conducted in the North-Eastern Federal District of the Caucasus in March-April 2023. To determine the Fasciola infection rate in animals, fecal samples were individually taken and examined by the FΓΌlleborn methods using saturated aqueous NaCL solution and sequential washing. The drug efficacy was recorded at 25-30 days after deworming in analogy with "critical test". The results were statistically processed by the Student-Fisher method using Microsoft Excel 2007. Results and discussion. The resulting TCB and SA complexes with polymers had an increased solubility (up to 59β70 times) that depended on the polymer nature. The efficacy of new TCB dosage forms against fascioliasis in sheep at a dose of 1.5 mg/kg, i.e. 0.5 mg/kg less than the therapeutic dose as compared with oral triclafascid was 90.0 and 100%, respectively, and 85.7% in cattle at a dose of 2.0 mg/kg for the active substance
Youth Leisure in Cultural Space of Modern City: State and Prospects of Development
The relevance of this article is the need to study the leisure sphere of modern youth, since free time is one of the important means of forming a young person's personality. The use of free time by young people is a kind of indicator of culture, the range of spiritual needs and interests of a particular personality of a young person. The aim of the study is to analyze the strategy of youth leisure in the cultural space of the modern city. Research methods: as a research method, we used the questionnaire method, which allows us to analyze in detail the main forms and dynamics of the development of modern youthβs leisure practices living in an urban environment. Results of the research: the article considers the problems and prospects of leisure strategiesβ development of young people living in the city. The features of organizing youth leisure in the city are described. The preferences of young people in leisure activities are revealed. The degree of satisfaction of young people with forms of leisure is analyzed. The article considers the respondents' awareness of the work of institutions of the social and cultural sphere in organizing leisure activities for young people in the city. The reasons that prevent young people from spending leisure time in accordance with their needs are identified. Alternative forms of leisure activities are considered. The novelty and originality of the study lies in the fact that for the first time the reasons why young people do not have the opportunity to build their leisure strategy in accordance with their needs are investigated: external reasons (lack of places, disinterest of organizers, certain forms of leisure are unattractive or unprofitable for entrepreneurs); internal reasons (strong employment at work, lack of energy after work, laziness). The reasons for the lack of interaction of young people with leisure and cultural organizations (lack of time; ignorance of where to address on this issue; unwillingness of the organizers to change the situation that is, ignoring the position of young people) are determined. It is revealed that young people show little interest in leisure activities organized by the authorities, since they are formal in nature and do not correspond to the leisure preferences of young people. For the first time, the main strategies for leisure activities for young people living in the city (meetings with friends, relatives, walks, computer games, viewing content, relaxing in silence, and reading) were identified. The strategies of leisure activities that are used to a lesser extent (visiting the cinema, theater; active recreation (Cycling, skating, various sports); attending concerts, exhibitions, master classes; learning foreign languages) are considered. It is revealed that young people are not satisfied with the available leisure opportunities in the city. The reasons for discontent are determined (limited material resources in the city for interesting forms of leisure; lack of cultural and leisure institutions in the city that would meet the requirements of young people; limited choice of institutions where you can spend your free time). There is a gap between the needs of young people in the field of leisure and the activities of the city's youth policy Department, which conducts events according to its own plan, without taking into account the opinion of young people. Young people's knowledge about events is examined and the problem is determined about unawareness of cultural and entertainment events that are associated with the lack of interest of young people and lack of desire of the organizers of the Department of culture to find out what interests this age group. Alternative forms of leisure that young people would like to see in the urban environment, as well as take part in them, are identified (such as cinemas, theaters, restaurants; amusement parks, attractions, water parks, bowling; master classes, courses, exhibitions; interest clubs (language, discussion, computer); Bicycle rental, roller skates, Quad bikes, go-karts; paragliding school; industrial tourism). Practical significance: the data Obtained in this work can be used in social psychology, pedagogy, age psychology, as well as for further theoretical development of this issue
Testing of the supramolecular complex of ivermectin Aniverm-2.0% against parasitosis on various types of livestock animals
The purpose of the research is to obtain and test a complex drug Aniverm-2.0% based on the ivermectin substance by free feeding in a mixture with concentrated feed against parasitosis of cattle, sheep, and horses.Materials and methods. Aniverm-2.0% obtained by mechanochemical technology was tested on a farm in the Shatoy Region, the Chechen Republic, on 900 sheep, 180 cattle and 156 horses in March-April 2023. To determine the infection rate, coproovoscopic examinations were conducted on 80 samples from sheep, 20 samples from young cattle and 30 samples from horses using the Fullebornβs flotation method with a saturated sodium chloride solution. Sheep were dewormed using a group method. The drug was mixed with feed per 0.3 mg/kg for the AS or 60 mg for the drug per animal. The young cattle were kept by tie-up housing and therefore they were given Aniverm-2.0% once at a dose of 0.2 mg/kg for the AS individually in a mixture with feed. The horses were given the drug in a group method at a dose of 0.2 mg/kg for the AS or 1.5 mg/kg for the drug. Fecal samples from all animals were examined before and 2 weeks after the drug.Results and discussion. A 100% rate of infection of the sheep by gastrointestinal nematodes (Strongylata, Nematodirus spp., Trichocephalus spp.) was determined with an average number of eggs 633.3 in 1 g of feces. In 20 fecal samples from the young cattle, 16 were found to have Strongylata eggs (prevalence = 80.0%) with 222.2β280.5 specimens of Strongylata eggs found in 1 g of feces. Strongylata eggs were found in all 30 examined fecal samples from the horses, on average, 253.3 specimens/g of feces (100%). At 2 weeks after treatment, nematode eggs were found in three out of 80 examined fecal samples from the sheep, which can be explained that the sheep did not eat the appropriate dose of the drug. The drug efficacy was determined to be 99.7%. One hundred percent efficacy of the drug was obtained on young cattle and horses
Π’Π²Π΅ΡΠ΄ΠΎΠ΄ΠΈΡΠΏΠ΅ΡΡΠ½ΡΠ΅ ΠΊΠΎΠΌΠΏΠ»Π΅ΠΊΡΠ½ΡΠ΅ ΠΏΡΠ΅ΠΏΠ°ΡΠ°ΡΡ ΡΡΠΈΠΊΠ»Π°Π±Π΅Π½Π΄Π°Π·ΠΎΠ»Π° Ρ ΡΠ½ΡΠ°ΡΠ½ΠΎΠΉ ΠΊΠΈΡΠ»ΠΎΡΠΎΠΉ ΠΈ ΠΈΡ ΡΠ°ΡΡΠΈΠΎΠ»ΠΎΡΠΈΠ΄Π½Π°Ρ Π°ΠΊΡΠΈΠ²Π½ΠΎΡΡΡ
The purpose of the research is to test the efficacy of triclafascid and two solid dispersion complex preparations based on the triclabendazole substance against fasciolosis in cattle and sheep. Materials and methods. Complex preparations of triclabendazole (TCB) formulations: Succinic Acid (SA): Polyvinylpyrrolidone (PVP) (1: 1 : 8) and TCB: SA: Arabinogalactan (AG) (1: 1 : 8) were obtained by combined solid-stategrinding of the components in a fiber drum on an LE-101 ball mill at a roll rotation speed of 60 rpm with a process module of 1: 17 for 1 to 6 hours with sampling for analysis (HPLC) for changes in the TCB solubility. A comparative test of the efficacy of triclafascid and new solid dispersions (SD) of TCB complexes with SA against fascioliasis of sheep and cattle was conducted in the North-Eastern Federal District of the Caucasus in March-April 2023. To determine the Fasciola infection rate in animals, fecal samples were individually taken and examined by the FΓΌlleborn methods using saturated aqueous NaCL solution and sequential washing. The drug efficacy was recorded at 25-30 days after deworming in analogy with "critical test". The results were statistically processed by the Student-Fisher method using Microsoft Excel 2007. Results and discussion. The resulting TCB and SA complexes with polymers had an increased solubility (up to 59β70 times) that depended on the polymer nature. The efficacy of new TCB dosage forms against fascioliasis in sheep at a dose of 1.5 mg/kg, i.e. 0.5 mg/kg less than the therapeutic dose as compared with oral triclafascid was 90.0 and 100%, respectively, and 85.7% in cattle at a dose of 2.0 mg/kg for the active substance.Π¦Π΅Π»Ρ ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΠΉ β ΠΈΡΠΏΡΡΠ°ΡΡ ΡΡΡΠ΅ΠΊΡΠΈΠ²Π½ΠΎΡΡΡ ΡΡΠΈΠΊΠ»Π°ΡΠ°ΡΡΠΈΠ΄Π° ΠΈ Π΄Π²ΡΡ
ΡΠ²ΡΡΠ΄ΠΎΠ΄ΠΈΡΠΏΠ΅ΡΡΠ½ΡΡ
ΠΊΠΎΠΌΠΏΠ»Π΅ΠΊΡΠ½ΡΡ
ΠΏΡΠ΅ΠΏΠ°ΡΠ°ΡΠΎΠ² Π½Π° ΠΎΡΠ½ΠΎΠ²Π΅ ΡΡΠ±ΡΡΠ°Π½ΡΠΈΠΈ ΡΡΠΈΠΊΠ»Π°Π±Π΅Π½Π΄Π°Π·ΠΎΠ»Π° ΠΏΡΠΈ ΡΠ°ΡΡΠΈΠΎΠ»ΡΠ·Π΅ ΠΊΡΡΠΏΠ½ΠΎΠ³ΠΎ ΡΠΎΠ³Π°ΡΠΎΠ³ΠΎ ΡΠΊΠΎΡΠ° ΠΈ ΠΎΠ²Π΅Ρ. ΠΠ°ΡΠ΅ΡΠΈΠ°Π»Ρ ΠΈ ΠΌΠ΅ΡΠΎΠ΄Ρ. ΠΠΎΠΌΠΏΠ»Π΅ΠΊΡΠ½ΡΠ΅ ΠΏΡΠ΅ΠΏΠ°ΡΠ°ΡΡ ΡΠΎΡΡΠ°Π²ΠΎΠ² ΡΡΠΈΠΊΠ»Π°Π±Π΅Π½Π΄Π°Π·ΠΎΠ» (Π’ΠΠ) : Π―Π½ΡΠ°ΡΠ½Π°Ρ ΠΊΠΈΡΠ»ΠΎΡΠ° (Π―Π) : ΠΠΎΠ»ΠΈΠ²ΠΈΠ½ΠΈΠ»ΠΏΠΈΡΡΠΎΠ»ΠΈΠ΄ΠΎΠ½ (ΠΠΠ) (1 : 1 : 8) ΠΈ Π’ΠΠ : Π―Π : ΠΡΠ°Π±ΠΈΠ½ΠΎΠ³Π°Π»Π°ΠΊΡΠ°Π½ (ΠΠ) (1 : 1 : 8) Π±ΡΠ»ΠΈ ΠΏΠΎΠ»ΡΡΠ΅Π½Ρ ΠΏΡΡΠ΅ΠΌ ΡΠΎΠ²ΠΌΠ΅ΡΡΠ½ΠΎΠ³ΠΎ ΡΠ²Π΅ΡΠ΄ΠΎΡΠ°Π·Π½ΠΎΠ³ΠΎ ΠΈΠ·ΠΌΠ΅Π»ΡΡΠ΅Π½ΠΈΡ ΠΊΠΎΠΌΠΏΠΎΠ½Π΅Π½ΡΠΎΠ² Π² ΠΊΠ°ΠΏΡΠΎΠ»ΠΎΠ½ΠΎΠ²ΠΎΠΌ Π±Π°ΡΠ°Π±Π°Π½Π΅ Π½Π° ΡΠ°ΡΠΎΠ²ΠΎΠΉ ΠΌΠ΅Π»ΡΠ½ΠΈΡΠ΅ LE-101 ΠΏΡΠΈ ΡΠΊΠΎΡΠΎΡΡΠΈ Π²ΡΠ°ΡΠ΅Π½ΠΈΡ Π²Π°Π»ΠΊΠΎΠ² 60 ΠΎΠ±/ΠΌΠΈΠ½ ΠΏΡΠΈ ΠΌΠΎΠ΄ΡΠ»Π΅ ΠΏΡΠΎΡΠ΅ΡΡΠ° 1 : 17 Π² ΡΠ΅ΡΠ΅Π½ΠΈΠ΅ 1β6 Ρ Ρ ΠΎΡΠ±ΠΎΡΠΎΠΌ ΠΏΡΠΎΠ± Π΄Π»Ρ ΠΏΡΠΎΠ²Π΅Π΄Π΅Π½ΠΈΡ Π°Π½Π°Π»ΠΈΠ·Π° (ΠΌΠ΅ΡΠΎΠ΄ ΠΠΠΠ₯) Π½Π° ΠΈΠ·ΠΌΠ΅Π½Π΅Π½ΠΈΠ΅ ΡΠ°ΡΡΠ²ΠΎΡΠΈΠΌΠΎΡΡΠΈ Π’ΠΠ. Π‘ΡΠ°Π²Π½ΠΈΡΠ΅Π»ΡΠ½ΠΎΠ΅ ΠΈΡΠΏΡΡΠ°Π½ΠΈΠ΅ ΡΡΡΠ΅ΠΊΡΠΈΠ²Π½ΠΎΡΡΠΈ ΡΡΠΈΠΊΠ»Π°ΡΠ°ΡΡΠΈΠ΄Π° ΠΈ Π½ΠΎΠ²ΡΡ
ΡΠ²Π΅ΡΠ΄ΡΡ
Π΄ΠΈΡΠΏΠ΅ΡΡΠΈΠΉ (Π’Π) ΠΊΠΎΠΌΠΏΠ»Π΅ΠΊΡΠΎΠ² Π’ΠΠ Ρ Π―Π ΠΏΡΠΈ ΡΠ°ΡΡΠΈΠΎΠ»ΡΠ·Π΅ ΠΎΠ²Π΅Ρ ΠΈ ΠΊΡΡΠΏΠ½ΠΎΠ³ΠΎ ΡΠΎΠ³Π°ΡΠΎΠ³ΠΎ ΡΠΊΠΎΡΠ° ΠΏΡΠΎΠ²ΠΎΠ΄ΠΈΠ»ΠΈ Π² Π‘Π΅Π²Π΅ΡΠΎ-ΠΠΎΡΡΠΎΡΠ½ΠΎΠΌ Π€Π΅Π΄Π΅ΡΠ°Π»ΡΠ½ΠΎΠΌ ΠΠΊΡΡΠ³Π΅ ΠΠ°Π²ΠΊΠ°Π·Π° Π² ΠΌΠ°ΡΡΠ΅-Π°ΠΏΡΠ΅Π»Π΅ 2023 Π³. ΠΠ»Ρ ΠΎΠΏΡΠ΅Π΄Π΅Π»Π΅Π½ΠΈΡ Π·Π°ΡΠ°ΠΆΠ΅Π½Π½ΠΎΡΡΠΈ ΠΆΠΈΠ²ΠΎΡΠ½ΡΡ
ΡΠ°ΡΡΠΈΠΎΠ»Π°ΠΌΠΈ ΠΈΠ½Π΄ΠΈΠ²ΠΈΠ΄ΡΠ°Π»ΡΠ½ΠΎ ΠΎΡΠ±ΠΈΡΠ°Π»ΠΈ ΠΏΡΠΎΠ±Ρ ΡΠ΅ΠΊΠ°Π»ΠΈΠΉ ΠΈ ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π»ΠΈ ΠΌΠ΅ΡΠΎΠ΄Π°ΠΌΠΈ Π€ΡΠ»Π»Π΅Π±ΠΎΡΠ½Π° Ρ ΠΏΡΠΈΠΌΠ΅Π½Π΅Π½ΠΈΠ΅ΠΌ Π½Π°ΡΡΡΠ΅Π½Π½ΠΎΠ³ΠΎ Π²ΠΎΠ΄Π½ΠΎΠ³ΠΎ ΡΠ°ΡΡΠ²ΠΎΡΠ° NaCL ΠΈ ΠΏΠΎΡΠ»Π΅Π΄ΠΎΠ²Π°ΡΠ΅Π»ΡΠ½ΡΡ
ΠΏΡΠΎΠΌΡΠ²Π°Π½ΠΈΠΉ. Π£ΡΡΡ ΡΡΡΠ΅ΠΊΡΠΈΠ²Π½ΠΎΡΡΠΈ ΠΏΡΠ΅ΠΏΠ°ΡΠ°ΡΠΎΠ² ΠΏΡΠΎΠ²ΠΎΠ΄ΠΈΠ»ΠΈ ΡΠ΅ΡΠ΅Π· 25β30 ΡΡΡ ΠΏΠΎΡΠ»Π΅ Π΄Π΅Π³Π΅Π»ΡΠΌΠΈΠ½ΡΠΈΠ·Π°ΡΠΈΠΈ ΠΏΠΎ ΡΠΈΠΏΡ Β«ΠΊΡΠΈΡΠΈΡΠ΅ΡΠΊΠΈΠΉ ΡΠ΅ΡΡΒ». ΠΠΎΠ»ΡΡΠ΅Π½Π½ΡΠ΅ ΡΠ΅Π·ΡΠ»ΡΡΠ°ΡΡ ΠΎΠ±ΡΠ°Π±ΠΎΡΠ°Π»ΠΈ ΡΡΠ°ΡΠΈΡΡΠΈΡΠ΅ΡΠΊΠΈ ΠΏΠΎ ΠΌΠ΅ΡΠΎΠ΄Ρ Π‘ΡΡΡΠ΄Π΅Π½ΡΠ°-Π€ΠΈΡΠ΅ΡΠ° Ρ ΠΈΡΠΏΠΎΠ»ΡΠ·ΠΎΠ²Π°Π½ΠΈΠ΅ΠΌ ΠΏΡΠΎΠ³ΡΠ°ΠΌΠΌΡ Microsoft Excel 2007. Π Π΅Π·ΡΠ»ΡΡΠ°ΡΡ ΠΈ ΠΎΠ±ΡΡΠΆΠ΄Π΅Π½ΠΈΠ΅. ΠΠΎΠ»ΡΡΠ΅Π½Π½ΡΠ΅ ΠΊΠΎΠΌΠΏΠ»Π΅ΠΊΡΡ Π’ΠΠ ΠΈ Π―Π Ρ ΠΏΠΎΠ»ΠΈΠΌΠ΅ΡΠ°ΠΌΠΈ ΠΎΠ±Π»Π°Π΄Π°Π»ΠΈ ΠΏΠΎΠ²ΡΡΠ΅Π½Π½ΠΎΠΉ ΡΠ°ΡΡΠ²ΠΎΡΠΈΠΌΠΎΡΡΡΡ (Π΄ΠΎ 59β70 ΡΠ°Π·), Π·Π°Π²ΠΈΡΡΡΠ΅ΠΉ ΠΎΡ ΠΏΡΠΈΡΠΎΠ΄Ρ ΠΏΠΎΠ»ΠΈΠΌΠ΅ΡΠΎΠ². ΠΡΡΠ΅ΠΊΡΠΈΠ²Π½ΠΎΡΡΡ Π½ΠΎΠ²ΡΡ
Π»Π΅ΠΊΠ°ΡΡΡΠ²Π΅Π½Π½ΡΡ
ΡΠΎΡΠΌ Π’ΠΠ ΠΏΡΠΈ ΡΠ°ΡΡΠΈΠΎΠ»ΡΠ·Π΅ ΠΎΠ²Π΅Ρ Π² Π΄ΠΎΠ·Π΅ 1,5 ΠΌΠ³/ΠΊΠ³, Ρ.Π΅. Π½Π° 0,5 ΠΌΠ³/ΠΊΠ³ ΠΌΠ΅Π½ΡΡΠ΅ ΡΠ΅ΡΠ°ΠΏΠ΅Π²ΡΠΈΡΠ΅ΡΠΊΠΎΠΉ Π΄ΠΎΠ·Ρ, ΡΠ΅ΠΌ Ρ ΡΡΠΈΠΊΠ»Π°ΡΠ°ΡΡΠΈΠ΄Π° ΠΏΡΠΈ ΠΏΠ΅ΡΠΎΡΠ°Π»ΡΠ½ΠΎΠΌ ΠΏΡΠΈΠΌΠ΅Π½Π΅Π½ΠΈΠΈ, ΡΠΎΡΡΠ°Π²ΠΈΠ»Π° ΡΠΎΠΎΡΠ²Π΅ΡΡΡΠ²Π΅Π½Π½ΠΎ 90,0 ΠΈ 100%, Ρ ΠΊΡΡΠΏΠ½ΠΎΠ³ΠΎ ΡΠΎΠ³Π°ΡΠΎΠ³ΠΎ ΡΠΊΠΎΡΠ° Π² Π΄ΠΎΠ·Π΅ 2,0 ΠΌΠ³/ΠΊΠ³ ΠΏΠΎ ΠΠ β 85,7%
ΠΠ»ΠΈΡΠ½ΠΈΠ΅ ΡΡΠΏΡΠ°ΠΌΠΎΠ»Π΅ΠΊΡΠ»ΡΡΠ½ΠΎΠ³ΠΎ ΠΊΠΎΠΌΠΏΠ»Π΅ΠΊΡΠ° ΠΈΠ²Π΅ΡΠΌΠ΅ΠΊΡΠΈΠ½Π° 2%-Π½ΠΎΠ³ΠΎ Π² ΠΏΠΎΠ²ΡΡΠ΅Π½Π½ΡΡ Π΄ΠΎΠ·Π°Ρ Π½Π° ΠΎΡΠ³Π°Π½ΠΈΠ·ΠΌ Π»ΠΎΡΠ°Π΄Π΅ΠΉ
The purpose of the research is to study eο¬ects of the 2.0% supramolecular complex of ivermectin in overdoses on the clinical condition of horses.Materials and methods. The experiment was conducted on 20 horses of diο¬erent breeds in the Seradin Equestrian Center, the North Caucasus Federal District, the Chechen Republic, in October 2020. The horses were divided according to the principle of analogues into 3 test groups and one control group of 5 animals each. The 2.0% supramolecular complex of ivermectin was administered to the horses from group 1 at a therapeutic dose of 0.2 mg/kg; group 2 received a tripled dose of 0.6 mg/kg, and the group 3, a 5-fold increased dose of 1,0 mg/kg for the active substance. The drug was administered once individually in a mixture with compound feed. The body temperature was measured with a non-contact thermometer, and the pulse rate and the respiratory rate were measured per 1 min. Urine of the horses was examined on days 1, 7 and 14 after the drug. The urine color, transparency and consistency were determined. Multifunctional test paper was used to study pH, protein, glucose, ketone bodies, nitrites, bilirubin, and urobilinogen. Blood was taken in the morning from the horsesβ jugular vein on days 1, 7 and 14 after the drug. Hematological and biochemical parameters were studied on analyzers.Results and discussion. Clinical fndings of the horses (body temperature, pulse and respiration) did not diο¬er from those of the control animals after the 2.0% supramolecular complex of ivermectin was administered in a therapeutic, tripled and 5-fold increased doses on days 1, 7 and 14. A slight increase in ketone bodies was observed in the urine on day 1, which may indicate the drug eο¬ect on the central nervous system at a 5-fold increased dose; all parameters were within the normal range on days 7 and 14. The 2.0% supramolecular complex of ivermectin in overdoses (0.6; 1.0 mg/kg for the active substance) did not adversely aο¬ect the horsesβ hematological or biochemical blood parameters.Π¦Π΅Π»Ρ ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΠΉ β ΠΈΠ·ΡΡΠ΅Π½ΠΈΠ΅ Π²Π»ΠΈΡΠ½ΠΈΡ ΡΡΠΏΡΠ°ΠΌΠΎΠ»Π΅ΠΊΡΠ»ΡΡΠ½ΠΎΠ³ΠΎ ΠΊΠΎΠΌΠΏΠ»Π΅ΠΊΡΠ° ΠΈΠ²Π΅ΡΠΌΠ΅ΠΊΡΠΈΠ½Π° 2,0%-Π½ΠΎΠ³ΠΎ Π² ΠΏΠΎΠ²ΡΡΠ΅Π½Π½ΡΡ
Π΄ΠΎΠ·Π°Ρ
Π½Π° ΠΊΠ»ΠΈΠ½ΠΈΡΠ΅ΡΠΊΠΎΠ΅ ΡΠΎΡΡΠΎΡΠ½ΠΈΠ΅ Π»ΠΎΡΠ°Π΄Π΅ΠΉ.ΠΠ°ΡΠ΅ΡΠΈΠ°Π»Ρ ΠΈ ΠΌΠ΅ΡΠΎΠ΄Ρ. ΠΠΏΡΡ ΠΏΡΠΎΠ²ΠΎΠ΄ΠΈΠ»ΠΈ Π² ΠΎΠΊΡΡΠ±ΡΠ΅ 2020 Π³. Π² Π‘Π΅Π²Π΅ΡΠΎΠΊΠ°Π²ΠΊΠ°Π·ΡΠΊΠΎΠΌ Π€Π΅Π΄Π΅ΡΠ°Π»ΡΠ½ΠΎΠΌ ΠΠΊΡΡΠ³Π΅ Π§Π΅ΡΠ΅Π½ΡΠΊΠΎΠΉ Π Π΅ΡΠΏΡΠ±Π»ΠΈΠΊΠΈ Π² ΠΊΠΎΠ½Π½ΠΎΡΠΏΠΎΡΡΠΈΠ²Π½ΠΎΠΌ ΠΊΠΎΠΌΠΏΠ»Π΅ΠΊΡΠ΅ Β«Π‘Π΅ΡΠ°Π΄ΠΈΠ½Β» Π½Π° 20 Π»ΠΎΡΠ°Π΄ΡΡ
ΡΠ°Π·Π½ΡΡ
ΠΏΠΎΡΠΎΠ΄. ΠΠΎΡΠ°Π΄Π΅ΠΉ ΡΠ°Π·Π΄Π΅Π»ΠΈΠ»ΠΈ ΠΏΠΎ ΠΏΡΠΈΠ½ΡΠΈΠΏΡ Π°Π½Π°Π»ΠΎΠ³ΠΎΠ² Π½Π° 3 ΠΏΠΎΠ΄ΠΎΠΏΡΡΠ½ΡΠ΅ ΠΈ ΠΎΠ΄Π½Ρ ΠΊΠΎΠ½ΡΡΠΎΠ»ΡΠ½ΡΡ Π³ΡΡΠΏΠΏΡ ΠΏΠΎ 5 ΠΆΠΈΠ²ΠΎΡΠ½ΡΡ
Π² ΠΊΠ°ΠΆΠ΄ΠΎΠΉ. ΠΠΎΡΠ°Π΄ΡΠΌ 1-ΠΉ Π³ΡΡΠΏΠΏΡ ΡΡΠΏΡΠ°ΠΌΠΎΠ»Π΅ΠΊΡΠ»ΡΡΠ½ΡΠΉ ΠΊΠΎΠΌΠΏΠ»Π΅ΠΊΡ ΠΈΠ²Π΅ΡΠΌΠ΅ΠΊΡΠΈΠ½Π° 2%-Π½ΡΠΉ Π½Π°Π·Π½Π°ΡΠ°Π»ΠΈ Π² ΡΠ΅ΡΠ°ΠΏΠ΅Π²ΡΠΈΡΠ΅ΡΠΊΠΎΠΉ Π΄ΠΎΠ·Π΅ 0,2 ΠΌΠ³/ΠΊΠ³, 2-ΠΉ β Π² ΡΡΠΈ ΡΠ°Π·Π° ΡΠ²Π΅Π»ΠΈΡΠ΅Π½Π½ΠΎΠΉ Π΄ΠΎΠ·Π΅ 0,6 ΠΌΠ³/ΠΊΠ³ ΠΈ 3-ΠΉ β Π² 5 ΡΠ°Π· ΡΠ²Π΅Π»ΠΈΡΠ΅Π½Π½ΠΎΠΉ Π΄ΠΎΠ·Π΅ 1,0 ΠΌΠ³/ΠΊΠ³ ΠΏΠΎ ΠΠ. ΠΡΠ΅ΠΏΠ°ΡΠ°Ρ Π·Π°Π΄Π°Π²Π°Π»ΠΈ ΠΎΠ΄Π½ΠΎΠΊΡΠ°ΡΠ½ΠΎ ΠΈΠ½Π΄ΠΈΠ²ΠΈΠ΄ΡΠ°Π»ΡΠ½ΠΎ Π² ΡΠΌΠ΅ΡΠΈ Ρ ΠΊΠΎΠΌΠ±ΠΈΠΊΠΎΡΠΌΠΎΠΌ. Π’Π΅ΠΌΠΏΠ΅ΡΠ°ΡΡΡΡ ΡΠ΅Π»Π° ΠΈΠ·ΠΌΠ΅ΡΡΠ»ΠΈ Π±Π΅ΡΠΊΠΎΠ½ΡΠ°ΠΊΡΠ½ΡΠΌ ΡΠ΅ΡΠΌΠΎΠΌΠ΅ΡΡΠΎΠΌ, ΡΠ°ΡΡΠΎΡΡ ΠΏΡΠ»ΡΡΠ° ΠΈ ΡΠΈΡΠ»ΠΎ Π΄ΡΡ
Π°ΡΠ΅Π»ΡΠ½ΡΡ
Π΄Π²ΠΈΠΆΠ΅Π½ΠΈΠΉ Π·Π° 1 ΠΌΠΈΠ½. ΠΠΎΡΡ Π»ΠΎΡΠ°Π΄Π΅ΠΉ ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π»ΠΈ Π½Π° 1, 7 ΠΈ 14-Π΅ ΡΡΡΠΊΠΈ ΠΏΠΎΡΠ»Π΅ Π΄Π°ΡΠΈ ΠΏΡΠ΅ΠΏΠ°ΡΠ°ΡΠ°. ΠΠΏΡΠ΅Π΄Π΅Π»ΡΠ»ΠΈ ΡΠ²Π΅Ρ, ΠΏΡΠΎΠ·ΡΠ°ΡΠ½ΠΎΡΡΡ ΠΈ ΠΊΠΎΠ½ΡΠΈΡΡΠ΅Π½ΡΠΈΡ ΠΌΠΎΡΠΈ. ΠΠ»Ρ ΠΈΠ·ΡΡΠ΅Π½ΠΈΡ ΡΠ, Π±Π΅Π»ΠΊΠ°, Π³Π»ΡΠΊΠΎΠ·Ρ, ΠΊΠ΅ΡΠΎΠ½ΠΎΠ²ΡΡ
ΡΠ΅Π», Π½ΠΈΡΡΠΈΡΠΎΠ², Π±ΠΈΠ»ΠΈΡΡΠ±ΠΈΠ½Π°, ΡΡΠΎΠ±ΠΈΠ»ΠΈΠ½ΠΎΠ³Π΅Π½Π° ΠΈΡΠΏΠΎΠ»ΡΠ·ΠΎΠ²Π°Π»ΠΈ ΡΠ½ΠΈΠ²Π΅ΡΡΠ°Π»ΡΠ½ΡΡ ΠΈΠ½Π΄ΠΈΠΊΠ°ΡΠΎΡΠ½ΡΡ Π±ΡΠΌΠ°Π³Ρ. ΠΡΠΎΠ²Ρ Π±ΡΠ°Π»ΠΈ ΡΡΡΠΎΠΌ ΠΈΠ· ΡΡΡΠΌΠ½ΠΎΠΉ Π²Π΅Π½Ρ Π»ΠΎΡΠ°Π΄Π΅ΠΉ Π½Π° 1, 7 ΠΈ 14-Π΅ ΡΡΡΠΊΠΈ ΠΏΠΎΡΠ»Π΅ Π΄Π°ΡΠΈ ΠΏΡΠ΅ΠΏΠ°ΡΠ°ΡΠ°. ΠΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΡ Π³Π΅ΠΌΠ°ΡΠΎΠ»ΠΎΠ³ΠΈΡΠ΅ΡΠΊΠΈΡ
ΠΈ Π±ΠΈΠΎΡ
ΠΈΠΌΠΈΡΠ΅ΡΠΊΠΈΡ
ΠΏΠΎΠΊΠ°Π·Π°ΡΠ΅Π»Π΅ΠΉ ΠΏΡΠΎΠ²ΠΎΠ΄ΠΈΠ»ΠΈ Π½Π° Π°Π½Π°Π»ΠΈΠ·Π°ΡΠΎΡΠ°Ρ
.Π Π΅Π·ΡΠ»ΡΡΠ°ΡΡ ΠΈ ΠΎΠ±ΡΡΠΆΠ΄Π΅Π½ΠΈΠ΅. ΠΠ»ΠΈΠ½ΠΈΡΠ΅ΡΠΊΠΈΠ΅ ΠΏΡΠΈΠ·Π½Π°ΠΊΠΈ Π»ΠΎΡΠ°Π΄Π΅ΠΉ (ΡΠ΅ΠΌΠΏΠ΅ΡΠ°ΡΡΡΠ° ΡΠ΅Π»Π°, ΠΏΡΠ»ΡΡ ΠΈ Π΄ΡΡ
Π°Π½ΠΈΠ΅) ΠΏΠΎΡΠ»Π΅ Π½Π°Π·Π½Π°ΡΠ΅Π½ΠΈΡ ΡΡΠΏΡΠ°ΠΌΠΎΠ»Π΅ΠΊΡΠ»ΡΡΠ½ΠΎΠ³ΠΎ ΠΊΠΎΠΌΠΏΠ»Π΅ΠΊΡΠ° ΠΈΠ²Π΅ΡΠΌΠ΅ΠΊΡΠΈΠ½Π° 2,0%-Π½ΠΎΠ³ΠΎ Π² ΡΠ΅ΡΠ°ΠΏΠ΅Π²ΡΠΈΡΠ΅ΡΠΊΠΎΠΉ, 3 ΠΈ 5 ΡΠ°Π· ΡΠ²Π΅Π»ΠΈΡΠ΅Π½Π½ΠΎΠΉ Π΄ΠΎΠ·Π°Ρ
Π½Π° 1, 7 ΠΈ 14-Π΅ ΡΡΡΠΊΠΈ Π½Π΅ ΠΎΡΠ»ΠΈΡΠ°Π»ΠΈΡΡ ΠΎΡ ΠΏΠΎΠΊΠ°Π·Π°ΡΠ΅Π»Π΅ΠΉ ΠΆΠΈΠ²ΠΎΡΠ½ΡΡ
ΠΊΠΎΠ½ΡΡΠΎΠ»ΡΠ½ΠΎΠΉ Π³ΡΡΠΏΠΏΡ. Π ΠΌΠΎΡΠ΅ ΠΎΡΠΌΠ΅ΡΠ΅Π½ΠΎ Π½Π΅Π±ΠΎΠ»ΡΡΠΎΠ΅ ΠΏΠΎΠ²ΡΡΠ΅Π½ΠΈΠ΅ ΠΊΠ΅ΡΠΎΠ½ΠΎΠ²ΡΡ
ΡΠ΅Π» Π½Π° 1-Π΅ ΡΡΡΠΊΠΈ, ΡΡΠΎ ΠΌΠΎΠΆΠ΅Ρ ΡΠ²ΠΈΠ΄Π΅ΡΠ΅Π»ΡΡΡΠ²ΠΎΠ²Π°ΡΡ ΠΎ Π²ΠΎΠ·Π΄Π΅ΠΉΡΡΠ²ΠΈΠΈ ΠΏΡΠ΅ΠΏΠ°ΡΠ°ΡΠ° Π² 5 ΡΠ°Π· ΠΏΠΎΠ²ΡΡΠ΅Π½Π½ΠΎΠΉ Π΄ΠΎΠ·Π΅ Π½Π° ΡΠ΅Π½ΡΡΠ°Π»ΡΠ½ΡΡ Π½Π΅ΡΠ²Π½ΡΡ ΡΠΈΡΡΠ΅ΠΌΡ; Π½Π° 7 ΠΈ 14-Π΅ ΡΡΡΠΊΠΈ Π²ΡΠ΅ ΠΏΠΎΠΊΠ°Π·Π°ΡΠ΅Π»ΠΈ Π½Π°Ρ
ΠΎΠ΄ΠΈΠ»ΠΈΡΡ Π² ΠΏΡΠ΅Π΄Π΅Π»Π°Ρ
Π½ΠΎΡΠΌΡ. Π‘ΡΠΏΡΠ°ΠΌΠΎΠ»Π΅ΠΊΡΠ»ΡΡΠ½ΡΠΉ ΠΊΠΎΠΌΠΏΠ»Π΅ΠΊΡΠ° ΠΈΠ²Π΅ΡΠΌΠ΅ΠΊΡΠΈΠ½Π° 2,0%-Π½ΡΠΉ Π² ΠΏΠΎΠ²ΡΡΠ΅Π½Π½ΡΡ
Π΄ΠΎΠ·Π°Ρ
(0,6; 1,0 ΠΌΠ³/ΠΊΠ³ ΠΏΠΎ ΠΠ) Π½Π΅ ΠΎΠΊΠ°Π·ΡΠ²Π°Π» ΠΎΡΡΠΈΡΠ°ΡΠ΅Π»ΡΠ½ΠΎΠ³ΠΎ Π²Π»ΠΈΡΠ½ΠΈΡ Π½Π° Π³Π΅ΠΌΠ°ΡΠΎΠ»ΠΎΠ³ΠΈΡΠ΅ΡΠΊΠΈΠ΅ ΠΈ Π±ΠΈΠΎΡ
ΠΈΠΌΠΈΡΠ΅ΡΠΊΠΈΠ΅ ΠΏΠΎΠΊΠ°Π·Π°ΡΠ΅Π»ΠΈ ΠΊΡΠΎΠ²ΠΈ Π»ΠΎΡΠ°Π΄Π΅ΠΉ
ΠΠΎΠΌΠΈΡΡΠΈΠΎΠ½Π½ΠΎΠ΅ ΠΈ ΠΏΡΠΎΠΈΠ·Π²ΠΎΠ΄ΡΡΠ²Π΅Π½Π½ΠΎΠ΅ ΠΈΡΠΏΡΡΠ°Π½ΠΈΠ΅ ΡΡΡΠ΅ΠΊΡΠΈΠ²Π½ΠΎΡΡΠΈ ΡΡΠΏΡΠ°ΠΌΠΎΠ»Π΅ΠΊΡΠ»ΡΡΠ½ΠΎΠ³ΠΎ ΠΊΠΎΠΌΠΏΠ»Π΅ΠΊΡΠ° ΡΡΠΈΠΊΠ»Π°Π±Π΅Π½Π΄Π°Π·ΠΎΠ»Π° ΡΡΠΈΠΊΠ»Π°ΡΠ°ΡΡΠΈΠ΄ ΠΏΡΠΈ ΡΠ°ΡΡΠΈΠΎΠ»ΡΠ·Π΅ ΠΊΡΡΠΏΠ½ΠΎΠ³ΠΎ ΡΠΎΠ³Π°ΡΠΎΠ³ΠΎ ΡΠΊΠΎΡΠ°
The purpose of the research: to conduct commission and field testing of efficacy of the supramolecular complex of triclabendazole Β«TriclafascidΒ» applied at the dose of 2,5-3,0 mg/kg against cattle fasciolosis. Materials and methods. Commission and field testing of Triclafascid were carried out in the private sector of the Chechen Republic in March-April 2017 on cattle naturally infected with Fasciola. Commission testing was performed on 30 animals infected with Fasciola that were divided into two equal groups of 15 animals each. Animals from the first group received triclafascid orally at the single therapeutic dose 2,5 mg a.i./kg (therapeutic dose 25 mg/kg) in water solution. The second group of animals as well as the first group received the substance of triclabendazole at five times lower dose (2,5 mg/kg) in water suspension. In field experiment, triclafascid was given individually to 108 animals at the dose of 3,0 mg a.i./kg (therapeutic dose 30 mg/kg) with compound feed. To determine the grade of animalsβ invasion with fascioles, fecal samples were examined by Fuelleborn's method using ammonium nitrate. The average number of Fasciola eggs in 1 g of feces was defined with the use of VIGIS counting chamber. Fecal samples were investigated; the efficacy of the preparation was evaluated 30 days after dehelmintization. The efficacy of triclafascid was estimated by a Β«critical testΒ» according to the Manual approved by World Association for the Advancement of Veterinary Parasitology (1995). Results and discussion. In commission testing of triclafascid for the treatment of cattle fasciolosis individually orally in water solution at the dose of 2,5 mg /kg and in field experiment at the dose of 3,0 mg /kg with feed compound at five times lower dose, 100 % efficacy was reached (in comparison with triclabendazole).Π¦Π΅Π»Ρ ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΠΉ: ΠΊΠΎΠΌΠΈΡΡΠΈΠΎΠ½Π½ΠΎΠ΅ ΠΈ ΠΏΡΠΎΠΈΠ·Π²ΠΎΠ΄ΡΡΠ²Π΅Π½Π½ΠΎΠ΅ ΠΈΡΠΏΡΡΠ°Π½ΠΈΠ΅ ΡΡΡΠ΅ΠΊΡΠΈΠ²Π½ΠΎΡΡΠΈ ΠΎΡΠ΅ΡΠ΅ΡΡΠ²Π΅Π½Π½ΠΎΠ³ΠΎ Π°Π½ΡΠΈΠ³Π΅Π»ΡΠΌΠΈΠ½ΡΠΈΠΊΠ° ΡΡΠΈΠΊΠ»Π° ΡΠ°ΡΡΠΈΠ΄Π° Π² Π΄ΠΎΠ·Π΅ 2,5-3,0 ΠΌΠ³/ΠΊΠ³ ΠΏΡΠΈ ΡΠ°ΡΡΠΈΠΎΠ»ΡΠ·Π΅ ΠΊΡΡΠΏΠ½ΠΎΠ³ΠΎ ΡΠΎΠ³Π°ΡΠΎΠ³ΠΎ ΡΠΊΠΎΡΠ°. ΠΠ°ΡΠ΅ΡΠΈΠ°Π»Ρ ΠΈ ΠΌΠ΅ΡΠΎΠ΄Ρ. ΠΠΎΠΌΠΈΡΡΠΈΠΎΠ½Π½ΠΎΠ΅ ΠΈ ΠΏΡΠΎΠΈΠ·Π²ΠΎΠ΄ΡΡΠ²Π΅Π½Π½ΠΎΠ΅ ΠΈΡΠΏΡΡΠ°Π½ΠΈΠ΅ ΡΡΠΈΠΊΠ»Π°ΡΠ°ΡΡΠΈΠ΄Π° ΠΏΡΠΎΠ²ΠΎΠ΄ΠΈΠ»ΠΈ Π² ΡΠ°ΡΡΠ½ΠΎΠΌ ΡΠ΅ΠΊΡΠΎΡΠ΅ Π§Π΅ΡΠ΅Π½ΡΠΊΠΎΠΉ ΡΠ΅ΡΠΏΡΠ±Π»ΠΈΠΊΠΈ Π² ΠΌΠ°ΡΡΠ΅-Π°ΠΏΡΠ΅Π»Ρ 2017 Π³. Π½Π° ΠΊΡΡΠΏΠ½ΠΎΠΌ ΡΠΎΠ³Π°ΡΠΎΠΌ ΡΠΊΠΎΡΠ΅, ΡΠΏΠΎΠ½ΡΠ°Π½Π½ΠΎ ΠΈΠ½Π²Π°Π·ΠΈΡΠΎΠ²Π°Π½Π½ΠΎΠΌ ΡΠ°ΡΡΠΈΠΎΠ»Π°ΠΌΠΈ. ΠΠΎΠΌΠΈΡΡΠΈΠΎΠ½Π½ΡΠΉ ΠΎΠΏΡΡ ΠΏΡΠΎΠ²ΠΎΠ΄ΠΈΠ»ΠΈ Π½Π° 30 ΡΠΏΠΎΠ½ΡΠ°Π½Π½ΠΎ ΠΈΠ½Π²Π°Π·ΠΈΡΠΎΠ²Π°Π½Π½ΡΡ
ΡΠ°ΡΡΠΈΠΎΠ»Π°ΠΌΠΈ ΠΆΠΈΠ²ΠΎΡΠ½ΡΡ
, ΠΊΠΎΡΠΎΡΡΡ
ΡΠ°ΡΠΏΡΠ΅Π΄Π΅Π»ΠΈΠ»ΠΈ ΠΏΠΎ ΠΏΡΠΈΠ½ΡΠΈΠΏΡ Π°Π½Π°Π»ΠΎΠ³ΠΎΠ² Π½Π° Π΄Π²Π΅ ΡΠ°Π²Π½ΠΎΡΠ΅Π½Π½ΡΠ΅ Π³ΡΡΠΏΠΏΡ ΠΏΠΎ 15 Π³ΠΎΠ»ΠΎΠ² Π² ΠΊΠ°ΠΆΠ΄ΠΎΠΉ. ΠΠΈΠ²ΠΎΡΠ½ΡΠ΅ ΠΏΠ΅ΡΠ²ΠΎΠΉ Π³ΡΡΠΏΠΏΡ ΠΏΠΎΠ»ΡΡΠ°Π»ΠΈ ΡΡΠΈΠΊΠ»Π°ΡΠ°ΡΡΠΈΠ΄ ΠΏΠ΅ΡΠΎΡΠ°Π»ΡΠ½ΠΎ Π² ΡΠ΅ΡΠ°ΠΏΠ΅Π²ΡΠΈΡΠ΅ΡΠΊΠΎΠΉ Π΄ΠΎΠ·Π΅ 2,5 ΠΌΠ³/ΠΊΠ³ ΠΏΠΎ ΠΠ (ΠΏΠΎ ΠΏΡΠ΅ΠΏΠ°ΡΠ°ΡΡ 25 ΠΌΠ³/ΠΊΠ³) Π² ΡΠΎΡΠΌΠ΅ Π²ΠΎΠ΄Π½ΠΎΠ³ΠΎ ΡΠ°ΡΡΠ²ΠΎΡΠ° ΠΎΠ΄Π½ΠΎΠΊΡΠ°ΡΠ½ΠΎ. ΠΡΠΎΡΠΎΠΉ Π³ΡΡΠΏΠΏΠ΅ ΠΆΠΈΠ²ΠΎΡΠ½ΡΡ
Π²Π²ΠΎΠ΄ΠΈΠ»ΠΈ ΡΡΠ±ΡΡΠ°Π½ΡΠΈΡ ΡΡΠΈΠΊΠ»Π°Π±Π΅Π½Π΄Π°Π·ΠΎΠ»Π° Π² ΡΠΎΡΠΌΠ΅ Π²ΠΎΠ΄Π½ΠΎΠΉ Π²Π·Π²Π΅ΡΠΈ Π² 5 ΡΠ°Π· ΡΠΌΠ΅Π½ΡΡΠ΅Π½Π½ΠΎΠΉ Π΄ΠΎΠ·Π΅ (2,5 ΠΌΠ³/ΠΊΠ³) Π² ΠΊΠ°ΡΠ΅ΡΡΠ²Π΅ ΠΊΠΎΠ½ΡΡΠΎΠ»Ρ Π°Π½Π°Π»ΠΎΠ³ΠΈΡΠ½ΠΎ ΠΊΠ°ΠΊ ΠΈ ΠΆΠΈΠ²ΠΎΡΠ½ΡΠΌ ΠΏΠ΅ΡΠ²ΠΎΠΉ Π³ΡΡΠΏΠΏΡ. Π ΠΏΡΠΎΠΈΠ·Π²ΠΎΠ΄ΡΡΠ²Π΅Π½Π½ΠΎΠΌ ΠΎΠΏΡΡΠ΅ ΡΡΠΈΠΊΠ»Π°ΡΠ°ΡΡΠΈΠ΄ Π·Π°Π΄Π°Π²Π°Π»ΠΈ 108 ΠΆΠΈΠ²ΠΎΡΠ½ΡΠΌ Π² Π΄ΠΎΠ·Π΅ 3,0 ΠΌΠ³/ΠΊΠ³ ΠΏΠΎ ΠΠ (ΠΏΠΎ ΠΏΡΠ΅ΠΏΠ°ΡΠ°ΡΡ 30 ΠΌΠ³/ΠΊΠ³) ΠΈΠ½Π΄ΠΈΠ²ΠΈΠ΄ΡΠ°Π»ΡΠ½ΠΎ Π² ΡΠΌΠ΅ΡΠΈ Ρ ΠΊΠΎΠΌΠ±ΠΈΠΊΠΎΡΠΌΠΎΠΌ. ΠΠ»Ρ ΠΎΠΏΡΠ΅Π΄Π΅Π»Π΅Π½ΠΈΡ ΡΡΠ΅ΠΏΠ΅Π½ΠΈ ΠΈΠ½Π²Π°Π·ΠΈΡΠΎΠ²Π°Π½Π½ΠΎΡΡΠΈ ΠΆΠΈΠ²ΠΎΡΠ½ΡΡ
ΡΠ°ΡΡΠΈΠΎΠ»Π°ΠΌΠΈ ΠΏΡΠΎΠ±Ρ ΡΠ΅ΠΊΠ°Π»ΠΈΠΉ ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π»ΠΈ ΠΌΠ΅ΡΠΎΠ΄ΠΎΠΌ Π€ΡΠ»Π»Π΅Π±ΠΎΡΠ½Π° Ρ ΠΈΡΠΏΠΎΠ»ΡΠ·ΠΎΠ²Π°Π½ΠΈΠ΅ΠΌ Π°ΠΌΠΌΠΈΠ°ΡΠ½ΠΎΠΉ ΡΠ΅Π»ΠΈΡΡΡ. Π‘ΡΠ΅Π΄Π½Π΅Π΅ ΡΠΈΡΠ»ΠΎ ΡΠΈΡ ΡΠ°ΡΡΠΈΠΎΠ» Π² 1 Π³ ΡΠ΅ΠΊΠ°Π»ΠΈΠΉ ΠΎΠΏΡΠ΅Π΄Π΅Π»ΡΠ»ΠΈ Ρ ΠΏΠΎΠΌΠΎΡΡΡ ΠΊΠ°ΠΌΠ΅ΡΡ ΠΠΠΠΠ‘. ΠΡΡΠ΅ΠΊΡΠΈΠ²Π½ΠΎΡΡΡ ΠΏΡΠ΅ΠΏΠ°ΡΠ°ΡΠ° ΠΎΡΠ΅Π½ΠΈΠ²Π°Π»ΠΈ ΡΠ΅ΡΠ΅Π· 30 ΡΡΡ ΠΏΠΎΡΠ»Π΅ Π΄Π΅Π³Π΅Π»ΡΠΌΠΈΠ½ΡΠΈΠ·Π°ΡΠΈΠΈ ΠΏΡΡΠ΅ΠΌ ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΡ ΠΏΡΠΎΠ± ΡΠ΅ΠΊΠ°Π»ΠΈΠΉ. Π£ΡΡΡ ΡΡΡΠ΅ΠΊΡΠΈΠ²Π½ΠΎΡΡΠΈ ΡΡΠΈΠΊΠ»Π°ΡΠ°ΡΡΠΈΠ΄Π° ΠΏΡΠΎΠ²ΠΎΠ΄ΠΈΠ»ΠΈ ΠΏΠΎ ΡΠΈΠΏΡ Β«ΠΊΡΠΈΡΠΈΡΠ΅ΡΠΊΠΈΠΉ ΡΠ΅ΡΡΒ» ΡΠΎΠ³Π»Π°ΡΠ½ΠΎ Π ΡΠΊΠΎΠ²ΠΎΠ΄ΡΡΠ²Ρ, ΠΎΠ΄ΠΎΠ±ΡΠ΅Π½Π½ΠΎΠΌΡ ΠΡΠ΅ΠΌΠΈΡΠ½ΠΎΠΉ ΠΡΡΠΎΡΠΈΠ°ΡΠΈΠ΅ΠΉ Π·Π° ΠΏΡΠΎΠ³ΡΠ΅ΡΡ Π²Π΅ΡΠ΅ΡΠΈΠ½Π°ΡΠ½ΠΎΠΉ ΠΏΠ°ΡΠ°Π·ΠΈΡΠΎΠ»ΠΎΠ³ΠΈΠΈ (1995 Π³). Π Π΅Π·ΡΠ»ΡΡΠ°ΡΡ ΠΈ ΠΎΠ±ΡΡΠΆΠ΄Π΅Π½ΠΈΠ΅. ΠΡΠΈ ΠΊΠΎΠΌΠΈΡΡΠΈΠΎΠ½Π½ΠΎΠΌ ΠΈΡΠΏΡΡΠ°Π½ΠΈΠΈ ΡΡΠΈΠΊΠ»Π°ΡΠ°ΡΡΠΈΠ΄Π° ΠΏΡΠΈ ΡΠ°ΡΡΠΈΠΎΠ»ΡΠ·Π΅ ΠΊΡΡΠΏΠ½ΠΎΠ³ΠΎ ΡΠΎΠ³Π°ΡΠΎΠ³ΠΎ ΡΠΊΠΎΡΠ° Π² Π΄ΠΎΠ·Π΅ 2,5 ΠΌΠ³/ ΠΊΠ³ ΠΈΠ½Π΄ΠΈΠ²ΠΈΠ΄ΡΠ°Π»ΡΠ½ΠΎ Π² ΡΠΎΡΠΌΠ΅ Π²ΠΎΠ΄Π½ΠΎΠ³ΠΎ ΡΠ°ΡΡΠ²ΠΎΡΠ° ΠΏΠ΅ΡΠΎΡΠ°Π»ΡΠ½ΠΎ ΠΈ Π² ΠΏΡΠΎΠΈΠ·Π²ΠΎΠ΄ΡΡΠ²Π΅Π½Π½ΠΎΠΌ ΠΎΠΏΡΡΠ΅ Π² Π΄ΠΎΠ·Π΅ 3,0 ΠΌΠ³/ΠΊΠ³ Π² ΡΠΌΠ΅ΡΠΈ Ρ ΠΊΠΎΡΠΌΠΎΠΌ Π² 5 ΡΠ°Π· ΡΠΌΠ΅Π½ΡΡΠ΅Π½Π½ΠΎΠΉ Π΄ΠΎΠ·Π΅ ΠΏΠΎ ΡΡΠ°Π²Π½Π΅Π½ΠΈΡ Ρ ΡΡΠ±ΡΡΠ°Π½ΡΠΈΠ΅ΠΉ ΡΡΠΈΠΊΠ»Π°Π±Π΅Π½Π΄Π°Π·ΠΎΠ»Π°, ΠΏΠΎΠ»ΡΡΠ΅Π½Π° 100%-Π½Π°Ρ ΡΡΡΠ΅ΠΊΡΠΈΠ²Π½ΠΎΡΡΡ