Certificação Rainforest Alliance em chocolates e cafés comercializados nos municípios de Ouro Fino e Pouso Alegre: Rainforest Alliance certification for chocolates and coffee sold in the municipalities of Ouro Fino and Pouso Alegre

O café é a segunda bebida mais consumida no mundo e no Brasil, o País se destaca como sendo o maior produtor de café do mundo. Segundo a Confederação da Agricultura e Pecuária, o cacau é uma fruta nativa da Amazônia, sua amêndoa é utilizada para a produção do pó e da manteiga de cacau. Ambos cultivos possuem problemáticas semelhantes como escravidão contemporânea para colheita e produção dos frutos e exploração dos recursos naturais, no caso do café, uso intenso de agrotóxicos. A Rainforest Alliance é uma organização internacional que trabalha para combater o desmatamento, garantir os direitos dos trabalhadores, etc. Este estudo teve como objetivo quantificar a porcentagem de embalagens de cafés e chocolates em barra que expõe o selo Rainforest Alliance no comércio varejista alimentício nas cidades de Ouro Fino e Pouso Alegre, do Estado de Minas Gerais. A porcentagem de chocolates em barra com o selo de sustentabilidade ambiental foi superior aos dos tipos de café Torrado e moído e Solúvel, e o chocolate em barra tipo Meio Amargo apresentou 21% de produtos certificados

Development of pitanga nectar with different sweeteners by sensory analysis: ideal pulp dilution, ideal sweetness, and sweetness equivalence

The objective of this study was to develop pitanga nectar formulations in which sucrose was replaced with different sweeteners. Consumer tests were conducted with 50 fruit juice consumers, and a just-about-right scale was used to determine the ideal pulp dilution and ideal sweetness with sucrose. Furthermore, the adequate concentrations of six sweeteners were determined to obtain the equivalent sweetness of sucrose using relative to these concentrations the magnitude estimation model with 19 selected assessors. The ideal dilution test resulted in 25% pulp, and the ideal sweetness test, 10% sucrose. Sweetener concentrations to replace sucrose were 0.0160%, 0.0541%, 0.1000%, 0.0999%, 0.0017%, and 0.0360%, respectively, for sucralose, aspartame, stevia 40% rebaudioside A, stevia 95% rebaudioside A, neotame, and a 2:1 cyclamate/saccharin blend. These results can be used to prepare pitanga nectar with different sweeteners and obtain the same sweetness intensity in less caloric products than that of nectar prepared with sucrose341174180CONSELHO NACIONAL DE DESENVOLVIMENTO CIENTÍFICO E TECNOLÓGICO - CNPQSem informaçã

Sensory profile and drivers of liking for grape nectar among smoker and nonsmoker consumers

Decreased gustatory and olfactory capacity is one of the problems caused by tobacco use. The objectives of this study were to determine the sensory profile of six grape nectar samples sweetened with different sweeteners and to verify the drivers of liking in two distinct consumer groups: smokers and nonsmokers. The sensory profile was constructed by twelve trained panelists using quantitative descriptive analysis (QDA). Consumer tests were performed with 112 smokers and 112 nonsmokers. Partial least squares regression analyses was used to identify the drivers of acceptance and rejection of the grape nectars among the two consumer groups. According to the QDA, the samples differed regarding six of the nineteen attributes generated. The absolute averages of the affective test were lower in the group of smokers; possibly because smoking influences acceptance and eating preferences, especially with regard to sweet foods. The results showed that the grape flavor was the major driver of preference for acceptance of the nectar, while astringency, wine aroma, bitterness and sweetness, and bitter aftertaste were drivers of rejection in the two groups of consumers, with some differences between the groups.164173Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES

ANÁLISE COMPARATIVA DO USO DE INIBIDORES DA ALFA-GLUCOSIDASE E DE INIBIDORES DA DPP-4 NO TRATAMENTO DA DIABETES TIPO 2

Considering the growing impact of type 2 diabetes on global public health, there is a justified need to explore effective therapeutic approaches. This study aimed to conduct a comparative analysis between alpha-glucosidase inhibitors and DPP-4 inhibitors, both used in the management of type 2 diabetes. To this end, a qualitative bibliographic review was conducted, covering multiple languages, using databases such as Scielo, Google Scholar, scientific journals, repositories, and virtual libraries. Inclusion and exclusion criteria were applied to select relevant studies that addressed the efficacy, side effects, mechanisms of action, and impact on glycemic control of these inhibitors. It was observed that DPP-4 inhibitors, such as Sitagliptin and Saxagliptin, are effective in reducing fasting glucose and glycated hemoglobin (HbA1C), in addition to presenting a favorable safety profile. On the other hand, alpha-glucosidase inhibitors, such as Acarbose, stand out in reducing postprandial glucose but are frequently associated with adverse gastrointestinal effects such as flatulence and diarrhea. It is concluded that both classes of drugs have their specific advantages, with DPP-4 inhibitors being more effective in reducing HbA1C and better tolerated, while alpha-glucosidase inhibitors are particularly useful for controlling postprandial glucose. The choice of treatment should be individualized, considering the efficacy, tolerability, and specific needs of patients. Future studies may explore therapeutic combinations to maximize benefits and minimize adverse effects, as well as investigate treatments based on genetic characteristics and specific biomarkers for a more personalized management of type 2 diabetes.Considerando o crescente impacto da diabetes tipo 2 na saúde pública global, justifica-se a necessidade de explorar abordagens terapêuticas eficazes. Este estudo objetivou realizar uma análise comparativa entre inibidores da alfa-glucosidase e inibidores da DPP-4, ambos utilizados no manejo da diabetes tipo 2. Para tanto, procedeu-se a uma revisão bibliográfica qualitativa, abrangendo múltiplos idiomas, utilizando bases de dados como Scielo, Google Acadêmico, revistas científicas, repositórios e bibliotecas virtuais. Critérios de inclusão e exclusão foram aplicados para selecionar estudos relevantes que abordassem a eficácia, efeitos colaterais, mecanismos de ação e impacto no controle glicêmico desses inibidores. Observou-se que os inibidores da DPP-4, como Sitagliptina e Saxagliptina, são eficazes na redução da glicemia de jejum e na hemoglobina glicada (HbA1C), além de apresentarem um perfil de segurança favorável. Por outro lado, os inibidores da alfa-glucosidase, como a Acarbose, destacam-se na redução da glicemia pós-prandial, mas são frequentemente associados a efeitos gastrointestinais adversos, como flatulência e diarreia. Conclui-se que ambas as classes de medicamentos têm suas vantagens específicas, sendo os inibidores da DPP-4 mais eficazes na redução da HbA1C e melhor tolerados, enquanto os inibidores da alfa-glucosidase são particularmente úteis para controlar a glicemia pós-prandial. A escolha do tratamento deve ser individualizada, considerando a eficácia, a tolerabilidade e as necessidades específicas dos pacientes. Estudos futuros podem explorar combinações terapêuticas para maximizar os benefícios e minimizar os efeitos adversos, bem como investigar tratamentos baseados em características genéticas e biomarcadores específicos para um manejo mais personalizado da diabetes tipo 2. &nbsp

Pervasive gaps in Amazonian ecological research

Biodiversity loss is one of the main challenges of our time,1,2 and attempts to address it require a clear un derstanding of how ecological communities respond to environmental change across time and space.3,4 While the increasing availability of global databases on ecological communities has advanced our knowledge of biodiversity sensitivity to environmental changes,5–7 vast areas of the tropics remain understudied.8–11 In the American tropics, Amazonia stands out as the world’s most diverse rainforest and the primary source of Neotropical biodiversity,12 but it remains among the least known forests in America and is often underrepre sented in biodiversity databases.13–15 To worsen this situation, human-induced modifications16,17 may elim inate pieces of the Amazon’s biodiversity puzzle before we can use them to understand how ecological com munities are responding. To increase generalization and applicability of biodiversity knowledge,18,19 it is thus crucial to reduce biases in ecological research, particularly in regions projected to face the most pronounced environmental changes. We integrate ecological community metadata of 7,694 sampling sites for multiple or ganism groups in a machine learning model framework to map the research probability across the Brazilian Amazonia, while identifying the region’s vulnerability to environmental change. 15%–18% of the most ne glected areas in ecological research are expected to experience severe climate or land use changes by 2050. This means that unless we take immediate action, we will not be able to establish their current status, much less monitor how it is changing and what is being lostinfo:eu-repo/semantics/publishedVersio

Pervasive gaps in Amazonian ecological research

Biodiversity loss is one of the main challenges of our time,1,2 and attempts to address it require a clear understanding of how ecological communities respond to environmental change across time and space.3,4 While the increasing availability of global databases on ecological communities has advanced our knowledge of biodiversity sensitivity to environmental changes,5,6,7 vast areas of the tropics remain understudied.8,9,10,11 In the American tropics, Amazonia stands out as the world's most diverse rainforest and the primary source of Neotropical biodiversity,12 but it remains among the least known forests in America and is often underrepresented in biodiversity databases.13,14,15 To worsen this situation, human-induced modifications16,17 may eliminate pieces of the Amazon's biodiversity puzzle before we can use them to understand how ecological communities are responding. To increase generalization and applicability of biodiversity knowledge,18,19 it is thus crucial to reduce biases in ecological research, particularly in regions projected to face the most pronounced environmental changes. We integrate ecological community metadata of 7,694 sampling sites for multiple organism groups in a machine learning model framework to map the research probability across the Brazilian Amazonia, while identifying the region's vulnerability to environmental change. 15%–18% of the most neglected areas in ecological research are expected to experience severe climate or land use changes by 2050. This means that unless we take immediate action, we will not be able to establish their current status, much less monitor how it is changing and what is being lost

Pervasive gaps in Amazonian ecological research

Biodiversity loss is one of the main challenges of our time,1,2 and attempts to address it require a clear understanding of how ecological communities respond to environmental change across time and space.3,4 While the increasing availability of global databases on ecological communities has advanced our knowledge of biodiversity sensitivity to environmental changes,5,6,7 vast areas of the tropics remain understudied.8,9,10,11 In the American tropics, Amazonia stands out as the world's most diverse rainforest and the primary source of Neotropical biodiversity,12 but it remains among the least known forests in America and is often underrepresented in biodiversity databases.13,14,15 To worsen this situation, human-induced modifications16,17 may eliminate pieces of the Amazon's biodiversity puzzle before we can use them to understand how ecological communities are responding. To increase generalization and applicability of biodiversity knowledge,18,19 it is thus crucial to reduce biases in ecological research, particularly in regions projected to face the most pronounced environmental changes. We integrate ecological community metadata of 7,694 sampling sites for multiple organism groups in a machine learning model framework to map the research probability across the Brazilian Amazonia, while identifying the region's vulnerability to environmental change. 15%–18% of the most neglected areas in ecological research are expected to experience severe climate or land use changes by 2050. This means that unless we take immediate action, we will not be able to establish their current status, much less monitor how it is changing and what is being lost

Rationale, study design, and analysis plan of the Alveolar Recruitment for ARDS Trial (ART): Study protocol for a randomized controlled trial

Background: Acute respiratory distress syndrome (ARDS) is associated with high in-hospital mortality. Alveolar recruitment followed by ventilation at optimal titrated PEEP may reduce ventilator-induced lung injury and improve oxygenation in patients with ARDS, but the effects on mortality and other clinical outcomes remain unknown. This article reports the rationale, study design, and analysis plan of the Alveolar Recruitment for ARDS Trial (ART). Methods/Design: ART is a pragmatic, multicenter, randomized (concealed), controlled trial, which aims to determine if maximum stepwise alveolar recruitment associated with PEEP titration is able to increase 28-day survival in patients with ARDS compared to conventional treatment (ARDSNet strategy). We will enroll adult patients with ARDS of less than 72 h duration. The intervention group will receive an alveolar recruitment maneuver, with stepwise increases of PEEP achieving 45 cmH(2)O and peak pressure of 60 cmH2O, followed by ventilation with optimal PEEP titrated according to the static compliance of the respiratory system. In the control group, mechanical ventilation will follow a conventional protocol (ARDSNet). In both groups, we will use controlled volume mode with low tidal volumes (4 to 6 mL/kg of predicted body weight) and targeting plateau pressure <= 30 cmH2O. The primary outcome is 28-day survival, and the secondary outcomes are: length of ICU stay; length of hospital stay; pneumothorax requiring chest tube during first 7 days; barotrauma during first 7 days; mechanical ventilation-free days from days 1 to 28; ICU, in-hospital, and 6-month survival. ART is an event-guided trial planned to last until 520 events (deaths within 28 days) are observed. These events allow detection of a hazard ratio of 0.75, with 90% power and two-tailed type I error of 5%. All analysis will follow the intention-to-treat principle. Discussion: If the ART strategy with maximum recruitment and PEEP titration improves 28-day survival, this will represent a notable advance to the care of ARDS patients. Conversely, if the ART strategy is similar or inferior to the current evidence-based strategy (ARDSNet), this should also change current practice as many institutions routinely employ recruitment maneuvers and set PEEP levels according to some titration method.Hospital do Coracao (HCor) as part of the Program 'Hospitais de Excelencia a Servico do SUS (PROADI-SUS)'Brazilian Ministry of Healt