1,748 research outputs found
Estimation of the mechanical properties of the eye through the study of its vibrational modes
Measuring the eye's mechanical properties in vivo and with minimally invasive
techniques can be the key for individualized solutions to a number of eye
pathologies. The development of such techniques largely relies on a
computational modelling of the eyeball and, it optimally requires the synergic
interplay between experimentation and numerical simulation. In Astrophysics and
Geophysics the remote measurement of structural properties of the systems of
their realm is performed on the basis of (helio-)seismic techniques. As a
biomechanical system, the eyeball possesses normal vibrational modes
encompassing rich information about its structure and mechanical properties.
However, the integral analysis of the eyeball vibrational modes has not been
performed yet. Here we develop a new finite difference method to compute both
the spheroidal and, specially, the toroidal eigenfrequencies of the human eye.
Using this numerical model, we show that the vibrational eigenfrequencies of
the human eye fall in the interval 100 Hz - 10 MHz. We find that compressible
vibrational modes may release a trace on high frequency changes of the
intraocular pressure, while incompressible normal modes could be registered
analyzing the scattering pattern that the motions of the vitreous humour leave
on the retina. Existing contact lenses with embebed devices operating at high
sampling frequency could be used to register the microfluctuations of the
eyeball shape we obtain. We advance that an inverse problem to obtain the
mechanical properties of a given eye (e.g., Young's modulus, Poisson ratio)
measuring its normal frequencies is doable. These measurements can be done
using non-invasive techniques, opening very interesting perspectives to
estimate the mechanical properties of eyes in vivo. Future research might
relate various ocular pathologies with anomalies in measured vibrational
frequencies of the eye.Comment: Published in PLoS ONE as Open Access Research Article. 17 pages, 5
color figure
State space c-reductions for concurrent systems in rewriting logic
We present c-reductions, a state space reduction technique.
The rough idea is to exploit some equivalence relation on states (possibly capturing system regularities) that preserves behavioral properties, and explore the induced quotient system. This is done by means of a canonizer
function, which maps each state into a (non necessarily unique) canonical representative of its equivalence class. The approach exploits the expressiveness of rewriting logic and its realization in Maude to enjoy several advantages over similar approaches: exibility and simplicity in
the definition of the reductions (supporting not only traditional symmetry reductions, but also name reuse and name abstraction); reasoning support for checking and proving correctness of the reductions; and automatization
of the reduction infrastructure via Maude's meta-programming
features. The approach has been validated over a set of representative case studies, exhibiting comparable results with respect to other tools
The apparent roughness of a sand surface blown by wind from an analytical model of saltation
We present an analytical model of aeolian sand transport. The model
quantifies the momentum transfer from the wind to the transported sand by
providing expressions for the thickness of the saltation layer and the apparent
surface roughness. These expressions are derived from basic physical principles
and a small number of assumptions. The model further predicts the sand
transport rate (mass flux) and the impact threshold (the smallest value of the
wind shear velocity at which saltation can be sustained). We show that, in
contrast to previous studies, the present model's predictions are in very good
agreement with a range of experiments, as well as with numerical simulations of
aeolian saltation. Because of its physical basis, we anticipate that our model
will find application in studies of aeolian sand transport on both Earth and
Mars
Spherical Functions Associated With the Three Dimensional Sphere
In this paper, we determine all irreducible spherical functions \Phi of any K
-type associated to the pair (G,K)=(\SO(4),\SO(3)). This is accomplished by
associating to \Phi a vector valued function H=H(u) of a real variable u, which
is analytic at u=0 and whose components are solutions of two coupled systems of
ordinary differential equations. By an appropriate conjugation involving Hahn
polynomials we uncouple one of the systems. Then this is taken to an uncoupled
system of hypergeometric equations, leading to a vector valued solution P=P(u)
whose entries are Gegenbauer's polynomials. Afterward, we identify those
simultaneous solutions and use the representation theory of \SO(4) to
characterize all irreducible spherical functions. The functions P=P(u)
corresponding to the irreducible spherical functions of a fixed K-type \pi_\ell
are appropriately packaged into a sequence of matrix valued polynomials
(P_w)_{w\ge0} of size (\ell+1)\times(\ell+1). Finally we proved that \widetilde
P_w={P_0}^{-1}P_w is a sequence of matrix orthogonal polynomials with respect
to a weight matrix W. Moreover we showed that W admits a second order symmetric
hypergeometric operator \widetilde D and a first order symmetric differential
operator \widetilde E.Comment: 49 pages, 2 figure
What’s Sex (Composition) Got to Do with It? The Importance of Sex Composition of Gangs for Female and Male Members’ Offending and Victimization
Sex composition of groups has been theorized in organizational sociology and found in prior work to structure female and male members’ behaviors and experiences. Peer group and gang literature similarly finds that the sex gap in offending varies across groups of differing sex ratios. Drawing on this and other research linking gang membership, offending, and victimization, we examine whether sex composition of gangs is linked to sex differences in offending in this sample, further assess whether sex composition similarly structures females’ and males’ victimization experiences, and if so, why. Self-report data from gang members in a multi-site, longitudinal study of 3,820 youths are employed. Results support previous findings about variations in member delinquency by both sex and sex composition of the gang and also indicate parallel variations in members’ victimization. These results are further considered within the context of facilitating effects such as gender dynamics, gang characteristics, and normative orientation
Lower critical field H_c1 and barriers for vortex entry in Bi_2Sr_2CaCu_2O_{8+delta} crystals
The penetration field H_p of Bi_2Sr_2CaCu_2O_{8+delta} crystals is determined
from magnetization curves for different field sweep rates dH/dt and
temperatures. The obtained results are consistent with theoretical reports in
the literature about vortex creep over surface and geometrical barriers. The
frequently observed low-temperature upturn of H_p is shown to be related to
metastable configurations due to barriers for vortex entry. Data of the true
lower critical field H_c1 are presented. The low-temperature dependence of H_c1
is consistent with a superconducting state with nodes in the gap function.
[PACS numbers: 74.25.Bt, 74.60.Ec, 74.60.Ge, 74.72.Hs
Experiments in vortex avalanches
Avalanche dynamics is found in many phenomena spanning from earthquakes to
the evolution of species. It can be also found in vortex matter when a type II
superconductor is externally driven, for example, by increasing the magnetic
field. Vortex avalanches associated with thermal instabilities can be an
undesirable effect for applications, but "dynamically driven" avalanches
emerging from the competition between intervortex interactions and quenched
disorder constitute an interesting scenario to test theoretical ideas related
with non-equilibrium dynamics. However, differently from the equilibrium phases
of vortex matter in type II superconductors, the study of the corresponding
dynamical phases - in which avalanches can play a role - is still in its
infancy. In this paper we critically review relevant experiments performed in
the last decade or so, emphasizing the ability of different experimental
techniques to establish the nature and statistical properties of the observed
avalanche behavior.Comment: To be published in Reviews of Modern Physics April 2004. 17 page
Atezolizumab in locally advanced or metastatic urothelial cancer : a pooled analysis from the Spanish patients of the IMvigor 210 cohort 2 and 211 studies
Funding: This study was funded by Roche Farma, Spain.The studies IMvigor 210 cohort 2 and IMvigor211 evaluated the efficacy of atezolizumab in patients with locally advanced or metastatic urothelial cancer (mUC) upon progression to platinum-based chemotherapy worldwide. Yet, the real impact of this drug in specific geographical regions is unknown. We combined individual-level data from the 131 patients recruited in Spain from IMvigor210 cohort 2 and IMvigor211 in a pooled analysis. Efficacy and safety outcomes were assessed in the overall study population and according to PD-L1 expression on tumour-infiltrating immune cells. Full data were available for 127 patients; 74 (58%) received atezolizumab and 53 (42%) chemotherapy. Atezolizumab patients had a numerically superior median overall survival although not reaching statistical significance (9.2 months vs 7.7 months). No statistically significant differences between arms were observed in overall response rates (20.3% vs 37.0%) or progression-free survival (2.1 months vs 5.3 months). Nonetheless, median duration of response was superior for the immunotherapy arm (non-reached vs 6.4 months; p = 0.005). Additionally, among the responders, the 12-month survival rates seemed to favour atezolizumab (66.7% vs 19.9%). When efficacy was analyzed based on PD-L1 expression status, no significant differences were found. Treatment-related adverse events of any grade occurred more frequently in the chemotherapy arm [46/57 (81%) vs 44/74 (59%)]. Patients who achieved an objective response on atezolizumab presented a longer median duration of response and numerically superior 12 month survival rates when compared with chemotherapy responders along with a more favorable safety profile. PD-L1 expression did not discriminate patients who might benefit from atezolizumab
Do UK universities communicate their brands effectively through their websites?
This paper attempts to explore the effectiveness of UK universities’ websites. The area of branding in higher education has received increasing academic investigation, but little work has researched how universities demonstrate their brand promises through their websites. The quest to differentiate through branding can be challenging in the university context, however. It is argued that those institutions that have a strong distinctive image will be in a better position to face a changing future. Employing a multistage methodology, the web pages of twenty UK universities were investigated by using a combination of content and multivariable analysis. Results indicated ‘traditional values’ such as teaching and research were often well communicated in terms of online brand but ‘emotional values’ like social responsibility and the universities’ environments were less consistently communicated, despite their increased topicality. It is therefore suggested that emotional values may offer a basis for possible future online differentiation
Conversion of the Mycotoxin Patulin to the Less Toxic Desoxypatulinic Acid by the Biocontrol Yeast Rhodosporidium kratochvilovae Strain LS11
Se describe en este artículo el descubrimiento de la degradación de la micotoxina patulina por una levaduraThe infection of stored apples by the fungus Penicillium expansum causes the contamination of fruits and fruit-derived
products with the mycotoxin patulin, which is a major issue in food safety. Fungal attack can be prevented by beneficial
microorganisms, so-called biocontrol agents. Previous time-course thin layer chromatography analyses showed that the aerobic
incubation of patulin with the biocontrol yeast Rhodosporidium kratochvilovae strain LS11 leads to the disappearance of the
mycotoxin spot and the parallel emergence of two new spots, one of which disappears over time. In this work, we analyzed the
biodegradation of patulin effected by LS11 through HPLC. The more stable of the two compounds was purified and characterized by
nuclear magnetic resonance as desoxypatulinic acid, whose formation was also quantitated in patulin degradation experiments. After
R. kratochvilovae LS11 had been incubated in the presence of 13C-labeled patulin, label was traced to desoxypatulinic acid, thus
proving that this compound derives from the metabolization of patulin by the yeast. Desoxypatulinic acid was much less toxic than
patulin to human lymphocytes and, in contrast to patulin, did not react in vitro with the thiol-bearing tripeptide glutathione. The
lower toxicity of desoxypatulinic acid is proposed to be a consequence of the hydrolysis of the lactone ring and the loss of functional
groups that react with thiol groups. The formation of desoxypatulinic acid from patulin represents a novel biodegradation pathway
that is also a detoxification process
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