905 research outputs found
On the accumulation of deleterious mutations during range expansions
We investigate the effect of spatial range expansions on the evolution of
fitness when beneficial and deleterious mutations co-segregate. We perform
individual-based simulations of a uniform linear habitat and complement them
with analytical approximations for the evolution of mean fitness at the edge of
the expansion. We find that deleterious mutations accumulate steadily on the
wave front during range expansions, thus creating an expansion load. Reduced
fitness due to the expansion load is not restricted to the wave front but
occurs over a large proportion of newly colonized habitats. The expansion load
can persist and represent a major fraction of the total mutation load thousands
of generations after the expansion. Our results extend qualitatively and
quantitatively to two-dimensional expansions. The phenomenon of expansion load
may explain growing evidence that populations that have recently expanded,
including humans, show an excess of deleterious mutations. To test the
predictions of our model, we analyze patterns of neutral and non-neutral
genetic diversity in humans and find an excellent fit between theory and data
D'Afrique en Amérique : la bonne et la méchante fille (ATU 480)
International audienceFor the first time we are proposing an attempt to quantify the contribution of African and European folklores to the elaboration of an African American narrative : The Kind and the Unkind Girls. We have based our findings on the work of Dupanloup and Bertorelle (2001) for estimating the relative contribution of many parental populations to a hybrid group. The results highlighted the existence of an essentially vertical transmission in certain oral traditions that could be correlated with the genetic transmission within populations that know this story, and the capacity of oral traditions to resist external cultural pressures.Nous proposons ici, pour la première fois, de quantifier la part prise par le folklore africain et le folklore européen dans l'élaboration d'un récit afroaméricain. Nous nous sommes pour cela appuyé sur la méthode développée par Dupanloup et Bertorelle (2001) qui permet d’estimer les contributions de populations parentales à une population métissée. Les résultats montrent l'existence d'une transmission essentiellement verticale dans certaines traditions orales, possiblement corrélées à la transmission génétique, ainsi que la capacité, pour une tradition, de survivre à de fortes pressions extérieures
Evolutionary simulations to detect functional lineage-specific genes
Motivation: Supporting the functionality of recent duplicate gene copies is usually difficult, owing to high sequence similarity between duplicate counterparts and shallow phylogenies, which hamper both the statistical and experimental inference. Results: We developed an integrated evolutionary approach to identify functional duplicate gene copies and other lineage-specific genes. By repeatedly simulating neutral evolution, our method estimates the probability that an ORF was selectively conserved and is therefore likely to represent a bona fide coding region. In parallel, our method tests whether the accumulation of non-synonymous substitutions reveals signatures of selective constraint. We show that our approach has high power to identify functional lineage-specific genes using simulated and real data. For example, a coding region of average length (∼1400 bp), restricted to hominoids, can be predicted to be functional in ∼94-100% of cases. Notably, the method may support functionality for instances where classical selection tests based on the ratio of non-synonymous to synonymous substitutions fail to reveal signatures of selection. Our method is available as an automated tool, ReEVOLVER, which will also be useful to systematically detect functional lineage-specific genes of closely related species on a large scale. Availability: ReEVOLVER is available at . Contact: [email protected] Supplementary Data: Supplementary Data are available at Bioinformatics onlin
Captive Breeding Programs Based on Family Groups in Polyploid Sturgeons
In species with long life cycles and discontinuous availability of individuals to reproduction, implementing a long-term captive breeding program can be difficult or impossible. In such cases, managing diversity among familiar groups instead of individuals could become a suitable approach to avoid inbreeding and increase the possibility to accomplish a breeding scheme. This is the case of several sturgeon species including the Adriatic sturgeon, whose recovery depends on the management of a few captive stocks directly descended from the same group of wild parents. In the present study, relatedness among 445 potential breeders was inferred with a novel software for pedigree reconstruction in tetraploids ("BreedingSturgeons"). This information was used to plan a breeding scheme considering familiar groups as breeding units and identifying mating priorities. A two-step strategy is proposed: a short-term breeding program, relying on the 13 remaining F0 individuals of certain wild origin; and a long-term plan based on F1 families. Simulations to evaluate the loss of alleles in the F2 generation under different pairing strategies and assess the number of individuals to breed, costs and logistical aquaculture constraints were performed. The strategy proposed is transferable to the several other tetraploid sturgeon species on the brink of extinction
Inference of Evolutionary Forces Acting on Human Biological Pathways.
Because natural selection is likely to act on multiple genes underlying a given phenotypic trait, we study here the potential effect of ongoing and past selection on the genetic diversity of human biological pathways. We first show that genes included in gene sets are generally under stronger selective constraints than other genes and that their evolutionary response is correlated. We then introduce a new procedure to detect selection at the pathway level based on a decomposition of the classical McDonald-Kreitman test extended to multiple genes. This new test, called 2DNS, detects outlier gene sets and takes into account past demographic effects and evolutionary constraints specific to gene sets. Selective forces acting on gene sets can be easily identified by a mere visual inspection of the position of the gene sets relative to their two-dimensional null distribution. We thus find several outlier gene sets that show signals of positive, balancing, or purifying selection but also others showing an ancient relaxation of selective constraints. The principle of the 2DNS test can also be applied to other genomic contrasts. For instance, the comparison of patterns of polymorphisms private to African and non-African populations reveals that most pathways show a higher proportion of nonsynonymous mutations in non-Africans than in Africans, potentially due to different demographic histories and selective pressures
Mitochondrial DNA Diversity in South America and the Genetic History of Andean Highlanders
We analyzed mtDNA sequence variation in 590 individuals from 18 south Amerindian populations. The spatial pattern of mtDNA diversity in these populations fits well the model proposed on the basis of Y-chromosome data. We found evidence of a differential action of genetic drift and gene flow in western and eastern populations, which has led to genetic divergence in the latter but not in the former. Although it is not possible to identify a pattern of genetic variation common to all South America, when western and eastern populations are analyzed separately, the mtDNA diversity in both regions fits the isolation-by-distance model, suggesting independent evolutionary dynamics. Maximum-likelihood estimates of divergence times between central and south Amerindian populations fall between 13,000 and 19,000 years, which is consistent with a Pleistocenic peopling of South America. Moreover, comparison of among-population variability of mtDNA and Y-chromosome DNA seems to indicate that South America is the only continent where the levels of differentiation are similar for maternal and paternal lineages
- …