84 research outputs found
A review of community-based solar home system projects in the Philippines
Solar Home Systems (SHS) are easy to deploy in island and in remote communities where grid connection is costly. However, issues related to maintenance of these systems emerge after they are deployed because of the remoteness and inaccessibility of the communities. This study looked into community-based programs in the Philippines and investigated the following: (1) social preparation, (2) role of the community in the project, and (3) sustainability of the program. In this paper, three communities under two government programs offering SHS are presented. These programs are the Solar Power Technology Support (SPOTS) program of the Department of Agrarian Reform (DAR) and the Household Electrification Program (HEP) of the Department of Energy (DOE). A focused group discussion and key informant interviews were conducted in two communities in Bukidnon province and in a community in Kalinga to obtain information from the project beneficiaries and SHS users on the preparation, implementation and maintenance of the projects. The results revealed that emphasis on the economic value of the technology, proper training of the locals on the technical and management aspects of the project, as well as the establishment of a supply chain for replacement parts are crucial factors for the sustainability of the programs
Effect of root age on the biomechanics of seminal and nodal roots of barley (<i>Hordeum vulgare L.</i>) in contrasting soil environments
Acknowledgments The James Hutton Institute receives funding from the Scottish Government. The authors would also like to thank Jim McNicol from Biomathematics and Statistics Scotland for his advice on statistical analysis.Peer reviewedPostprin
A Systems Biology Approach Reveals the Role of a Novel Methyltransferase in Response to Chemical Stress and Lipid Homeostasis
Using small molecule probes to understand gene function is an attractive approach that allows functional characterization of genes that are dispensable in standard laboratory conditions and provides insight into the mode of action of these compounds. Using chemogenomic assays we previously identified yeast Crg1, an uncharacterized SAM-dependent methyltransferase, as a novel interactor of the protein phosphatase inhibitor cantharidin. In this study we used a combinatorial approach that exploits contemporary high-throughput techniques available in Saccharomyces cerevisiae combined with rigorous biological follow-up to characterize the interaction of Crg1 with cantharidin. Biochemical analysis of this enzyme followed by a systematic analysis of the interactome and lipidome of CRG1 mutants revealed that Crg1, a stress-responsive SAM-dependent methyltransferase, methylates cantharidin in vitro. Chemogenomic assays uncovered that lipid-related processes are essential for cantharidin resistance in cells sensitized by deletion of the CRG1 gene. Lipidome-wide analysis of mutants further showed that cantharidin induces alterations in glycerophospholipid and sphingolipid abundance in a Crg1-dependent manner. We propose that Crg1 is a small molecule methyltransferase important for maintaining lipid homeostasis in response to drug perturbation. This approach demonstrates the value of combining chemical genomics with other systems-based methods for characterizing proteins and elucidating previously unknown mechanisms of action of small molecule inhibitors
May Measurement Month 2018: a pragmatic global screening campaign to raise awareness of blood pressure by the International Society of Hypertension
Aims
Raised blood pressure (BP) is the biggest contributor to mortality and disease burden worldwide and fewer than half of those with hypertension are aware of it. May Measurement Month (MMM) is a global campaign set up in 2017, to raise awareness of high BP and as a pragmatic solution to a lack of formal screening worldwide. The 2018 campaign was expanded, aiming to include more participants and countries.
Methods and results
Eighty-nine countries participated in MMM 2018. Volunteers (≥18 years) were recruited through opportunistic sampling at a variety of screening sites. Each participant had three BP measurements and completed a questionnaire on demographic, lifestyle, and environmental factors. Hypertension was defined as a systolic BP ≥140 mmHg or diastolic BP ≥90 mmHg, or taking antihypertensive medication. In total, 74.9% of screenees provided three BP readings. Multiple imputation using chained equations was used to impute missing readings. 1 504 963 individuals (mean age 45.3 years; 52.4% female) were screened. After multiple imputation, 502 079 (33.4%) individuals had hypertension, of whom 59.5% were aware of their diagnosis and 55.3% were taking antihypertensive medication. Of those on medication, 60.0% were controlled and of all hypertensives, 33.2% were controlled. We detected 224 285 individuals with untreated hypertension and 111 214 individuals with inadequately treated (systolic BP ≥ 140 mmHg or diastolic BP ≥ 90 mmHg) hypertension.
Conclusion
May Measurement Month expanded significantly compared with 2017, including more participants in more countries. The campaign identified over 335 000 adults with untreated or inadequately treated hypertension. In the absence of systematic screening programmes, MMM was effective at raising awareness at least among these individuals at risk
May measurement month 2018: a pragmatic global screening campaign to raise awareness of blood pressure by the International Society of Hypertension (vol 40, pg 2006, 2019)
China's maritime silk road to oil : influence in the Middle East through naval modernization
This thesis explores the prospect of a PRC naval role in the Persian Gulf by 2025 and its implications for the United States Navy, focusing in particular on Beijing's evolving relationship with Iran. Since the last years of the Cold War, China's relationships with the United States and Russia have improved significantly, and China no longer sees these former adversaries as imminent threats. As a result, the People's Liberation Army (PLA) has shifted its strategy from a defensive posture to a forward-looking one. Concurrently, economic developments and progress have raised China's aspirations to become the new regional power in Asia. As such, the PRC's economic sustainability will depend greatly on imported oil. The Persian Gulf will be a strategic focus for China in the near future.http://archive.org/details/chinasmaritimesi109452160Approved for public release; distribution is unlimited
Action research on addressing the negative impacts of informal economy in an online micro food business: Using the legalist approach and motives theories towards the goal of sustainability and growth
This action research is about addressing the negative impacts of operating under the informal economy and how it inhibits an online micro food business to achieve sustainable growth. Established during the peak of the COVID-19 pandemic in June 2020, Nini’s Oven began with zero plans and was launched overnight. However, albeit the business’s continued increase in demand month on month since it started, there are still a lot of aspects that limit its growth. With the help of a system mapping tool, it was identified that all manifestations of the issues were brought about by the informal nature of business. Guided by the Legalist Approach and Motives theories, as well as essential strategic management frameworks, and with the help of the collaborators, this action research had been successful in helping Nini’s Oven to graduate out of informality.
The first cycle of this action research addressed the inefficient production brought by the limited capacity and manpower of the company. The crucial steps completed in this cycle were official business registration and acquisition of a formal address. However, upon the business’s move, the lack of formal standard operating procedures and rules and regulations of the company became more apparent—these focal issues were addressed in the second cycle. Since the action points taken were broad and complex, the Covey’s Matrix was utilized in identifying important action points, while the process of change had been guided by McKinsey’s 7S Framework.
Overall, the interventions made have helped trigger the micro business to take the first few crucial steps towards achieving its desired growth and planning for sustainability
Performance of Schuyler Heim Composite Bridge Deck Replacement: Port of Los Angeles, California
Impurity profiling of methamphetamine hydrochloride drugs seized in the Philippines
Methamphetamine hydrochloride is one of the most widely used illicit drugs in the Philippines. In this study, we describe the application of cluster analysis of trace impurities in the profiling of the seized methamphetamine drug samples.
Thirty milligrams of a homogenized drug sample were dissolved in 1 mL of pH 10.5 buffer solution and extracted with ethyl acetate containing three internal standards. The trace impurities were identified using gas chromatography–mass spectrometry (GC–MS) and quantified by gas chromatography with a flame ionization detector (GC–FID).
Following previously reported methodologies, 30 impurity peaks were selected from the GC–FID chromatograms. The peak areas and retention times were referenced to the internal standards. The peak areas of the selected peaks were then grouped for cluster analysis. In order to check for consistency of clustering, two further cluster analyses were performed using 40 and 50 impurity peaks. Changes in clustering were observed in going from 30 to 40 impurity peaks, while analyses using 40 and 50 impurity peaks gave similar results. Thus, for the seized drug samples used in this study, cluster analysis using at least 40 impurity peaks showed better consistency of clustering as compared to analysis using 30 peaks only.
Ten of the impurity peaks were identified, of which four were identified for the first time in methamphetamine drug samples. These are p-bromotoluene, N-benzyl amphetamine, N-ethyl amphetamine, and N-ethyl methamphetamine. The presence of phenyl-2-propanone (P2P), N,N-dimethyl amphetamine, and N-formyl amphetamine is indicative that these casework samples were synthesized using the Leuckart method
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