Inestabilidad de laderas en el Valle del Meredal (Asturias, NO de España)

[Resumen] En el valle del Meredal se han identificado 64 movimientos en masa que incluyenmovimientos complejos, deslizamientos rotacionales, flujos y avalanchas rocosas, cuyo desarrollo está condicionado por el diferente comportamiento mecánico de los materiales del sustrato. La aplicación de distintos criterios de cronología relativa basados en el grado de superposición y conservación de las formas ha permitido diferenciar cinco clases de movimientos en masa en cuanto a su edad. Desde el punto de vista regional, la incisión de la red fluvial asociada a los cambios climáticos cuaternarios y a la elevación del margen cantábrico parece ser el factor determinante del origen de esta dinámica.[Abstract] In the Meredal valley 64 landslides, including complex movements, rock slumps,flows and rock avalanches have been identified. The development of these landslides is conditioned by the mechanical behaviour of the different bedrock lithologies. Five chronological classes of movements have been established by applying several relative chronology criteria, as superposition and preservation degree of the landslides. From the regional point of view, fluvial drainage incision linked to quaternary climate changes and to the uplift of the cantabrian margin seems to be determinant in the origin of this dynamics

Clinical guideline SEOM: cancer of unknown primary site

Cancer of unknown primary site is a histologically confirmed cancer which is manifested in advanced stage, with no identifiable primary site after the use of standard diagnostic procedures. Patients are initially placed into one of categories based upon the examination of the initial biopsy: adenocarcinoma, squamous cell carcinoma, neuroendocrine carcinoma and poorly differentiated carcinoma. Appropriate patient management requires an understanding of several clinicopathologic features that help to identify several subsets of patients with more responsive tumors

Undetectable Levels of CSF Amyloid-β Peptide in a Patient with 17β-Hydroxysteroid Dehydrogenase Deficiency

17β-hydroxysteroid dehydrogenase 10 (HSD10) deficiency is a rare X-linked inborn error of isoleucine catabolism. Although this protein has been genetically implicated in Alzheimer's disease pathogenesis, studies of amyloid-β peptide (Aβ) in patients with HSD10 deficiency have not been previously reported. We found, in a severely affected child with HSD10 deficiency, undetectable levels of Aβ in the cerebrospinal fluid, together with low expression of brain-derived neurotrophic factor, α-synuclein, and serotonin metabolites. Confirmation of these findings in other patients would help elucidating mechanisms of synaptic dysfunction in this disease, and highlight the role of Aβ in both early and late periods of life

Inverse Low Gain Avalanche Detectors (iLGADs) for precise tracking and timing applications

Low Gain Avalanche Detector (LGAD) is the baseline sensing technology of the recently proposed Minimum Ionizing Particle (MIP) end-cap timing detectors (MTD) at the Atlas and CMS experiments. The current MTD sensor is designed as a multi-pad matrix detector delivering a poor position resolution, due to the relatively large pad area, around 1 $mm^2$; and a good timing resolution, around 20-30 ps. Besides, in his current technological incarnation, the timing resolution of the MTD LGAD sensors is severely degraded once the MIP particle hits the inter-pad region since the signal amplification is missing for this region. This limitation is named as the LGAD fill-factor problem. To overcome the fill factor problem and the poor position resolution of the MTD LGAD sensors, a p-in-p LGAD (iLGAD) was introduced. Contrary to the conventional LGAD, the iLGAD has a non-segmented deep p-well (the multiplication layer). Therefore, iLGADs should ideally present a constant gain value over all the sensitive region of the device without gain drops between the signal collecting electrodes; in other words, iLGADs should have a 100${\%}$ fill-factor by design. In this paper, tracking and timing performance of the first iLGAD prototypes is presented.Comment: Conference Proceedings of VCI2019, 15th Vienna Conference of Instrumentation, February 18-22, 2019, Vienna, Austri

Lack of maintenance of motorway fences works against their intended purpose with potential negative impacts on protected species

Linear infrastructure intrusions into natural ecosystems, such as motorways and high-speed railways, causes direct loss of habitat but also impacts fauna through collisions. Wildlife road mortality is well documented and extensive conservation legislation exists in many countries to minimise the negative impact of these infrastructures. However, although these measures are implemented because of legislation, these structures are often not adequately maintained. Here we present data on the functionality of perimeter fences along two motorways in Malaga province (southern Spain) erected to prevent collisions with the common chameleon (Chamaeleo chamaeleon). We sampled the fences along the 14 km of the two motorways included in the 17 1 × 1 km squares of the study area. Our results show that the reptile fence is permeable throughout at those points where the metal sheeting was absent and where the vegetation had overgrown around the fence, hence allowing chameleons to cross. Given our results, we conclude that this situation is likely to be similar in other regions of Spain and in other countries. This is because construction/concessionary companies do not consider the environmental impact of construction projects in the medium and long term, and environmental authorities do not ensure that companies comply with the legislation

One-pot synthesis of compact DNA silica particles for gene delivery and extraordinary DNA preservation

Repairing genetic defects using exogenous DNA is a major challenge the science is currently facing. This requires the design of vectors that can effectively encapsulate, protect and target nucleic acids to specific cells safely and precisely. Here we have designed silica-based physiologically responsive particles to encapsulate, store, and transfer DNA. Unlike existing vectors (e.g., viral or lipidic particles), these DNA@SiO2 systems are very stable at room temperature. We also demonstrate how they protect the encapsulated DNA from exposure to different biological and physicochemical stresses, including DNase, denaturation temperatures (>100 °C), or reactive oxygen species (ROS). Remarkably, upon cellular uptake, these vectors dissolve safely unpacking the DNA and transfecting the cells.Acknowledgments: We are grateful to D. Munoz for her technical support and Dr. Kirst for his criticisms of the manuscript. MLF acknowledges the financial support from the Spanish Instituto de Salud Carlos iii, and the European Union FEDER funds under Projects ref. PI22/00030 and PI19/00349, co-funded by the European Regional Development Fund, “Investing in your future” and Grant TED2021-129248 BeI00 funded by MCIN/AEI/10.13039/501100011033 and by the “European Union Next Generation EU/PRTR”. We also thank the Gobierno Regional de Cantabria and IDIVAL for the project Refs IDI 20/22, INNVAL21/19, and IDI-020-022 fellowship to ARV and technological and administrative services. MACD acknowledges financial support from the Spanish Ministerio de Economía y Competitividad under grant PID2020-113704RB-I00, Xunta de Galicia/FEDER (IN607A 2018/5 and Centro Singular de Investigacion de Galicia, Acc. 2019e2022, ED431G 2019e06), 0712/ACUINANO1E, 0624/ 2IQBIONEURO6E cofounded by FEDER through the program Interreg V-A Espana-Portugal (POCTEP), and NANOCULTURE (ERDF: 1.102.531) Interreg Atlantic Area, the European Union (European Regional Development Fund-ERDF). LMC acknowledges the Margarita Salas requalification grants for the training of young doctors Ref.: REC-Salas21, Uvigo-UC (Ministerio de Universidades). Figures and graphs have been created with BioRender software (BioRender.com, License ID: 9519A1C8-0002). We are grateful to Dr. Lansford, Dr. Parton, Dr. Greene, Dr. Davidson, Dr. Bement and Dr. Voeltz for the plasmids references in Table S1 (obtained fron Addgene)

Penetration of ultraviolet‐B radiation in oligotrophic regions of the oceans during the Malaspina 2010 expedition

Few studies have investigated ultraviolet (UV) radiation in the open ocean besides its harmful effects on organisms and influence on biogeochemical processes. Here, we assessed UV attenuation, with particular focus on UV‐B, across the (sub)tropical ocean during the Malaspina 2010 Circumnavigation. Vertical UV radiometer profiles together with Chl‐ a concentration, and UV absorption by CDOM ( a CDOM ( λ )) and by suspended particulate matter ( a p ( λ )) were measured at 117 stations. At photosynthetically active radiation (PAR) and across UV‐A and UV‐B wavelengths, the lowest downwelling attenuation coefficients ( K d ) during the expedition were recorded in ultra‐oligotrophic regions at 5°–15°S (mean K d (305 nm): 0.129 m −1 , mean K d (313 nm): 0.107 m −1 ) in the Indian and South Pacific Oceans. The waters here were comparatively more transparent than at 5°–15°N (mean K d (305 nm): 0.239 m −1 , mean K d (313 nm): 0.181 m −1 ) where equatorial upwelling occurs. K d was highest near the Costa Rica Dome ( K d (313 nm): 0.226 m −1 ) and at the confluence of the Benguela and Agulhas currents ( K d (313 nm): 0.251 m −1 ). The contribution of a p ( λ ) toward nonwater absorption ( a nw ( λ )) was significantly lower at 305 nm than at 313 and 320 nm, suggesting the contribution of absorption by detritus and phytoplankton particles decreases compared with that of CDOM absorption as UV‐B wavelength decreases. Both a CDOM ( λ ) and a p ( λ ) at UV‐B wavelengths were lowest in the Indian Ocean whereas K d was lowest in the South Pacific. This finding emphasizes that other factors besides absorption, such as scattering by reflective phytoplankton or inorganic particles, strongly influence UV‐B attenuation in open ocean waters.Plain Language Summary: We assessed water transparency to UV‐B radiation across the tropical and subtropical ocean as part of the Malaspina 2010 Expedition. UV‐B radiometer profiles, Chlorophyll‐a, and UV‐B absorption by organic matter and suspended particles were measured at 117 stations. The most UV‐B transparent waters were found in regions where nutrients are extremely low, particularly at 5°–15°S in the Indian and South Pacific Oceans. Here, ocean waters were considerably more transparent than 5°–15°N, which suggests that at a given depth southern hemisphere marine organisms experience higher UV‐B exposure than their northern counterparts. The least UV‐B transparent waters were near the Costa Rica Dome and at the confluence of the Benguela and Agulhas currents. UV‐B absorption by organic matter and suspended particles, and Chl‐ a concentration were lowest in the Indian Ocean. The contribution of suspended particles toward nonwater absorption was significantly lower at 305 nm than at 313 and 320 nm, and higher in the clearest waters of the Indian Ocean than in the Subtropical South Pacific. Absorptions by organic matter and suspended particles were lowest in the Indian Ocean whereas UV‐B attenuation was lowest in the South Pacific, which highlights the complex relationship between optical properties in the UV‐B spectrum.Ministerio de Ciencia e Innovación | Ref. CSD2008-00077King Abdullah University of Science and Technology | Ref. BAS/1/1072-01-0

Effect of cooling rate during solidification on the hard phases of M23C6-type of cast CoCrMo alloy

Microstructural morphology of CoCrMo alloy by control of the cooling rate during the solidification was investigated. Samples were obtained using both an induction furnace for slow cooling rate and electric arc furnace for fast cooling rate. Microstructural characterizations were performed with metallographic techniques. It was found that the difference between the formation temperature of hard secondary phases of M23C6-type carbides determine the reduction of carbide size by increasing the cooling rate

Effect of cooling rate during solidification on the hard phases of M23C6-type of cast CoCrMo alloy

Microstructural morphology of CoCrMo alloy by control of the cooling rate during the solidification was investigated. Samples were obtained using both an induction furnace for slow cooling rate and electric arc furnace for fast cooling rate. Microstructural characterizations were performed with metallographic techniques. It was found that the difference between the formation temperature of hard secondary phases of M23C6-type carbides determine the reduction of carbide size by increasing the cooling rate

Failure analysis of Co–Cr hip resurfacing prosthesis during solidification

In this study a failure originated during solidification process into the femoral stem component of Hip Resurfacing prosthesis was investigated. Visual inspection, optical microscopy, scanning electron microscopy (SEM), energy dispersive spectroscopy (EDS) and a commercial software simulation ProCAST were carried out in order to determine the cause and solution of this failure. The results exhibited hot tearing, shrinkage porosity and metal oxide films due to inadequate heat dissipation during solidification process, as a consequence of poor investment casting ceramic mold configuration. Also in this paper was improved the casting design solving this kind of defects