The Lantern Vol. 63, No. 2, Spring 1996

• Poet, Lead Me On • St. Patrick\u27s Day • The Last Three Days • The Impressionable • Roundabout • The Bench • Carnivorous • Kyrie • Second Glance • Porch • Cruel Design • A Mime • Flaxen Crown • My Embryonic Ocean of Love • Stone Matrix • Voices from the Past • Skipping the Bullfight: Toreadors and Gaudi • Another Part of My Lacolonialism • Translucent Pane • Linguistics • Treehouse • A Disagreeable Music Piece • Vigil • A Brief History of American Poetry in Englishhttps://digitalcommons.ursinus.edu/lantern/1148/thumbnail.jp

Status Report of the DPHEP Study Group: Towards a Global Effort for Sustainable Data Preservation in High Energy Physics

Data from high-energy physics (HEP) experiments are collected with significant financial and human effort and are mostly unique. An inter-experimental study group on HEP data preservation and long-term analysis was convened as a panel of the International Committee for Future Accelerators (ICFA). The group was formed by large collider-based experiments and investigated the technical and organisational aspects of HEP data preservation. An intermediate report was released in November 2009 addressing the general issues of data preservation in HEP. This paper includes and extends the intermediate report. It provides an analysis of the research case for data preservation and a detailed description of the various projects at experiment, laboratory and international levels. In addition, the paper provides a concrete proposal for an international organisation in charge of the data management and policies in high-energy physics

Electroanalytical detection of pindolol: comparison of unmodified and reduced graphene oxide modified screen-printed graphite electrodes

Recent work has reported the first electroanalytical detection of pindolol using reduced graphene oxide (RGO) modified glassy carbon electrodes [S. Smarzewska and W. Ciesielski, Anal. Methods, 2014, 6, 5038] where it was reported that the use of RGO provided significant improvements in the electroanalytical signal in comparison to a bare (unmodified) glassy carbon electrode. We demonstrate, for the first time, that the electroanalytical quantification of pindolol is actually possible using bare (unmodified) screenprinted graphite electrodes (SPEs). This paper addresses the electroanalytical determination of pindolol utilising RGO modified SPEs. Surprisingly, it is found that bare (unmodified) SPEs provide superior electrochemical signatures over that of RGO modified SPEs. Consequently the electroanalytical sensing of pindolol is explored at bare unmodified SPEs where a linear range between 0.1 μM–10.0 μM is found to be possible whilst offering a limit of detection (3σ) corresponding to 0.097 μM. This provides a convenient yet analytically sensitive method for sensing pindolol. The optimised electroanalytical protocol using the unmodified SPEs, which requires no pre-treatment (electrode polishing) or electrode modification step (such as with the use of RGO), was then further applied to the determination of pindolol in urine samples. This work demonstrates that the use of RGO modified SPEs have no significant benefits when compared to the bare (unmodified) alternative and that the RGO free electrode surface can provide electro-analytically useful performances

Scrapie infection investigated by magnetic resonance imaging and Fourier transform infrared microscopy

NRC publication: Ye

Bonobos and chimpanzees preferentially attend to familiar members of the dominant sex

Social animals must carefully track consequential events and opportunities for social learning. However, the competing demands of the social world produce trade-offs in social attention, defined as directed visual attention towards conspecifics. A key question is how socioecology shapes these biases in social attention over evolution and development. Chimpanzees, Pan troglodytes, and bonobos, Pan paniscus, provide ideal models for addressing this question because they have large communities with fission–fusion grouping, divergent sex-based dominance hierarchies and occasional intergroup encounters. Using noninvasive eye-tracking measures, we recorded captive apes’ attention to side-by-side images of familiar and unfamiliar conspecifics of the same sex. We tested four competing hypotheses about the influence of taxonomically widespread socioecological pressures on social attention, including intergroup conflict, dominance, dispersal and mating competition. Both species preferentially attended to familiar over unfamiliar conspecifics when viewing the sex that typically occupies the highest ranks in the group: females for bonobos, and males for chimpanzees. However, they did not demonstrate attentional biases between familiar and unfamiliar members of the subordinate sex. Findings were consistent across species despite differences in which sex tends to be more dominant. These results suggest that sex-based dominance patterns guide social attention across Pan. Our findings reveal how socioecological pressures shape social attention in apes and likely contribute to the evolution of social cognition across primates

Erratum to “Bonobos and chimpanzees preferentially attend to familiar members of the dominant sex” [Animal Behaviour 177 (2021) 193–206] (Animal Behaviour (2021) 177 (193–206), (S000334722100138X), (10.1016/j.anbehav.2021.04.027))

It was discovered that the original online version of the above article contained errors that were not the fault of the authors. The affiliations of two authors, Fumihiro Kano and Christopher Krupenye, were listed incorrectly on the title page of the article. The Publisher decided to ‘resupply’ (repost and replace) the XML and online PDF of the article. The printed issue has also been correspondingly altered. Elsevier regrets and apologizes for any inconvenience caused by posting (and printing) a new version of this article online, but hopes that the reader will understand the reasons for doing so.</p

Chemical scaffold recycling: Structure-guided conversion of an HIV integrase inhibitor into a potent influenza virus RNA-dependent RNA polymerase inhibitor designed to minimize resistance potential

Influenza is one of the leading causes of disease-related mortalities worldwide. Several strategies have been implemented during the past decades to hinder the replication cycle of influenza viruses, all of which have resulted in the emergence of resistant virus strains. The most recent example is baloxavir marboxil, where a single mutation in the active site of the target endonuclease domain of the RNA-dependent-RNA polymerase renders the recent FDA approved compound ∼1000-fold less effective. Raltegravir is a first-in-class HIV inhibitor that shows modest activity to the endonuclease. Here, we have used structure-guided approaches to create rationally designed derivative molecules that efficiently engage the endonuclease active site. The design strategy was driven by our previously published structures of endonuclease-substrate complexes, which allowed us to target functionally conserved residues and reduce the likelihood of resistance mutations. We succeeded in developing low nanomolar equipotent inhibitors of both wild-type and baloxavir-resistant endonuclease. We also developed macrocyclic versions of these inhibitors that engage the active site in the same manner as their 'open' counterparts but with reduced affinity. Structural analyses provide clear avenues for how to increase the affinity of these cyclic compounds