135 research outputs found

    Inferring Multiple Graphical Structures

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    Gaussian Graphical Models provide a convenient framework for representing dependencies between variables. Recently, this tool has received a high interest for the discovery of biological networks. The literature focuses on the case where a single network is inferred from a set of measurements, but, as wetlab data is typically scarce, several assays, where the experimental conditions affect interactions, are usually merged to infer a single network. In this paper, we propose two approaches for estimating multiple related graphs, by rendering the closeness assumption into an empirical prior or group penalties. We provide quantitative results demonstrating the benefits of the proposed approaches. The methods presented in this paper are embeded in the R package 'simone' from version 1.0-0 and later

    Superfluid toroidal currents in atomic condensates

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    The dynamics of toroidal condensates in the presence of condensate flow and dipole perturbation have been investigated. The Bogoliubov spectrum of condensate is calculated for an oblate torus using a discrete-variable representation and a spectral method to high accuracy. The transition from spheroidal to toroidal geometry of the trap displaces the energy levels into narrow bands. The lowest-order acoustic modes are quantized with the dispersion relation ωmωs\omega \sim |m| \omega_s with m=0,±1,±2,...m=0,\pm 1,\pm 2, .... A condensate with toroidal current κ\kappa splits the m|m| co-rotating and counter-rotating pair by the amount: ΔE2m2κ<r2>\Delta E \approx 2 |m|\hbar^2 \kappa < r^{-2}>. Radial dipole excitations are the lowest energy dissipation modes. For highly occupied condensates the nonlinearity creates an asymmetric mix of dipole circulation and nonlinear shifts in the spectrum of excitations so that the center of mass circulates around the axis of symmetry of the trap. We outline an experimental method to study these excitations.Comment: 8 pages, 8 figure

    Spectral method for the time-dependent Gross-Pitaevskii equation with a harmonic trap

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    We study the numerical resolution of the time-dependent Gross-Pitaevskii equation, a non-linear Schroedinger equation used to simulate the dynamics of Bose-Einstein condensates. Considering condensates trapped in harmonic potentials, we present an efficient algorithm by making use of a spectral Galerkin method, using a basis set of harmonic oscillator functions, and the Gauss-Hermite quadrature. We apply this algorithm to the simulation of condensate breathing and scissors modes.Comment: 23 pages, 5 figure

    Role of quantum statistics in the photoassociation of Bose-Einstein condensates

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    We show that the photoassociation of an atomic Bose-Einstein condensate to form condensed molecules is a chemical process which not only does not obey the Arrhenius rules for chemical reactions, but that it can also depend on the quantum statistics of the reactants. Comparing the predictions of a truncated Wigner representation for different initial quantum states, we find that, even when the quantum prediction for an initial coherent state is close to the Gross-Pitaevskii prediction, other quantum states may result in very different dynamics

    Non-minimal Maxwell-Modified Gauss-Bonnet Cosmologies: Inflation and Dark Energy

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    In this paper we show that power-law inflation can be realized in non-minimal gravitational coupling of electromagnetic field with a general function of Gauss-Bonnet invariant. Such a non-minimal coupling may appear due to quantum corrections. We also consider modified Maxwell-F(G)F(G) gravity in which non-minimal coupling between electromagnetic field and f(G)f(G) occur in the framework of modified Gauss-Bonnet gravity. It is shown that inflationary cosmology and late-time accelerated expansion of the universe are possible in such a theory.Comment: 10 pages, no figur

    Gravity and Electromagnetism with Y(R)F2Y(R)F^2-type Coupling and Magnetic Monopole Solutions

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    We investigate Y(R)F2 Y(R) F^2 -type coupling of electromagnetic fields to gravity. After we derive field equations by a first order variational principle from the Lagrangian formulation of the non-minimally coupled theory, we look for static, spherically symmetric, magnetic monopole solutions. We point out that the solutions can provide possible geometries which may explain the flatness of the observed rotation curves of galaxies.Comment: 10 page

    Non-minimal ln(R)F2\ln(R)F^2 Couplings of Electromagnetic Fields to Gravity: Static, Spherically Symmetric Solutions

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    We investigate the non-minimal couplings between the electromagnetic fields and gravity through the natural logarithm of the curvature scalar. After we give the Lagrangian formulation of the non-minimally coupled theory, we derive field equations by a first order variational principle using the method of Lagrange multipliers. We look at static, spherically symmetric solutions that are asymptotically flat. We discuss the nature of horizons for some candidate black hole solutions according to various values of the parameters R0R_0 and a1a_1.Comment: 12 pages, 5 figures, accepted for publication in EPJ

    Dermatophylosis in Santa Inês sheep from Distrito Federal

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    Relataram-se quatro casos de dermatofilose em ovinos da raça Santa Inês, no período de um ano. Microscopicamente observaram-se filamentos na forma de "trilho de bonde" e zoósporos nos quatro casos. A tentativa do isolamento do microrganismo foi realizada por meio do método de Haalstra e em apenas um caso obteve-se sucesso, observando-se colônias de aparência lisa, formato circular, cor amarelada e hemolítica em ágar sangue. O exame direto com coloração de Gram mostrou-se um método bastante eficiente na confirmação da presença do microrganismo afetando a epiderme em razão da morfologia típica do agente.Four cases of dermatophylosis were reported in Santa Inês sheep in a study period of one year. Microscopically, septate filaments and coccoid forms zoospores were observed. Attempts to isolate the microorganisms were accomplished using Haastra's method and it was successful in only one case. Dermatophilus congolensis samples have grown on blood agar, colonies where hemolytic, small, round and pigmentation vary from yellow to orange. The gram staining method was efficient to confirm the presence of the microorganism affecting the epidermis due to typical morphology of the agent

    Quantum superchemistry: Role of trapping profile and quantum statistics

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    The process of Raman photoassociation of a trapped atomic condensate to form condensed molecules has been labeled superchemistry because it can occur at 0 K and experiences coherent bosonic stimulation. We show here that the differences from ordinary chemical processes go even deeper, with the conversion rates depending on the quantum state of the reactants, as expressed by the Wigner function. We consider different initial quantum states of the trapped atomic condensate and different forms of the confining potentials, demonstrating the importance of the quantum statistics and the extra degrees of freedom which massive particles and trapping potentials make available over the analogous optical process of second-harmonic generation. We show that both mean-field analyses and quantum calculations using an inappropriate initial condition can make inaccurate predictions for a given system. This is possible whether using a spatially dependent analysis or a zero-dimensional approach as commonly used in quantum optics

    Bartonella Clarridgeiae Bacteremia Detected In An Asymptomatic Blood Donor

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    Human exposure to Bartonella clarridgeiae has been reported only on the basis of antibody detection. 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Henselae, and Rickettsia felis in fleas from Morocco (2011) Ann Trop Med Parasitol, 105, pp. 493-498. , http://dx.doi.org/10.1179/1364859411Y.0000000038Kordick, D.L., Brown, T.T., Shin, K., Breitschwerdt, E.B., Clinical and pathologic evaluation of chronic Bartonella henselae or Bartonella clarridgeiae infection in cats (1999) J Clin Microbiol, 37, pp. 1536-1547Chomel, B.B., Carlos, E.T., Kasten, R.W., Yamamoto, K., Chang, C.C., Carlos, R.S., Abenes, M.V., Pajares, C.M., Bartonella henselae and Bartonella clarridgeiae infection in domestic cats from the Philippines (1999) Am J Trop Med Hyg, 60, pp. 593-597Dehio, C., Bartonella interactions with endothelial cells and erythrocytes (2001) Trends Microbiol, 9, pp. 279-285. , http://dx.doi.org/10.1016/S0966-842X(01)02047-9Dehio, C., Meyer, M., Berger, J., Schwarz, H., Lanz, C., Interaction of Bartonella henselae with endothelial cells results in bacterial aggregation on the cell surface and the subsequent engulfment and internalisation of the bacterial aggregate by a unique structure, the invasome (1997) J Cell Sci, 110 (18), pp. 2141-2154Braga Mdo, S., Diniz, P.P., André, M.R., Bortoli, C.P., Machado, R.Z., Molecular characterisation of Bartonella species in cats from São Luís, state of Maranhão, North-Eastern Brazil (2012) Mem Inst Oswaldo Cruz, 107, pp. 772-777. , http://dx.doi.org/10.1590/S0074-02762012000600011Eremeeva, M.E., Gerns, H.L., Lydy, S.L., Goo, J.S., Ryan, E.T., Mathew, S.S., Ferraro, M.J., Koehler, J.E., Bacteremia, fever, and splenomegaly caused by a newly recognized Bartonella species (2007) N Engl J Med, 356, pp. 2381-2387. , http://dx.doi.org/10.1056/NEJMoa065987Chomel, B.B., Boulouis, H.J., Breitschwerdt, E.B., Kasten, R.W., Vayssier-Taussat, M., Birtles, R.J., Koehler, J.E., Dehio, C., Ecological fitness and strategies of adaptation of Bartonella species to their hosts and vectors (2009) Vet Res, 40, p. 29. , http://dx.doi.org/10.1051/vetres/2009011Breitschwerdt, E.B., Maggi, R.G., Duncan, A.W., Nicholson, W.L., Hegarty, B.C., Woods, C.W., Bartonella species in blood of immunocompetent persons with animal and arthropod contact (2007) Emerg Infect Dis, 13, pp. 938-941. , http://dx.doi.org/10.3201/eid1306.061337Carson, J.L., Grossman, B.J., Kleinman, S., Tinmouth, A.T., Marques, M.B., Fung, M.K., Holcomb, J.B., Djulbegovic, B., Red blood cell transfusion: A clinical practice guideline from the AABB (2012) Ann Intern Med, 157, pp. 49-58. , http://dx.doi.org/10.7326/0003-4819-157-1-201206190-00429Ramirez-Arcos, S., Goldman, M., Blajchman, M., Bacterial contamination (2012) Transfusion Reaction, 4, pp. 153-189. , Popovsky MA (ed), American Association Of Blood Banks, Bethesda, MDVamvakas, E.C., Blajchman, M.A., Transfusion-related mortality: The ongoing risks of allogeneic blood transfusion and the available strategies for their prevention (2009) Blood, 113, pp. 3406-3417. , http://dx.doi.org/10.1182/blood-2008-10-167643Magalhães, R.F., Cintra, M.L., Barjas-Castro, M.L., Del Negro, G.M., Okay, T.S., Velho, P.E., Blood donor infected with Bartonella henselae (2010) Transfus Med, 20, pp. 280-282. , http://dx.doi.org/10.1111/j.1365-3148.2010.01001.xMagalhães, R.F., Pitassi, L.H., Salvadego, M., De Moraes, A.M., Barjas-Castro, M.L., Velho, P.E., Bartonella henselae survives after the storage period of red blood cell units: Is it transmissible by transfusion? (2008) Transfus Med, 18, pp. 287-291. , http://dx.doi.org/10.1111/j.1365-3148.2008.00871.xLin, J.W., Chen, C.M., Chang, C.C., Unknown fever and back pain caused by Bartonella henselae in a veterinarian after a needle puncture: A case report and literature review (2011) Vector Borne Zoonotic Dis, 11, pp. 589-591. , http://dx.doi.org/10.1089/vbz.2009.0217Oliveira, A.M., Maggi, R.G., Woods, C.W., Breitschwerdt, E.B., Suspected needle stick transmission of Bartonella vinsonii subspecies berkhoffii to a veterinarian (2010) J Vet Intern Med, 24, pp. 1229-1232. , http://dx.doi.org/10.1111/j.1939-1676.2010.0563.xOhl, M.E., Spach, D.H., Bartonella quintana and urban trench fever (2000) Clin Infect Dis, 31, pp. 131-135. , http://dx.doi.org/10.1086/313890Daly, J.S., Worthington, M.G., Brenner, D.J., Moss, C.W., Hollis, D.G., Weyant, R.S., Steigerwalt, A.G., O'Connor, S.P., Rochalimaea elizabethae sp. Nov. Isolated from a patient with endocarditis (1993) J Clin Microbiol, 31, pp. 872-881Oksi, J., Rantala, S., Kilpinen, S., Silvennoinen, R., Vornanen, M., Veikkolainen, V., Eerola, E., Pulliainen, A.T., Cat scratch disease caused by Bartonella grahamii in an immunocompromised patient (2013) J Clin Microbiol, 51, pp. 2781-2784. , http://dx.doi.org/10.1128/JCM.00910-13Breitschwerdt, E.B., Mascarelli, P.E., Schweickert, L.A., Maggi, R.G., Hegarty, B.C., Bradley, J.M., Woods, C.W., Hallucinations, sensory neuropathy, and peripheral visual deficits in a young woman infected with Bartonella koehlerae (2011) J Clin Microbiol, 49, pp. 3415-3417. , http://dx.doi.org/10.1128/JCM.00833-11Raoult, D., Roblot, F., Rolain, J.M., Besnier, J.M., Loulergue, J., Bastides, F., Choutet, P., First isolation of Bartonella alsatica from a valve of a patient with endocarditis (2006) J Clin Microbiol, 44, pp. 278-279. , http://dx.doi.org/10.1128/JCM.44.1.278-279.2006Welch, D.F., Carroll, K.C., Hofmeister, E.K., Persing, D.H., Robison, D.A., Steigerwalt, A.G., Brenner, D.J., Isolation of a new subspecies, Bartonella vinsonii subsp. Arupensis, from a cattle rancher: Identity with isolates found in conjunction with Borrelia burgdorferi and Babesia microti among naturally infected mice (1999) J Clin Microbiol, 37, pp. 2598-2601Probert, W., Louie, J.K., Tucker, J.R., Longoria, R., Hogue, R., Moler, S., Graves, M., Fritz, C.L., Meningitis due to a "Bartonella washoensis"-like human pathogen (2009) J Clin Microbiol, 47, pp. 2332-2335. , http://dx.doi.org/10.1128/JCM.00511-09Kosoy, M., Morway, C., Sheff, K.W., Bai, Y., Colborn, J., Chalcraft, L., Dowell, S.F., Petersen, L.R., Bartonella tamiae sp. Nov., a newly recognized pathogen isolated from three human patients from Thailand (2008) J Clin Microbiol, 46, pp. 772-775. , http://dx.doi.org/10.1128/JCM.02120-07Maggi, R.G., Kosoy, M., Mintzer, M., Breitschwerdt, E.B., Isolation of Candidatus Bartonella melophagi from human blood (2009) Emerg Infect Dis, 15, pp. 66-68. , http://dx.doi.org/10.3201/eid1501.081080Lin, E.Y., Tsigrelis, C., Baddour, L.M., Lepidi, H., Rolain, J.M., Patel, R., Raoult, D., Candidatus Bartonella mayotimonensis and endocarditis (2010) Emerg Infect Dis, 16, pp. 500-503. , http://dx.doi.org/10.3201/eid1603.081673Breitschwerdt, E.B., Maggi, R.G., Cadenas, M.B., De Paiva Diniz, P.P., A groundhog, a novel Bartonella sequence, and my father's death (2009) Emerg Infect Dis, 15, pp. 2080-2086. , http://dx.doi.org/10.3201/eid1512.AD151
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