Microbiological changes in meat and minced meat from beavers (Castor fiber L.) during refrigerated and frozen storage

This study aims to evaluate the microbiological status, pH, and water activity of European beaver meat to establish its shelf-life and microbiological safety. In this study, the microbiological profiles of meat and minced meat obtained from the carcasses of beavers were investigated. Microbial evaluation of the chilled meat was performed within 24 h after hunting, on the 7th day and 14th day, and the evaluation of the frozen meat was made during the 11th week of storage. Meat samples were analysed for total viable count (TVC), psychrotrophic bacteria count (PBC), Enterobacteriaceae count (EBC), Escherichia coli count (EC), total staphylococcal count (TSC), lactic acid bacteria count (LABC) and total yeast and mould counts (TYMC). Tests for the presence of pathogenic bacteria from the genus Salmonella and Listeria were also performed. Additionally, the pH and water activity were determined. The initial amount of TVC was 4.94 log CFU/g in meat samples and 4.80 log CFU/g in minced meat. After 14 days of storage, the TVC increased to 8.33 in meat samples and 8.08 log CFU/g in minced meat. Pathogenic bacteria such as Listeria and Salmonella were not found in the beaver meat tested. The microbiological state of meat stored frozen for 11 weeks was comparable to the state found in meat stored refrigerated for seven days regarding the number of microorganisms

Capsule endoscopy for screening colon tumors

Department of General Surgery with a course of endoscopy of the Federal State Budgetary Educational Institution of Higher Education and Medical University of the Ministry of Health of Russia, Leningrad Regional Oncologic Dispensary, Department of Faculty Surgery. prof. A.A. Rusanov of the Federal State Budgetary Educational Institution of Higher Education and Medical University of the Ministry of Health of Russia, Sankt-Petersburg, Russia, Al XIII-lea Congres al Asociației Chirurgilor „Nicolae Anestiadi” și al III-lea Congres al Societății de Endoscopie, Chirurgie miniminvazivă și Ultrasonografie ”V.M.Guțu” din Republica MoldovaIntroduction: Most of the colon tumors are detected in the later stages. The introduction of new, minimally invasive technologies into clinical practice allows to improve the results of the diagnosis of neoplasms. Material and methods: Capsule endoscopy is a procedure for colon examination using a miniature camera, which takes more than 10,000 images of colon at a speed of 4 to 24 frames per second. For the patient, the procedure itself does not cause discomfort. On the day of the study, the patient may do his usual activities. The indications for capsular examination of the colon may be suspected tumor of the colon, a positive test of fecal occult blood test, and the patient is over 50 years old. We made a decision to launch a pilot project for screening the colon among health care workers in Oncology Dispensary of Leningrad Region. Results: In the years 2017-2018, we performed 67 capsule colon examinations for medical workers who had not previously performed a colonoscopy. A total colon investigation was performed in 58 patients (87%). Among these patients 2 malignant tumors of the colon (3.5%) were detected. Colon epithelial neoplasia was detected in 11 patients (19%). These findings contributed to perform colonoscopy with endoscopic polypectomy. Conclusion: Capsule endoscopy of the colon can be used for examination, in cases where colonoscopy is not possible. Capsule endoscopy helps to convince the patient of the need to perform colonoscopy. Capsule endoscopy is a safe method for screening colorectal cancer

Gaudin Models and Bending Flows: a Geometrical Point of View

In this paper we discuss the bihamiltonian formulation of the (rational XXX) Gaudin models of spin-spin interaction, generalized to the case of sl(r)-valued spins. In particular, we focus on the homogeneous models. We find a pencil of Poisson brackets that recursively define a complete set of integrals of the motion, alternative to the set of integrals associated with the 'standard' Lax representation of the Gaudin model. These integrals, in the case of su(2), coincide wih the Hamiltonians of the 'bending flows' in the moduli space of polygons in Euclidean space introduced by Kapovich and Millson. We finally address the problem of separability of these flows and explicitly find separation coordinates and separation relations for the r=2 case.Comment: 27 pages, LaTeX with amsmath and amssym

Events in the affective city: Affect, attention and alignment in two ordinary urban events

In a representational regime, planned urban events are used by urban planners to render urban projects visible and acceptable. As a corollary of the focus of urban studies on their representational dimension and in spite of a burgeoning literature on the notion of affective urbanism, the experiential character of events remains surprisingly unexplored. This paper argues that an ordinary regime of events is mobilised by city-makers to act on the embodied, affective experience of the city and on the ways urban dwellers know and act upon the city. By analysing planned urban events in their embodied, experiential dimension, we focus on the ways in which, through the design of ephemeral material dispositives, urbanists attempt to encourage citizens to incorporate ways of knowing and acting on space and on the modalities of knowing and acting that are at play. We stage an encounter between critical event studies and Ingoldian approaches to affect and attention, examining two urban events in a Swiss canton. We show how intense encounters with urban matter are staged in an attempt to modulate affects, guide attention, and produce alignment with a specific political project, asking urban dwellers either to embody a project still in the making or to cultivate expectations regarding an already-written future

Multi-Scalar-Singlet Extension of the Standard Model - the Case for Dark Matter and an Invisible Higgs Boson

We consider a simple extension of the Standard Model by the addition of N real scalar gauge singlets \vp that are candidates for Dark Matter. By collecting theoretical and experimental constraints we determine the space of allowed parameters of the model. The possibility of ameliorating the little hierarchy problem within the multi-singlet model is discussed. The Spergel-Steinhardt solution of the Dark Matter density cusp problem is revisited. It is shown that fitting the recent CRESST-II data for Dark Matter nucleus scattering implies that the standard Higgs boson decays predominantly into pairs of Dark Matter scalars. It that case discovery of the Higgs boson at LHC and Tevatron is impossible. The most likely mass of the dark scalars is in the range 15 GeV \lsim \mvp \lsim 50 GeV with BR(h \to \vp\vp) up to 96%.Comment: 18 pages, 15 figure

The Universal One-Loop Effective Action

We present the universal one-loop effective action for all operators of dimension up to six obtained by integrating out massive, non-degenerate multiplets. Our general expression may be applied to loops of heavy fermions or bosons, and has been checked against partial results available in the literature. The broad applicability of this approach simplifies one-loop matching from an ultraviolet model to a lower-energy effective field theory (EFT), a procedure which is now reduced to the evaluation of a combination of matrices in our universal expression, without any loop integrals to evaluate. We illustrate the relationship of our results to the Standard Model (SM) EFT, using as an example the supersymmetric stop and sbottom squark Lagrangian and extracting from our universal expression the Wilson coefficients of dimension-six operators composed of SM fields.Comment: 30 pages, v2 contains additional comments and corrects typos, version accepted for publication in JHE

Autologous hematopoietic cell transplantation for T-cell prolymphocytic leukemia: a retrospective study on behalf of the Chronic Malignancies Working Party of the EBMT.

Not available

EBMT prospective observational study on allogeneic hematopoietic stem cell transplantation in T-prolymphocytic leukemia (T-PLL)

Preliminary data suggest that allogeneic stem cell transplantation (allo-SCT) may be effective in T-prolymphocytic leukemia (T-PLL). The purpose of the present observational study was to assess the outcome of allo-SCT in patients aged 65 years or younger with a centrally confirmed diagnosis of T-PLL. Patients were consecutively registered with the EBMT at the time of transplantation and followed by routine EBMT monitoring but with an extended dataset. Between 2007 and 2012, 37 evaluable patients (median age 56 years) were accrued. Pre-treatment contained alemtuzumab in 95% of patients. Sixty-two percent were in complete remission (CR) at the time of allo-SCT. Conditioning contained total body irradiation with 6 Gy or more (TBI6) in 30% of patients. With a median follow-up of 50 months, the 4-year non-relapse mortality, relapse incidence, progression-free (PFS) and overall survival were 32, 38, 30 and 42%, respectively. By univariate analysis, TBI6 in the conditioning was the only significant predictor for a low relapse risk, and an interval between diagnosis and allo-SCT of more than 12 months was associated with a lower NRM. This study confirms for the first time prospectively that allo-SCT can provide long-term disease control in a sizable albeit limited proportion of patients with T-PLL.Peer reviewe

Ischemic Heart Disease Modifies the Association of Atrial Fibrillation With Mortality in Heart Failure With Reduced Ejection Fraction

Background: The CASTLE‐AF (Catheter Ablation versus Standard Conventional Therapy in Patients With Left Ventricular Dysfunction and Atrial Fibrillation) trial recently reported that catheter ablation of atrial fibrillation (AF) improves survival in heart failure (HF) with reduced ejection fraction (HFrEF). However, established AF was not associated with mortality in trials of contemporary HFrEF pharmacotherapies. We investigated whether HFrEF pathogenesis may influence the conclusions of studies evaluating the prognostic impact of AF. Methods and Results: Using a prospective cohort study of 791 patients with HFrEF, with AF determined using 24‐hour ambulatory ECG monitoring, univariable and multivariable Cox regression analyses were used to define the association between AF and mode‐specific mortality (mean follow‐up of 5.4 years). One‐year HF‐related hospitalization was assessed with binary logistic regression analysis. One‐year cardiac remodeling was assessed in a subgroup (n=378) using echocardiography. AF was present in 28.2% of patients, with 9.4% of these being paroxysmal. While AF was associated with increased risk of all‐cause mortality (hazard ratio, 1.27; 95% confidence interval 1.03–1.57), with diverging survival curves after 1 year of follow‐up, this association was lost in age‐sex–adjusted analyses. However, AF was associated with increased risk of age‐sex–adjusted all‐cause mortality in people with ischemic pathogenesis, with a statistically significant interaction between pathogenesis and AF. This was predominantly attributed to progressive HF deaths. After 1 year, HF hospitalization and cardiac remodeling were not associated with AF, even in people with ischemic pathogenesis. Conclusions: AF is associated with increased risk of death in HFrEF of ischemic pathogenesis, predominantly due to progressive HF deaths during long‐term follow‐up. HFrEF pathogenesis should be considered in trial design and interpretation

Testosterone replacement therapy among HIV-infected men in the CFAR Network of Integrated Clinical Systems

The objectives of this study were to determine the rate of testosterone replacement therapy (TRT) initiation, TRT predictors and associated monitoring in HIV-infected men