9 research outputs found
Membrane lipid interactions in intestinal ischemia/reperfusion-induced Injury
Ischemia, lack of blood flow, and reperfusion, return of blood flow, is a common phenomenon affecting millions of Americans each year. Roughly 30,000 Americans per year experience intestinal ischemia-reperfusion (IR), which is associated with a high mortality rate. Previous studies of the intestine established a role for neutrophils, eicosanoids, the complement system and naturally occurring antibodies in IR-induced pathology. Furthermore, data indicate involvement of a lipid or lipid-like moiety in mediating IR-induced damage. It has been proposed that exposure of neo-antigens are recognized by antibodies, triggering action of the complement cascade. While it is evident that the pathophysiology of IR-induced injury is complex and multi-factorial, we focus this review on the involvement of eicosanoids, phospholipids and neo-antigens in the early pathogenesis. Lipid changes occurring in response to IR, neo-antigens exposed and the role of a phospholipid transporter, phospholipid scramblase 1 will be discussed
Emergence of Cranio-Cervico-Facial Soft Tissue Emphysema after Dental Hygiene Treatment Using Airflow (Case Report)
The authors report an interesting case of dangerous complications during dental hygienist treatment. Soft tissue emphysema during, and after stomatological procedures is described in several works. Such a complication after „airflowing“ has not yet been published in literature
The role of non-tariff measures in EU dairy trade with Russia
This article investigates Russian non-tariff measures (NTMs) on dairy products and their implications for EU dairy exports. Based on survey results, numerous and detailed Russian standards on imported dairy products are considered by respondents as redundant and unnecessary from a food safety perspective. Conformity assessment procedures are identified as a major problem when exporting to Russia. They are nontransparent, time-consuming and expose exporters to significant risk that their products may be refused entry at the Russian border. Audits by Russian inspectors seem to be subject to arbitrary rules and exporting companies face great uncertainty because of unclear and often changing rules. Both fixed and variable costs may increase due to Russian non-tariff measures, adding an estimated 5–10% of export value to costs. The gravity model estimates indicate that, after controlling for other variables, non-tariff measures are more restrictive on US exports to Russia than on EU exports to Russia, while New Zealand’s exports to Russia are least affected by NTMs. Overall, the estimates do not confirm that Russia’s NTMs are significantly more restrictive than is the case with other countries’ NTMs. Although Russian standards for dairy imports are inhibiting trade they are not more restrictive than those implemented by other countries.JRC.J.4-Agriculture and Life Sciences in the Econom
Sleep deprivation predisposes liver to oxidative stress and phospholipid damage: a quantitative molecular imaging study
Sleep disorders are associated with an increased rate of various metabolic disturbances, which may be related to oxidative stress and consequent lipid peroxidation. Since hepatic phosphatidylcholine plays an important role in metabolic regulation, the aim of the present study was to determine phosphatidylcholine expression in the liver following total sleep deprivation. To determine the effects of total sleep deprivation, we used adult rats implanted for polygraphic recording. Phosphatidylcholine expression was examined molecularly by the use of time-of-flight secondary ion mass spectrometry, along with biochemical solid-phase extraction. The parameters of oxidative stress were investigated by evaluating the hepatic malondialdehyde levels as well as heat shock protein 25 immunoblotting and immunohistochemistry. In normal rats, the time-of-flight secondary ion mass spectrometry spectra revealed specific peaks (m/z 184 and 224) that could be identified as molecular ions for phosphatidylcholine. However, following total sleep deprivation, the signals for phosphatidylcholine were significantly reduced to nearly one-third of the normal values. The results of solid-phase extraction also revealed that the phosphatidylcholine concentration was noticeably decreased, from 15.7 µmol g–1 to 9.4 µmol g–1, after total sleep deprivation. By contrast, the biomarkers for oxidative stress were drastically up-regulated in the total sleep deprivation-treated rats as compared with the normal ones (4.03 vs. 1.58 nmol mg–1 for malondialdehyde levels, and 17.1 vs. 6.7 as well as 1.8 vs. 0.7 for heat shock protein 25 immunoblotting and immunoreactivity, respectively). Given that phosphatidylcholine is the most prominent component of all plasma lipoproteins, decreased expression of hepatic phosphatidylcholine following total sleep deprivation may be attributed to the enhanced oxidative stress and the subsequent lipid peroxidation, which would play an important role in the formation or progression of total sleep deprivation-induced metabolic diseases