It was an experience that totally blew up in my face : Steve Railsback and Turkey shoot

The schlock horror film Turkey Shoot is widely regarded as one of the most disreputable Australian exploitation titles in a genre already well noted for controversy. This short article frames the controversies that surround the film from production to critical reception, which sets the scene for an interview by Mark Harley with the film\u27s star Steve Railsback, who reflects on the movie\u27s production, his role, the controversy and the film\u27s reception. <br /

Bipolar Affective Disorder - A national clinical guideline

A national clinical guideline - SIGN

Osteoprotegerin (OPG), The Endogenous Inhibitor of Receptor Activator of NF-κB Ligand (RANKL), is Dysregulated in BRCA Mutation Carriers

AbstractBreast cancer development in BRCA1/2 mutation carriers is a net consequence of cell-autonomous and cell nonautonomous factors which may serve as excellent targets for cancer prevention. In light of our previous data we sought to investigate the consequences of the BRCA-mutation carrier state on RANKL/osteoprotegerin (OPG) signalling.We analysed serum levels of RANKL, OPG, RANKL/OPG complex, oestradiol (E2), and progesterone (P) during menstrual cycle progression in 391 BRCA1/2-mutation carriers and 782 noncarriers. These studies were complemented by analyses of RANKL and OPG in the serum and mammary tissues of female cynomolgus macaques (n=88) and serum RANKL and OPG in postmenopausal women (n=150).BRCA-mutation carriers had lower mean values of free serum OPG in particular in BRCA1-mutation carriers (p=0.018) compared with controls. Among BRCA1/2 mutation carriers, lower OPG levels were associated with germline mutation locations known to confer an increased breast cancer risk (p=0.003). P is associated with low OPG levels in serum and tissue, particularly in BRCA-mutation carriers (rho=−0.216; p=0.002). Serum OPG levels were inversely correlated (rho=−0.545, p<0.001) with mammary epithelial proliferation measured by Ki67 expression and increased (p=0.01) in postmenopause.The P–RANKL/OPG system is dysregulated in BRCA-mutation carriers. These and previously published data provide a strong rationale for further investigation of antiprogestogens or an anti-RANKL antibody such as denosumab for breast cancer prevention

Bipolar Affective Disorder - A national clinical guideline

A national clinical guideline - SIGN

Critical assessment of automated flow cytometry data analysis techniques

Traditional methods for flow cytometry (FCM) data processing rely on subjective manual gating. Recently, several groups have developed computational methods for identifying cell populations in multidimensional FCM data. The Flow Cytometry: Critical Assessment of Population Identification Methods (FlowCAP) challenges were established to compare the performance of these methods on two tasks: (i) mammalian cell population identification, to determine whether automated algorithms can reproduce expert manual gating and (ii) sample classification, to determine whether analysis pipelines can identify characteristics that correlate with external variables (such as clinical outcome). This analysis presents the results of the first FlowCAP challenges. Several methods performed well as compared to manual gating or external variables using statistical performance measures, which suggests that automated methods have reached a sufficient level of maturity and accuracy for reliable use in FCM data analysis.