Sedimentology of the Irene and la toma formations from the neogene of the Claromecó basin, Buenos Aires

La cuenca de Claromecó se ubica entre los positivos de Tandil y Ventania. La Formación Irene fue definida para el ámbito del sudoeste de esta Pampa Interserrana, Buenos Aires, para margas claras diaclasadas y lajadas que alcanzan 7 m de espesor en la Estación Irene del Ferrocarril General Roca. Estas rocas que comprenden lo que fue denominado "Araucanense" están subyaciendo limos arenosos carbonáticos rojizos que corresponden a sedimentos pampeanos de la Formación La Toma. De acuerdo a los contenidos fosilíferos y la presencia de escorias, estos sedimentos que coronan las lomas han sido equiparados a las Formaciones Monte Hermoso y Chapadmalal. Se postula entonces una edad pliocena para la porción aflorante (superior) de la Formación Irene y para la formación La Toma. El paisaje es de lomas coronadas por limos entoscados.The Claromecó Basin is located between the horst of Tandil and Ventania. The Irene formation is defined to the west of the Interserrana ("between ranges") Plain, Buenos Aires Province, for light-coloured carbonatic siltstones with joints that sums 7 m thick at the locality close to Irene Railway Station. These rocks comprising the Araucanense are underlying reddish sandy silts assigned to the Pampian sediments of La Toma Formation. According to the fossiliferous and escoria content, these sediments were similar to those outcropping as Monte Hermoso and Chapadmalal formations. It is therefore assumed a Pliocene age for the upper levels of the Irene Formation, as well as to the La Toma Formation. The hilly landscape is crowned by silt with calcretes.Fil: Isla, Federico Ignacio. Universidad Nacional de Mar del Plata. Facultad de Ciencias Exactas y Naturales. Instituto de Geología de Costas y del Cuaternario. Provincia de Buenos Aires. Gobernación. Comisión de Investigaciones Científicas. Instituto de Geología de Costas y del Cuaternario; ArgentinaFil: Dondas, Alejandro. Provincia de Buenos Aires. Municipalidad de General Pueyrredon. Secretaría de Cultura. Museo Municipal de Ciencias Naturales Lorenzo Scaglia; ArgentinaFil: Oliva, Cristian. Museo Municipal de Ciencias Naturales Carlos Darwin. Punta Alta; Argentin

Relict intrapampean dunes in Daireaux and Centinela del Mar, Buenos Aires.

Los sedimentos denominados informalmente "pampeanos" son reconocidos como un paquete de limos y limos arenosos depositados desde el Plioceno superior hasta el Pleistoceno superior, con dos intercalaciones marinas hacias el este, reconocidas fundamentalmente por acumulaciones de valvas marinas: el Interensenadense, y el Belgranense. En el oeste de la provincia de Buenos Aires una extensa área ha sido denominada Mar de arena. En canales próximos a Daireaux  y en acantilados marinos de Centinela del Mar, se describieron depósitos arenosos con estratificación diagonal de mesoescala que prueban la presencia de campos de arena por debajo de los depósitos limosos. Las edades del Pleistoceno superior han sido confirmadas por las asociaciones de vertebrados recuperados. En Centinela del Mar, la edad de estos médanos transversales que conformaban una barrera litoral ha sido también confirmada por su vinculación con el máximo nivel del mar alcanzado durante el interglacial Sangamon (Pleistoceno superior, 120.000 años AP).The sediments informally called "pampeanos" are recognized as a package of silts and sandy silts deposited from the Upper Pliocene to Upper Pleistocene, interfingered with two transgressions to the east, discriminated by shells concentrations: the Interensenadan and the Belgranian transgressions. To the west of the Buenos Aires province, an extended area with dunes was called Sand Sea. Within channels excavated in Daireaux, and sea cliffs from Centinela del Mar, mesoscale crossbeding were described probing the presence of sand fields overlaid by silt deposits. Upper Pleistocene ages were confirmed by the assemblages of vertebrate remains. In Centinela del Mar, the age of these transverse dunes that are composing a littoral barrier was also confirmed in their relation to the maximum sea level highstand reached during the Sangamon interglacial (Upper Pleistocene; 120,000 years BP).Fil: Isla, Federico Ignacio. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mar del Plata. Instituto de Investigaciones Marinas y Costeras. Universidad Nacional de Mar del Plata. Facultad de Ciencias Exactas y Naturales. Instituto de Investigaciones Marinas y Costeras; ArgentinaFil: Dondas, Alejandro. Museo Municipal de Ciencias Naturales "L. Scaglia"; ArgentinaFil: Taglioretti, Matias Luciano. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mar del Plata. Instituto de Investigaciones Marinas y Costeras. Universidad Nacional de Mar del Plata. Facultad de Ciencias Exactas y Naturales. Instituto de Investigaciones Marinas y Costeras; Argentin

Late complications following permanent pacemaker implantation

The objective of the work was to determine prospectively the rate of late complications (6, 12 months) following first implantation of a permanent pacemaker or generator replacement. To illustrate our pathology using 3 case reports with particular problems concerning the diagnosis and treatment options. We studied 126 consecutive patients with definite indications for permanent pacemaker implantation, included between 2006 and 2009. Generator replacement was required in 12 patients because of pulse generator electrical failure. In all cases a W I pacemaker was used. Implantation of the lead-catheter used right/left subclavian vein (108 cases vs. 18 cases) access. We realized a clinical follow-up (local pocket integrity, signs/symptoms for ipsilateral superior limb deep venous thrombosis or pulmonary thromboembolism-TEP) combined with biologic (D-dimers, fibrinogen, platelets), microbiologic (wound secretion, hemocultures) and imaging methods. Imaging follow-up protocol used venous ultrasound, ipsilateral superior limb phlebography, perfusion lung scintigram, transtoracic and transesophageal echocardiography. The overall rate of late complications was 23.8% in our study. There were infectious, thromboembolic complications and pacemaker syndrome signs/symptoms. Local pocket-related infection (pocket erosion/necrosis) with Staphylococcus aureus/epidermidis wad found in 7.14% of cases; in two cases Enterobacter/ Staphylococcus aureus septicemia complicated local infection. Infective endocarditis complicated evolution in one case (vegetation on the stimulation catheter). Late infectious complications rate was significantly lower after first implantation of the permanent pacemaker comparing generator replacement (1.4% vs. 6.5%) and also in the subgroup with prophylactic antibiotherapy (0.6% vs. 3.1%). Pacing electrode thrombosis was defined by ultrasound in 10 patients (12.6%) and by phlebography in 19.04%; echocardiography detected one case of thrombosis in right atrium and manifest TEP complicated evolution. In 2 cases there were clinical signs for superior limb deep venous thrombosis. Perfusion lung scintigram revealed high /intermediate probability for TEP in 5 patients, respectively 2 patients. In 3.17% of cases both types of complications were present. Pacemaker syndrome was manifest through mild symptoms/signs in 2 cases. Our data are comparable with literature concerning the rate of late infectious and thromboembolic complications. Pacing electrode thrombosis is frequently asymptomatic and underestimated in clinical terms. For this reason, the decision for anticoagulation is better individualized. Even conducted in rigorous asepsis conditions invasive technique is better followed by antibiotheraphy. The low incidence of pacemaker syndrome is in relation with follow-up period

Morphometry of paleocaves at the Chapadmalal "Formation" assigned to fossorial rodent Actenomys sp. (Rodentia, Caviomorpha), Paedotherium (Notoungulata), and to other fossil mammals

En la “Formación” Chapadmalal, aflorante en las barrancas que se extienden desde Mar del Plata a Miramar, se diferencian paleocuevas que han sido asignadas al roedor fósil Actenomys sp. (Rodentia, Caviomorpha). La asignación se basa en la elevada frecuencia de restos de Actenomys sp. hallados en estas bioestructuras y en su capacidad cavadora. Si bien es evidente que Actenomys sp. construía cuevas, y muchas de las paleocuevas le corresponden, no es la única especie coetánea que pudo haberlas construido. Se analizaron morfométricamente las paleocuevas aflorantes en las barrancas costeras de Mar del Plata-Miramar correspondientes a los Pisos/Edad Chapadmalalense y Marplatense y la identificación de los posibles constructores. Se seleccionaron las paleocuevas en sección transversal y se tomaron dos medidas estructurales, correspondientes al diámetro transverso y dorsoventral, con las que se construyó un índice estructural. Se registró el material fósil asociado a las mismas en los casos donde estaba expuesto. Los análisis estadísticos incluyeron distribución de frecuencias, correlaciones, análisis de residuales y diferencia de medias, en las medidas individuales y en el índice. Se identifican cuevas construidas por Actenomys sp., en estadios juveniles y adultos, y por Paedotherium sp. Se reconocen diferencias métricas entre las cuevas del Chapadmalalense y Marplatense, posiblemente asociadas a una diferencia en la abundancia relativa de Paedotherium sp. y Actenomys sp. Asimismo se refuerza la existencia de cuevas de Lagostomopsis sp. y se identifica la posible construcción, o uso oportunista, de las mismas por Eumysops sp., Dolicavia sp. y otros cávidos.Paleocaves assigned to fossorial rodent Actenomys sp. (Rodentia, Caviomorpha) are present at the Chapadmalal "Formation", cropping out from Mar del Plata to Miramar. The assignation is based on the high frequency of fossil material of Actenomys sp. within the paleocaves and in the digging capacity recognized for the genera. Although it is evident that Actenomys sp. built caves and most of these correspond to the genera, it is not the only coetaneal mammal with the capacity of construction of these structures. Paleocaves of Chapadmalalan and Marplatan age were analyzed morphometrically and the generic assignation of their producers was evaluated. Paleocaves in transverse section were selected, its dorsoventral and lateromedial diameter was measured and used for calculating a structural index. The fossil material exposed in paleocaves was determined to a specific level in all possible cases. The statistical analyses performed include frequency distributions, correlations, residual analyses, and mean differences on individual measurements and on the index. Paleocaves constructed by Actenomys sp., in juvenile and adult stages, and by Paedotherium sp. are recognized. Metric difference between paleocaves of Chapadmalalan and Marplatan ages are recognized, in possible association with a different abundance of Paedotherium sp. and Actenomys sp. The presence of paleocaves of Lagostomopsis sp. is reinforced and is suggested the possible construction, or opportunistic use, of paleocaves by Eumysops sp., Dolicavia sp. and other Caviidae.Fil: Elissamburu, Andrea. Universidad Nacional de La Plata. Facultad de Cienicas Naturales y Museo. Laboratorio de Anatomía Comparada; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata; ArgentinaFil: Dondas, Pedro Alejandro. Universidad Nacional de La Plata. Facultad de Cienicas Naturales y Museo. Laboratorio de Anatomía Comparada; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata; ArgentinaFil: de Santi, Luciano Jose Maria. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata; Argentina. Universidad Nacional de La Plata. Facultad de Cienicas Naturales y Museo. Laboratorio de Anatomía Comparada; Argentin

Presencia de Proscelidodon Patrius (Xenarthra, Scelidotheriinae) en la formación Chapadmalal (Plioceno Superior), Mar del Plata, Buenos Aires, Argentina: implicancias Bioestratigráficas

El objetivo del presente trabajo es dar a conocer y discutir las implicancias bioestratigráficas del primer registro de Proscelidodon patrius (Ameghino) para la Formación Chapadmalal (Plioceno superior), Mar del Plata, Buenos Aires, Argentina. Dicho espécimen se encuentra representado por un cráneo y mandíbula parcial en buen estado de preservación de un individuo juvenil.Fil: Taglioretti, Matias Luciano. Universidad Nacional de Mar del Plata. Facultad de Ciencias Exactas y Naturales. Instituto de Geología de Costas y del Cuaternario; ArgentinaFil: Miño Boilini, Ángel Ramón. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Nordeste. Centro de Ecologia Aplicada del Litoral (i); ArgentinaFil: Scaglia, Fernando. Museo de Ciencias Naturales “Lorenzo Scaglia”; ArgentinaFil: Dondas, Alejandro. Museo de Ciencias Naturales “Lorenzo Scaglia”; Argentin

Recent Development in Palladium-Catalyzed Domino Reactions: Access to Materials and Biologically Important Carbo- and Heterocycles

The chemistry of palladium complexes has no limits. Many domino processes (even multicomponent) are continuously appearing in the literature. Carbocyclic and heterocyclic molecules are efficiently prepared under the atom-economy principle using the smallest amount of the catalyst. The importance of the applications in many scientific areas of all of these cyclic skeletons made this general methodology much more attractive.We gratefully acknowledge financial support from the Spanish Ministerio de Economía y Competitividad (MINECO) (projects CTQ2013-43446-P and CTQ2014-51912-REDC), the Spanish Ministerio de Economía, Industria y Competitividad, Agencia Estatal de Investigación (AEI), and Fondo Europeo de Desarrollo Regional (FEDER, EU) (projects CTQ2016-76782-P and CTQ2016-81797-REDC), the Generalitat Valenciana (PROMETEOII/2014/017), University of Alicante and Mersin University (Project. MEU-2017-COL-01007-M150D)

New 99mTc - silica nanoparticles radiotracer biodistribution studied through scintigraphy

Aim of the study: Silica nanoparticles (SNP) are a new and versatile tool for targeting drug delivery. Our aim was to investigate biodistribution of a new SNP derivate in guinea pigs, in order to identify the possible uses as a drug carrier. Materials: SNP were prepared at the Institute o f Chemistry and Bioanalytics, University o f Applied Sciences Northwestern Switzerland, Muttenz, Switzerland. One 124 nm size SNP derivate was used: AA124 - SNP carrying OH groups on the surface. Methods: The procedure of 99mTc - SNP coupling was an in-house preparation performed as follows: 1- first of all, SNP were suspended in EtOH (5mg/ml) and sonicated for 15 or 20 min for better disper­sion. 2- to this suspension, 200MBq/lml of Na99mTc04 solution was added and the suspension was stirred gently. 3- an excess of NaBH4 reducing agent was added quickly to the suspension and stirred for minimum 1 hour. Scintigraphic study design: Groups of 4 animals were intravenously administered with 37MBq/kg/ animal 99mTc-coupled AA124 SNP. Control groups received 37MBq/kg animal 99mTc. A dual head Siemens gamma camera with high resolution parallel collimators was used. The image acquisitions protocol started with a dynamic image acquisition for 60 seconds (1 image/sec), followed by a dynamic image acquisition for 4 minutes (1 image/min) and static planar images (256x256 Matrix, Zoom 2) every 15 minutes for a duration of 2h. The animals were sacrificed after 120 min and different organs were extracted entirely and submited to gamma camera. Results: Following the i.v. administration, AA124 SNP did not penetrate the blood brain barrier. SNP were present in all the organs investigated except the brain, with different target/non target indexes, that were graphically represented for each of them. Conclusion: These step results represent a promising support for the idea of using the AA124 as container for modular drug delivery system with promising future in therapeutics

Catch and release’ cascades: a resin-mediated three-component cascade approach to small molecules

The application of a ‘catch and release’ approach to palladium-catalysed multi-component cascade reactions leads to diverse libraries of pharmacologically interesting small molecules in high yield and with excellent purity

X=Y–ZH compounds as potential 1,3-dipoles. Part 64: Synthesis of highly substituted conformationally restricted and spiro nitropyrrolidines via Ag(I) catalysed azomethine ylide cycloadditions

1,3-Dipolar reactions of imines of both acyclic and cyclic α-amino esters with a range of nitroolefins using a combination of AgOAc or Ag2O with NEt3 are described. In most cases the reactions were highly regio- and stereospecific and endo-cycloadducts were obtained in good yield. However, in a few cases the initially formed cycloadducts underwent base catalysed epimerisation. The stereochemistry of the cycloadducts was assigned from NOE data and established unequivocally in several cases by X-ray crystallography