73 research outputs found

    La percusión corporal y su aplicación al aula de educación primaria: propuesta de intervención

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    El presente Trabajo Fin de Grado plantea un estudio sobre la importancia de la Educación Musical en Educación Primaria. Se ha desarrollado una propuesta de intervención que gira en torno a la percusión corporal. Para ello, se hace un marco teórico sobre la presencia de la corporeidad en el currículo educativo en referente a la Educación Musical. Además, se plantea la percusión corporal como un concepto defendido por varios músico-pedagogos, su presencia en el ámbito cultural y su repercusión biológica. También se exponen varias corrientes pedagógico-musicales relacionadas con el cuerpo y el movimiento, a través de la obra de Hemsy de Gainza desde los precursores del siglo XX, hasta las metodologías más actuales en España, en cuanto a percusión corporal se refiere. Finalmente, se hace una conclusión sobre los aprendizajes adquiridos y una valoración sobre el proceso de enseñanza y aprendizaje en el área de Educación MusicalGrado en Educación Primari

    Políticas de apoio à ecoinovação na Europa no período recente

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    Trabalho de Conclusão de Curso (Graduação)Cada vez mais a relação entre desenvolvimento econômico e meio ambiente desafiam a sustentabilidade dos modelos econômicos vigentes e forçam o modelo econômico-produtivo para uma “Economia Verde”, na qual a produção e consumo são ambientalmente sustentáveis. Para que isso ocorra, é necessário um novo modelo de inovação e criação que desde sua concepção respeite os princípios ambientais. Nesse contexto, o conceito de ecoinovação emerge, na busca por soluções alternativas para a melhora na eficiência dos processos produtivos, gerenciais e organizacionais e a diminuição do seu impacto final. Buscando-se entender não apenas a teoria de políticas públicas para ecoinovação, mas também a prática, este trabalho tem como objetivo analisar a experiência europeia de fomento direto e indireto à ecoinovação dado a vanguarda do continente europeu no assunto não apenas em quesitos acadêmicos, mas também na criação e implementação destas práticas. Em geral, conclui-se que a maturidade das políticas ambientais e de inovação, bem como os conhecimentos e vanguarda de pesquisa acerca da ecoinovação levou a Europa a promover não apenas um instrumento exclusivo de fomento à ecoinovação, mas também bastante completo em suprir as complexidades deste tópico, combinando diversas ferramentas de promoção e criando sinergias entre as políticas vizinhas para suprir de maneira mais específica as barreiras e determinantes da ecoinovação no contexto europeu

    Endothelial dysfunction is an early indicator of sepsis and neutrophil degranulation of septic shock in surgical patients

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    Producción CientíficaBackground: Stratification of the severity of infection is currently based on the Sequential Organ Failure Assessment (SOFA) score, which is difficult to calculate outside the ICU. Biomarkers could help to stratify the severity of infection in surgical patients. Methods: Levels of ten biomarkers indicating endothelial dysfunction, 22 indicating emergency granulopoiesis, and six denoting neutrophil degranulation were compared in three groups of patients in the first 12 h after diagnosis at three Spanish hospitals. Results: There were 100 patients with infection, 95 with sepsis and 57 with septic shock. Seven biomarkers indicating endothelial dysfunction (mid-regional proadrenomedullin (MR-ProADM), syndecan 1, thrombomodulin, angiopoietin 2, endothelial cell-specific molecule 1, vascular cell adhesion molecule 1 and E-selectin) had stronger associations with sepsis than infection alone. MR-ProADM had the highest odds ratio (OR) in multivariable analysis (OR 11·53, 95 per cent c.i. 4·15 to 32·08; P = 0·006) and the best area under the curve (AUC) for detecting sepsis (0·86, 95 per cent c.i. 0·80 to 0·91; P < 0·001). In a comparison of sepsis with septic shock, two biomarkers of neutrophil degranulation, proteinase 3 (OR 8·09, 1·34 to 48·91; P = 0·028) and lipocalin 2 (OR 6·62, 2·47 to 17·77; P = 0·002), had the strongest association with septic shock, but lipocalin 2 exhibited the highest AUC (0·81, 0·73 to 0·90; P < 0·001). Conclusion: MR-ProADM and lipocalin 2 could be alternatives to the SOFA score in the detection of sepsis and septic shock respectively in surgical patients with infection.Instituto de Salud Carlos III (grants PI15/01959, PI15/01451 and PI16/01156

    Viral RNA load in plasma is associated with critical illness and a dysregulated host response in COVID‑19

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    Background. COVID-19 can course with respiratory and extrapulmonary disease. SARS-CoV-2 RNA is detected in respiratory samples but also in blood, stool and urine. Severe COVID-19 is characterized by a dysregulated host response to this virus. We studied whether viral RNAemia or viral RNA load in plasma is associated with severe COVID-19 and also to this dysregulated response. Methods. A total of 250 patients with COVID-19 were recruited (50 outpatients, 100 hospitalized ward patients and 100 critically ill). Viral RNA detection and quantification in plasma was performed using droplet digital PCR, targeting the N1 and N2 regions of the SARS-CoV-2 nucleoprotein gene. The association between SARS-CoV-2 RNAemia and viral RNA load in plasma with severity was evaluated by multivariate logistic regression. Correlations between viral RNA load and biomarkers evidencing dysregulation of host response were evaluated by calculating the Spearman correlation coefficients. Results. The frequency of viral RNAemia was higher in the critically ill patients (78%) compared to ward patients (27%) and outpatients (2%) (p < 0.001). Critical patients had higher viral RNA loads in plasma than non-critically ill patients, with non-survivors showing the highest values. When outpatients and ward patients were compared, viral RNAemia did not show significant associations in the multivariate analysis. In contrast, when ward patients were compared with ICU patients, both viral RNAemia and viral RNA load in plasma were associated with critical illness (OR [CI 95%], p): RNAemia (3.92 [1.183–12.968], 0.025), viral RNA load (N1) (1.962 [1.244–3.096], 0.004); viral RNA load (N2) (2.229 [1.382–3.595], 0.001). Viral RNA load in plasma correlated with higher levels of chemokines (CXCL10, CCL2), biomarkers indicative of a systemic inflammatory response (IL-6, CRP, ferritin), activation of NK cells (IL-15), endothelial dysfunction (VCAM-1, angiopoietin-2, ICAM-1), coagulation activation (D-Dimer and INR), tissue damage (LDH, GPT), neutrophil response (neutrophils counts, myeloperoxidase, GM-CSF) and immunodepression (PD-L1, IL-10, lymphopenia and monocytopenia). Conclusions. SARS-CoV-2 RNAemia and viral RNA load in plasma are associated with critical illness in COVID-19. Viral RNA load in plasma correlates with key signatures of dysregulated host responses, suggesting a major role of uncontrolled viral replication in the pathogenesis of this disease.This work was supported by awards from the Canadian Institutes of Health Research, the Canadian 2019 Novel Coronavirus (COVID-19) Rapid Research Funding initiative (CIHR OV2 – 170357), Research Nova Scotia (DJK), Atlantic Genome/Genome Canada (DJK), Li-Ka Shing Foundation (DJK), Dalhousie Medical Research Foundation (DJK), the “Subvenciones de concesión directa para proyectos y programas de investigación del virus SARS‐CoV2, causante del COVID‐19”, FONDO–COVID19, Instituto de Salud Carlos III (COV20/00110, CIBERES, 06/06/0028), (AT) and fnally by the “Convocatoria extraordinaria y urgente de la Gerencia Regional de Salud de Castilla y León, para la fnanciación de proyectos de investigación en enfermedad COVID-19” (GRS COVID 53/A/20) (CA). DJK is a recipient of the Canada Research Chair in Translational Vaccinology and Infammation. APT was funded by the Sara Borrell Research Grant CD018/0123 funded by Instituto de Salud Carlos III and co-fnanced by the European Development Regional Fund (A Way to Achieve Europe programme). The funding sources did not play any role neither in the design of the study and collection, not in the analysis, in the interpretation of data or in writing the manuscript

    Diagnostic investigation of 100 cases of abortion in sheep in Uruguay: 2015-2021

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    The aim of this work was to identify causes of abortion through laboratory investigations in sheep flocks in Uruguay. One hundred cases of abortion, comprising 58 fetuses, 36 fetuses with their placentas, and 6 placentas were investigated in 2015-2021. Cases were subjected to gross and microscopic pathologic examinations, and microbiological and serological testing for the identification of causes of abortion, including protozoal, bacterial, and viral pathogens. An etiologic diagnosis was determined in 46 (46%) cases, including 33 (33%) cases caused by infectious pathogens, as determined by the detection of a pathogen along with the identification of fetoplacental lesions attributable to the detected pathogen. Twenty-seven cases (27%) were caused by Toxoplasma gondii, 5 (5%) by Campylobacter fetus subspecies fetus, and 1 (1%) by an unidentified species of Campylobacter. Fourteen cases (14%) had inflammatory and/or necrotizing fetoplacental lesions compatible with an infectious etiology. Although the cause for these lesions was not clearly identified, T. gondii was detected in 4 of these cases, opportunistic bacteria (Bacillus licheniformis, Streptococcus sp.) were isolated in 2 cases, and bovine viral diarrhea virus 1 subtype i (BVDV-1i) was detected in another. Campylobacter jejuni was identified in 1 (1%) severely autolyzed, mummified fetus. BVDV-2b was identified incidentally in one fetus with an etiologic diagnosis of toxoplasmosis. Microscopic agglutination test revealed antibodies against ≥1 Leptospira serovars in 15/63 (23.8%) fetuses; however, Leptospira was not identified by a combination of qPCR, culture, fluorescent antibody testing nor immunohistochemistry. Neospora caninum, Chlamydia abortus, Chlamydia pecorum, Coxiella burnetii and border disease virus were not detected in any of the analyzed cases. Death was attributed to dystocia in 13 (13%) fetuses delivered by 8 sheep, mostly from one highly prolific flock. Congenital malformations including inferior prognathism, a focal hepatic cyst, and enterohepatic agenesis were identified in one fetus each, the latter being the only one considered incompatible with postnatal life. Toxoplasmosis, campylobacteriosis and dystocia were the main identified causes of fetal losses. Despite the relatively low overall success rate in establishing an etiologic diagnosis, a systematic laboratory workup in cases of abortion is of value to identify their causes and enables zoonotic pathogens surveillance.INIA: PL_27 N-23398ANII: FCE_3_2018_1_148540ANII: FSA_1_2018_1_15268

    Cualificación en los Objetivos establecidos en la Agenda 2030 de estudiantes y profesores en el Máster Universitario en Profesor de Educación Secundaria Obligatoria y Bachillerato, Formación Profesional y Enseñanza de Idiomas (MUPES)

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    Memoria ID2022-157 Ayudas de la Universidad de Salamanca para la innovación docente, curso 2022-2023

    130 Miarco : ampliación almacén Paterna : seguimiento de obra

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    Trabajo fin de grado modalidad convenios con empresas e instituciones. Empresa: Edificación, logística industrial y terciaria, S.A.[ES] El presente trabajo Final de Grado, trata sobre el estudio y análisis de un seguimiento de ejecución de una nave industrial mediante Convenio de Prácticas. Se ha realizado en una constructora valenciana, esta constructora es Edificación Logística Industrial y Terciaria, S.L. la cual pertenece al Grupo PAVASAL. El seguimiento se realiza mediante visitas de obra semanales, con el fin de realizar un trabajo analítico de obra, obteniendo resultados reales aplicables a una obra de tipología industrial. Los campos de estudios que se han seguido son los siguientes: Calidad en la obra, Programa económico de la obra, Diario de actividades y seguimiento y Seguridad y Salud.[EN] This Degree Final Project treats about an industrial unit execution monitoring, it is carried out by a Collective Bargaining Agreement in a valencian construction company which bellows at PAVASAL’s group. This monitoring is carried out trough weekly visits to the construction work, with the purpose of making an analytical labour, obtaining true results which could be applicable in an industrial unit, which terms had been studied are these ones: Quality control, Economical program, Health and security, and Daily.Doncel Pérez, C. (2018). 130 Miarco : ampliación almacén Paterna : seguimiento de obra. http://hdl.handle.net/10251/106751TFG
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