GESTIÓN DEL CONOCIMIENTO ORGANIZATIVO, INNOVACIÓN TECNOLÓGICA Y RESULTADOS. UNA INVESTIGACIÓN EMPÍRICA

RESUMENEn este trabajo se analiza, desde un Enfoque basado en el Conocimiento, el efecto de un conjunto de prácticas organizativas sobre los resultados de la empresa, teniendo en cuenta su agrupación en dos bloques: las que están relacionadas con la exploración del conocimiento, y las que lo están con la explotación del mismo. Tras llevar a cabo un estudio empírico en una muestra de empresas industriales innovadoras, se encuentra que el efecto conjunto de estas prácticas sobre el resultado es mayor que si éstas son consideradas de forma autónoma, lo que sugiere la necesidad de plantear estrategias que integren a las mismas en un marco común con el fin de obtener sinergias y alcanzar resultados organizativos óptimos.ABSTRACTThis paper explores, from a knowledge-based view of the firm, the effect of a set of organizational practices on firm performance, highlighting their grouping into two blocks: practices related to knowledge exploration and those related to knowledge exploitation. After developing an empirical study in a sample of innovative industrial companies, we found that the joint effect of these practices on firm performance is higher than their single consideration. Thus, it suggests a need of establishing strategies that integrate these practices in a common framework with the aim of obtaining synergies and achieving optimal organizational performance

Evaluation of Aloe Vera Coated Polylactic Acid Scaffolds for Bone Tissue Engineering

3D-printed polylactic acid (PLA) scaffolds have been demonstrated as being a promising tool for the development of tissue-engineered replacements of bone. However, this material lacks a suitable surface chemistry to efficiently interact with extracellular proteins and, consequently, to integrate into the surrounding tissue when implanted in vivo. In this study, aloe vera coatings have been proposed as a strategy to improve the bioaffinity of this type of structures. Aloe vera coatings were applied at three different values of pH (3, 4 and 5), after treating the surface of the PLA scaffolds with oxygen plasma. The surface modification of the material has been assessed through X-ray photoelectron spectroscopy (XPS) analysis and water contact angle measurements. In addition, the evaluation of the enzymatic degradation of the structures showed that the pH of the aloe vera extracts used as coating influences the degradation rate of the PLA-based scaffolds. Finally, the cell metabolic activity of an in vitro culture of human fetal osteoblastic cells on the samples revealed an improvement of this parameter on aloe vera coated samples, especially for those treated at pH 3. Hence, these structures showed potential for being applied for bone tissue regeneration

A Hubble Space Telescope ACS Search for Brown Dwarf Binaries in the Pleiades Open Cluster

We present the results of a high-resolution imaging survey for brown dwarf binaries in the Pleiades open cluster. The observations were carried out with the Advance Camera for Surveys onboard the Hubble Space Telescope. Our sample consists of 15 bona-fide brown dwarfs. We confirm 2 binaries and detect their orbital motion, but we did not resolve any new binary candidates in the separation range between 5.4AU and 1700AU and masses in the range 0.035--0.065~Msun. Together with the results of our previous study (Martin et al., 2003), we can derive a visual binary frequency of 13.3$^{+13.7}_{-4.3}$\% for separations greater than 7~AU masses between 0.055--0.065~M_{\sun} and mass ratios between 0.45--0.9$<q<$1.0. The other observed properties of Pleiades brown dwarf binaries (distributions of separation and mass ratio) appear to be similar to their older counterparts in the field.Comment: 29 pages, 7 figures, 6 tables, accepted for publication in Ap

Multiple protostellar systems. I. A deep near infrared survey of Taurus and Ophiuchus protostellar objects

(Abridged) We performed a deep infrared imaging survey of 63 embedded young stellar objects (YSOs) located in the Taurus and Ophiuchus clouds to search for companions. The sample includes Class I and flat infrared spectrum protostellar objects. We find 17 companions physically bound to 15 YSOs with angular separations in the range 0.8-10" (110-1400 AU) and derive a companion star fraction of 23+/-9 % and 29+/-7 % for embedded YSOs in Taurus and Ophiuchus, respectively. In spite of different properties of the clouds and especially of the prestellar cores, the fraction of wide companions, 27+/-6 % for the combined sample, is identical in the two star-forming regions. This suggests that the frequency and properties of wide multiple protostellar systems are not very sensitive to specific initial conditions. Comparing the companion star fraction of the youngest YSOs still surrounded by extended envelopes to that of more evolved YSOs, we find evidence for a possible evolution of the fraction of wide multiple systems, which seems to decrease by a factor of about 2 on a timescale of about 10^5 yr. Somewhat contrary to model predictions, we do not find evidence for a sub-clustering of embedded sources at this stage on a scale of a few 100 AU that could be related to the formation of small-N protostellar clusters. Possible interpretations for this discrepancy are discussed.Comment: Accepted for publication in Astronomy & Astrophysics; 16 pages, 3 embedded figures, 1 JPEG figur

Regulation of N-Myc downstream regulated gene 2 by bile acids

Here we report that bile acid chenodeoxycholic acid (CDCA) and synthetic farnesoid X receptor (FXR) agonist GW4064 robustly induced tumor suppressor N-Myc downstream regulated gene 2 (NDRG2) expression in human hepatoma cells and primary hepatocytes. Knockdown of FXR abolished the induction by CDCA, whereas overexpre ssion of a constitutively active form of FXR increased NDRG2 expression. A FXR-response element was identified within intronic regions of human and murine genes. Moreover, mice given GW4064 exhib it an increase of Ndrg2 expression in liver and kidney, where both NDRG2 and FXR are enriched. The identification of NDRG2 as a bile acid regulated gene may provide novel knowledge toward the understanding of NDRG2 physiological function and the link between metabolism and cancer

Tidal dwarf galaxies as a test of fundamental physics

Within the cold dark matter (CDM) framework tidal dwarf galaxies (TDGs) cannot contain dark matter, so the recent results by Bournaud et al. (2007) that 3 rotating TDGs do show significant evidence for being dark matter dominated is inconsistent with the current concordance cosmological theory unless yet another dark matter component is postulated. We confirm that the TDG rotation curves are consistent with Newtonian dynamics only if either an additional dark matter component is postulated, or if all 3 TDGs happen to be viewed nearly edge-on, which is unlikely given the geometry of the tidal debris. We also find that the observed rotation curves are very naturally explained without any free parameters within the modified Newtonian dynamics (MOND) framework if inclinations are adopted as derived by Bournaud et al. We explore different inclination angles and two different assumptions about the external field effect. The results do not change significantly, and we conclude therefore that Newtonian dynamics has severe problems while MOND does exceedingly well in explaining the observed rotation curves of the 3 TDGs studied by Bournaud et al.Comment: Accepted for publication in A&A Letters, 5 pages, 3 figure

Modelling Circumbinary Gas Flows in Close T Tauri Binaries

Young close binaries open central gaps in the surrounding circumbinary accretion disc, but the stellar components may still gain mass from gas crossing through the gap. It is not well understood how this process operates and how the stellar components are affected by such inflows. Our main goal is to investigate how gas accretion takes place and evolves in close T Tauri binary systems. In particular, we model the accretion flows around two close T Tauri binaries, V4046 Sgr and DQ Tau, both showing periodic changes in emission lines, although their orbital characteristics are very different. In order to derive the density and velocity maps of the circumbinary material, we employ two-dimensional hydrodynamic simulations with a locally isothermal equation of state. The flow patterns become quasi-stable after a few orbits in the frame co-rotating with the system. Gas flows across the circumbinary gap through the co-rotating Lagrangian points, and local circumstellar discs develop around both components. Spiral density patterns develop in the circumbinary disc that transport angular momentum efficiently. Mass is preferentially channelled towards the primary and its circumstellar disc is more massive than the disc around the secondary. We also compare the derived density distribution to observed line profile variability. The line profile variability tracing the gas flows in the central cavity shows clear similarities with the corresponding observed line profile variability in V4046 Sgr, but only when the local circumstellar disc emission was excluded. Closer to the stars normal magnetospheric accretion may dominate while further out the dynamic accretion process outlined here dominates. Periodic changes in the accretion rates onto the stars can explain the outbursts of line emission observed in eccentric systems such as DQ Tau.Comment: Accepted for publication in MNRA