Organización contable y desarrollo empresarial en la comunidad campesina San Francisco de la Buena Esperanza. Paita, 2019

En la presente investigación se tuvo como objetivo determinar la relación entre Organización contable y el desarrollo empresarial en la Comunidad Campesina San Francisco de Buena Esperanza de Paita, 2019. Fue una investigación cuantitativa, de tipo descriptivo relacional – correlacional, con un diseño no experimental. Los resultados arrojaron que el 62% de los comuneros considera la organización contable como deficiente y el 72% considera al desarrollo empresarial como regular; por otra parte, el 56%considera a la gestión del conocimiento como regular, mientras que el 28% lo considera como deficiente; la ejecución contable es considerada por el 76% como deficiente y el 22% como regular; finalmente se obtuvo que el 52% considera las fuentes de salida como regular y el 38% las considera como deficiente. Todos los resultados obtenidos, permitieron concluir que, existe una correlación positiva baja entre la organización contable y el desarrollo empresarial; la organización contable y la gestión del conocimiento presentan una correlación positiva moderada; por otra parte, existe una correlación positiva baja, entre la ejecución contable y el desarrollo empresarial; finalmente se concluye que no existe relación entre las fuentes de salida y el crecimiento económico; sin embargo, la comunidad si presenta desarrollo empresarial, que es necesario potenciar

Politicas públicas para la formación de recursos humanos de alto nivel

El propósito de este documento es compartir y reflexionar de manera conjunta la experiencia de una política pública diseñada para para la formación de recursos humanos de alto nivel en México. (Párrafo extraído del texto a modo de resumen)Mesa 37/ Sociología política de la educación. Políticas educativas, Gestión institucional y el escenario de la educación como derechoFacultad de Humanidades y Ciencias de la Educació

Politicas públicas para la formación de recursos humanos de alto nivel

El propósito de este documento es compartir y reflexionar de manera conjunta la experiencia de una política pública diseñada para para la formación de recursos humanos de alto nivel en México. (Párrafo extraído del texto a modo de resumen)Mesa 37/ Sociología política de la educación. Políticas educativas, Gestión institucional y el escenario de la educación como derechoFacultad de Humanidades y Ciencias de la Educació

El crecimiento empresarial y su influencia en la rentabilidad de mypes del sector ferretero en el Cercado de Lima, 2020

El objetivo del trabajo de tesis fue determinar la relación entre el crecimiento empresarial y la rentabilidad del sector ferretero en el cercado de Lima. Se trabajó con una muestra de 20 micro empresarios de mypes de una población de 250. A los cuales se les aplicó dos cuestionarios tipo Likert de elaboración propia de 20 preguntas cada uno. Los instrumentos de investigación fueron sometidos a juicio de expertos y el Alfa de Cronbach fueron de 0,755 y 0,805 para crecimiento empresarial y rentabilidad, respectivamente. Se empleó un diseño correlacional, la variable crecimiento empresarial tuvo dos dimensiones, el factor interno y el factor externo y la variable rentabilidad, con sus dimensiones rentabilidad económica y rentabilidad financiera, Los resultados indicaron que se encontró relación entre el crecimiento y la rentabilidad, con un coeficiente de Pearson de ,824, con un nivel de error de 0,01, entre el factor interno y la rentabilidad financiera del 0,565, con un nivel de error del 0,01 y entre el factor externo y la rentabilidad de 0,515 con un nivel de error del 0,01.The objective of the thesis work was to determine the relationship between business growth and the profitability of the hardware sector in the area of Lima. We worked with a sample of 20 micro entrepreneurs from mypes from a population of 250. To which two Likert-type questionnaires of their own elaboration of 20 questions each were applied. The research instruments were subjected to expert judgment and Cronbach's Alpha was 0.755 and 0.805 for business growth and profitability, respectively. A correlational design was used, the business growth variable had two dimensions, the internal factor and the external factor and the profitability variable, with its dimensions economic profitability and financial profitability. The results indicated that a relationship was found between growth and profitability, with a Pearson coefficient of .824, with an error level of 0.01, between the internal factor and financial profitability of 0.565, with an error level of 0.01 and between the external factor and profitability of 0.515 with a 0.01 level of error

Ghrelin attenuates hepatocellular injury and liver fibrogenesis in rodents and influences fibrosis progression in humans

El pdf del artículo es la versión pre-print.-- et al-There are no effective antifibrotic therapies for patients with liver diseases. We performed an experimental and translational study to investigate whether ghrelin, an orexigenic hormone with pleiotropic properties, modulates liver fibrogenesis. Recombinant ghrelin was administered to rats with chronic (bile duct ligation) and acute (carbon tetrachloride) liver injury. Hepatic gene expression was analyzed by way of microarray analysis and quantitative polymerase chain reaction. The hepatic response to chronic injury was also evaluated in wild-type and ghrelin-deficient mice. Primary human hepatic stellate cells were used to study the effects of ghrelin in vitro. Ghrelin hepatic gene expression and serum levels were assessed in patients with chronic liver diseases. Ghrelin gene polymorphisms were analyzed in patients with chronic hepatitis C. Recombinant ghrelin treatment reduced the fibrogenic response, decreased liver injury and myofibroblast accumulation, and attenuated the altered gene expression profile in bile duct-ligated rats. Moreover, ghrelin reduced the fibrogenic properties of hepatic stellate cells. Ghrelin also protected rats from acute liver injury and reduced the extent of oxidative stress and inflammation. Ghrelin-deficient mice developed exacerbated hepatic fibrosis and liver damage after chronic injury. In patients with chronic liver diseases, ghrelin serum levels decreased in those with advanced fibrosis, and ghrelin gene hepatic expression correlated with expression of fibrogenic genes. In patients with chronic hepatitis C, polymorphisms of the ghrelin gene (994CT and 604GA) influenced the progression of liver fibrosis. Conclusion: Ghrelin exerts antifibrotic effects in the liver and may represent a novel antifibrotic therapy. Copyright © 2010 by the American Association for the Study of Liver Diseases.Supported by grants from the Ministerio de Ciencia e Investigación (SAF2005-06245), from the Instituto de Salud Carlos III (FIS2005-050567, FIS 2008-PI08/0237 and PI070497), and from the European Community FP6 (LSHB-CT-2007-036644 - DIALOK) and by fellowships from Institut d’Investigacions Biomèdiques August Pi i Sunyer (to M. M. and M. D.), the Fundación Bilbao Vizcaya Argentaria (to M. D.) and the Fundació Clínic (to P. S. B.).Peer Reviewe

Molecular mechanism of Ena/VASP-mediated actin-filament elongation

Ena/VASP proteins have important functions in actin-dependent processes. A model for the actin elongation activity of Ena/VASP based on the affinity and saturation state of WH2-domain-mediated actin monomer binding is presented

Systemic inflammatory response and serum lipopolysaccharide levels predict multiple organ failure and death in alcoholic hepatitis

Alcoholic hepatitis (AH) frequently progresses to multiple organ failure (MOF) and death. However, the driving factors are largely unknown. At admission, patients with AH often show criteria of systemic inflammatory response syndrome (SIRS) even in the absence of an infection. We hypothesize that the presence of SIRS may predispose to MOF and death. To test this hypothesis, we studied a cohort including 162 patients with biopsy-proven AH. The presence of SIRS and infections was assessed in all patients, and multivariate analyses identified variables independently associated with MOF and 90-day mortality. At admission, 32 (19.8%) patients were diagnosed with a bacterial infection, while 75 (46.3%) fulfilled SIRS criteria; 58 patients (35.8%) developed MOF during hospitalization. Short-term mortality was significantly higher among patients who developed MOF (62.1% versus 3.8%, P <0.001). The presence of SIRS was a major predictor of MOF (odds ratio = 2.69, P=0.025) and strongly correlated with mortality. Importantly, the course of patients with SIRS with and without infection was similar in terms of MOF development and short-term mortality. Finally, we sought to identify serum markers that differentiate SIRS with and without infection. We studied serum levels of high-sensitivity C-reactive protein, procalcitonin, and lipopolysaccharide at admission. All of them predicted mortality. Procalcitonin, but not high-sensitivity C-reactive protein, serum levels identified those patients with SIRS and infection. Lipopolysaccharide serum levels predicted MOF and the response to prednisolone

The cross-sectional GRAS sample: A comprehensive phenotypical data collection of schizophrenic patients

<p>Abstract</p> <p>Background</p> <p>Schizophrenia is the collective term for an exclusively clinically diagnosed, heterogeneous group of mental disorders with still obscure biological roots. Based on the assumption that valuable information about relevant genetic and environmental disease mechanisms can be obtained by association studies on patient cohorts of ≥ 1000 patients, if performed on detailed clinical datasets and quantifiable biological readouts, we generated a new schizophrenia data base, the GRAS (Göttingen Research Association for Schizophrenia) data collection. GRAS is the necessary ground to study genetic causes of the schizophrenic phenotype in a 'phenotype-based genetic association study' (PGAS). This approach is different from and complementary to the genome-wide association studies (GWAS) on schizophrenia.</p> <p>Methods</p> <p>For this purpose, 1085 patients were recruited between 2005 and 2010 by an invariable team of traveling investigators in a cross-sectional field study that comprised 23 German psychiatric hospitals. Additionally, chart records and discharge letters of all patients were collected.</p> <p>Results</p> <p>The corresponding dataset extracted and presented in form of an overview here, comprises biographic information, disease history, medication including side effects, and results of comprehensive cross-sectional psychopathological, neuropsychological, and neurological examinations. With >3000 data points per schizophrenic subject, this data base of living patients, who are also accessible for follow-up studies, provides a wide-ranging and standardized phenotype characterization of as yet unprecedented detail.</p> <p>Conclusions</p> <p>The GRAS data base will serve as prerequisite for PGAS, a novel approach to better understanding 'the schizophrenias' through exploring the contribution of genetic variation to the schizophrenic phenotypes.</p

Ethnic group inequalities in coverage with reproductive, maternal and child health interventions:cross-sectional analyses of national surveys in 16 Latin American and Caribbean countries

Background Latin American and Caribbean populations include three main ethnic groups: indigenous people, people of African descent, and people of European descent. We investigated ethnic inequalities among these groups in population coverage with reproductive, maternal, newborn, and child health interventions. Methods We analysed 16 standardised, nationally representative surveys carried out from 2004 to 2015 in Latin America and the Caribbean that provided information on ethnicity or a proxy indicator (household language or skin colour) and on coverage of reproductive, maternal, newborn, and child health interventions. We selected four outcomes: coverage with modern contraception, antenatal care coverage (defined as four or more antenatal visits), and skilled attendants at birth for women aged 15-49 years; and coverage with three doses of diphtheria-pertussis-tetanus (DPT3) vaccine among children aged 12-23 months. We classified women and children as indigenous, of African descent, or other ancestry (reference group) on the basis of their self-reported ethnicity or language. Mediating variables included wealth quintiles (based on household asset indices), woman's education, and urban-rural residence. We calculated crude and adjusted coverage ratios using Poisson regression. Findings Ethnic gaps in coverage varied substantially from country to country. In most countries, coverage with modern contraception (median coverage ratio 0.82, IQR 0.66-0.92), antenatal care (0.86, 0.75-0.94), and skilled birth attendants (0.75, 0.68-0.92) was lower among indigenous women than in the reference group. Only three countries (Nicaragua, Panama, and Paraguay) showed significant gaps in DPT3 coverage between the indigenous and the reference groups. The differences were attenuated but persisted after adjustment for wealth, education, and residence. Women and children of African descent showed similar coverage to the reference group in most countries. Interpretation The lower coverage levels for indigenous women are pervasive, and cannot be explained solely by differences in wealth, education, or residence. Interventions delivered at community level-such as vaccines-show less inequality than those requiring access to services, such as birth attendance. Regular monitoring of ethnic inequalities is essential to evaluate existing initiatives aimed at the inclusion of minorities and to plan effective multisectoral policies and programmes.Entidad financiadora: Bill & Melinda Gates Foundation; Wellcome Trus

Robust estimation of bacterial cell count from optical density

Optical density (OD) is widely used to estimate the density of cells in liquid culture, but cannot be compared between instruments without a standardized calibration protocol and is challenging to relate to actual cell count. We address this with an interlaboratory study comparing three simple, low-cost, and highly accessible OD calibration protocols across 244 laboratories, applied to eight strains of constitutive GFP-expressing E. coli. Based on our results, we recommend calibrating OD to estimated cell count using serial dilution of silica microspheres, which produces highly precise calibration (95.5% of residuals &lt;1.2-fold), is easily assessed for quality control, also assesses instrument effective linear range, and can be combined with fluorescence calibration to obtain units of Molecules of Equivalent Fluorescein (MEFL) per cell, allowing direct comparison and data fusion with flow cytometry measurements: in our study, fluorescence per cell measurements showed only a 1.07-fold mean difference between plate reader and flow cytometry data