Telemonitoring, Telemedicine and Time in Range During the Pandemic: Paradigm Change for Diabetes Risk Management in the Post-COVID Future

People with diabetes are at greater risk for negative outcomes from COVID-19. Though this risk is multifactorial, poor glycaemic control before and during admission to hospital for COVID-19 is likely to contribute to the increased risk. The COVID-19 pandemic and restrictions on mobility and interaction can also be expected to impact on daily glucose management of people with diabetes. Telemonitoring of glucose metrics has been widely used during the pandemic in people with diabetes, including adults and children with T1D, allowing an exploration of the impact of COVID-19 inside and outside the hospital setting on glycaemic control. To date, 27 studies including 69,294 individuals with T1D have reported the effect of glycaemic control during the COVID-19 pandemic. Despite restricted access to diabetes clinics, glycaemic control has not deteriorated for 25/27 cohorts and improved in 23/27 study groups. Significantly, time in range (TIR) 70–180 mg/dL (3.9–10 mmol/L) increased across 19/27 cohorts with a median 3.3% (− 6.0% to 11.2%) change. Thirty per cent of the cohorts with TIR data reported an average clinically significant TIR improvement of 5% or more, possibly as a consequence of more accurate glucose monitoring and improved connectivity through telemedicine. Periodic consultations using telemedicine enables care of people with diabetes while limiting the need for in-person attendance at diabetes clinics. Reports that sustained hyperglycaemia and early-stage diabetic ketoacidosis may go untreated because of the lockdown and concerns about potential exposure to the risk of infection argue for wider access to glucose telemonitoring. Therefore, in this paper we have critically reviewed reports concerning use of telemonitoring in the acute hospitalized setting as well as during daily diabetes management. Furthermore, we discuss the indications and implications of adopting telemonitoring and telemedicine in the present challenging time, as well as their potential for the future

High-Precision Spectroscopy of O 20 Benchmarking Ab Initio Calculations in Light Nuclei

: The excited states of unstable ^{20}O were investigated via γ-ray spectroscopy following the ^{19}O(d,p)^{20}O reaction at 8 AMeV. By exploiting the Doppler shift attenuation method, the lifetimes of the 2_{2}^{+} and 3_{1}^{+} states were firmly established. From the γ-ray branching and E2/M1 mixing ratios for transitions deexciting the 2_{2}^{+} and 3_{1}^{+} states, the B(E2) and B(M1) were determined. Various chiral effective field theory Hamiltonians, describing the nuclear properties beyond ground states, along with a standard USDB interaction, were compared with the experimentally obtained data. Such a comparison for a large set of γ-ray transition probabilities with the valence space in medium similarity renormalization group ab initio calculations was performed for the first time in a nucleus far from stability. It was shown that the ab initio approaches using chiral effective field theory forces are challenged by detailed high-precision spectroscopic properties of nuclei. The reduced transition probabilities were found to be a very constraining test of the performance of the ab initio models

High-Precision Spectroscopy of 20{20}O Benchmarking Ab Initio Calculations in Light Nuclei

International audienceHigh-precision spectroscopy of 20O benchmarking ab-initio calculations in light nucleiI. Zanon,1, 2 E. Cl´ement,3 A. Goasduff,1 J. Men´endez,4 T. Miyagi,5, 6, 7 M. Assi´e,8 M. Ciemala,9F. Flavigny,10 A. Lemasson,3 A. Matta,10 D. Ramos,3 M. Rejmund,3 L. Achouri,10 D. Ackermann,3D. Barrientos,11 D. Beaumel,8 G. Benzoni,12 A.J. Boston,13 H.C. Boston,13 S. Bottoni,14, 12 A. Bracco,12, 14D. Brugnara,1, 15 G. de France,3 N. de Sereville,8 F. Delaunay,10 P. Desesquelles,8 F. Didierjean,16C. Domingo-Prato,17 J. Dudouet,18 J. Eberth,19 D. Fern´andez,20 C. Foug`eres,3 A. Gadea,17 F. Galtarossa,8V. Girard-Alcindor,3 V. Gonzales,21 A. Gottardo,1 F. Hammache,8 L.J. Harkness-Brennan,13 H. Hess,19D.S Judson,13 A. Jungclaus,22 A. Ka¸ska¸s,23 Y.H. Kim,24 A. Ku¸so˘glu,25 M. Labiche,26 S. Leblond,3C. Lenain,10 S.M. Lenzi,27 S. Leoni,12 H. Li,3 J. Ljungvall,8 J. Lois-Fuentes,20 A. Lopez-Martens,8A. Maj,28 R. Menegazzo,27 D. Mengoni,15, 27 C. Michelagnoli,3, 24 B. Million,12 D.R. Napoli,1 J. Nyberg,29G. Pasqualato,15, 27 Zs. Podolyak,30 A. Pullia,12 B. Quintana,31 F.Recchia,15, 27 D. Regueira-Castro,20 P. Reiter,19K. Rezynkina,32 J.S. Rojo,33 M.D. Salsac,34 E. Sanchis,21 M. S¸enyi˘git,23 M. Siciliano,34, 35 D. Sohler,36O. Stezowski,18 Ch. Theisen,34 A. Utepov,3, 10 J.J. Valiente-Dob´on,1 D. Verney,8 and M. Zielinska341INFN Laboratori Nazionali di Legnaro, Legnaro, Italy.2Dipartimento di Fisica e Scienze della Terra, Universit`a di Ferrara, Ferrara, Italy.3Grand Acc´el´erateur National d’Ions Lourds (GANIL), CEA/DRF-CNRS/IN2P3, Caen, France4Department of Quantum Physics and Astrophysics and Institute of Cosmos Sciences, University of Barcelona, Spain5Technische Universit¨at Darmstadt, Department of Physics, Darmstadt, Germany6ExtreMe Matter Institute, GSI Helmholtzzentrum f¨ur Schwerionenforschung GmbH, Darmstadt, Germany7Max-Planck-Institut f¨ur Kernphysik, Heidelberg, Germany8Universit´e Paris-Saclay, CNRS/IN2P3, IJCLab, 91405 Orsay, France9IFJ PAN, Krakow, Poland.10Universit´e de Caen Normandie, ENSICAEN, CNRS/IN2P3, LPC Caen UMR6534, F-14000 Caen, France.11CERN, CH-1211 Geneva 23, Switzerland12INFN Sezione di Milano, I-20133 Milano, Italy13Oliver Lodge Laboratory, The University of Liverpool, Liverpool, UK.14Dipartimento di Fisica, Universit`a di Milano, Milano, Italy15Dipartimento di Fisica, Universit`a di Padova, Padova, Italy.16Universit´e de Strasbourg, IPHC, Strasbourg, France.17Instituto de Fisica Corpuscolar, CSIC-Universidad de Valencia, E-46071 Valencia, Spain.18Universit´e de Lyon, Universit´e Lyon-1, CNRS/IN2P3,UMR5822, IP2I, F-69622 Villeurbanne Cedex, France19Institut f¨ur Kernphysik, Universit¨at zu K¨oln, Z¨ulpicher Str. 77, D-50937 K¨oln, Germany20IGFAE and Dpt. de F´ısica de Part´ıculas, Univ. of Santiago de Compostela, Santiago de Compostela, Spain21Departamento de Ingenier´ıa Electr´onica, Universitat de Valencia, Burjassot, Valencia, Spain22Instituto de Estructura de la Materia, CSIC, Madrid, E-28006 Madrid, Spain23Department of Physics, Faculty of Science, Ankara University, 06100 Besevler - Ankara, Turkey24Institue Laue-Langevin, Grenoble, France.25Department of Physics, Faculty of Science, Istanbul University, Vezneciler/Fatih, Istanbul, Turkey.26STFC Daresbury Laboratory, Daresbury, Warrington, WA4 4AD, UK27INFN, Sezione di Padova, I-35131 Padova, Italy.28The Henryk Niewodnicza´nski Institute of Nuclear Physics,Polish Academy of Sciences, 31-342 Krak´ow, Poland29Department of Physics and Astronomy, Uppsala University, SE-75120 Uppsala, Sweden30Department of Physics, University of Surrey, Guildford, GU2 7XH, UK31Laboratorio de Radiaciones Ionizantes, Departamento de F´ısica Fundamental,Universidad de Salamanca, E-37008 Salamanca, Spain32Universit´e de Strasbourg, CNRS, IPHC UMR 7178, F-67000 Strasbourg, France33Department of Physics, University of York, York, UK.34Irfu, CEA, Universit´e Paris-Saclay, F-91191 Gif-sur-Yvette, France35Physics Division, Argonne National Laboratory, Lemont (IL) 60439, United States.36Institute for Nuclear Research, Atomki, 4001 Debrecen, HungaryThe excited states of unstable 20O were investigated via γ-ray spectroscopy following the19O(d, p)20O reaction at 8 AMeV. By exploiting the Doppler Shift Attenuation Method, the lifetimeof the 2+2 and 3+1 states were firmly established. From the γ-ray branching and E2/M1 mixing ratiosfor transitions deexciting the 2+2 and 3+1 states, the B(E2) and B(M1) were determined. Variouschiral effective field theory Hamiltonians, describing the nuclear properties beyond ground states,along with a standard USDB interaction, were compared with the experimentally obtained data.Such a comparison for a large set of γ-ray transition probabilities with the valence space in medium 2similarity renormalization group ab-initio calculations was performed for the first time in a nucleusfar from stability. It was shown that the ab-initio approaches using chiral EFT forces are challengedby detailed high-precision spectroscopic properties of nuclei. The reduced transition probabilitieswere found to be a very constraining test of the performance of the ab-initio model

High-Precision Spectroscopy of 20{20}O Benchmarking Ab Initio Calculations in Light Nuclei

International audienceHigh-precision spectroscopy of 20O benchmarking ab-initio calculations in light nucleiI. Zanon,1, 2 E. Cl´ement,3 A. Goasduff,1 J. Men´endez,4 T. Miyagi,5, 6, 7 M. Assi´e,8 M. Ciemala,9F. Flavigny,10 A. Lemasson,3 A. Matta,10 D. Ramos,3 M. Rejmund,3 L. Achouri,10 D. Ackermann,3D. Barrientos,11 D. Beaumel,8 G. Benzoni,12 A.J. Boston,13 H.C. Boston,13 S. Bottoni,14, 12 A. Bracco,12, 14D. Brugnara,1, 15 G. de France,3 N. de Sereville,8 F. Delaunay,10 P. Desesquelles,8 F. Didierjean,16C. Domingo-Prato,17 J. Dudouet,18 J. Eberth,19 D. Fern´andez,20 C. Foug`eres,3 A. Gadea,17 F. Galtarossa,8V. Girard-Alcindor,3 V. Gonzales,21 A. Gottardo,1 F. Hammache,8 L.J. Harkness-Brennan,13 H. Hess,19D.S Judson,13 A. Jungclaus,22 A. Ka¸ska¸s,23 Y.H. Kim,24 A. Ku¸so˘glu,25 M. Labiche,26 S. Leblond,3C. Lenain,10 S.M. Lenzi,27 S. Leoni,12 H. Li,3 J. Ljungvall,8 J. Lois-Fuentes,20 A. Lopez-Martens,8A. Maj,28 R. Menegazzo,27 D. Mengoni,15, 27 C. Michelagnoli,3, 24 B. Million,12 D.R. Napoli,1 J. Nyberg,29G. Pasqualato,15, 27 Zs. Podolyak,30 A. Pullia,12 B. Quintana,31 F.Recchia,15, 27 D. Regueira-Castro,20 P. Reiter,19K. Rezynkina,32 J.S. Rojo,33 M.D. Salsac,34 E. Sanchis,21 M. S¸enyi˘git,23 M. Siciliano,34, 35 D. Sohler,36O. Stezowski,18 Ch. Theisen,34 A. Utepov,3, 10 J.J. Valiente-Dob´on,1 D. Verney,8 and M. Zielinska341INFN Laboratori Nazionali di Legnaro, Legnaro, Italy.2Dipartimento di Fisica e Scienze della Terra, Universit`a di Ferrara, Ferrara, Italy.3Grand Acc´el´erateur National d’Ions Lourds (GANIL), CEA/DRF-CNRS/IN2P3, Caen, France4Department of Quantum Physics and Astrophysics and Institute of Cosmos Sciences, University of Barcelona, Spain5Technische Universit¨at Darmstadt, Department of Physics, Darmstadt, Germany6ExtreMe Matter Institute, GSI Helmholtzzentrum f¨ur Schwerionenforschung GmbH, Darmstadt, Germany7Max-Planck-Institut f¨ur Kernphysik, Heidelberg, Germany8Universit´e Paris-Saclay, CNRS/IN2P3, IJCLab, 91405 Orsay, France9IFJ PAN, Krakow, Poland.10Universit´e de Caen Normandie, ENSICAEN, CNRS/IN2P3, LPC Caen UMR6534, F-14000 Caen, France.11CERN, CH-1211 Geneva 23, Switzerland12INFN Sezione di Milano, I-20133 Milano, Italy13Oliver Lodge Laboratory, The University of Liverpool, Liverpool, UK.14Dipartimento di Fisica, Universit`a di Milano, Milano, Italy15Dipartimento di Fisica, Universit`a di Padova, Padova, Italy.16Universit´e de Strasbourg, IPHC, Strasbourg, France.17Instituto de Fisica Corpuscolar, CSIC-Universidad de Valencia, E-46071 Valencia, Spain.18Universit´e de Lyon, Universit´e Lyon-1, CNRS/IN2P3,UMR5822, IP2I, F-69622 Villeurbanne Cedex, France19Institut f¨ur Kernphysik, Universit¨at zu K¨oln, Z¨ulpicher Str. 77, D-50937 K¨oln, Germany20IGFAE and Dpt. de F´ısica de Part´ıculas, Univ. of Santiago de Compostela, Santiago de Compostela, Spain21Departamento de Ingenier´ıa Electr´onica, Universitat de Valencia, Burjassot, Valencia, Spain22Instituto de Estructura de la Materia, CSIC, Madrid, E-28006 Madrid, Spain23Department of Physics, Faculty of Science, Ankara University, 06100 Besevler - Ankara, Turkey24Institue Laue-Langevin, Grenoble, France.25Department of Physics, Faculty of Science, Istanbul University, Vezneciler/Fatih, Istanbul, Turkey.26STFC Daresbury Laboratory, Daresbury, Warrington, WA4 4AD, UK27INFN, Sezione di Padova, I-35131 Padova, Italy.28The Henryk Niewodnicza´nski Institute of Nuclear Physics,Polish Academy of Sciences, 31-342 Krak´ow, Poland29Department of Physics and Astronomy, Uppsala University, SE-75120 Uppsala, Sweden30Department of Physics, University of Surrey, Guildford, GU2 7XH, UK31Laboratorio de Radiaciones Ionizantes, Departamento de F´ısica Fundamental,Universidad de Salamanca, E-37008 Salamanca, Spain32Universit´e de Strasbourg, CNRS, IPHC UMR 7178, F-67000 Strasbourg, France33Department of Physics, University of York, York, UK.34Irfu, CEA, Universit´e Paris-Saclay, F-91191 Gif-sur-Yvette, France35Physics Division, Argonne National Laboratory, Lemont (IL) 60439, United States.36Institute for Nuclear Research, Atomki, 4001 Debrecen, HungaryThe excited states of unstable 20O were investigated via γ-ray spectroscopy following the19O(d, p)20O reaction at 8 AMeV. By exploiting the Doppler Shift Attenuation Method, the lifetimeof the 2+2 and 3+1 states were firmly established. From the γ-ray branching and E2/M1 mixing ratiosfor transitions deexciting the 2+2 and 3+1 states, the B(E2) and B(M1) were determined. Variouschiral effective field theory Hamiltonians, describing the nuclear properties beyond ground states,along with a standard USDB interaction, were compared with the experimentally obtained data.Such a comparison for a large set of γ-ray transition probabilities with the valence space in medium 2similarity renormalization group ab-initio calculations was performed for the first time in a nucleusfar from stability. It was shown that the ab-initio approaches using chiral EFT forces are challengedby detailed high-precision spectroscopic properties of nuclei. The reduced transition probabilitieswere found to be a very constraining test of the performance of the ab-initio model