The influence of contextual reward statistics on risk preference

Decision theories mandate that organisms should adjust their behaviour in the light of the contextual reward statistics. We tested this notion using a gambling choice task involving distinct contexts with different reward distributions. The best fitting model of subjects' behaviour indicated that the subjective values of options depended on several factors, including a baseline gambling propensity, a gambling preference dependent on reward amount, and a contextual reward adaptation factor. Combining this behavioural model with simultaneous functional magnetic resonance imaging we probed neural responses in three key regions linked to reward and value, namely ventral tegmental area/substantia nigra (VTA/SN), ventromedial prefrontal cortex (vmPFC) and ventral striatum (VST). We show that activity in the VTA/SN reflected contextual reward statistics to the extent that context affected behaviour, activity in the vmPFC represented a value difference between chosen and unchosen options while VST responses reflected a non-linear mapping between the actual objective rewards and their subjective value. The findings highlight a multifaceted basis for choice behaviour with distinct mappings between components of this behaviour and value sensitive brain regions

Risk taking for potential losses but not gains increases with time of day

Humans exhibit distinct risk preferences when facing choices involving potential gains and losses. These preferences are believed to be subject to neuromodulatory influence, particularly from dopamine and serotonin. As neuromodulators manifest circadian rhythms, this suggests decision making under risk might be affected by time of day. Here, in a large subject sample collected using a smartphone application, we found that risky options with potential losses were increasingly chosen over the course of the day. We observed this result in both a within-subjects design (N = 2599) comparing risky options chosen earlier and later in the day in the same individuals, and in a between-subjects design (N = 26,720) showing our effect generalizes across ages and genders. Using computational modelling, we show this diurnal change in risk preference reflects a decrease in sensitivity to increasing losses, but no change was observed in the relative impacts of gains and losses on choice (i.e., loss aversion). Thus, our findings reveal a striking diurnal modulation in human decision making, a pattern with potential importance for real-life decisions that include voting, medical decisions, and financial investments

Thermodynamics of an Anyon System

We examine the thermal behavior of a relativistic anyon system, dynamically realized by coupling a charged massive spin-1 field to a Chern-Simons gauge field. We calculate the free energy (to the next leading order), from which all thermodynamic quantities can be determined. As examples, the dependence of particle density on the anyon statistics and the anyon anti-anyon interference in the ideal gas are exhibited. We also calculate two and three-point correlation functions, and uncover certain physical features of the system in thermal equilibrium.Comment: 18 pages; in latex; to be published in Phys. Rev.

A Conformally Invariant Holographic Two-Point Function on the Berger Sphere

We apply our previous work on Green's functions for the four-dimensional quaternionic Taub-NUT manifold to obtain a scalar two-point function on the homogeneously squashed three-sphere (otherwise known as the Berger sphere), which lies at its conformal infinity. Using basic notions from conformal geometry and the theory of boundary value problems, in particular the Dirichlet-to-Robin operator, we establish that our two-point correlation function is conformally invariant and corresponds to a boundary operator of conformal dimension one. It is plausible that the methods we use could have more general applications in an AdS/CFT context.Comment: 1+49 pages, no figures. v2: Several typos correcte

Particle-Vortex Duality and the Modular Group: Applications to the Quantum Hall Effect and Other 2-D Systems

We show how particle-vortex duality implies the existence of a large non-abelian discrete symmetry group which relates the electromagnetic response for dual two-dimensional systems in a magnetic field. For conductors with charge carriers satisfying Fermi statistics (or those related to fermions by the action of the group), the resulting group is known to imply many, if not all, of the remarkable features of Quantum Hall systems. For conductors with boson charge carriers (modulo group transformations) a different group is predicted, implying equally striking implications for the conductivities of these systems, including a super-universality of the critical exponents for conductor/insulator and superconductor/insulator transitions in two dimensions and a hierarchical structure, analogous to that of the quantum Hall effect but different in its details. Our derivation shows how this symmetry emerges at low energies, depending only weakly on the details of dynamics of the underlying systems.Comment: 22 pages, LaTeX, 2 figures, uses revte

Model-based analyses: Promises, pitfalls, and example applications to the study of cognitive control

We discuss a recent approach to investigating cognitive control, which has the potential to deal with some of the challenges inherent in this endeavour. In a model-based approach, the researcher defines a formal, computational model that performs the task at hand and whose performance matches that of a research participant. The internal variables in such a model might then be taken as proxies for latent variables computed in the brain. We discuss the potential advantages of such an approach for the study of the neural underpinnings of cognitive control and its pitfalls, and we make explicit the assumptions underlying the interpretation of data obtained using this approach

Quantification of three macrolide antibiotics in pharmaceutical lots by HPLC: Development, validation and application to a simultaneous separation

A new validated high performance liquid chromatographic (HPLC) method with rapid analysis time and high efficiency, for the analysis of erythromycin, azithromycin and spiramycin, under isocratic conditions with ODB RP18 as a stationary phase is described. Using an eluent composed of acetonitrile –2-methyl-2-propanol –hydrogenphosphate buffer, pH 6.5, with 1.5% triethylamine (33:7: up to 100, v/v/v), delivered at a flow-rate of 1.0 mL min-1. Ultra Violet (UV) detection is performed at 210 nm. The selectivity is satisfactory enough and no problematic interfering peaks are observed. The procedure is quantitatively characterized and repeatability, linearity, detection and quantification limits are very satisfactory. The method is applied successfully for the assay of the studied drugs in pharmaceutical dosage forms as tablets and powder for oral suspension. Recovery experiments revealed recovery of 97.13–100.28%

Highly-parallelized simulation of a pixelated LArTPC on a GPU

The rapid development of general-purpose computing on graphics processing units (GPGPU) is allowing the implementation of highly-parallelized Monte Carlo simulation chains for particle physics experiments. This technique is particularly suitable for the simulation of a pixelated charge readout for time projection chambers, given the large number of channels that this technology employs. Here we present the first implementation of a full microphysical simulator of a liquid argon time projection chamber (LArTPC) equipped with light readout and pixelated charge readout, developed for the DUNE Near Detector. The software is implemented with an end-to-end set of GPU-optimized algorithms. The algorithms have been written in Python and translated into CUDA kernels using Numba, a just-in-time compiler for a subset of Python and NumPy instructions. The GPU implementation achieves a speed up of four orders of magnitude compared with the equivalent CPU version. The simulation of the current induced on 10^3 pixels takes around 1 ms on the GPU, compared with approximately 10 s on the CPU. The results of the simulation are compared against data from a pixel-readout LArTPC prototype

Trypanotolerance in East African Orma Boran cattle

Comparative studies on two types of East African zebu (Bos indicus) Boran cattle, on a beef ranch in Kenya, have indicated that a Boran type bred by the Orma tribe has a superior response to tsetse fly challenge. The Orma Boran when compared with an improved Boran was found to have lower trypanosome infection rates and, when untreated, better control of anaemia and decreased mortality

Genetic variation in packed red cell volume and frequency of parasitaemia in East African Zebu cattle exposed to drug-resistant trypanosomes

Nine hundred and thirty-six East African Zebu village calves in an area of high trypanosomiasis risk in south-western Ethiopia were monitored monthly with their dams from birth to 3 years of age. Mean packed red cell volume (PCV) and the frequency of detected parasitaemia were calculated for each offspring and its dam measured simultaneously over 6 month `wet' and `dry' seasons from March 1986 to February 1992. Six-month residual values for offspring, corrected for solutions of fixed environmental effects, herd, year, season, etc., estimated by least squares analysis of variance, were regressed against corresponding residual values for their dams. The common environment component of variance, not already corrected for and remaining in these residual values, was estimated by regression of offspring values against those for the cows that gave birth closest to the offspring's own date of birth. When corrected for this component, offspring-dam regression coefficients for mean PCV, averaged over calves for each dam, were found to increase from 0.08 + 0.05 (SE) to 0.26 + 0.06 from 4 to 21 months of age. When also corrected for frequency of parasitaemia and treatment, regression coefficients were reduced, but the increasing trend with age was maintained. Offspring-dam regression coefficients for frequency of parasitaemia showed, if anything, an opposite trend. Application of an `animal model' to offspring over 21 months of age and their dams gave heritability estimates of 0.32 + 0.07 for PCV, 0.18 + 0.07 for PCV, corrected for frequency of parasitaemia, and 0.08 + 0.05 for frequency of parasitaemia