Associations of Polyethylenimine-Coated AN69ST Membrane in Continuous Renal Replacement Therapy with the Intensive Care Outcomes: Observations from a Claims Database from Japan.

BACKGROUND/AIMS: Polyethylenimine-coated polyacrylonitrile (AN69ST) membrane is expected to improve the outcomes of critically ill patients treated by continuous renal replacement therapy (CRRT). METHODS: Using a Japanese health insurance claim database, we identified adult patients receiving CRRT in intensive care units (ICUs) from April 2014 to October 2015. We used a multivariable logistic regression model to assess in-hospital mortality and Fine and Gray's proportional subhazards model to assess the ICU length of stay (ICU-LOS) accounting for the competing risks. RESULTS: Of 2,469 ICU patients, 156 were treated by AN69ST membrane. Crude in-hospital mortality was 50.0% in the AN69ST group and 54.0% in the non-AN69ST group. Adjusted odds ratio (OR) of AN69ST membrane use for in-hospital mortality was 0.65 (95% CI 0.45-0.93). The use of AN69ST membrane was also independently associated with shorter ICU-LOS. CONCLUSION: This retrospective observational study suggested that CRRT with AN69ST membrane might be associated with better in-hospital outcomes

Transcriptomic Profile of Distal Middle Cerebral Artery from Moyamoya Disease Patients Reveals a Potential Unique Pathway

BACKGROUND: Moyamoya disease (MMD) is a peculiar disease, characterized by progressive steno-occlusion of the distal ends of bilateral internal carotid arteries and their proximal branches. Numerous studies of MMD investigated as a singular pathway, thus overlooked the complexity of MMD pathobiology. AIM: In this study, we sought to investigate the gene expression in the involved arteries to reveal the novel mechanism of MMD. MATERIALS AND METHODS: Eight middle cerebral artery (MCA) specimens were obtained from six patients underwent surgical procedure superficial temporal artery to MCA (STA-MCA bypass) for MMD and two control patients. We performed RNA extraction and microarray analysis with Agilent Whole Human Genome DNA microarray 4x44K ver.2.0 (Agilent Tech., Inc., Wilmington, DE, USA). RESULTS: From 42,405 gene probes assayed, 921 gene probes were differentially regulated in MCA of patients with MMD. Subsequent pathway analysis with PANTHER database revealed that angiogenesis, inflammation, integrin, platelet-derived growth factor (PDGF), and WNT pathways were distinctly regulated in MMD. Among genes in aforementioned pathways, SOS1 and AKT2 were the mostly distinctly regulated genes and closely associated with RAS pathway. CONCLUSION: The gene expression in MCA of patients with MMD was distinctly regulated in comparison with control MCA; presumably be useful for elucidating MMD pathobiology

Optical photometry of the UCM Lists I and II. II-B band surface photometry and morphological discussion

We present Johnson B surface photometry for the UCM Survey galaxies. One-dimensional bulge-disk decomposition is attempted, discussing on fitting functions and computational procedures. The results from this decomposition, jointly with concentration indices and an asymmetry coefficient, are employed to study the morphological properties of these galaxies. We also compare our results with the previous morphological classification established using Gunn r imaging data and with other samples of galaxies. No major statistical differences in morphology are found between red and blue data, although some characteristics such as size and luminosity concentration vary. We find a correlation between luminosity and size. Several parameters are used to segregate the objects according to their morphological type.Comment: 19 pages, 20 PostScript figures, accepted for publication in A&A, also available via anonymous ftp at ftp://cutrex.fis.ucm.es/pub/OUT/pag/PAPERS/AA0

Identification of A-colored Stars and Structure in the Halo of the Milky Way from SDSS Commissioning Data

A sample of 4208 objects with magnitude 15 < g* < 22 and colors of main sequence A stars has been selected from 370 square degrees of Sloan Digital Sky Survey (SDSS) commissioning observations. The data is from two long, narrow stripes, each with an opening angle of greater than 60 deg, at Galactic latitudes 36 < abs(b) < 63 on the celestial equator. An examination of the sample's distribution shows that these stars trace considerable substructure in the halo. Large overdensities of A-colored stars in the North at (l,b,R) = (350, 50, 46 kpc) and in the South at (157, -58, 33 kpc) and extending over tens of degrees are present in the halo of the Milky Way. Using photometry to separate the stars by surface gravity, both structures are shown to contain a sequence of low surface gravity stars consistent with identification as a blue horizontal branch (BHB). Both structures also contain a population of high surface gravity stars two magnitudes fainter than the BHB stars, consistent with their identification as blue stragglers (BSs). From the numbers of detected BHB stars, lower limits to the implied mass of the structures are 6x10^6 M_sun and 2x10^6 M_sun. The fact that two such large clumps have been detected in a survey of only 1% of the sky indicates that such structures are not uncommon in the halo. Simple spheroidal parameters are fit to a complete sample of the remaining unclumped BHB stars and yield (at r < 40 kpc) a fit to a halo distribution with flattening (c/a = 0.65+/-0.2) and a density falloff exponent of alpha = -3.2+/-0.3.Comment: AASTeX v5_0, 26 pages, 1 table, 20 figures, ApJ accepte

Chloroquine and inhibition of Toll-like receptor 9 protect from sepsis-induced acute kidney injury

Mortality from sepsis has remained high despite recent advances in supportive and targeted therapies. Toll-like receptors (TLRs) sense bacterial products and stimulate pathogenic innate immune responses. Mice deficient in the common adapter protein MyD88, downstream from most TLRs, have reduced mortality and acute kidney injury (AKI) from polymicrobial sepsis. However, the identity of the TLR(s) responsible for the host response to polymicrobial sepsis is unknown. Here, we show that chloroquine, an inhibitor of endocytic TLRs (TLR3, 7, 8, 9), improves sepsis-induced mortality and acute kidney injury in a clinically relevant polymicrobial sepsis mouse model, even when administered 6h after the septic insult. Chloroquine administration attenuated the decline in renal function, splenic apoptosis, serum markers of damage to other organs, and prototypical serum pro- and anti-inflammatory cytokines TNF-alpha and IL-10. An oligodeoxynucleotide inhibitor (H154) of TLR9 and TLR9-deficient mice mirror the actions of chloroquine in all functional parameters that we tested. In addition, chloroquine decreased TLR9 protein abundance in spleen, further suggesting that TLR9 signaling may be a major target for the protective actions of chloroquine. Our findings indicate that chloroquine improves survival by inhibiting multiple pathways leading to polymicrobial sepsis, and that chloroquine and TLR9 inhibitors represent viable broad-spectrum and targeted therapeutic strategies, respectively, that are promising candidates for further clinical development

SDSS Standard Star Catalog for Stripe 82: the Dawn of Industrial 1% Optical Photometry

We describe a standard star catalog constructed using multiple SDSS photometric observations (at least four per band, with a median of ten) in the $ugriz$ system. The catalog includes 1.01 million non-variable unresolved objects from the equatorial stripe 82 ($|\delta_{J2000}|<$ 1.266$^\circ$) in the RA range 20h 34m to 4h 00m, and with the corresponding $r$ band (approximately Johnson V band) magnitudes in the range 14--22. The distributions of measurements for individual sources demonstrate that the photometric pipeline correctly estimates random photometric errors, which are below 0.01 mag for stars brighter than (19.5, 20.5, 20.5, 20, 18.5) in $ugriz$, respectively (about twice as good as for individual SDSS runs). Several independent tests of the internal consistency suggest that the spatial variation of photometric zeropoints is not larger than $\sim$0.01 mag (rms). In addition to being the largest available dataset with optical photometry internally consistent at the $\sim$1% level, this catalog provides practical definition of the SDSS photometric system. Using this catalog, we show that photometric zeropoints for SDSS observing runs can be calibrated within nominal uncertainty of 2% even for data obtained through 1 mag thick clouds, and demonstrate the existence of He and H white dwarf sequences using photometric data alone. Based on the properties of this catalog, we conclude that upcoming large-scale optical surveys such as the Large Synoptic Survey Telescope will be capable of delivering robust 1% photometry for billions of sources.Comment: 63 pages, 24 figures, submitted to AJ, version with correct figures and catalog available from http://www.astro.washington.edu/ivezic/sdss/catalogs/stripe82.htm

Scalelength of disc galaxies

We have derived disk scale lengths for 30374 non-interacting disk galaxies in all five SDSS bands. Virtual Observatory methods and tools were used to define, retrieve, and analyse the images for this unprecedentedly large sample classified as disk/spiral galaxies in the LEDA catalogue. Cross correlation of the SDSS sample with the LEDA catalogue allowed us to investigate the variation of the scale lengths for different types of disk/spiral galaxies. We further investigat asymmetry, concentration, and central velocity dispersion as indicators of morphological type, and are able to assess how the scale length varies with respect to galaxy type. We note however, that the concentration and asymmetry parameters have to be used with caution when investigating type dependence of structural parameters in galaxies. Here, we present the scale length derivation method and numerous tests that we have carried out to investigate the reliability of our results. The average r-band disk scale length is 3.79 kpc, with an RMS dispersion of 2.05 kpc, and this is a typical value irrespective of passband and galaxy morphology, concentration, and asymmetry. The derived scale lengths presented here are representative for a typical galaxy mass of $10^{10.8\pm 0.54} \rm{M}_\odot$, and the RMS dispersion is larger for more massive galaxies. Distributions and typical trends of scale lengths have also been derived in all the other SDSS bands with linear relations that indicate the relation that connect scale lengths in one passband to another. Such transformations could be used to test the results of forthcoming cosmological simulations of galaxy formation and evolution of the Hubble sequence.Comment: Accepter for publication in MNRAS (15 pages, 15 figures, and 3 tables

Ensemble Properties of Comets in the Sloan Digital Sky Survey

We present the ensemble properties of 31 comets (27 resolved and 4 unresolved) observed by the Sloan Digital Sky Survey (SDSS). This sample of comets represents about 1 comet per 10 million SDSS photometric objects. Five-band (u,g,r,i,z) photometry is used to determine the comets' colors, sizes, surface brightness profiles, and rates of dust production in terms of the Af{\rho} formalism. We find that the cumulative luminosity function for the Jupiter Family Comets in our sample is well fit by a power law of the form N(< H) \propto 10(0.49\pm0.05)H for H < 18, with evidence of a much shallower fit N(< H) \propto 10(0.19\pm0.03)H for the faint (14.5 < H < 18) comets. The resolved comets show an extremely narrow distribution of colors (0.57 \pm 0.05 in g - r for example), which are statistically indistinguishable from that of the Jupiter Trojans. Further, there is no evidence of correlation between color and physical, dynamical, or observational parameters for the observed comets.Comment: 19 pages, 8 tables, 11 figures, to appear in Icaru

The Milky Way Tomography With SDSS. III. Stellar Kinematics

We study Milky Way kinematics using a sample of 18.8 million main-sequence stars with r 20 degrees). We find that in the region defined by 1 kpc < Z < 5 kpc and 3 kpc < R < 13 kpc, the rotational velocity for disk stars smoothly decreases, and all three components of the velocity dispersion increase, with distance from the Galactic plane. In contrast, the velocity ellipsoid for halo stars is aligned with a spherical coordinate system and appears to be spatially invariant within the probed volume. The velocity distribution of nearby (Z < 1 kpc) K/M stars is complex, and cannot be described by a standard Schwarzschild ellipsoid. For stars in a distance-limited subsample of stars (< 100 pc), we detect a multi-modal velocity distribution consistent with that seen by HIPPARCOS. This strong non-Gaussianity significantly affects the measurements of the velocity-ellipsoid tilt and vertex deviation when using the Schwarzschild approximation. We develop and test a simple descriptive model for the overall kinematic behavior that captures these features over most of the probed volume, and can be used to search for substructure in kinematic and metallicity space. We use this model to predict further improvements in kinematic mapping of the Galaxy expected from Gaia and the Large Synoptic Survey Telescope.NSF AST-615991, AST-0707901, AST-0551161, AST-02-38683, AST-06-07634, AST-0807444, PHY05-51164NASA NAG5-13057, NAG5-13147, NNXO-8AH83GPhysics Frontier Center/Joint Institute for Nuclear Astrophysics (JINA) PHY 08-22648U.S. National Science FoundationMarie Curie Research Training Network ELSA (European Leadership in Space Astrometry) MRTN-CT-2006-033481Fermi Research Alliance, LLC, United States Department of Energy DE-AC02-07CH11359Alfred P. Sloan FoundationParticipating InstitutionsJapanese MonbukagakushoMax Planck SocietyHigher Education Funding Council for EnglandMcDonald Observator