36 research outputs found

    Energy Informatics - Current and Future Research Directions

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    Due to the increasing importance of producing and consuming energy more sustainably, Energy Informatics (EI) has evolved into a thriving research area within the CS/IS community. The arti- cle attempts to characterize this young and dynamic field of research by de- scribing current EI research topics and methods and provides an outlook of how the field might evolve in the fu- ture. It is shown that two general re- search questions have received the most attention so far and are likely to dominate the EI research agenda in the coming years: How to leverage infor- mation and communication technol- ogy (ICT) to (1) improve energy effi- ciency, and (2) to integrate decentral- ized renewable energy sources into the power grid. Selected EI streams are reviewed, highlighting how the re- spective research questions are broken down into specific research projects and how EI researchers have made con- tributions based on their individual academic background

    The Dynamics of Plasma Membrane, Metabolism and Respiration (PM-M-R) in Penicillium ochrochloron CBS 123824 in Response to Different Nutrient Limitations-A Multi-level Approach to Study Organic Acid Excretion in Filamentous Fungi.

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    Filamentous fungi are important cell factories. In contrast, we do not understand well even basic physiological behavior in these organisms. This includes the widespread phenomenon of organic acid excretion. One strong hurdle to fully exploit the metabolic capacity of these organisms is the enormous, highly environment sensitive phenotypic plasticity. In this work we explored organic acid excretion in Penicillium ochrochloron from a new point of view by simultaneously investigating three essential metabolic levels: the plasma membrane H+-ATPase (PM); energy metabolism, in particular adenine and pyridine nucleotides (M); and respiration, in particular the alternative oxidase (R). This was done in strictly standardized chemostat culture with different nutrient limitations (glucose, ammonium, nitrate, and phosphate). These different nutrient limitations led to various quantitative phenotypes (as represented by organic acid excretion, oxygen consumption, glucose consumption, and biomass formation). Glucose-limited grown mycelia were used as the reference point (very low organic acid excretion). Both ammonium and phosphate grown mycelia showed increased organic acid excretion, although the patterns of excreted acids were different. In ammonium-limited grown mycelia amount and activity of the plasma membrane H+-ATPase was increased, nucleotide concentrations were decreased, energy charge (EC) and catabolic reduction charge (CRC) were unchanged and alternative respiration was present but not quantifiable. In phosphate-limited grown mycelia (no data on the H+-ATPase) nucleotide concentrations were still lower, EC was slightly decreased, CRC was distinctly decreased and alternative respiration was present and quantifiable. Main conclusions are: (i) the phenotypic plasticity of filamentous fungi demands adaptation of sample preparation and analytical methods at the phenotype level; (ii) each nutrient condition is unique and its metabolic situation must be considered separately; (iii) organic acid excretion is inversely related to nucleotide concentration (but not EC); (iv) excretion of organic acids is the outcome of a simultaneous adjustment of several metabolic levels to nutrient conditions

    Retrofitting Admission Control in an Internet-Scale Application

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    In this paper we propose a methodology to retrofit admission control in an Internet-scale, production application. Admission control requires less effort to improve the availability of an application, in particular when making it scalable is costly. This can occur due to the integration of 3rd-party legacy code or handling large amounts of data, and is further motivated by lean thinking, which argues for building a minimum viable product to discover customer requirements. Our main contribution consists in a method to generate an amplified workload, that is realistic enough to test all kinds of what-if scenarios, but does not require an exhaustive transition matrix. This workload generator can then be used to iteratively stress-test the application, identify the next bottleneck and add admission control. To illustrate the usefulness of the approach, we report on our experience with adding admission control within SimScale, a Software-as-a-Service start-up for engineering simulations, that already features 50,000 users
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