Anti-PrP antibodies block PrPSc replication in prion-infected cell cultures by accelerating PrPC degradation.

manuscript received October 15, 2003; revised manuscript received December 15, 2003; accepted December 16, 2003. We thanks P. Rondard, O Bischof, J.-L. Laplanche and J.-P. Pin for their fruitful discussions. we are grateful to S. barrère for her assistance in the statistical analysis of the data and H. McMahon for her assistance in reading the manuscript

Barth syndrome mutations that cause tafazzin complex lability

Complexes containing tafazzin, which remodels newly synthesized cardiolipin, are destabilized by mutations associated with Barth syndrome

Hormonal regulation of mitochondrial oxidative phosphorylation

Due to the character of the original source materials and the nature of batch digitization, quality control issues may be present in this document. Please report any quality issues you encounter to [email protected], referencing the URI of the item.Not availabl

Regulatory and kinetic properties of malate dehydrogenase from plant nuclei

Nuclei and mitochondria were isolated from hypocotyledonary hook sections of bush beans (Phaseolus vulgaris). Different methods of extraction were surveyed. The nuclei were purified by use of Triton x-100 and sucrose density gradient. Approximately less than 1% of the nuclear enzyme activity was due to mitochondrial contamination. In vitro, Triton was found to have no significant effect on the malate dehydrogenase (E.C. 1.1.1.37, MDH) activity of the nuclei or nuclear enzyme. However, the MDH activity of suspension of whole nuclei untreated with Triton was increased by Triton in vitro; this rise in activity was attributed to the lysis of contaminating mitochondria. Malate dehydrogenase and cytochrome c oxidase activity of the enzyme fractions from nuclei (n-MDH) and mitochondria (m-MDH) were assayed. Ratio of MDH: cytochrome c oxidase in nuclei and mitochondria, were significantly different (42.5 vs. 5.2). The rise in the activity of MDH following sonication of nuclei or mitochondria was 97 for n-MDK and about 5 for m-MDH. ..

Désorientale

Résumé apéritif Une salle d’attente dans un hôpital parisien. Kimiâ Sadr est seule parmi des couples. Seule pour poursuivre une procréation médicalement assistée. Seule avec sur les genoux un tube de carton rempli du « sperme décongelé et lavé » d’un certain Pierre… La gynécologue tarde. Kimiâ remonte en pensée le cours de son existence… Kimiâ Sadr est née à Téhéran en 1971. Dix ans plus tard, avec sa mère et ses sœurs ainées, elle a fui l’Iran à travers les montagnes du Kurdistan pour gagner..

Two new mountainous species of Lactuca (Cichorieae, Asteraceae) from Iran, one presenting a new, possibly myrmecochorous achene variant

It is shown that the concept of the Iranian endemic Lactuca polyclada in the sense of both its original author Boissier and its current use actually admixes two entirely different species, as was first noted by Beauverd a hundred years ago but has been neglected by later workers. One is a putative relative of L. rosularis, the other was recognised by Beauverd as a member of the genus Cicerbita. The name L. polyclada Boiss. is lectotypified here, maintaining its use as established by Beauverd for the Cicerbita species. Both species are morphologically delimited and mature achenes of Cicerbita polyclada are illustrated for the first time. The putative relative of Lactuca rosularis, a rare local endemic of the summit area of Kuh e-Dena, which has remained without a valid name by now, is described as a new species, Lactuca denaensis N. Kilian & Djavadi, and illustrated. A third member of the Lactuca rosularis group, L. hazaranensis Djavadi & N. Kilian, discovered among a recent collection and apparently being a rare chasmophyte of the Hazaran mountain massif in the province of Kerman, Iran, is described as a species new to science, illustrated and delimited from the other two species. This new species has peculiar achenes representing a hitherto unknown variant: the body of the beaked achenes is divided into two segments by a transversal constriction in the distal third. The proximal segment contains the embryo, the distal segment is solid with a lipid-containing yellow tissue. The easily detachable pappus and the equally easily detachable beak potentially obstruct dispersal by wind. Since detachment of the beak also exposes the lipid-containing tissue of the distal segment, its potential as an elaiosome and myrmecochory as a possible mode of dispersal are discussed

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STRASBOURG-Medecine (674822101) / SudocPARIS-BIUM (751062103) / SudocSudocFranceF