Creep motion of a granular pile induced by thermal cycling

We report a time-resolved study of the dynamics associated with the slow compaction of a granular column submitted to thermal cycles. The column height displays a complex behavior: for a large amplitude of the temperature cycles, the granular column settles continuously, experiencing a small settling at each cycle; By contrast, for small-enough amplitude, the column exhibits a discontinuous and intermittent activity: successive collapses are separated by quiescent periods whose duration is exponentially distributed. We then discuss potential mechanisms which would account for both the compaction and the transition at finite amplitude.Comment: 4 pages, 5 figures, accepted for publication in Physical Review Letters (05sep08

Dynamics of soap bubble bursting and its implications to volcano acoustics

In order to assess the physical mechanisms at stake when giant gas bubbles burst at the top of a magma conduit, laboratory experiments have been performed. An overpressurized gas cavity is initially closed by a thin liquid film, which suddenly bursts. The acoustic signal produced by the bursting is investigated. The key result is that the amplitude and energy of the acoustic signal strongly depend on the film rupture time. As the rupture time is uncontrolled in the experiments and in the field, the measurement of the acoustic excess pressure in the atmosphere, alone, cannot provide any information on the overpressure inside the bubble before explosion. This could explain the low energy partitioning between infrasound, seismic and explosive dynamics often observed on volcanoes

Creep in reactive colloidal gels: A nanomechanical study of cement hydrates

From soft polymeric gels to hardened cement paste, amorphous solids under constant load exhibit a pronounced time-dependent deformation called creep. The microscopic mechanism of such a phenomenon is poorly understood in amorphous materials and constitutes an even greater challenge in densely packed and chemically reactive granular systems. Both features are prominently present in hydrating cement pastes composed of calcium silicate hydrate (C-S-H) nanoparticles, whose packing density increases as a function of time, while cement hydration is taking place. Performing nanoindentation tests and porosity measurements on a large collection of samples at various stages of hydration, we show that the creep response of hydrating cement paste is mainly controlled by the interparticle distance and results from slippage between (C-S-H) nanoparticles. Our findings provide a unique insight into the microscopic mechanism underpinning the creep response in aging granular materials, thus paving the way for the design of concrete with improved creep resistance

Transverse intrafascicular multichannel electrode (TIME) system for treatment of phantom limb pain in amputees

International audienceAIM: Phantom limb pain (PLP) develops in the lost limb in 50-80% of amputees. Today, it is not completely understood why the pain occurs, and no effective treatments are available. The favorable effect of electrical stimulation on PLP has been demonstrated. Our aim is to develop a novel system for manipulation of sensations by application of multi-channel microstimulation to the nerve stump of an amputee and explore this method as a treatment for clinched fist PLP (see figure). RESULTS: 1) Electrode design. Non-corrugated TIME electrodes with different dimensions and 8-12 active sites have been manufactued and tested in vivo and in vitro testing in the rat and pig. Methods for corrugated prototypes were developed and the first prototypes were realized. 2) Electrode selectivity modeling. A peripheral nerve model is under development to evaluate the electrode's selective stimulation properties and to optimize electrode design. Simulated currents and neural activity generated were qualitatively assessed using experimental data obtained from rat nerves. 3) Implant modeling. To optimize the implantation procedure, a theoretical peripheral nervous tissue model and a 3D FEM was implemented. Both models closely reproduce the experimental peripheral nervous tissue behaviour and simulate the insertion forces transmitted to the electrode during implantation. 4) Multi-channel stimulators and connectors. A 12-pole prototype, bench-top stimulator has been implemented and successfully tested in animal experiments. A high-count, implantable connector between stimulator and electrode has been designed. 5) Biocompatibility. Electrode materials were evaluated and did not induce immune rejection and significant inflammatory reaction after in vivo implantation in the rat. Electrode implantation will require an understanding of the fascicular characteristics of the target nerve. Morphological characteristics of the rat, pig and human nerves are currently evaluated and compared. 6) Animal testing. First TIME electrodes test were carried out in the acute rat and acute pig. Results indicated selective stimulation of different fascicles with graded recruitment. 7) Clinical evaluation: To quantify the location of artificially evoked sensations and evaluate the strength of artificially evoked sensations a psychophysical testing platform is under development. Main inclusion criteria for patient recruitment have been identified and protocols have been defined. CONCLUSION: The feasibility of the corrugated version of the TIME electrode has yet to be explored. Further work designing, optimizing and testing the TIME electrode and all technological developments will be carried out including theoretical stimulations and animal experimental work before the optimal electrode for human implant will be chosen

Time-Resolved Mechanical Spectroscopy of Soft Materials via Optimally Windowed Chirps

The ability to measure the bulk dynamic behavior of soft materials with combined time and frequency resolution is instrumental for improving our fundamental understanding of connections between the microstructural dynamics and the macroscopic mechanical response. Current state-of-the-art techniques are often limited by a compromise between resolution in the time and frequency domains, mainly due to the use of elementary input signals that have not been designed for fast time-evolving systems such as materials undergoing gelation, curing, or self-healing. In this work, we develop an optimized and robust excitation signal for time-resolved mechanical spectroscopy through the introduction of joint frequency- and amplitude-modulated exponential chirps. Inspired by the biosonar signals of bats and dolphins, we optimize the signal profile to maximize the signal-to-noise ratio while minimizing spectral leakage with a carefully designed modulation of the envelope of the chirp, obtained using a cosine-tapered window function. A combined experimental and numerical investigation reveals that there exists an optimal range of window profiles (around 10% of the total signal length) that minimizes the error with respect to standard single-frequency sweep techniques. The minimum error is set by the noise floor of the instrument, suggesting that the accuracy of an optimally windowed-chirp (OWCh) sequence is directly comparable to that achievable with a standard frequency sweep, while the acquisition time can be reduced by up to 2 orders of magnitude, for comparable spectral content. Finally, we demonstrate the ability of this optimized signal to provide time- and frequency-resolved rheometric data by studying the fast gelation process of an acid-induced protein gel using repeated OWCh pulse sequences. The use of optimally windowed chirps enables a robust time-resolved rheological characterization of a wide range of soft materials undergoing rapid mutation and has the potential to become an invaluable rheometric tool for researchers across different disciplines

Bringing sensation to prosthetic hands—chronic assessment of implanted thin-film electrodes in humans

Direct stimulation of peripheral nerves with implantable electrodes successfully provided sensory feedback to amputees while using hand prostheses. Longevity of the electrodes is key to success, which we have improved for the polyimide-based transverse intrafascicular multichannel electrode (TIME). The TIMEs were implanted in the median and ulnar nerves of three trans-radial amputees for up to six months. We present a comprehensive assessment of the electrical properties of the thin-film metallization as well as material status post explantationem. The TIMEs stayed within the electrochemical safe limits while enabling consistent and precise amplitude modulation. This lead to a reliable performance in terms of eliciting sensation. No signs of corrosion or morphological change to the thin-film metallization of the probes was observed by means of electrochemical and optical analysis. The presented longevity demonstrates that thin-film electrodes are applicable in permanent implant systems

Effects of mesenchymal stem cell therapy, in association with pharmacologically active microcarriers releasing VEGF, in an ischaemic stroke model in the rat

Few effective therapeutic interventions are available to limit brain damage and functional deficits after ischaemic stroke. Within this context, mesenchymal stem cell (MSC) therapy carries minimal risks while remaining efficacious through the secretion of trophic, protective, neurogenic and angiogenic factors. The limited survival rate of MSCs restricts their beneficial effects. The usefulness of a three-dimensional support, such as a pharmacologically active microcarrier (PAM), on the survival of MSCs during hypoxia has been shown in vitro, especially when the PAMs were loaded with vascular endothelial growth factor (VEGF). In the present study, the effect of MSCs attached to laminin-PAMs (LM-PAMs), releasing VEGF or not, was evaluated in vivo in a model of transient stroke. The parameters assessed were infarct volume, functional recovery and endogenous cellular reactions. LM-PAMs induced the expression of neuronal markers by MSCs both in vitro and in vivo. Moreover, the prolonged release of VEGF increased angiogenesis around the site of implantation of the LM-PAMs and facilitated the migration of immature neurons towards the ischaemic tissue. Nonetheless, MSCs/LM-PAMs-VEGF failed to improve sensorimotor functions. The use of LM-PAMs to convey MSCs and to deliver growth factors could be an effective strategy to repair the brain damage caused by a stroke