Antidiabetic and antimicrobial activities of fractions and compounds isolated from Berberis brevissima Jafri and Berberis parkeriana Schneid

Methanol extracts of the roots of B. brevissima and B. parkeriana were examined for antidiabetic and antimicrobial activities. Six compounds i.e berberine, 8-oxo-berberine, dehydrocheilanthifoline, columbamine, jatrorrhizine and glutamic acid were isolated from the active fractions of these species for the first time. The antidiabetic activity was determined against Protein Tyrosine Phosphatase 1B (PTP 1B), a negative insulin regulator while the antimicrobial activity was performed against four bacterial strains: Mycobacterium marinum ATCC BAA535, sporadic Methicillin Resistant Staphylococcus aureus (SMRSA), endemic Methicillin Resistant Staphylococcus aureus (EMRSA) and Escherichia coli ATCC.8739 at different concentrations. Amongst the isolated compounds 8-oxo-berberine was found to be the most active antidiabetic (29 % of the positive control) while jatrorrhizine was the most active and selective antimicrobial against SMRSA and EMRSA (-1.2 % of the DMSO (D) control)

Genetic Evaluation and Selection Response of Birth Weight and Weaning Weight in Male Saburai Goats

ABSTRACT. Penelitian ini bertujuan untuk mengestimasi parameter genetik (heritabilitas, korelasi genetik) dan nilai pemuliaan serta menggunakan parameter-parameter tersebut untuk mengestimasi respon seleksi dan respon seleksi sifat berkorelasi untuk bobot lahir dan bobot sapih kambing Saburai jantan. Data bobot lahir dan bobot sapih 90 cempe jantan kambing Saburai (data dari tahun 2017-2018) yang dihasilkan dari sembilan ekor pejantan dan 45 ekor induk digunakan dalam penelitian ini. Heritabilitas, korelasi genetik dan fenotipik diestimasi menggunakan data saudara tiri sebapak. Hasil penelitian menunjukkan bahwa nilai heritabilitas estimasi untuk bobot lahir dan bobot sapih adalah termasuk kategori sedang (masing-masing 0,30±0,08 dan 0,22±0,07). Korelasi genetik antara bobot lahir dan bobot sapih dikategorikan sebagai positif tinggi (0,42±0,06), sedangkan korelasi fenotip antara kedua sifat ini adalah 0,10 (rendah) dan korelasi lingkungan 0,56 (tinggi). Respon seleksi meningkat dengan meningkatnya intensitas seleksi, berkisar antara 0,11 kg sampai 0,28 kg untuk bobot lahir dan antara 0,60 kg sampai 1,54 kg untuk bobot sapih, pada proporsi seleksi antara 50% sampai 5%. Respon seleksi sifat-sifat berkorelasi yang diharapkan terhadap seleksi bobot lahir secara langsung berdampak pada bobot sapih berkisar antara 0,29 kg hingga 0,75 kg pada proporsi seleksi 50% sampai 5%. Heritabilitas sedang dan korelasi genetik yang positif antara bobot lahir dan bobot sapih menunjukkan bahwa seleksi untuk salah satu dari dua sifat ini bisa berhasil dan peningkatan bobot lahir akan meningkatkan bobot sapih kambing Saburai jantan juga. Seleksi tidak langsung yaitu seleksi bobot lahir akan berdampak pada respon seleksi bobot sapih yang lebih rendah dibandingkan dengan seleksi langsung terhadap bobot sapih.  (Evaluasi genetik dan respon seleksi bobot lahir dan bobot sapih pada kambing Saburai jantan) ABSTRAK. This research aimed to estimate genetic parameters (heritability, genetic correlation) and breeding value and used these parameters to estimate selection responses and correlated response to selection of birth and weaning weight of male Saburai goats. Data of birth and weaning weight of ninety male Saburai kids (2017-2018) generated from nine bucks and 45 does were used in this study. Heritability, genetic and phenotypic correlation were estimated using paternal half-sib data. The results showed that heritability estimates for birth and weaning weight were moderate category (0.30±0.08 and 0.22±0.07, respectively). Genetic correlation between birth and weaning weight was categorized as a high positive value (0.42±0.06), while phenotype correlations between the two traits were 0.10 (low), and environmental correlations were 0.56 (high). Responses to selection increased with increasing selection intensity ranging from 0.11 kg to 0.28 kg and 0.60 kg to 1.54 kg for birth and weaning weight, respectively, at 50% to 5% selection proportion. The response of the selection of correlated traits expected to direct birth weight selection impacted on weaning weight ranged from 0.29 kg to 0.75 kg at a selection proportion of 50% to 5%. The moderate heritability and positive genetic correlation between birth and weaning weight suggested that selection for any of these two traits should be successful and improving birth weight will improve the weaning weight of male Saburai goats as well. However, indirect selection (birth weight selection) will impact on the lower response for weaning weight compared to direct selection for weaning weight

Penentuan Sistem Pemuliabiakan dalam Populasi Kambing Saburai untuk Meningkatkan Kinerja Pertumbuhannya

  The research was conducted with a record of the growth performance of Saburai goats from 2013 to 2015 in the Saburai goat seed source area, Sumberejo District, Tanggamus Regency, Lampung Province. The research objective was to determine the appropriate breeding system to improve the growth performance of the offspring. This goal is achieved through heritability (h2) and repeatability (r) of growth performance (weight and body size at birth, weaning, and age one year). The h2 value was estimated using the step-by-step retreat method, the repeatability (r) was estimated using the permission class method. The results showed that the h2 and r values ​​of growth performance at birth, weaning, and age of one year were medium-class respectively. The h2 value at birth (body weight (BW) 0.10, height (TB) 0.11, body length (PB) 0.13, chest circumference (LD) 0.12, hip height (TP) 0.14) ) and the values ​​at birth (BW 0.12, TB 0.16, PB 0.14, LD 0.14, TP 0.16) are the lowest. The h2 value at weaning age (BW 0.16, TB 0.15, PB 0.16, LD 0.17, TP 0.17) and the r-value at weaning age (BW 0.16, TB 0.15, PB 0 , 16, LD 0.17, TP 0.17) were higher at birth. The value of h2 for one year of age (BW 0.18, TB 0.17, PB 0.16, LD 0.18, TP 0.19) and one year age value (BW 0.21, TB 0.22, PB 0, 22, LD 0.21, TP 0.21) the highest. It is provided that individual selection on the growth performance of weaning age and one year of age is an appropriate breeding system to improve the growth performance of Saburai goats. &nbsp

PERBANDINGAN BERAT LAHIR, PERSENTASE JENIS KELAMIN ANAK DAN SIFAT PROLIFIK INDUK KAMBING PERANAKAN ETAWAH PADA PARITAS PERTAMA DAN KEDUA DI KOTA METRO

The aim of research was to compare birth weight, sex of kids, prolificacy of does between the first and second parity of Ettawa grade goat at Metro City to select replacement stock that was prolific and high at birth weight. Survey method was used in this research to observe birth weight of male and female kid, percentage of male and female kid, percentage of does foals single kid and twin, litter size between the first and second parity. Survey was conducted by observation recording of 80 heads of doe. Result of this research indicated that birth weight of male kid of the first parity (2,60 ± 0,26 kg) and the second parity (2,67 ± 0,18 kg) were higher (P<0,05) than that of female kid of the first parity (2,43± 0,21 kg) and the second parity (2,48 ± 0,15 kg), 46 % kids of the first parity and 42 % kids of the second parity were male, 54 % kids of the first parity and 58 % kids of the second parity were  female, 45 % does of the first parity and 40 % does of the second parity foal twin kids, 55 % does of the first parity and 60 % does of the second parity foal single kid, litter size of of the second parity (1,56±0,50 heads) was higher (P<0.05) than that of the first parity (1,41±0,50 heads) It could be concluded that prolificacy of does of the first and second parity were not good and kids born at the second parity and high at birth weight could be choosen as replacement stock. Key words : Birth weight, Percentage of sex, Prolific, First and Second Parity, Ettawa grade goat, Metro City

Estimation of Repeatability Value of Weaning Weight and Most Probable Producing Ability (MPPA) of Saburai Doe in Tanggamus Regency

The aim of this study was to estimate the value of repeatability of weaning weight and Most Probable Producing Ability (MPPA) value of Saburai Doe in village breeding center (VBC), located in Tanggamus Regency. This research was conducted in Sumberejo and Gisting districts in January to May 2018.  Data collected in this study included the recording data of kids’ birth, birth weight, weaning age, weaning weight, offspring sex from 122 doe who have given birth twice from 2015 to 2017.  The study was carried out by using survey method to know weaning weight, estimated repeatability values, and MPPA values of Saburai doe in Sumberejo and Gisting district. Results of this research shows that the average corrected weaning weight of Saburai Doe in Sumberejo and Gisting district were 16.59±3.45 and 16.93±2.90, with the repeatability value were 0.76 and 0.59 (high category), respectively. The result also shows that the average value of MPPA of Saburai Doe were 16.59±2.98 and 16.93±2.15, respectively. There were 10 doe with the highest MPPA value consisting of 5 does from Sumberejo district K2 22.07, Y3 21.95, Y4 21.80, K1 21.39, AD3 21.38 and 5 does from Gisting District D3 22.03, B1 21.09, D4 20.98, A1 20.83, D5 20.74. It is suggested to select Saburai Doe with the best MPPA to improve productivity of Saburai Doe for the next generation

Estimasi Korelasi Genetik antara Bobot Lahir dengan Bobot Sapih pada Kambing Saburai di Sentra Pembibitan Kabupaten Tanggamus Provinsi Lampung

ABSTRAKPenelitian ini bertujuan untuk mengetahui estimasi nilai korelasi genetik antara berat lahir dan berat sapih pada kambing saburai di Kabupaten Tanggamus. Penelitian dilakukan pada bulan Juli-Agustus 2018, berlokasi di Sentra pembibitan kambing saburai di Kabupaten Tanggamus. Materi penelitian ini sebanyak data 136 indukan dan data 150 anakan kambing saburai. Metode penelitian yaitu survei menggunakan data recording dan kuesioner. Variabel yang diamati adalah berat lahir dan berat sapih induk, berat lahir dan berat sapih cempe, umur sapih, umur induk saat melahirkan, tipe kelahiran cempe, dan jenis kelamin cempe. Hasil penelitian  menunjukkan bahwa berat lahir dan berat sapih induk masing-masing adalah 3,10±0,47 dan 12,15± 2,29; berat lahir dan berat sapih cempe masing-masing adalah 3,25±0,48 dan 12,60± 2,77. Korelasi genetik berat lahir dan berat sapih di Sentra Pembibitan Kabupaten Tanggamus adalah  0,37. Kesimpulan dari penelitian ini adalah seleksi peningkatan bobot lahir akan meningkatkan bobot sapih kambing saburai.Kata kunci: bobot lahir, bobot sapih, kambing saburai, korelasi genetikABSTRACTThis study aims to determine the estimation of genetic correlation values of birth weights and weaning weights in Saburai goats in Tanggamus regency. The study was conducted in July-August 2018, located in the breeding area, Tanggamus Regency. The materials of research were data from 136 doe and 150 kids. The research was conducted by survey method using the recording data and questionnaire. The variables observed were birth weight and weaning weight of doe, birth weight and weaning weight of the kid, weaning age, doe’s age at parturition, birth type of kid, and sex of kid. The results of this study indicate that the average birth weight of doe was 3.10±0.47, the weaning weight of doe was 12.15±2.29, the birth weight of kid was 3.25±0.48, and weaning weight of kid was 12.60±2.77. It can be concluded that the estimation of genetic correlation between birth weight and weaning weight of saburai goat was high with score of 0.37. Selection on birth weight can increase weaning weight in saburai goat. Keywords: birth weight, weaning weight, saburai goat, genetic correlatio

SELEKSI INDUK KAMBING SABURAI BERDASARKAN NILAI MOST PROBABLE PRODUCING ABILITY BOBOT LAHIR DAN BOBOT SAPIH

Estimasi nilai Most Probable Producing Ability (MPPA) induk kambing Saburai berdasarkan kinerja keturunannya sangat penting dalam pemilihan induk kambing. Penelitian ini dilakukan untuk memilih kinerja induk kambing Saburai terbaik berdasarkan nilai MPPA menggunakan kinerja berat lahir (BL) dan berat sapih (BS) anak kambing di Unit Pelaksana Teknis Daerah (UPTD) Pusat Pembibitan Kambing, Kecamatan Gedongtataan, Kabupaten Pesawaran, Provinsi Lampung. Penelitian ini menggunakan metode survei yang dilakukan pada April-Juni 2019. Dua puluh lima induk kambing Saburai menghasilkan 34 anak pada paritas pertama dan 33 anak pada paritas kedua digunakan dalam penelitian ini. Data BL dan BS disesuaikan terhadap jenis kelamin jantan, tipe jenis kelahiran tunggal, dan umur induk. Nilai ripitabilitas diestimasi menggunakan metode korelasi antar kelas dan digunakan untuk menghitung nilai MPPA. Hasil penelitian menunjukkan bahwa rata-rata BL anak kambing pada paritas pertama dan kedua, masing-masing adalah 3,09 ± 0,42 kg dan 3,28 ± 0,54 kg, sedangkan rata-rata BS pada paritas pertama dan kedua, masing-masing adalah 17,20 ± 1,69 kg dan 17,36 ± 2,24 kg. Nilai ripitabilitas yang didapat untuk BL dan BS, masing-masing adalah 0,49±0,08 dan 0,55 ±0,06. Rata-rata nilai MPPA untuk BL dan BS, masing-masing adalah 3,19 ± 0,27 kg dan 17,28 ± 1,23 kg. Enam induk kambing Saburai (B2, B1, C1, A3, D3, dan C8) memiliki nilai MPPA BL dan BS lebih tinggi dari rata-rata nilai MPPA populasi. Keenam induk ini sebaiknya dipertahankan dalam populasi untuk meningkatkan mutu genetik kambing Saburai. Kata kunci: Berat lahir, Berat sapih, Induk Kambing Saburai, Nilai MPPA, Ripitabilitas

STATUS SOSIAL EKONOMI PETERNAK KAMBING PERANAKAN ETAWA (PE) DI DESA SUNGAI LANGKA, KECAMATAN GEDONG TATAAN, KABUPATEN PESAWARAN PROVINSI LAMPUNG

The aim of this research was to know social economic status of farmer groups Ettawa crossbred goat during the production and cost value of the milk. The research was held  on July – August 2016 in Ettawa farmer groups in Sungai Langka Village, Gedong Tataan District, Pesawaran Regency, Lampung Province. Material of this research were 40 samples from three farmer groups : Tunas Muda, Sehati jaya  and Margarini 6. The method of this research was a survey with purposive random sampling. Data were analyzed by descriptive analysis. The result showed each farmer groups had different social economic status during production and cost value of the milk. Keywords : Ettawa Crossbred Goat , Social Economic Status, Sungai Langka Village

Effects of antiplatelet therapy on stroke risk by brain imaging features of intracerebral haemorrhage and cerebral small vessel diseases: subgroup analyses of the RESTART randomised, open-label trial

Background Findings from the RESTART trial suggest that starting antiplatelet therapy might reduce the risk of recurrent symptomatic intracerebral haemorrhage compared with avoiding antiplatelet therapy. Brain imaging features of intracerebral haemorrhage and cerebral small vessel diseases (such as cerebral microbleeds) are associated with greater risks of recurrent intracerebral haemorrhage. We did subgroup analyses of the RESTART trial to explore whether these brain imaging features modify the effects of antiplatelet therapy

PROFESIONALISME GURU PENDIDIKAN AGAMA ISLAM DALAM PEMBELAJARAN SISWA DI SEKOLAH DASAR NEGERI 124/VIII DESA SIDOREJO KABUPATEN TEBO

Skripsi ini dilatar belakangi oleh daya upaya guru dalam pembelajaran, pengamatan secara kritis dalam perencanaan,pelaksanaan,penilaian aspek keprofesional guru saat pembelajaran . Tujuan penelitian ini adalah guna untuk menyempurnakan kegiatan belajar mengajar dalam belajar di Sekolah Dasar 124/VIII Rimbo Ilir. Penelitian ini merupakan Penelitian Kualitatif deskriptif dengan desain penelitian bersifat emergent, evolving, dan developing karena penelitian dijelaskan melalui gambaran, umum yang bersifat sementara, apa yang akan dapat diteliti dan bersifat fleksibel serta masih mengalami perubahan. Adapun metode pengumpulan data menggunakan metode observasi, wawancara dan dokumentasi. Teknik analisis data menggunakan reduksi data, penyajian data, verifikasi atau penarikan kesimpulan. Hasil penelitian dan pembahasan menunjukkan bahwa penerapan aspek kompetensi professional guru pendidikan agama islam dalam pembelajar di kelas VI di Sekolah Dasar 124/VIII Rimbo Ilir menunjukkan secara khusus sudah di laksanakan secara efektif. Guru menguasai materi, struktur konsep, dan pola pikir keilmuan yang mendukung mata pelajaran yang di miliki, mengembangkan materi pembelajaran yang dimiliki secara kreatif, mengembangkan keprofesional secara berkelanjutan dengan tindakan reflektif, memahami dan melaksanakan pengembangan peserta didik. Memahami dan menyelenggarakan administrasi sekolah, memanfaatkan teknologi informasi dan komunikasi untuk mengembangkan diri. Faktor penghambat kompetensi professional guru antara lain faktor individu, faktor oraganisasi dan faktor psikologi. Penerapan aspek kompetensi professional berdampak pada hasil kinerja guru Pendidikan Agama Islam kelas VI dan kualitas hasil belajar siswa dari segi kognitif, efektik, dan psikomotorik. Dari hasil ini di ketahuin penerapan aspek kompetensi profesionalisme guru dalam pembelajaran di terapkan secara efektif