Nuevo régimen de protección legal a las personas con discapacidad mental: antecedentes, análisis y trámite legislativo –Ley 1306 de 2009–

Esta publicación tiene por objeto hacer una presentación académica y jurídica del contenido de la citada norma; teniendo en cuenta su importancia para el ordenamiento jurídico colombiano, pues se trata de la reforma a una parte significativa del Código Civil en cuanto al carácter de los asuntos que aborda. Adicionalmente, se hace un análisis del contenido y se brindan las herramientas necesarias para la enseñanza, por parte de los docentes dedicados a ello en los programas de derecho, así como para el entendimiento de sus alcances por parte de los estudiantes

Enhanced removal of a pesticides mixture by single cultures and consortia of free and immobilized Streptomyces strains

Pesticides are normally used to control specific pests and to increase the productivity in crops; as a result, soils are contaminated with mixtures of pesticides. In this work, the ability of Streptomyces strains (either as pure or mixed cultures) to remove pentachlorophenol and chlorpyrifos was studied. The antagonism among the strains and their tolerance to the toxic mixture was evaluated. Results revealed that the strains did not have any antagonistic effects and showed tolerance against the pesticides mixture. In fact, the growth of mixed cultures was significantly higher than in pure cultures. Moreover, a pure culture (Streptomyces sp. A5) and a quadruple culture had the highest pentachlorophenol removal percentages (10.6% and 10.1%, resp.),while Streptomyces sp.M7 presented the best chlorpyrifos removal (99.2%).Mixed culture of all Streptomyces spp. when assayed either as free or immobilized cells showed chlorpyrifos removal percentages of 40.17% and 71.05%, respectively, and for pentachlorophenol 5.24% and 14.72%, respectively, suggesting better removal of both pesticides by using immobilized cells. These results reveal that environments contaminated with mixtures of xenobiotics could be successfully cleaned up by using either free or immobilized cultures of Streptomyces, through in situ or ex situ remediation techniques.Fil: Fuentes, María Soledad. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán. Planta Piloto de Procesos Industriales Microbiológicos; ArgentinaFil: Briceño, Gabriela E.. Universidad de la Frontera; Chile;Fil: Sáez, Juliana María. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán. Planta Piloto de Procesos Industriales Microbiológicos; ArgentinaFil: Benimeli, Claudia Susana. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico - CONICET - Tucumán. Unidad de Administración Territorial; Argentina. Universidad del Norte Santo Tomás de Aquino; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán. Planta Piloto de Procesos Industriales Microbiológicos; ArgentinaFil: Diez, Maria Cecilia. Universidad de la Frontera; Chile;Fil: Amoroso, Maria Julia del R.. Universidad Nacional de Tucumán. Facultad de Bioquímica, Química y Farmacia; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán. Planta Piloto de Procesos Industriales Microbiológicos; Argentina. Universidad del Norte Santo Tomás de Aquino; Argentin

Mudanças e continuidades nas práticas pedagógicas com tic, Neuquén, Argentina

Este artículo presenta los resultados de un estudio que abordó como problema el proceso de inclusión de las Tecnologías de la Información y Comunicación (tic) en las escuelas de nivel medio, con el modelo de una computadora portátil por alumno y por docente, centrado en las prácticas de enseñanza que los profesores generaron en los inicios del Programa Conectar Igualdad en la Argentina. Estas prácticas se analizaron en el ámbito de la cotidianeidad que les da significado, abarcando siete escuelas de la provincia de Neuquén y sus experiencias durante el año 2012. Se interpretan los cambios en tensión con las permanencias que marcan estilos de trabajo docente con enfoques que hasta ese momento no contemplaban estas tecnologías. Se abordó la investigación desde la metodología cualitativa, relevando información a través de entrevistas a docentes, directores y referentes tic.This article presents the results of a study about the inclusion process of information and communication technologies (tic in spanish) in middle school. The study centers on the argentinian program «Conectar Igualdad», which provides a portable computer for every student and every teacher, and on the teaching techniques developed by teachers at the beginning of the program. Teaching practices were analyzed in day-to-day life of classrooms during 2012 at seven schools within the province of Neuquen. Changes in tension with continuities of teachers working styles are interpreted with theoretical and methodological approaches that did not contemplate these technologies until now. The study follows a qualitative methodology, getting information by intervieweing teachers, headteachers, and referents in tics.Este artigo apresenta os resultados de um estudo que abordou como problema o processo de inclusão das Tecnologias da Informação e da Comunicação (tic) em escolas de ensino médio, com o modelo de um computador portátil por aluno e por docente, centrado nas práticas educacionais que os professores geraram no início do Programa «Conectar Igualdad» na Argentina. Essas práticas foram analisadas no contexto do cotidiano que lhes dá sentido, abrangendo sete escolas da província de Neuquén e suas experiências durante o ano de 2012. São interpretadas as mudanças em tensão com as continuidades que marcam estilos de trabalho docente com abordagens que até então não contemplavam essas tecnologias. a pesquisa foi abordada a partir da metodologia qualitativa, colhendo informação através de entrevistas a docentes, diretores e especialistas em tic.Fil: Aguiar, Diego Sebastian. Universidad Nacional de Río Negro. Sede Andina. Centro de Estudios en Ciencia, Tecnología, Cultura y Desarrollo; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Patagonia Norte; ArgentinaFil: Capuano, Ana Maria. Universidad Nacional de Río Negro; ArgentinaFil: Diez, Angelica María. Universidad Nacional de Río Negro; ArgentinaFil: Fourés, Cecilia. Universidad Nacional de Río Negro; ArgentinaFil: Silin, Irene. Universidad Nacional de Río Negro; Argentin

Mudanças e continuidades nas práticas pedagógicas com TIC, Neuquén, Argentina

This article presents the results of a study about the inclusion process of information and communication technologies (TIC in spanish) in middle school. The study centers on the argentinian program “Conectar Igualdad”, which provides a portable computer for every  student and every teacher, and on the teaching techniques developed by teachers at the beginning of the program. Teaching practices were analyzed in day-to-day life of classrooms during 2012 at seven schools within the province of Neuquen. Changes in tension with continuities of teachers working styles are interpreted with theoretical and methodological approaches that did not contemplate these technologies until now. The study follows a qualitative methodology, getting information by intervieweing teachers, headteachers, and referents in TICs.Este artículo presenta los resultados de un estudio que abordó como problema el proceso de inclusión de las Tecnologías de la Información y Comunicación (TIC) en las escuelas de nivel medio con el modelo de una computadora portátil por alumno y por docente, centrado en las prácticas de enseñanza que los profesores generaron en los inicios del Programa Conectar Igualdad en la Argentina. Estas prácticas se analizaron en el ámbito de la cotidianeidad que les da significado, abarcando siete escuelas de la provincia de Neuquén y sus experiencias durante el año 2012. Se interpretan los cambios en tensión con las permanencias que marcan estilos de trabajo docentes con enfoques que hasta ese momento no contemplaban estas tecnologías. Se abordó la investigación desde la metodología cualitativa, relevando información a través de entrevistas a docentes, directores y referentes TIC.  Este artigo apresenta os resultados de um estudo que abordou como problema o processo de inclusão das Tecnologias da Informação e da Comunicação (TIC) em escolas de ensino médio, com o modelo de um computador portátil por aluno e por docente, centrado nas práticas educacionais que os professores geraram no início do Programa “Conectar Igualdad” na Argentina. Essas práticas foram analisadas no contexto do cotidiano que lhes dá sentido, abrangendo sete escolas da província de Neuquén e suas experiências durante o ano de 2012. São interpretadas as mudanças em tensão com as continuidades que marcam estilos de trabalho docente com abordagens que até então não contemplavam essas tecnologias. a pesquisa foi abordada a partir da metodologia qualitativa, colhendo informação através de entrevistas a docentes, diretores e especialistas em TIC

Linking the impact of bacteria on phytoplankton growth with microbial community composition and co-occurrence patterns

The interactions between microalgae and bacteria have recently emerged as key control factors which might contribute to a better understanding on how phytoplankton communities assemble and respond to environmental disturbances. We analyzed partial 16S rRNA and 18S rRNA genes from a total of 42 antibiotic bioassays, where phytoplankton growth was assessed in the presence or absence of an active bacterial community. A significant negative impact of bacteria was observed in 18 bioassays, a significant positive impact was detected in 5 of the cases, and a non-detectable effect occurred in 19 bioassays. Thalasiossira spp., Chlorophytes, Vibrionaceae and Alteromonadales were relatively more abundant in the samples where a positive effect of bacteria was observed compared to those where a negative impact was observed. Phytoplankton diversity was lower when bacteria negatively affect their growth than when the effect was beneficial. The phytoplankton-bacteria co-occurrence subnetwork included many significant Chlorophyta-Alteromonadales and Bacillariophyceae-Alteromonadales positive associations. Phytoplankton-bacteria co-exclusions were not detected in the network, which contrasts with the negative effect of bacteria on phytoplankton growth frequently detected in the bioassays, suggesting strong competitive interactions. Overall, this study adds strong evidence supporting the key role of phytoplanktonbacteria interactions in the microbial communities.Agencia Estatal de Investigación | Ref. CTM2017-83362-RAgencia Estatal de Investigación | Ref. PID2019-110011RB-C33Xunta de Galicia | Ref. ED481A-2019/290Xunta de Galicia | Ref. ED481A-2018/288Universidade de Vigo/CISU

Different alterations of glomerular filtration rate and their association with uric acid in children and adolescents with type 1 diabetes or with overweight/obesity

GFR alterations were different between youths with T1D and with OW/OB. Higher uric acid, older age, and puberty were related to lower GFR values in OW/OB children. Longitudinal studies will determine if low GFR is consequence of a rapid GFR decline in pediatric patients with OW/OB. Keywords: children; diabetes; hyperfiltration; obesity; renal disease; uric acid

Servicio de venta de ensaladas frescas

Debido a la coyuntura por la pandemia los hábitos y estilo de vida de las personas dio un giro abrupto, ya que tuvieron que adoptar una nueva cultura saludable que tiene como principal característica la inocuidad de los alimentos que se consumen, lo cual motivó a desarrollar este plan de negocios, ya que ofrece comodidad, facilidad, simplicidad y ahorro de tiempo al momento de comprar ensaladas. La estrategia de trabajo que se aplicará es la estrategia de diferenciación en el servicio de ventas de ensaladas verduras. Por otro lado, los resultados determinaron que la cantidad de hogares en los 5 distritos con nivel socioeconómico alto y medio alto de Lima moderna tienen como promedios de gastos mensuales en alimentos en el NSE A de S/. 1,846 y NSE B de S/ 1,473. Además, están interesados a consumir las ensaladas ofrecidas por la empresa VERBOLD tendría la oportunidad de satisfacer 2,493 hogares. Finalmente, cabe destacar los resultados de los análisis financieros ofrece una visión tentadora, con respecto al estado de ganancias y pérdidas, cabe decir que el balance es positivo y mantiene un crecimiento promedio de 2.5% en los cinco años proyectados. Con relación a la tasa interna de retorno de la inversión, esta asciende a 43.45%; y, en cuanto al Wacc o promedio ponderado del costo de capital, asciende al 34.4%, lo cual permite determinar si la inversión por realizarse tiene una estructura óptima de financiamiento. Además, la proyección de ventas realizadas, lo cual se determinó que el punto de equilibrio, teniendo en cuenta la cantidad de pedidos por año es de 52,643. Asimismo, las estrategias de marketing implementadas y buen manejo del capital de trabajo.Due to the pandemic, people's habits and lifestyle took an abrupt turn, since they had to adopt a new healthy culture whose main characteristic is the safety of the food they eat, which motivated the development of this business plan, since it offers comfort, ease, simplicity and time savings when buying salads. The work strategy to be applied is the differentiation strategy in the sales service of vegetable salads. On the other hand, the results determined that the number of households in the 5 districts with high and medium-high socioeconomic level of modern Lima have an average monthly food expenditure in the NSE A of S/. 1,846 and NSE B of S/. 1,473. In addition, they are interested in consuming the salads offered by the company VERBOLD would have the opportunity to satisfy 2,493 households. Finally, it is worth noting that the results of the financial analysis offer a tantalizing vision. With respect to the profit and loss statement, the balance sheet is positive and maintains an average growth rate of 2.5% over the five years projected. The internal rate of return on investment is 43.45%, and the WACC or weighted average cost of capital is 34.4%, which allows us to determine whether the investment to be made has an optimal financing structure. In addition, the projection of realized sales, this determined that the break-even point, taking into account the number of orders per year is 52,643. Also, the marketing strategies implemented and good working capital management.Trabajo de investigació

Cultivos puente verde como herramienta para manejar la nutrición nitrogenada de maíz

El uso de cultivos puente verde se viene generalizando en la región y resulta muy importante conocer en qué medida se ve afectada la disponibilidad de agua y nitrógeno en el cultivo de maíz. Este artículo nos acerca resultados respecto a ello.EEA BalcarceFil: Crespo, Cecilia. Universidad Nacional de Mar del Plata. Facultad de Ciencias Agrarias; Argentina.Fil: Crespo, Cecilia. Instituto Nacional de Tecnología Agropecuaria (INTA). Chacra Experimental Integrada Barrow; Argentina.Fil: Corral, Raúl Alejandro. Instituto Nacional de Tecnología Agropecuaria (INTA). Chacra Experimental Integrada Barrow; Argentina.Fil: Corral, Raúl A. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina.Fil: Diez, Santiago. Universidad de Buenos Aires. Facultad de Agronomía; Argentina.Fil: Delgado, Santiago. Universidad Nacional de Mar del Plata. Facultad de Ciencias Agrarias; Argentina.Fil: Domínguez, Germán. Universidad Nacional de Mar del Plata. Facultad de Ciencias Agrarias; Argentina.Fil: Agostini, María. Universidad Nacional de Mar del Plata. Facultad de Ciencias Agrarias; Argentina.Fil: Cendoya, Gabriela. Universidad Nacional de Mar del Plata. Facultad de Ciencias Agrarias; Argentina.Fil: Sainz Rozas, Hernán Rene. Instituto Nacional de Tecnología Agropecuaria (INTA). Estación Experimental Agropecuaria Balcarce; Argentina.Fil: Sainz Rozas, Hernán Rene. Universidad Nacional de Mar del Plata. Facultad de Ciencias Agrarias; Argentina.Fil: Sainz Rozas, Hernán Rene. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina.Fil: García, Gisela. Universidad Nacional de Mar del Plata. Facultad de Ciencias Agrarias; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina.Fil: Studdert, Guillermo. Universidad Nacional de Mar del Plata. Facultad de Ciencias Agrarias; Argentina

Axicabtagene ciloleucel compared to tisagenlecleucel for the treatment of aggressive B-cell lymphoma

Axicabtagene ciloleucel (axi-cel) and tisagenlecleucel (tisa-cel) are CD19-targeted chimeric antigen receptor (CAR) T cells approved for relapsed/refractory (R/R) large B-cell lymphoma (LBCL). We performed a retrospective study to evaluate safety and efficacy of axi-cel and tisa-cel outside the setting of a clinical trial. Data from consecutive patients with R/R LBCL who underwent apheresis for axi-cel or tisa-cel were retrospectively collected from 12 Spanish centers. A total of 307 patients underwent apheresis for axi-cel (n=152) and tisa-cel (n=155) from November 2018 to August 2021, of which 261 (85%) received a CAR T infusion (88% and 82%, respectively). Median time from apheresis to infusion was 41 days for axi-cel and 52 days for tisa-cel (P=0.006). None of the baseline characteristics were significantly different between both cohorts. Both cytokine release syndrome and neurologic events (NE) were more frequent in the axi-cel group (88% vs. 73%, P=0.003, and 42% vs. 16%, P= 2 and progressive disease before lympho-depletion. Safety and efficacy results in our real-world experience were comparable with those reported in the pivotal trials. Patients treated with axi-cel experienced more toxicity but similar non-relapse mortality compared with those re-ceiving tisa-cel. Efficacy was not significantly different between both products

Axicabtagene ciloleucel compared to tisagenlecleucel for the treatment of aggressive B-cell lymphoma

Axicabtagene ciloleucel (axi-cel) and tisagenlecleucel (tisa-cel) are CD19-targeted chimeric antigen receptor (CAR) T cells approved for relapsed/refractory (R/R) large B-cell lymphoma (LBCL). We performed a retrospective study to evaluate safety and efficacy of axi-cel and tisa-cel outside the setting of a clinical trial. Data from consecutive patients with R/R LBCL who underwent apheresis for axi-cel or tisa-cel were retrospectively collected from 12 Spanish centers. A total of 307 patients underwent apheresis for axi-cel (n=152) and tisa-cel (n=155) from November 2018 to August 2021, of which 261 (85%) received a CAR T infusion (88% and 82%, respectively). Median time from apheresis to infusion was 41 days for axi-cel and 52 days for tisa-cel (P =0.006). None of the baseline characteristics were significantly different between both cohorts. Both cytokine release syndrome and neurologic events (NE) were more frequent in the axi-cel group (88% vs. 73%, P =0.003, and 42% vs. 16%, P <0.001, respectively). Infections in the first 6 months post-infusion were also more common in patients treated with axi-cel (38% vs. 25%, P =0.033). Non-relapse mortality was not significantly different between the axi-cel and tisa-cel groups (7% and 4%, respectively, P =0.298). With a median follow-up of 9.2 months, median PFS and OS were 5.9 and 3 months, and 13.9 and 11.2 months for axi-cel and tisa-cel, respectively. The 12-month PFS and OS for axi-cel and tisa-cel were 41% and 33% (P =0.195), 51% and 47% (P =0.191), respectively. Factors associated with lower OS in the multivariate analysis were increased lactate dehydrogenase, ECOG ≥2 and progressive disease before lympho-depletion. Safety and efficacy results in our real-world experience were comparable with those reported in the pivotal trials. Patients treated with axi-cel experienced more toxicity but similar non-relapse mortality compared with those receiving tisa-cel. Efficacy was not significantly different between both products