Advances in Nutrition, Dietary Supplements and Ergogenic Aids for Athletic Performance: Trends and Future Prospects

[EN] Sports nutrition is a scientific discipline that explores the relationship between nutrients and physical exercise performance. It examines how nutrients such as carbohydrates, proteins, fats, vitamins, and minerals affect energy metabolism, muscle function, and recovery during exercise. Sports nutrition research aims to determine the optimal nutrient intake for athletes following their training, performance goals, and body composition. Additionally, it considers the impact of various dietary patterns, such as plant-based and ketogenic diets, on athletic performance. Overall, it seeks to understand how to optimize dietary intake to support athletic performance and maintain or enhance health status [1]. Recently, the prospect of using in sports nutrition to reduce the risk of injury and optimize recovery in athletes has increasingly been studied. For instance, ingesting a post-match recovery beverage containing native whey protein and carbohydrates may reduce exercise-induced elevation in muscle damage indicators and sustain physical performance in rugby players [2]. In injured athletes, a comprehensive systematic integrative review by Giraldo-Vallejo et al. (2023) showed the positive impact of energy availability, and high protein and carbohydrate diets content, as well as the potential use of collagen, creatine monohydrate, omega-3 (fish oils), and vitamin D to support tissue repair and reduce inflammation [3]

Integral antimicrobial control: a strategy against nosocomial infections in veterinary

91-99El desarrollo de mecanismos de prevenci?n y control frente a los microorganismos nosocomiales son esfuerzos importantes para desarrollar en los hospitales tanto humanos como veterinarios. Entre las estrategias encaminadas a reducir la flora microbiana pat?gena y la resistencia a m?ltiples f?rmacos en los hospitales, se encuentran la reducci?n de la diseminaci?n de microorganismos por parte del personal a los animales, evitar la adquisici?n de microorganismos de equipos hospitalarios y de infraestructura, la realizaci?n de programas permanentes de limpieza, desinfecci?n y esterilizaci?n y un uso racional de los antimicrobianos. El presente art?culo describe los principios fundamentales del control microbiol?gico hospitalario, basado en el contexto m?dico veterinario en Colombia.ABSTRACT. The development of preventive and control mechanisms to nosocomial microorganisms are important efforts to develop both human and veterinary hospitals. Among those strategies aimed to reduce both pathogenic microbial flora and multidrug resistance in hospitals are the reduction of microorganisms dissemination from staff to animals, avoiding acquisition of microorganisms from hospital equipment sand infrastructure, conducting permanent cleaning, disinfection and sterilization programs; and a rational use of antimicrobials. The present document describes the fundamental principles of in hospital microbiological control, fitted to the veterinary medical context in Colombia

Molecular and metabolic insights of creatine supplementation on resistance training

In recent years the research problem in the field of sports supplementation has changed to explain the metabolic mechanisms by which creatine (Cr) administration enhances the performance of certain sports or simply benefits the muscular adaptation. In this review for first time the biochemical mechanisms of Cr ingestion in a cell signaling insight were analyzed, focusing on energetic bioavailability enhancement and optimization of the temporal and spatial buffering of Cr/PCr/CK system. Moreover, intensification in proliferation and differentiation processes of muscle cells (IGF-I/PI3K/Akt-PKB, SPHK1/MAPK/p38/MRFs, mTOR, cellular swelling, mitotic activity of satellite cells, actin polymerization, and myoblast fusion) and inactivation and/or reduction in the expression of ergolitic metabolites (GSK3β, myostatin and AMPK regulation) were examined. In this way, we explained from a metabolic point of view the increase in muscle mass, strength, fatigue resistance, and performance of high intensity sports after Cr monohydrate supplementation.En los últimos años el problema de investigación en el campo de la suplementación deportiva ha cambiado al punto de explicar los mecanismos metabólicos por los cuales la administración de creatina (Cr) incrementa el rendimiento en ciertos deportes o simplemente beneficia la adaptación muscular. Esta revisión analiza por primera vez los mecanismos bioquímicos de la ingesta de Cr desde la perspectiva de señalización celular, enfocándose en la mayor biodisponibilidad energética de Cr y optimización de la acción buffer espacial/ temporal que ofrece el sistema Cr/PCr/CK. Además, se examinan aspectos relacionados con el incremento en los procesos de proliferación y diferenciación de células musculares (IGF-I/PI3K/Akt-PKB, SPHK1/ MAPK/p38/MRFs, mTOR, hinchamiento celular, actividad mitótica de células satélite, polimerización de actina y fusión de mioblastos) y la inactivación y/o reducción en la expresión de proteínas con funciones ergolíticas (GSK3β, miostatina y regulación de AMPK). De esta manera, se explican el aumento de la masa muscular, la fuerza, la resistencia a la fatiga y el rendimiento en ejercicios de alta intensidad, producidos por la suplementación con monohidrato de Cr, desde un punto de vista metabólico

Strength training in elderly: An useful tool against sarcopenia

The loss of muscle mass and strength in elderly population (especially after the age of 65–70) represents a public health problem. Due to the high prevalence of frailty in older adults, cardiovascular or low-intensity exercise is implemented as first choice option. Although beneficial these training schemes are not as effective as strength-based resistance training for increasing muscle strength and hypertrophy. In fact, when performed progressively and under professional supervision, strength-based training has been proposed as an important and valid methodology to reduce sarcopenia-related problems. In this mini-review, we not only summarize the benefits of weight resistance training but also highlight practical recommendations and other non-conventional methods (e.g., suspension training) as part of an integral anti-sarcopenia strategy. Future directions including cluster set configurations and high-speed resistance training are also outlined

Usefulness of ultrasound as neurolocalization technique for the anesthetic blockade of the pelvic limb in dogs

P?ginas 10-16Recurso Electr?nicoEn este estudio, se evalu? la utilidad de la ecograf?a como t?cnica de neurolocalizaci?n para el bloqueo anest?sico de los nervios perif?ricos ci?tico, femoral, y plexo lumbar en el perro. Las caracter?sticas de estas estructuras nerviosas fueron estudiadas mediante disecci?n anat?mica realizada en 12 cad?veres caninos. La utilidad de esta t?cnica ecoguiada para el bloqueo anest?sico de estos nervios fue evaluada en 27 cad?veres caninos mediante la inyecci?n de un colorante alrededor de estos nervios y la posterior evaluaci?n del patr?n de tinci?n obtenido. Adicionalmente, la efectividad de esta t?cnica ecoguiada para el bloqueo anest?sico de los nervios ci?tico y emoral fue evaluada en nueve Beagles experimentales, mediante la inyecci?n de un anest?sico local cerca a los nervios estudiados, y la posterior evaluaci?n del d?ficit motor obtenido en la extremidad bloqueada. Los resultados de este estudio validan la utilidad de la ecograf?a como t?cnica de neurolocalizaci?n con el fin de llevar a cabo el bloqueo anest?sico del nervio ci?tico en la cara lateral del muslo y para los nervios femoral y obturador mediante un abordaje ventral suprainguinal.ABSTRACT. This study evaluated the usefulness of ultrasound as a neurolocalization technique for the anesthetic blockade of peripheral nerves such as sciatic, femoral and lumbar plexus in the dog. The characteristics of these neural structures were studied by anatomical dissection performed in 12 canine cadavers. The usefulness of this ultrasound-guided technique for the anesthetic blockade of those nerves was evaluated in 27 dog cadavers by injecting of a staining solution around the nerves followed by evaluation of the staining pattern obtained. Additionally, the effectiveness of this ultrasound-guided technique for the sciatic and the femoral nerve blockade was evaluated in 9 experimental Beagles, by injecting local anesthetic closely to these nerves and the subsequent evaluation of motor deficit in the blocked limb. The results of this study validate the usefulness of ultrasound as a neurolocalization technique with the aim to carry out an anesthetic blockade of the sciatic nerve in the lateral aspect of the thigh and also for the femoral and obturator nerves through a ventral suprainguinal approach. Keywords: Dog, Femora

Metabolic Basis of Creatine in Health and Disease: A Bioinformatics-Assisted Review

Creatine (Cr) is a ubiquitous molecule that is synthesized mainly in the liver, kidneys, and pancreas. Most of the Cr pool is found in tissues with high-energy demands. Cr enters target cells through a specific symporter called Na+/Cl--dependent Cr transporter (CRT). Once within cells, creatine kinase (CK) catalyzes the reversible transphosphorylation reaction between [Mg2+:ATP4-]2- and Cr to produce phosphocreatine (PCr) and [Mg2+:ADP3-]-. We aimed to perform a comprehensive and bioinformatics-assisted review of the most recent research findings regarding Cr metabolism. Specifically, several public databases, repositories, and bioinformatics tools were utilized for this endeavor. Topics of biological complexity ranging from structural biology to cellular dynamics were addressed herein. In this sense, we sought to address certain pre-specified questions including: (i) What happens when creatine is transported into cells? (ii) How is the CK/PCr system involved in cellular bioenergetics? (iii) How is the CK/PCr system compartmentalized throughout the cell? (iv) What is the role of creatine amongst different tissues? and (v) What is the basis of creatine transport? Under the cellular allostasis paradigm, the CK/PCr system is physiologically essential for life (cell survival, growth, proliferation, differentiation, and migration/motility) by providing an evolutionary advantage for rapid, local, and temporal support of energy- and mechanical-dependent processes. Thus, we suggest the CK/PCr system acts as a dynamic biosensor based on chemo-mechanical energy transduction, which might explain why dysregulation in Cr metabolism contributes to a wide range of diseases besides the mitigating effect that Cr supplementation may have in some of these disease states

Un manojo documental de Bernardo de Balbuena: práctica administrativa y construcción biográfica

This paper offers an annotated edition of a set of documents, almost all unpublished, related to some of the main biographical circumstances of Bernardo de Balbuena, which allows to do a reflection on the administrative context of selffashioning.Se ofrece la edición anotada de un conjunto de documentos, casi todos inéditos, relativos a algunas de las principales coyunturas biográficas de Bernardo de Balbuena, lo que permite hacer una reflexión sobre el contexto administrativo en el que se generan las denominadas “escrituras del yo”

La ocupación solutrense del Abrigo de la Boja (Mula, Murcia, España)

El relleno pleistoceno del Abrigo de la Boja (ADB) empieza con un nivel adscrito al Magdaleniense superior, seguido de un potente paquete con ocupación difusa bajo el cual se desarrolla una secuencia depositada durante el último máximo glacial caracterizada por una serie de estructuras de combustión, de tipo hogar plano/amorfo (open hearth), existiendo también hogares de cubeta. Destaca un hogar enlosado, completo y muy bien conservado, excavado en 2012 y adscrito provisionalmente al Solutreogravetiense. Los niveles solutrenses subyacentes son ricos en elementos de adorno, entre los cuales conchas perforadas de Littorina obtusata y Smaragdia viridis; su industria lítica incluye raspadores, algunas puntas, y escasos buriles. La datación 14C de muestras de carbón de Juniperus sp. sitúa este paquete entre 16990 ± 70 BP (VERA-5364a), a techo, y 20980 ± 120 BP (VERA-5366), a muro. The Pleistocene fill of the La Boja rock shelter (ADB) starts with an Upper Magdalenian level, followed by a thick package with poorly defined occupations under which there is a Last Glacial Maximum sequence with combustion features, mostly of the open hearth type. A particularly well preserved and seemingly complete stone-paved hearth of probable Solutreogravettian age was excavated in 2012. The abundant ornaments in the Solutrean levels include pierced Littorina obtusata and Smaragdia viridis shells and the stone tool assem- blages feature endscrapers, some points and rare burins. The 14C dating of Juniperus sp. charcoal samples places this sequence between 16990 ± 70 BP (VERA-5364a), at the top, and 20980 ± 120 BP (VERA-5366), at the bottom

A Bioinformatics-Assisted Review on Iron Metabolism and Immune System to Identify Potential Biomarkers of Exercise Stress-Induced Immunosuppression

The immune function is closely related to iron (Fe) homeostasis and allostasis. The aim of this bioinformatics-assisted review was twofold; (i) to update the current knowledge of Fe metabolism and its relationship to the immune system, and (ii) to perform a prediction analysis of regulatory network hubs that might serve as potential biomarkers during stress-induced immunosuppression. Several literature and bioinformatics databases/repositories were utilized to review Fe metabolism and complement the molecular description of prioritized proteins. The Search Tool for the Retrieval of Interacting Genes (STRING) was used to build a protein-protein interactions network for subsequent network topology analysis. Importantly, Fe is a sensitive double-edged sword where two extremes of its nutritional status may have harmful effects on innate and adaptive immunity. We identified clearly connected important hubs that belong to two clusters: (i) presentation of peptide antigens to the immune system with the involvement of redox reactions of Fe, heme, and Fe trafficking/transport; and (ii) ubiquitination, endocytosis, and degradation processes of proteins related to Fe metabolism in immune cells (e.g., macrophages). The identified potential biomarkers were in agreement with the current experimental evidence, are included in several immunological/biomarkers databases, and/or are emerging genetic markers for different stressful conditions. Although further validation is warranted, this hybrid method (human-machine collaboration) to extract meaningful biological applications using available data in literature and bioinformatics tools should be highlighted.The ‘Bioinformatics-assisted Review’ is a project developed and supported by the Research Division at the Dynamical Business and Science Society—DBSS International SAS. The APC was funded by the Exercise & Sport Nutrition Laboratory (ESNL) at Texas A&M University, the POWER LAB at University of Central Florida and the Sport Genomics Research Group at University of the Basque Country UPV/EHU