Anhedonia and Pessimism in Hospitalized Depressed Adolescents

This longitudinal study investigates whether anhedonia and pessimistic attributional style represent a clinical state or a trait in hospitalized depressed adolescents. 81 consecutive adolescent inpatients were screened with the Beck Depression Inventory (BDI) and the clinician-rated Major Depressive Disorder (MDD) criteria sheet. 51 patients with BDI score ≥10 and/or ≥4 symptoms on MDD criteria sheet were assessed at Time 1 upon admission, with 39 patients (78%) assessed at discharge (Time 2) with the Pleasure Scale for Children and Children's Attributional Style Questionnaire—Revised. Anhedonia and pessimism at admission were associated with BDI scores at admission and discharge as well as number of depressive symptoms and depression severity. MDD diagnosis was associated with anhedonia, but not with pessimism. Pessimism—but not anhedonia—improved significantly by discharge. Results suggest that while some adolescents exhibit enduring anhedonia, pessimistic attributional style appears to be a concomitant feature of an acute depressive state

Modelling and analysis of pH responsive hydrogels for the development of biomimetic photo-actuating structures

ABSTRACTPhoto-actuating structures inspired by the chemical sensing and signal transmission observed in sun-tracking leaves have recently been proposed by Dicker et al. The proposed light tracking structures are complex, multicomponent material systems, principally composed of a reversible photoacid or base, combined with a pH responsive hydrogel actuator. New modelling and characterization approaches for pH responsive hydrogels are presented in order to facilitate the development of the proposed structures. The model employs Donnan equilibrium for the prediction of hydrogel swelling in systems where the pH change is a variable resulting from the equilibrium interaction of all free and fixed (hydrogel) species. The model allows for the fast analysis of a variety of combinations of material parameters, allowing for the design space for the proposed photo-actuating structures to be quickly established. In addition, experimental examination of the swelling of a polyether-based polyurethane and poly(acrylic acid) interpenetrating network hydrogel is presented. The experiment involves simultaneously performing a titration of the hydrogel, and undertaking digital image correlation (DIC) to determine the hydrogel’s state of swelling. DIC allows for the recording of the hydrogel’s state of swelling with previously unattained levels of resolution. Experimental results provide both model material properties, and a means for model validation.</jats:p

The Radio - 2 mm Spectral Index of the Crab Nebula Measured with GISMO

We present results of 2 mm observations of the Crab Nebula, obtained using the Goddard-IRAM Superconducting 2 Millimeter Observer (GISMO) bolometer camera on the IRAM 30 m telescope. Additional 3.3 mm observations with the MUSTANG bolometer array on the Green Bank Telescope are also presented. The integrated 2 mm flux density of the Crab Nebula provides no evidence for the emergence of a second synchrotron component that has been proposed. It is consistent with the radio power law spectrum, extrapolated up to a break frequency of log(nu_{b} [GHz]) = 2.84 +/- 0.29 or nu_{b} = 695^{+651}_{-336} GHz. The Crab Nebula is well-resolved by the ~16.7" beam (FWHM) of GISMO. Comparison to radio data at comparable spatial resolution enables us to confirm significant spatial variation of the spectral index between 21 cm and 2 mm. The main effect is a spectral flattening in the inner region of the Crab Nebula, correlated with the toroidal structure at the center of the nebula that is prominent in the near-IR through X-ray regime.Comment: Accepted for publication in the Ap

Thermodynamic evolution of the z=1.75z=1.75 galaxy cluster IDCS J1426.5+3508

We present resolved thermodynamic profiles out to 500 kpc, about $r_{500}$, of the $z=1.75$ galaxy cluster IDCS J1426.5+3508 with 40 kpc resolution. Thanks to the combination of Sunyaev-Zel'dovich and X-ray datasets, IDCS J1426.5+3508 becomes the most distant cluster with resolved thermodynamic profiles. These are derived assuming a non-parametric pressure profile and a very flexible model for the electron density profile. The shape of the pressure profile is flatter than the universal pressure profile. The IDCS J1426.5+3508 temperature profile is increasing radially out to 500 kpc. To identify the possible future evolution of IDCS J1426.5+3508 , we compared it with its local descendants that numerical simulations show to be $0.65\pm0.12$ dex more massive. We found no evolution at 30 kpc, indicating a fine tuning between cooling and heating at small radii. At $30<r<300$ kpc, our observations show that entropy and heat must be deposited with little net gas transfer, while at 500 kpc the gas need to be replaced by a large amount of cold, lower entropy gas, consistent with theoretical expectation of a filamentary gas stream, which brings low entropy gas to 500 kpc and energy at even smaller radii. At $r \gtrsim 400$ kpc the polytropic index takes a low value, which indicates the presence of a large amount of non-thermal pressure. Our work also introduces a new definition of the evolutionary rate, which uses unscaled radii, unscaled thermodynamic quantities, and different masses at different redshifts to compare ancestors and descendants. It has the advantage of separating cluster evolution, dependence on mass, pseudo-evolution and returns a number with unique interpretation, unlike other definitions used in literature.Comment: MNRAS, in press. In v2 we only corrected author affiliations and spellin

Gene expression signatures modulated by epidermal growth factor receptor activation and their relationship to cetuximab resistance in head and neck squamous cell carcinoma.

BACKGROUND: Aberrant activation of signaling pathways downstream of epidermal growth factor receptor (EGFR) has been hypothesized to be one of the mechanisms of cetuximab (a monoclonal antibody against EGFR) resistance in head and neck squamous cell carcinoma (HNSCC). To infer relevant and specific pathway activation downstream of EGFR from gene expression in HNSCC, we generated gene expression signatures using immortalized keratinocytes (HaCaT) subjected to ligand stimulation and transfected with EGFR, RELA/p65, or HRASVal12D. RESULTS: The gene expression patterns that distinguished the HaCaT variants and conditions were inferred using the Markov chain Monte Carlo (MCMC) matrix factorization algorithm Coordinated Gene Activity in Pattern Sets (CoGAPS). This approach inferred gene expression signatures with greater relevance to cell signaling pathway activation than the expression signatures inferred with standard linear models. Furthermore, the pathway signature generated using HaCaT-HRASVal12D further associated with the cetuximab treatment response in isogenic cetuximab-sensitive (UMSCC1) and -resistant (1CC8) cell lines. CONCLUSIONS: Our data suggest that the CoGAPS algorithm can generate gene expression signatures that are pertinent to downstream effects of receptor signaling pathway activation and potentially be useful in modeling resistance mechanisms to targeted therapies

The Atacama Cosmology Telescope: Physical Properties of Sunyaev-Zel'dovich Effect Clusters on the Celestial Equator

We present the optical and X-ray properties of 68 galaxy clusters selected via the Sunyaev-Zel'dovich Effect at 148 GHz by the Atacama Cosmology Telescope (ACT). Our sample, from an area of 504 square degrees centered on the celestial equator, is divided into two regions. The main region uses 270 square degrees of the ACT survey that overlaps with the co-added ugriz imaging from the Sloan Digital Sky Survey (SDSS) over Stripe 82 plus additional near-infrared pointed observations with the Apache Point Observatory 3.5-meter telescope. We confirm a total of 49 clusters to z~1.3, of which 22 (all at z>0.55) are new discoveries. For the second region the regular-depth SDSS imaging allows us to confirm 19 more clusters up to z~0.7, of which 10 systems are new. We present the optical richness, photometric redshifts, and separation between the SZ position and the brightest cluster galaxy (BCG). We find no significant offset between the cluster SZ centroid and BCG location and a weak correlation between optical richness and SZ-derived mass. We also present X-ray fluxes and luminosities from the ROSAT All Sky Survey which confirm that this is a massive sample. One of the newly discovered clusters, ACT-CL J0044.4+0113 at z=1.1 (photometric), has an integrated XMM-Newton X-ray temperature of kT_x=7.9+/-1.0 keV and combined mass of M_200a=8.2(-2.5,+3.3)x10^14 M_sun/h70 placing it among the most massive and X-ray-hot clusters known at redshifts beyond z=1. We also highlight the optically-rich cluster ACT-CL J2327.4-0204 (RCS2 2327) at z=0.705 (spectroscopic) as the most significant detection of the whole equatorial sample with a Chandra-derived mass of M_200a=1.9(-0.4,+0.6)x10^15 M_sun/h70, comparable to some of the most massive known clusters like "El Gordo" and the Bullet Cluster.Comment: 18 pages, 12 figures. Accepted to the Astrophysical Journal. New version includes minor changes in the accepted pape

The APEX-CHAMP+ view of the Orion Molecular Cloud 1 core - Constraining the excitation with submillimeter CO multi-line observations

A high density portion of the Orion Molecular Cloud 1 (OMC-1) contains the prominent, warm Kleinmann-Low (KL) nebula that is internally powered by an energetic event plus a farther region in which intermediate to high mass stars are forming. Its outside is affected by ultraviolet radiation from the neighboring Orion Nebula Cluster and forms the archetypical photon-dominated region (PDR) with the prominent bar feature. Its nearness makes the OMC-1 core region a touchstone for research on the dense molecular interstellar medium and PDRs. Using the Atacama Pathfinder Experiment telescope (APEX), we have imaged the line emission from the multiple transitions of several carbon monoxide (CO) isotopologues over the OMC-1 core region. Our observations employed the 2x7 pixel submillimeter CHAMP+ array to produce maps (~ 300 arcsec x 350 arcsec) of 12CO, 13CO, and C18O from mid-J transitions (J=6-5 to 8-7). We also obtained the 13CO and C18O J=3-2 images toward this region. The 12CO line emission shows a well-defined structure which is shaped and excited by a variety of phenomena, including the energetic photons from hot, massive stars in the nearby Orion Nebula's central Trapezium cluster, active high- and intermediate-mass star formation, and a past energetic event that excites the KL nebula. Radiative transfer modeling of the various isotopologic CO lines implies typical H2 densities in the OMC-1 core region of ~10^4-10^6 cm^-3 and generally elevated temperatures (~ 50-250 K). We estimate a warm gas mass in the OMC-1 core region of 86-285 solar masses.Comment: 11 pages, 9 figures, accepted by A&

Sub-millimeter to centimeter excess emission from the Magellanic Clouds. I. Global spectral energy distribution

In order to reconstruct the global SEDs of the Magellanic Clouds over eight decades in spectral range, we combined literature flux densities representing the entire LMC and SMC respectively, and complemented these with maps extracted from the WMAP and COBE databases covering the missing the 23--90 GHz (13--3.2 mm) and the poorly sampled 1.25--250 THz (240--1.25 micron). We have discovered a pronounced excess of emission from both Magellanic Clouds, but especially the SMC, at millimeter and sub-millimeter wavelengths. We also determined accurate thermal radio fluxes and very low global extinctions for both LMC and SMC. Possible explanations are briefly considered but as long as the nature of the excess emission is unknown, the total dust masses and gas-to-dust ratios of the Magellanic Clouds cannot reliably be determined.Comment: Accepted for publication by A&