Métodos geofísicos de exploração aplicados ao estudo da perigosidade sísmica

Nas últimas décadas os métodos geofísicos ganharam papel de relevo na avaliação da perigosidade do risco sísmico e na sua mitigação. A detecção de falhas activas em ambientes intra placa onde as taxas de movimentação são relativamente baixas (<0,3 mm/ano) e as roturas superficiais são obliteradas pela erosão e sedimentação, levaram à utlização daqueles métodos na investigação paleossismológica. A nível da mitigação, em que a avaliação dos efeitos de sítio é essencial, é necessário um conhecimento das propriedades mecânicas das primeiras dezenas de metros da sub-superfície e da estrutura das bacias sedimentares, que são obtidos a partir de sondagens geotécnicas e métodos geofísicos. A utilização dos métodos sísmicos, eléctricos e electromagnéticos na identificação de falhas e na estrutura do subsolo, a delimitação de bacias a partir de métodos potenciais e a caracterização das propriedades mecânicas do subsolo são analisadas no presente trabalho, com exemplos de aplicação em Portugal

Transport systems and mobility for smart cities

Nowadays, cities appear to be the best place to live, attracting more and more people and activities. However, not only does this movement represent a threat to the environment but also provides challenges and opportunities for everyone, e.g., people, companies, organizations, and governments. To provide a good urban quality of life, the efficiency of all assets, buildings, infrastructures, and all systems, as well as taking care of the natural environment, must be addressed and achieved. This paper will, therefore, present the available literature on the subject to discuss the present context, the main challenges, as well as the concept of smart cities, with future cities relying on the mobility and evolution of transport systems for smart, sustainable, resilient, and inclusive mobility. As a result of the research, it is possible to infer that an integrated smart mobility approach can support the efficiency of all transport networks for everyone, today and tomorrow, while faced with the threat of climate change and the challenges of citizens.(undefined

Microcystin-LR activates the ERK1/2 kinases and stimulates the proliferation of the monkey kidney-derived cell line Vero-E6

Microcystin-LR (MCLR) is a peptide produced by freshwater cyanobacteria that induces severe hepatotoxicity in humans and animals. MCLR is also a potent tumour promoter and it has been proposed that this activity is mediated by the inhibition of protein phosphatases PP1/PP2A, possibly through the activation of proto-oncogenes c-jun, c-fos and c-myc. However, the mechanisms underlying MCLR-induced tumour promotion are still largely unknown, particularly in non-liver cells. In previous studies we have demonstrated that micromolar concentrations of MCLR induce cytotoxic effects in the kidney Vero-E6 cell line. The purpose of the present work was to evaluate whether the exposure to subcytotoxic concentrations of MCLR was sufficient to induce the proliferation of Vero-E6 cells. Through BrdU incorporation assay we show that at nanomolar concentrations MCLR stimulates cell cycle progression in Vero-E6 kidney cell line. Moreover, the analysis of mitogen-activated protein kinases p38, JNK and ERK1/2 activity revealed that the proliferative effect of MCLR is associated with the activation of the pro-proliferative ERK1/2 pathway. These results emphasise the importance to confirm in vivo the impact of MCLR on tumour promotion at kidney level

Next Generation Application Processor Based on the IEEE 1451.1 Standard and Web Services

Over the last decade, the 1451.1 Std has been a reference model to develop smart and open distributed measurement and control systems. Now, that the 1451.1 Std is about to be revised, there is the opportunity to enrich it with emergent and successful technologies as is the case of Web Services. Following this idea, we present a prototype of Network Capable Application Processor (NCAP) that runs on the .NET Framework and exposes its functionality through a set of Web Services. The prototype takes advantage of three key technologies: (i) the abstraction layer proposed by the 1451.1 Std; (ii) the interoperability provided by Web Services; and (iii) the productivity supplied by the .NET Framework

Using a Commercial Framework to Implement and Enhance the IEEE 1451.1 Standard

In 1999, the 1451.1 Std was published defining a common object model and interface specification to develop open, multi-vendor distributed measurement and control systems. However, despite the well-known advantages of the model, few have been the initiatives to implement it. In this paper we describe the implementation of a NCAP – Network Capable Application Processor, in a well-known and well-proven infrastructure: the Microsoft .NET Framework. The choice of a commercial framework was part of our strategy: to take advantage of several “of the shelf” technologies and adapt them to produce a NCAP prototype, called NCAP/XML. In addition, a solution to enhance the 1451.1 Std is presented by proposing a new format for inter-NCAP communication based on XML (eXtended Markup Language)

IEEE 1451.1 Standard and XML Web Services: a Powerful Combination to Build Distributed Measurement and Control Systems

In 2005, we presented the NCAP/XML, a prototype of NCAP (Network Capable Application Processor) that runs under the .NET Framework and makes available its functionality through a set of Web Services using XML (eXtended Markup Language). Giving continuity to this project, it is time to explain how to use the NCAP/XML to build a Distributed Measurement and Control System (DMCS) compliant with the 1451.1 Std. This paper is divided in two main parts: in the first part, we present the new software architecture of NCAP/XML (which suffered some changes since the first version), and secondly, we describe the network configuration of a Web-enabled DMCS, which includes several NCAP/XML stations, a database and a Web Server

Sex-related inequalities in management of patients with acute coronary syndrome-results from the EURHOBOP study

Background: Real‐world data from different levels of hospital specialisation would help to understand if differences in management between women and men with acute coronary syndrome (ACS) are still a priority target. We aimed to identify sex inequalities in management of patients with different types of ACS. Methods: We analysed 1757 patients with a non‐ST‐elevation ACS (NSTEACS) and 1184 with ST elevation myocardial infarction (STEMI) or left bundle branch block (non‐classifiable (NC) ACS (STEMI/NC ACS group), consecutively discharged from ten Portuguese hospitals with different specialisation levels, between 2008 and 2010. We estimated odds ratios (OR) and 95% confidence intervals (95% CI) for the association between sex and the performance of coronary angiography, reperfusion and revascularisation. Results: Among STEMI/NC ACS, men had higher probability of performing coronary angiography than women (adjusted OR = 1.64, 95% CI: 1.11‐2.44), while among NSTEACS patients there was no significant difference by sex (adjusted OR = 1.26, 95% CI: 0.99‐1.62). In patients who underwent coronary angiography, there was no difference in proportion of women and men submitted to revascularisation, regardless of the ACS type. Although men with STEMI/NC ACS were more likely to undergo reperfusion (crude OR = 2.17, 95% CI: 1.68‐2.81), the effect became not significant after multivariable adjustment (adjusted OR = 1.33, 95% CI: 0.96‐1.84). Conclusion: Women diagnosed with STEMI/NC, but not NSTEACS, had lower probability when compared with men to be submitted to coronary angiography. There was no difference in performance of reperfusion and revascularisation by sex.Executive Agency for Health and Consumers, Grant/Award Number: 2008 13 12 - EURHOBOP; Universidade do Porto (EPIUnit), Grant/Award Number: POCI-01-0145-FEDER-006862

Performance Evaluation of a Web-Service-Based DMCS

The paper describes a set of experiments conducted on a service-oriented middleware infrastructure in order to evaluate its performance and applicability in the context of Distributed Measurement and Control Systems (DMCS). The infrastructure, entirely based on Web Services, was built using the Windows Communication Foundation (WCF), a software package released by Microsoft to develop distributed applications. The experiments were performed on a real plant equipped with all the instrumentation needed to run control loops for pressure, level, flow and temperature, quantities widely found in the process industry. The work focus on measuring the time delays associated with control loops and remote calls. The methodology of each experiment is described, results are presented and conclusions are drawn

Open Controller for Distributed Instrumentation Systems

The paper presents a controller designed to be highly interoperable in the context of distributed instrumentation systems. Interoperability is achieved by adopting strong standards – the IEEE 1451.1 Std to be more precise – and by using cross-platform, manufacturer-independent technologies such as Web Services. The 1451.1 Std contributes with its information model to represent data and organize functionalities through a well-defined hierarchy of objects. Web Services are used to implement both communication models, the client/server model for one-to-one communications, and the publish/subscribe model for one-to-many communications. Being supported by all the major software companies around the world, Web Services have the chance to become the first wide-used middleware solution and the answer for many interoperability problems. The controller was developed using the .NET Framework and tested in the Windows XP operating system