3 research outputs found
Bicuspid Aortic Valve: Identifying Knowledge Gaps and Rising to the Challenge From the International Bicuspid Aortic Valve Consortium (BAVCon).
Since its estimated first description >500 years ago by
Leonardo da Vinci, the bicuspid aortic valve (BAV) has
progressively built a reputation; initially, as a curious valvular
phenotype with a tendency to develop obstruction and insufficiency.
In more contemporary times, however, the BAV is
recognized as underlying almost 50% of isolated severe aortic
stenosis cases requiring surgery, and has been extensively
associated with ominous outcomes such as bacterial endocarditis
and aortic dissection. These associations, coupled with
the high prevalence of BAV in humans, have prompted investigative
efforts into the condition, which although insightful,
have generated more questions than answers. This review
describes our current knowledge of BAV, but, more importantly,
it highlights knowledge gaps and areas where basic and
clinical research is warranted. Our review has 2 sections. The
first section outlines the multifaceted challenge of BAV, our
current understanding of the condition, and barriers that may
hamper the advancement of the science. The second section
proposes a roadmap to discovery based on current imaging,
molecular biology, and genetic tools, recognizing their advantages
and limitations