Factors of enterprise competitiveness in the commercial sector

El objetivo de la presente investigación fue describir los factores de competitividad empresarial presentes en el sector comercial de México y Colombia, con los enfoques teóricos de Kreitner y Kinicki (2007), Bañuls (2009), Weitz (2015), Ortiz y Arredondo (2014), Rodríguez y Rodríguez (2017) y Ramírez M, (2018).Con una metodología de tipo descriptivo transeccional de campo. La población de estudio, estuvo constituida por el personal de las empresas comerciales de Súper Almacén Olímpica (SAO) y tiendas COPPEL, considerando como universo de la población, el sector comercial de Colombia y México. La muestra fue de ciento veinte (120) informantes claves; específicamente el personal administrativo fijo que labora en dichas empresas. Se utilizó la técnica de la encuesta mediante un cuestionario, estructurado por (12) ítems, con una escala tipo Likert, de selección de respuestas múltiples. Se obtuvo como resultado que los factores de competitividad empresarial presentes en el sector comercial son la innovación, flexibilidad productiva y calidad, ubicándose en una categoría moderadamente satisfactoria, considerando como oportunidad de mejora el indicador tecnología, se recomienda diseñar estrategias para fortalecer los recursos técnicos y procedimientos empleados para el sector productivo, donde se promueva en la organización actitudes a favor de la visión estratégica, dirigidas a implementar las mejores prácticas específicas de gestión humana, generando efectos positivos en el desempeño del talento humano.Theobjective of thisresearchwas to describe thefactors of businesscompetitiveness in thecommercial sector of México and Colombia, withthetheoreticalapproaches of Kreitner and Kinicki (2007), Bañuls (2009), Weitz (2015), Ortiz and Arredondo (2014), Rodríguez and Rodríguez (2017) and Ramírez M, (2018). With a methodology of descriptivetransecional of field. Thestudypopulation, wasconstitutedbythe staff of the trading companies of OlympicSuper Store (SAO) and shops COPPEL, whereas as a universe of thepopulation, thecommercial sector of Colombia and México. Thesamplewas of onehundredtwenty (120) keyinformants; specificallythe staff fixedworking in thesecompanies. Usedthetechnique of thesurveyusing a questionnaire, structuredby (12) itemswith a scale Likert-type of multiple-choiceselection.Wasobtained as a result of businesscompetitivenessfactorspresent in thecommercial sector are innovation, productiveflexibility and quality, in a moderatelysatisfactorycategory, whereas as opportunity for improvementtheindicatortechnology, itisrecommended to designstrategies to strengthenthetechnicalresources and proceduresused for theproduction sector, whereattitudes in favour of thestrategicvision, aimed at implementingthebest be promoted in theOrganizationspecificpractices of human resourcesmanagement, generating positive effectsonthe performance of human talent

Autoimmune neurological conditions associated with Zika virus infection

Zika virus (ZIKV) is an emerging flavivirus rapidly spreading throughout the tropical Americas. mosquitoes is the principal way of transmission of the virus to humans. ZIKV can be spread by transplacental, perinatal, and body fluids. ZIKV infection is often asymptomatic and those with symptoms present minor illness after 3 to 12 days of incubation, characterized by a mild and self-limiting disease with low-grade fever, conjunctivitis, widespread pruritic maculopapular rash, arthralgia and myalgia. ZIKV has been linked to a number of central and peripheral nervous system injuries such as Guillain-Barré syndrome (GBS), transverse myelitis (TM), meningoencephalitis, ophthalmological manifestations, and other neurological complications. Nevertheless, mechanisms of host-pathogen neuro-immune interactions remain incompletely elucidated. This review provides a critical discussion about the possible mechanisms underlying the development of autoimmune neurological conditions associated with Zika virus infection

Factores que influyen en la decisión de las adolescentes a realizarse abortos peligrosos

El presente trabajo de investigación de tipo cualitativo identifica los factores influyentes que conllevaron a un grupo de adolescentes a practicarse un aborto peligrosos, dichos factores que se describieron en dos grupos, los factores personales y los factores sociales, destacando aspectos importantes que engloban definiciones acerca de la adolescencia, los diferentes tipos de abortos y los diferentes métodos utilizados para este fin.This research qualitative identifies the influential factors that led to a group of teenagers are having a dangerous abortion, those factors described in two groups, personal factors and social factors, highlighting important aspects that include definitions of adolescence, different types of abortions and the different methods used for this purpose.INTRODUCCIÓN MARCO DE REFERENCIA Descripción Del Problema Pregunta Problema Justificación Social Disciplinar Teórica Objetivo General Definición de Conceptos MARCO TEÓRICO Adolescentes Aborto Métodos para la realización del aborto METODOLOGÍA Tipos de estudio Muestra Criterios de inclusión Criterios de exclusión Técnica de recolección y análisis de datos Principios éticos Propiedad intelectual Nivel de riesgo ANÁLISIS Y RESULTADOS Descripción de los factores que influyen en las adolescentes a realizarse abortos peligrosos Categoría 1. Factores Personales Categoría 2. Factores Sociales Otros hallazgos CONCLUSIONES RECOMENDACIONES BIBLIOGRAFÍA ANEXOSPregradoProfesional en Enfermerí

Endothelial Damage in Sepsis: The Importance of Systems Biology

The early diagnosis and appropriate stratification of sepsis continues to be one of the most important challenges in modern medicine. Single isolated biomarkers have not been enough to improve diagnostic and prognostic strategies and to progress toward therapeutic goals. The information generated by the human genome project has allowed a more holistic approach to the problem. The integration of genomics, transcriptomics, proteomics and metabolomics in sepsis has allowed us to progress in the knowledge of new pathways which are pathophysiologically involved in this disease. Thus, we have understood the importance of and complex interaction between the inflammatory response and the endothelium. Understanding the role of important parts of the microcirculation, such as the endothelial glycocalyx and its interaction with the inflammatory response, has provided early recognition elements for clinical practice that allow the rational use of traditional medical interventions in sepsis. This comprehensive approach, which differs from the classical mechanistic approach, uses systems biology to increase the diagnostic and prognostic spectrum of endothelial damage biomarkers in sepsis, and to provide information on new pathways involved in the pathophysiology of the disease. This, in turn, provides tools for perfecting traditional medical interventions, using them at the appropriate times according to the disease's pathophysiological context, while at the same time discovering new and improved therapeutic alternatives. We have the challenge of transferring this ideal scenario to our daily clinical practice to improve our patients' care. The purpose of this article is to provide a general description of the importance of systems biology in integrating the complex interaction between the endothelium and the inflammatory response in sepsis

Tras la crisis, políticas públicas a favor del crecimiento económico

Índice I. Introducción Alma Chapoy y Patricia Rodríguez II. El temor a la inflación: un corolario de la crisis financiera Patricia Rodríguez III. Reflexiones críticas sobre el mecanismo de transmisión de la política monetaria del Banco de México Josefina León IV. Efectos de flujos-acervos de las políticas fiscal y monetaria en México Violeta Rodríguez V. Banca de Desarrollo, microempresas y pobreza Nora Ampudia VI. Financiarización de las entidades públicas en México. Un obstáculo al desarrollo Roberto Soto VII. Gastos de financiarización en la administración pública Diana Vicher VIII. Estrategias de la banca global en México Elizabeth Concha IX. Inversión, deuda y empresas: proceso de financiarización en México Teresa López y Jorge Bustamante. . . Este trabajo es fruto de sesudas discusiones en el seno de la Unidad de Economía Fiscal y Financiera del Instituto de Investigaciones Económicas de la UNAM. Los autores son destacados especialistas de la UNAM y de otras instituciones del país y del extranjero. En esta obra se acometen cuestiones de gran actualidad y de vital importancia para el futuro del país, teniendo como tónica la defensa de la soberanía nacional, basada no en actitudes emotivas, sino en argumentos firmemente sustentados en hechos y cifras. Estaría de más insistir en su trascendencia en momentos en que la corriente de pensamiento imperante y las instituciones financieras internacionales, insisten en que para estimular su desarrollo, los países en desarrollo y los emergentes deben mantener baja la inflación, equilibrado el presupuesto y abierta la cuenta de capital. Todas esas medidas en realidad han traído bajo crecimiento, alto desempleo y bajo uso del capital productivo. Prácticamente todos los autores alertan acerca de los peligros concretos que derivarían de seguirse aplicando en nuestro país ese tipo de políticas..

Cytokines and Inflammatory Mediators in Systemic Lupus Erythematosus

Systemic lupus erythematosus (SLE) is an autoimmune disease characterised by a breakdown in immune tolerance that induces an attack on normal tissues by the immune system. The dysfunction within both the innate and adaptive immune systems increases cytokine production, B lymphocytic overproduction of autoantibodies, and T lymphocyte activity. Cytokines and inflammatory mediators have been associated with several clinical endpoints, including the activity of disease and outcomes. In fact, some of them have been associated with different clinical subphenotypes (e.g., lupus nephritis), suggesting their role as biomarkers, and, in some cases, therapeutic targets. Thus, knowledge of the pathophysiological processes associated with the development of SLE could aid in setting up better diagnostic and therapeutic approaches to reduce the high burden of disease, and thus improve quality of life and outcomes. Herein, the authors have compiled a concise review of the clinically relevant cytokines and inflammatory mediators associated with SLE and its manifestations

Cytokine and autoantibody clusters interaction in systemic lupus erythematosus

Background: Evidence supports the existence of different subphenotypes in systemic lupus erythematosus (SLE) and the pivotal role of cytokines and autoantibodies, which interact in a highly complex network. Thus, understanding how these complex nonlinear processes are connected and observed in real-life settings is a major challenge. Cluster approaches may assist in the identification of these subphenotypes, which represent such a phenomenon, and may contribute to the development of personalized medicine. Therefore, the relationship between autoantibody and cytokine clusters in SLE was analyzed. Methods: This was an exploratory study in which 67 consecutive women with established SLE were assessed. Clinical characteristics including disease activity, a 14-autoantibody profile, and a panel of 15 serum cytokines were measured simultaneously. Mixed-cluster methodology and bivariate analyses were used to define autoantibody and cytokine clusters and to identify associations between them and related variables. Results: First, three clusters of autoantibodies were defined: (1) neutral, (2) antiphospholipid antibodies (APLA)-dominant, and (3) anti-dsDNA/ENA-dominant. Second, eight cytokines showed levels above the threshold thus making possible to find 4 clusters: (1) neutral, (2) chemotactic, (3) G-CSF dominant, and (4) IFN?/Pro-inflammatory. Furthermore, the disease activity was associated with cytokine clusters, which, in turn, were associated with autoantibody clusters. Finally, when all biomarkers were included, three clusters were found: (1) neutral, (2) chemotactic/APLA, and (3) IFN/dsDNA, which were also associated with disease activity. Conclusion: These results support the existence of three SLE cytokine-autoantibody driven subphenotypes. They encourage the practice of personalized medicine, and support proof-of-concept studies. © 2017 The Author(s)

México en la trampa del financiamiento. El sendero del no desarrollo

México se encuentra hoy día en medio de la trampa del financiamiento para el desarrollo. La financiarización transformó la rentabilidad económica en función del capital financiero y ahora no existe un sendero de crecimiento y desarrollo. La transición económica del modelo de sustitución de importaciones al modelo primario-exportador y maquilador ha conllevado una reorganización tanto del Estado como de los grupos de poder empresarial y financiero. Al inicio de la segunda década de este siglo, México se encuentra en el remolino de una crisis financiera, que culmina las crisis recurrentes por las que el país ha pasado en el transcurso de las últimas décadas. Se podría afirmar hoy que la economía mexicana de mayor crecimiento quizás es la que los migrantes llevan a cabo no solo en los estados fronterizos como Texas y California, sino en el resto de la Unión Americana. La trampa del financiamiento significa, sin lugar a dudas, la presencia de la financiarización con diferentes modalidades. En este libro, el lector encontrará buenos ejemplos de la interferencia de la financiarización en el desarrollo económico

Association between convalescent plasma treatment and mortality in COVID-19: a collaborative systematic review and meta-analysis of randomized clinical trials.

Funder: laura and john arnold foundationBACKGROUND: Convalescent plasma has been widely used to treat COVID-19 and is under investigation in numerous randomized clinical trials, but results are publicly available only for a small number of trials. The objective of this study was to assess the benefits of convalescent plasma treatment compared to placebo or no treatment and all-cause mortality in patients with COVID-19, using data from all available randomized clinical trials, including unpublished and ongoing trials (Open Science Framework, https://doi.org/10.17605/OSF.IO/GEHFX ). METHODS: In this collaborative systematic review and meta-analysis, clinical trial registries (ClinicalTrials.gov, WHO International Clinical Trials Registry Platform), the Cochrane COVID-19 register, the LOVE database, and PubMed were searched until April 8, 2021. Investigators of trials registered by March 1, 2021, without published results were contacted via email. Eligible were ongoing, discontinued and completed randomized clinical trials that compared convalescent plasma with placebo or no treatment in COVID-19 patients, regardless of setting or treatment schedule. Aggregated mortality data were extracted from publications or provided by investigators of unpublished trials and combined using the Hartung-Knapp-Sidik-Jonkman random effects model. We investigated the contribution of unpublished trials to the overall evidence. RESULTS: A total of 16,477 patients were included in 33 trials (20 unpublished with 3190 patients, 13 published with 13,287 patients). 32 trials enrolled only hospitalized patients (including 3 with only intensive care unit patients). Risk of bias was low for 29/33 trials. Of 8495 patients who received convalescent plasma, 1997 died (23%), and of 7982 control patients, 1952 died (24%). The combined risk ratio for all-cause mortality was 0.97 (95% confidence interval: 0.92; 1.02) with between-study heterogeneity not beyond chance (I2 = 0%). The RECOVERY trial had 69.8% and the unpublished evidence 25.3% of the weight in the meta-analysis. CONCLUSIONS: Convalescent plasma treatment of patients with COVID-19 did not reduce all-cause mortality. These results provide strong evidence that convalescent plasma treatment for patients with COVID-19 should not be used outside of randomized trials. Evidence synthesis from collaborations among trial investigators can inform both evidence generation and evidence application in patient care