2,394 research outputs found
Gli insetti al servizio degli inquirenti
Per molti anni gli insetti che popolavano la superficie e gli orifizi dei cadaveri sono stati considerati solo una presenza poco gradevole del lavoro dei medici legali e delle Forze dell'Ordine coinvolte nelle indagini inerenti a crimini violenti. Ma come gli intriganti romanzi di Deawer e della Cornwell ci hanno insegnato, gli insetti costituiscono dei silenziosi custodi di preziosi informazioni sull'accadimento di fatti a volte inspiegabili. Tuttavia mentre le varie branche delle scienze criminalistiche (la biologia, la balistica, la chimica, ecc.) hanno avuto nel tempo una crescita esponenziale, affinando tecniche e metodologie, lo studio degli insetti associati alla scena criminis è stato, nel nostro Paese per molto tempo sottovalutato o addirittura ignorato. L'Entomologia Forense è un ramo della zoologia dedicata allo studio degli insetti e di altri artropodi, dal cui esame è possibile ricavare elementi decisivi per la persecuzione di un reato. Negli ultimi anni tale disciplina ha visto crescere l'interesse da parte degli scienziati forensi, dei Medici Legali e delle Forze dell'Ordine, soprattutto in Europa e negli USA, dove esistono figure professionali specialistiche che affiancano la magistratura inquirente nella risoluzione di casi di morti sospette ed altri reati accomunati dalla presenza di insetti. Purtroppo in Italia solo da pochi anni si è sviluppato l'interesse verso la materia e ancora oggi gli entomologi forensi non lavorano sistematicamente accanto agli organi di Giustizia.
Lo scopo del presente lavoro è una disamina delle potenzialità dell'Entomologia Forense e delle relative applicazioni come strumento spesso determinante per la risoluzione di intriganti e complessi casi giudiziari
Usefulness of point shear wave elastography to assess the effects of extracorporeal shockwaves on spastic muscles in children with cerebral palsy: an uncontrolled experimental study
Neutron irradiation test on ATLAS MDT chambers
Abstract The Monitored Drift Tubes (MDT) chambers of the ATLAS muon spectrometer are crucial for the identification of high-momentum final-state muons, which represent very promising and robust signatures of physics at the LHC. They will operate in a high rate and high background environment and therefore their performances should not significantly degrade for the whole ATLAS data taking. The maximum expected total flux, mainly consisting of neutrons and photons in the MeV range, is of the order of 5 kHz/cm 2 for the barrel MDTs, while at SLHC, with machine working at higher luminosity, fluxes can be 10 times higher. To test detector robustness, a MDT test chamber was exposed to intensive neutron irradiation at the TAPIRO ENEA-Casaccia Research Center facility
A RAB35-p85/PI3K axis controls oscillatory apical protrusions required for efficient chemotactic migration
High USP6NL levels in breast cancer sustain chronic AKT phosphorylation and GLUT1 stability fueling aerobic glycolysis
USP6NL, also named RN-tre, is a GTPase activating protein (GAP) involved in control of endocytosis and signal transduction. Here we report that USP6NL is overexpressed in breast cancer (BC), mainly of the basal-like/integrative cluster 10 subtype. Increased USP6NL levels were accompanied by gene amplification and were associated with worse prognosis in the METABRIC dataset, retaining prognostic value in multivariable analysis. High levels of USP6NL in BC cells delayed endocytosis and degradation of the epidermal growth factor receptor (EGFR), causing chronic AKT activation. In turn, AKT stabilized the glucose transporter GLUT1 at the plasma membrane, increasing aerobic glycolysis. In agreement, elevated USP6NL sensitized BC cells to glucose deprivation, indicating that their glycolytic capacity relies on this protein. Depletion of USP6NL accelerated EGFR/AKT downregulation and GLUT1 degradation, impairing cell proliferation exclusively in BC cells that harbored increased levels of USP6NL. Overall, these findings argue that USP6NL overexpression generates a metabolic rewiring that is essential to foster the glycolytic demand of BC cells and promote their proliferation
The LBNO long-baseline oscillation sensitivities with two conventional neutrino beams at different baselines
The proposed Long Baseline Neutrino Observatory (LBNO) initially consists of
kton liquid double phase TPC complemented by a magnetised iron
calorimeter, to be installed at the Pyh\"asalmi mine, at a distance of 2300 km
from CERN. The conventional neutrino beam is produced by 400 GeV protons
accelerated at the SPS accelerator delivering 700 kW of power. The long
baseline provides a unique opportunity to study neutrino flavour oscillations
over their 1st and 2nd oscillation maxima exploring the behaviour, and
distinguishing effects arising from and matter. In this paper we
show how this comprehensive physics case can be further enhanced and
complemented if a neutrino beam produced at the Protvino IHEP accelerator
complex, at a distance of 1160 km, and with modest power of 450 kW is aimed
towards the same far detectors. We show that the coupling of two independent
sub-MW conventional neutrino and antineutrino beams at different baselines from
CERN and Protvino will allow to measure CP violation in the leptonic sector at
a confidence level of at least for 50\% of the true values of
with a 20 kton detector. With a far detector of 70 kton, the
combination allows a sensitivity for 75\% of the true values of
after 10 years of running. Running two independent neutrino
beams, each at a power below 1 MW, is more within today's state of the art than
the long-term operation of a new single high-energy multi-MW facility, which
has several technical challenges and will likely require a learning curve.Comment: 21 pages, 12 figure
Calibration model for the MDT chambers of the ATLAS Muon Spectrometer
The calibration procedures defined for the Monitored Drift Tube detectors of the ATLAS Muon Spectrometer are reviewed with special emphasis on the model developed and on the data processing. The calibration is based upon track segments reconstructed in the spectrometer, therefore the achievable accuracy depends upon the muon tracks statistics. The calibration parameters have to be produced, validated and made available to be used in reconstruction within one day from the end of the LHC fill. These requirements on the statistics and the latency dictated the development of a dedicated data stream for calibration. The data collection, processing and computing is described
Multiplicity and transverse momentum fluctuations in inelastic proton-proton interactions at the CERN Super Proton Synchrotron
Measurements of multiplicity and transverse momentum fluctuations of charged
particles were performed in inelastic p+p interactions at 20, 31, 40, 80 and
158 GeV/c beam momentum. Results for the scaled variance of the multiplicity
distribution and for three strongly intensive measures of multiplicity and
transverse momentum fluctuations \$\Delta[P_{T},N]\$, \$\Sigma[P_{T},N]\$ and
\$\Phi_{p_T}\$ are presented. For the first time the results on fluctuations
are fully corrected for experimental biases. The results on multiplicity and
transverse momentum fluctuations significantly deviate from expectations for
the independent particle production. They also depend on charges of selected
hadrons. The string-resonance Monte Carlo models EPOS and UrQMD do not describe
the data. The scaled variance of multiplicity fluctuations is significantly
higher in inelastic p+p interactions than in central Pb+Pb collisions measured
by NA49 at the same energy per nucleon. This is in qualitative disagreement
with the predictions of the Wounded Nucleon Model. Within the statistical
framework the enhanced multiplicity fluctuations in inelastic p+p interactions
can be interpreted as due to event-by-event fluctuations of the fireball energy
and/or volume.Comment: 18 pages, 12 figure
Measurements of , , , and proton production in proton-carbon interactions at 31 GeV/ with the NA61/SHINE spectrometer at the CERN SPS
Measurements of hadron production in p+C interactions at 31 GeV/c are
performed using the NA61/ SHINE spectrometer at the CERN SPS. The analysis is
based on the full set of data collected in 2009 using a graphite target with a
thickness of 4% of a nuclear interaction length. Inelastic and production cross
sections as well as spectra of , , p, and are
measured with high precision. These measurements are essential for improved
calculations of the initial neutrino fluxes in the T2K long-baseline neutrino
oscillation experiment in Japan. A comparison of the NA61/SHINE measurements
with predictions of several hadroproduction models is presented.Comment: v1 corresponds to the preprint CERN-PH-EP-2015-278; v2 matches the
final published versio
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