67 research outputs found
Phase II study of epirubicin, oxaliplatin and docetaxel combination in metastatic gastric or gastroesophageal junction adenocarcinoma
- Author
- Publication venue
- BioMed Central
- Publication date
- 01/01/2009
- Field of study
<p>Abstract</p> <p>Background</p> <p>This phase II study was designed to evaluate the activity and safety of a combination of epirubicin, oxaliplatin and docetaxel in metastatic gastric or gastroesophageal junction (GEJ) adenocarcinoma.</p> <p>Methods</p> <p>Forty patients with measurable distant metastases received epirubicin 50 mg/m<sup>2</sup>, docetaxel 60 mg/m<sup>2 </sup>followed by oxaliplatin 100 mg/m<sup>2 </sup>on day 1 of each 21-day cycle. Primary end point was response rates (RR).</p> <p>Results</p> <p>All patients were evaluable. The overall RR was 47.5% (95% confidence interval (CI) 32–63). The disease control was 80%. Median time for response was 6 weeks. Median time to progression was 6.3 months (95% CI 5.4–7.2) and the median overall survival time was 12.1 months (95% CI 10.7–13.5). Grade 3/4 neutropenia occurred in 50% of patients with two episodes of febrile neutropenia (5%). Other non-hematological grade 3 toxicities included sensory neuropathy in two patiens (5%), vomiting and mucositis in two patients (5%) and diarrhea in one patient (2.5%).</p> <p>Conclusion</p> <p>The combination of epirubicin, oxaliplatin and docetaxel was found to be effective and well tolerated in patiens with metastatic gastric or GEJ adenocarcinoma and maybe an appropriate regimen to be used in the neoadjuvant setting and with molecularly targeted agents.</p
Original Climax Films: historicizing the British hardcore pornography film business
- Author
- Alilunas Peter.
- Chibnall Steve.
- Chibnall Steve.
- Cox Barry
- Di Lauro Al
- Flint David.
- Goldstein Murray.
- Hebditch David
- Heffernan Kevin.
- Kerekes David.
- Kuhn Annette.
- Larsson Mariah.
- Long Stanley
- Manchester Colin.
- McGillivray David.
- Mort Frank.
- Nordstrøm Jon.
- Pearson John.
- Perkins Murray.
- Reekie Duncan.
- Robertson Geoffrey.
- Sheridan Simon.
- Stevenson Jack.
- Summers Judith.
- Tarrant Shira.
- Taylor Lawrence S.
- Thompson Dave.
- Tomkinson Martin.
- Walsh David.
- Weeks Jeffrey.
- Wood Franklyn.
- Publication venue
- 'Informa UK Limited'
- Publication date
- 07/12/2018
- Field of study
This article presents findings from my research into the British hardcore pornography business. Porn studies has given little coverage to the British pornography business, with much of the academic literature focusing on the American adult entertainment industry. Recently, there has been a rising interest in the historical framework of porn cinemas both in popular culture and in academic work. This article contributes to this debate, taking both a cultural and an economic approach to explore the conditions that led to the emergence of British hardcore production as an alternative economy in the 1960s. In this economy, entrepreneurs make use of new technologies to produce artefacts that are exchanged for an economic benefit, while circumventing laws to distribute their artefacts. To historicize this economy, I draw on ethnohistorical research, which includes interviews with people involved in the British hardcore business and archival research. I argue that a combination of glamour filmmaking, a relaxation of political and cultural attitudes towards sexuality, the location of Soho, London, and emerging technologies for producing films collectively contribute to the emergence of an alternative economy of British hardcore production. I focus specifically on the practices of two entrepreneurs within this economy, Ivor Cook and Mike Freeman, considering how their actions inadvertently created the British hardcore film business, and played a significant role in the development of hardcore production outside of the United Kingdom
Characterisation of male breast cancer: a descriptive biomarker study from a large patient series
- Author
- A Albergaria
- A Hurtado
- A Pich
- A Pinero
- A Stang
- AC Wolff
- ALR Lubbock
- AM Shaaban
- AM Shaaban
- C Rudlowski
- D Rayson
- DC Allred
- DJ Best
- DM Plesan
- FS Al-Joudi
- G Masci
- GM Callagy
- I Johansson
- J Brandt
- J Ferlay
- J Wang-Rodriguez
- J White
- J Zhu
- JL Clark
- JP Leone
- K He
- KS Zaret
- L Di Lauro
- L Ottini
- LM McShane
- M Dowsett
- M Ferreira
- MG Joshi
- MH Abreu
- MM Lacle
- MP Humphries
- P Willsher
- R Kornegoor
- R Zhou
- RS Gonzalez
- S Badve
- S Deb
- S Gill
- S Giordano
- S Liukkonen
- S Milias
- SA Andres
- T Younis
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2017
- Field of study
Male breast cancer (MBC) is rare. We assembled 446 MBCs on tissue microarrays and assessed clinicopathological information, together with data from 15 published studies, totalling 1984 cases. By immunohistochemistry we investigated 14 biomarkers (ERα, ERβ1, ERβ2, ERβ5, PR, AR, Bcl-2, HER2, p53, E-cadherin, Ki67, survivin, prolactin, FOXA1) for survival impact. The main histological subtype in our cohort and combined analyses was ductal (81%, 83%), grade 2; (40%, 44%), respectively. Cases were predominantly ERα (84%, 82%) and PR positive (74%, 71%), respectively, with HER2 expression being infrequent (2%, 10%), respectively. In our cohort, advanced age (>67) was the strongest predictor of overall (OS) and disease free survival (DFS) (p = 0.00001; p = 0.01, respectively). Node positivity negatively impacted DFS (p = 0.04). FOXA1 p = 0.005) and AR p = 0.009) were both positively prognostic for DFS, remaining upon multivariate analysis. Network analysis showed ERα, AR and FOXA1 significantly correlated. In summary, the principle phenotype of MBC was luminal A, ductal, grade 2. In ERα+ MBC, only AR had prognostic significance, suggesting AR blockade could be employed therapeutically
Outcomes from elective colorectal cancer surgery during the SARS-CoV-2 pandemic
- Author
- 14 | COVIDSurg COllabOratIVe Tzovaras G. (General University Hospital of Larissa)
- Aawsaj Y.
- Abad Gurumeta A.
- Abad-Motos A.
- Abate E.
- Abbott D.
- Abdalla M.
- Abdeldayem H.
- Abdelkader Salama I.
- Abdelkarim M.
- Abdur-Rahman L.
- Abel M. K.
- Aboelkassem Ibrahim A.
- Abou Chaar M. K.
- Abreu da Silva A.
- Abubakar A.
- Acebes García F.
- Achalandabaso Boira M. Sales Mallafré R. (Hospital Universitari de Tarragona Joan XXIII)
- Acher A.
- Acrich E.
- Adamina M.
- Aderombi A.
- Adeyeye A.
- Adiamah A.
- Afonso J.
- Agapov M.
- Agnes A.
- Agostini C.
- Agresta F.
- Aguado H. (Hellín Hospital)
- Aguilar Gonzalez M. Talukder S. (West Suffolk Hospital)
- Ahmed Z.
- Ahmeidat A.
- Ahn J. H.
- Aiken T.
- Aimé A.
- Akalin M.
- Akaydin E.
- Akhtar M. A.
- Akhter Rahman M. M.
- Akin E.
- Al Awwad S.
- Al Habes H.
- Al Maadany F. S. (Al-Jalaa Hospital)
- Al- Khayal K.
- Al- Najjar H.
- Al-Habsi R.
- Al-Masri M.
- Al-Mohammad A.
- Alaa S.
- AlAamer O.
- Aladeojebi A.
- Alam F.
- Alawneh F. (King Hussein Cancer Center). Libya: Alkadeeki G.
- Albertsmeier M.
- Alcaide Matas F.
- Aldokali N.
- Alemanno G.
- Alfieri S.
- Alghamdi M.
- Alhamed A.
- Alharthi M.
- Alhassan N.
- Ali M.
- Ali S.
- Aliyeva Z.
- Aljiffry M.
- Alma Mater Studiorum University of Bologna)
- Almeida A. C.
- Almeida J. I.
- Almeida-Reis R.
- Alnumani T. (King Fahad 16 | COVIDSurg COllabOratIVe General Hospital)
- Alobeed O.
- Alonso de la Fuente N. Jimenez Toscano M. (Hospital del Mar)
- Alonso Poza A.
- Alonso- Lamberti L.
- Alqannas M.
- Alselaim N. (King Saud Bin Abdulaziz University for Health Sciences
- Alshammari S.
- Alsharif F.
- Altintoprak F.
- Alvarez E.
- Alyami M.
- Alzamanan M.
- Amaral M. J.
- Amin Sahid N.
- Amira G.
- Amorim E.
- Anania G.
- Anastasi A.
- Andrade R.
- Angelou D.
- Annamalai S.
- Annessi V.
- Antic A.
- Antonopoulou M. I.
- Anula R.
- Aou Sassari)
- Aprile A.
- Argentina: Alurralde C.
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- Arrowsmith L. Campbell W. (Causeway Hospital)
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- Campus Benjamin Franklin)
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- Cassinotti E. (Fondazione IRCCS Ca’ Granda – Ospedale Maggiore Policlinico di Milano)
- Castellammare di Stabia)
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- Clifford R.
- Clinical Centre of Serbia)
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- Coughlin P.
- COVIDSurg COllabOratIVe | 15 Violante T. (IRCCS Azienda Ospedaliero – Universitaria di Bologna
- Cozza V.
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- Cuneo)
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- Davies R. J.
- Day A. (East Surrey Hospital)
- De Andres Olabarria U.
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- De Lacy F. B.
- De Manzoni Garberini A. (Ospedale Civile Spirito Santo)
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- De Nardi P.
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- De Sousa X. (Centro Hospitalar de Setúbal)
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- Delimpalta C.
- Dellaportas D.
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- Demir H.
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- Demyttenaere S.
- Denet C.
- Depalma N.
- Department of Biomedical Sciences
- Derksen T.
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- Dincer H. A. Erol T. (Hacettepe University Hospital)
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- Donati D.
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- Duchalais E. (Nantes University Hospital). Germany: Bork U.
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- EPE)
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- General Surgery Department)
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- Government Medical College). Ireland: Aremu M.
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- Health Affairs
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- Sánchez- Pernaute A.
- Sánchez- Rubio M.
- Sánchez-García S.
- Taddei A.
- Tadic B.
- Taibi A. (Chu Limoges)
- Talal El-Abur I.
- Talwar R. (Luton and Dunstable University Hospital)
- Tammaro P.
- Tan J. A.
- Tan X. S.
- Tanal M.
- Tang A. M.
- Tanzanu M.
- Tartaglia D. (Azienda Ospedaliero Universitaria Pisana)
- Tasis N. (Athens Naval and Veterans Hospital)
- Tatar O. C.
- Tavares F.
- Tayeh S. (Homerton University Hospital)
- Tebala G. D.
- Teixeira J. (Centro Hospitalar Universitário do Algarve – Unidade de Faro)
- Teixeira M. (Centro Hospitalar do Tamega e Sousa)
- Tejero- Pintor F. J. (Hospital Universitario Río Hortega)
- Testa V. (Santa Croce E. Carle Hospital
- Tewari N. (University Hospitals Coventry and Warwickshire NHS Trusts)
- Tezas S. (Furness General Hospital)
- Thaha M.
- Thanapal M. R. (Hospital Kuala Lumpur)
- Theodosopoulos T.
- Theophilidou E. (Royal Derby Hospital)
- Thian A.
- Thomas A. (Royal Liverpool University Hospital)
- Thompson D. (Morriston Hospital Swansea)
- Thornhill M. (Dell Seton Medical Center at the University of Texas)
- Thrumurthy S. (Epsom and St Helier University Hospitals NHS Trust)
- Thulasiraman S. V.
- Timbrell S.
- Tirloni L.
- Titu S. (Prof. Dr. Ion Chiricuta Institute of Oncology). Russia: Garmanova T.
- Tonini V. (S. Orsola-Malpighi Hospital)
- Torres A. (Hospital Clínico de Madrid)
- Torres Arcos C.
- Townson A.
- Trabulsi N. (King Abdulaziz University Hospital)
- Travaglio E. (Regina Montis Regalis Hospital
- Tribillon E. (Institut Mutualiste Montsouris)
- Troncoso Pereira P. (Hospital Mateu Orfila)
- Tropeano F. P. (Federico II University Hospital)
- Trujillo Díaz J.
- Tsai L.
- Tsarkov P.
- Tsiamalou I.
- Tsiaoussis I.
- TU Dresden)
- Tucci R. (Azienda Ospedaliera Universitaria Careggi)
- Tufo A. (Ospedale del Mare)
- Tugmen C.
- Tulina I. (Clinic of Coloproctology and Minimally Invasive Surgery
- Tuncer K.
- Turnbull A. (Victoria Hospital Kirkcaldy)
- Turrado-Rodriguez V.
- Turri G. (Azienda Ospedaliera Universitaria Integrata di Verona)
- Tweedle E. (Addenbrooke’s Hospital)
- Ugarte-Sierra B. (Hospital Universitario de Galdakao)
- Uludağ S. S.
- Umair M.
- Universiti Sains Malaysia)
- University of Amsterdam)
- Università di Ferrara)
- Université Mohammed V Rabat). Netherlands: Hompes R.
- Uras C. (Acibadem Maslak Hospital)
- Urbani A. (Azienda Ospedaliero Universitaria San’anna)
- Urbieta A. (Hospital Universitario la Paz)
- Uslu G.
- Utkan N. Z.
- Uyanik M. S. (Samsun Training and Research Hospital)
- Uzunoglu F. G. (University Medical Center Hamburg–Eppendorf). Greece: Antonakis P.
- Vaccarella G. (Azienda Ospedaliera Ospedali Riuniti Villa Sofia-Cervello)
- Valbuena Jabares V. (Marqués de Valdecilla University Hospital)
- Valdes- Hernandez J. (Hospital Universitario Virgen Macarena)
- Valero Soriano M. (Hospital General Reina Sofía)
- Valle Rubio A. (Getafe University Hospital)
- Valverde S. (Hospital Clinic Barcelona)
- Van den Eynde J.
- Van den Eynde R. (Uz Leuven). Bulgaria: Sokolov M. (University Hospital Alexandrovska). Canada: Boutros M.
- Varma M. (University of California
- Vasljević J.
- Vassiliu P. (Attikon University General Hospital)
- Vaz Pereira R.
- Vaz S. (Centro Hospitalar e Universitário de São João)
- Velchuru V.
- Velickovic D. (Clinic for Digestive Surgery
- Velidedeoglu M.
- Venn M. (Royal London Hospital)
- Venskutonis D. (Lithuanian University of Health Sciences Kaunas Clinical Hospital). Madagascar: Rasoaherinomenjanahary F.
- Vera Mansilla C. (Hospital Universitario Principe de Asturias)
- Verberne C. (John Radcliffe Hospital)
- Vergari R. (Ospedali Riuniti di Ancona)
- Vernon L. (Cork University Hospital)
- Vervoort D.
- Vescio G. (University ‘Magna Graecia’ of Catanzaro)
- Vezakis A. (Aretaieion Hospital)
- Videira J. F. (IPO Porto). Réunion: Kassir R.
- Vieira B. (Centro Hospitalar de Trás-Os-Montes e Alto Douro
- Vieira Caroço T. (IPO Coimbra)
- Vieira Paiva Lopes A. C. (Hospital de Torres Vedras – Centro Hospitalar do Oeste)
- Vignali A. (San Raffaele Scientific Institute
- Vigorita V. (Álvaro Cunqueiro Hospital)
- Vijayan D. (Queen Elizabeth Hospital Birmingham)
- Villalabeitia Ateca I. (Hospital Universitario Cruces)
- Vimalachandran D. (Countess of Chester Hospital)
- Viswanath Y. K. S. (James Cook University Hospital)
- Vitali A. (Ospedale San Giovanni di Dio)
- Vitone L. (Royal Blackburn Hospital)
- Vives R. V. (Bellvitge University Hospital)
- Vo U. G. (Fiona Stanley Hospital)
- Von Papen M.
- Vovola F. (Ospedali Riuniti Azienda Ospedaliera Universitaria Foggia)
- Vucic N.
- Vázquez Fernández A. (Hospital Clínico Universitario de Valladolid)
- Wadham B. (The University Hospital of South Manchester)
- Walkes K. (Queen Elizabeth Hospital). Belgium: Flamey N.
- Wani R. (Sher-I-Kashmir Institute of Medical Sciences)
- Waqar S. H. (Pakistan Institute of Medical Sciences). Poland: Major P. (Jagiellonian University Medical College). Portugal: Azevedo C.
- Warren O. (Chelsea and Westminster Hospital)
- Watson L. J. (Sunderland Royal Hospital)
- Watson N. (King’s Mill Hospital)
- Weitz J.
- Welsch T. (Carl-Gustav-Carus University Hospital
- Werner J. (LMU Klinikum Campus Innenstadt)
- Westwood E. (James Paget University NHS Foundation Trust Hospital)
- Whelan M. (Tallaght University Hospital)
- Whitmore H. (Torbay and South Devon NHS Trust)
- Wilkin R. J. W. (South Warwickshire NHS Foundation Trust)
- Wilkins A. (Hull University Teaching Hospitals NHS Trust)
- Williams G. (Royal Gwent Hospital)
- Williams K. (St George’s Hospital)
- Wilson M. (Forth Valley Royal Hospital)
- Wimmer A. (Paracelsus Medical University Salzburg). Barbados: Barker D.
- Wong M.
- Worku D. (Queens Medical Centre)
- Wullschleger M. (Gold Coast University Hospital)
- Xavier R. G.
- Xenaki S.
- Xynos E. (University Hospital of Heraklion Crete and Interclinic Hospital of Crete). Hong Kong: Futaba K.
- Yang W.
- Yassin N. (Royal Wolverhampton NHS Trust)
- Ye G.
- Yesantharao P.
- Yetkin S. G. (Sisli Hamidiye Etfal Training and Research Hospital)
- Yeşilyurt D. (University of Health Sciences Tepecik Training and Research Hospital)
- Yiallourou A. (Nicosia General Hospital). Czechia: Martinek L.
- Yıldırım A.
- Yildiz A. (Yildirim Beyazit University Yenimahalle Training and Research Hospital). Uganda: Lule H.
- Young R. (York Teaching Hospitals NHS Trust)
- Yousof E. A. (Assiut University Hospital)
- Youssef M. (Norfolk and Norwich University Hospital)
- Yurttas C. (University Hospital Tuebingen)
- Yánez C. (Royo Villanova)
- Yüksel E. (Kocaeli University Teaching Hospital)
- Zafar S. N. (University of Wisconsin)
- Zakaria A. D.
- Zakaria Z. (School of Medical Sciences and Hospital
- Zambon M. (Policlinico Umberto I Sapienza University of Rome)
- Zanus G. (Ca’ Foncello Treviso – DISCOG – Università di Padova)
- Zegarac M. (Institute for Oncology and Radiology of Serbia)
- Zelić M. (University Hospital Center Rijeka)
- Zengin A. K. (Istanbul Universty – Cerrahpaşa Medical Faculty)
- Zerbib P. (CHU Lille)
- Zervas K.
- Zese M. (Santa Maria degli Angeli Hospital ULSS 5 – Adria)
- Zhang H. (Concord Repatriation General Hospital)
- Zizzo M. (Azienda Unità Sanitaria Locale – IRCCS di Reggio Emilia)
- Zografos C. (Laiko University Hospital)
- Zorrilla Ortúzar J. (Hospital General Universitario Gregorio Marañón)
- Zourntou S. (General Hospital of Larissa ‘Koutlimpaneio and Triantafylleio’)
- Zubaidi A. M. (King Saud University). Serbia: Aleksić L.
- Ângelo M.
- Çelebi F.
- Çolak E.
- Öfner D. (Medical University of Innsbruck)
- Öhlberger L.
- Özçelık M. F.
- Öğücü H.
- Überrück L.
- Ćoza I.
- Publication venue
- 'Wiley'
- Publication date
- 01/01/2020
- Field of study
This study aimed to describe the change in surgical practice and the impact of SARS-CoV-2 on mortality after surgical resection of colorectal cancer during the initial phases of the SARS-CoV-2 pandemic
SARS-CoV-2 susceptibility and COVID-19 disease severity are associated with genetic variants affecting gene expression in a variety of tissues
- Author
- Aarno Palotie
- Abdolmajid Hosseini
- Abdulaziz AlMalik
- Abdulraheem Alshareef
- Achille Iolascon
- Adam S. Butterworth
- Afshar Etemadi Aleagha
- Agnese Verzuri
- Agostino Ognibene
- Agostino Riva
- Ahmadreza Niavarani
- Ahna Girshick
- Aida Fiz-Lopez
- Alba Parra Martınez
- Albandary M. Alowayn
- Albert Tenesa
- Albert V. Smith
- Alessandra Guarnaccia
- Alessandra Renieri
- Alessandra Stella
- Alessandra Vergori
- Alessandro Pancrazzi
- Alessia Giorli
- Alex Serra-Llovich
- Alex Soriano
- Alex Stuckey
- Alexander Labkowsky
- Alexander T. Williams
- Alexander W. Charney
- Alexandra Aksentijevich
- Alexandre Belisle
- Ali Amirsavadkouhi
- Ali Sobh
- Alice Donati
- Alicia de Felipe Mimbrera
- Alicia R. Martin
- Alireza Adamsara
- Altaf Ali
- Amal Al Mutairi
- Amin K. Khattab
- Amr M. Yassen
- Amr Samir
- Amy Trankiem
- Anastasia Lucas
- Andre G. Uitterlinden
- Andrea Antinori
- Andrea Cossarizza
- Andrea Ganna
- Andrea Ganna
- Andrea Martın-Nalda
- Andrea Tommasi
- Andres Metspalu
- Andrew Beck
- Andrew P. Boughton
- Anil P. S. Ori
- Ann E. Woolley
- Anna Canaccini
- Anna Carreras
- Anna Dominguez-Mayoral
- Anna L. Guyatt
- Anna M. Planas
- Anna Maria Pinto
- Annarita Giliberti
- Anne E. Justice
- Anne Kallaste
- Anne Marie O’Connell
- Anne Richmond
- Anne Richmond
- Anne-Sophie Sauvage
- Annique Claringbould
- Anoud Albader
- Antonella D’Arminio Monforte
- Antonella Vincenti
- Antonio Di Biagio
- Antonio Perrella Francesco Bianchi
- Anu Tamm
- Anurag Verma
- Archie Campbell
- Archie Campbell
- Arianna Emiliozzi
- Arianna Gabrieli
- Aris Baras
- Arthur Timothy D
- Asher Haug Baltzell
- Ashish Yadav
- Athanasios Kousathanas
- Attia A. S. Mohamed
- Aubrey Annis
- Augusto Rendon
- Avromie Karp
- Bader Alghamdi
- Bahareh Sharififard
- Bandar A. Suliman
- Barbara Rossetti
- Bari Britvan
- Bartlomiej P. Przychodzen
- Beatriz Cortes
- Beatriz Dietl
- Ben M. Brumpton
- Benjamin M. Neale
- Benoit Misset
- Bernard Lambermont
- Bhavi Trivedi
- Binglan Li
- Biswarup Ghosh
- Bjørn Olav Asvold
- Bluma Brenner
- Brett L. Collins
- Brooke Rhead
- Brooke Wolford
- Brooke Wolford
- Brooke Wolford Sebastian Zo¨ llner
- Bruno Frediani
- Carlo Rivolta
- Carlos Domingo
- Carlota Dobano
- Carmelo Piscopo
- Carmen Marciano
- Carolina Medina-Gomez
- Caroline Cusick
- Caroline Hayward
- Caroline Hayward
- Caterina Lo Rizzo
- Catherine A. Ball
- Catherine E. Bee
- Catherine John
- Cathy Voide
- Cesira Nencioni
- Charlotte Guzman
- Chiara Barbieri
- Chiara Batini
- Chiara Fallerini
- Chiara Gabbi
- Chiara Spertilli
- Chloe Fawns-Ritchie
- Chloe Fawns-Ritchie
- Chris C. A. Spencer
- Chris Tselios
- Christelle Meuris
- Christian Von Frenckell
- Christine Stevens
- Christine Stevens
- Christopher A. Odhams
- Christopher J. Griffiths
- Christopher J. O’Donnell
- Christopher R. Gignoux
- Christos Polymeropoulos
- Chureerat Phokaew
- Claire Churchhouse
- Claudia Suardi
- Claudio Ferri
- Clive Hoggart
- Cotton Seed
- CRiPSI
- Cristen Willer
- Cristina Mussini
- D'Antonio Matteo
- D'Antonio-Chronowska Agnieszka
- Daiana Aguero
- Dan Mason
- Daniel Auld
- Daniel E. Kaufmann
- Daniel I. Chasman
- Daniel J. Wilson
- Daniel King
- Daniel M. Jordan
- Daniel Rader
- Daniel Rhodes
- Daniela Francisci
- Danielle Henry
- Danilo Tacconi
- Danny Park
- Darin Adra
- Dave J. Carey
- David A. van Heel
- David Bennett
- David Bernardo
- David Dalmau
- David H. Wyllie
- David J. Porteous
- David J. Porteous
- David R. Morrison
- David Torrents
- Davide Grassi
- Davide Romani
- Deema AlZahrani
- Derrick W. Crook
- Dhryata Kamdar
- Diana Alaverdian
- Diego Ripamonti
- Dionysios Neofytos
- Doaa Shahin
- Domenico A. Coviello
- Dona Baraka
- Donatella Acquilini
- Dorota Pasko
- Douglas M. Shaw
- Duncan Emma
- Duncan S. Palmer
- Ebrahim S. Mahmoud
- Ebtehal Alsolm
- Eco (E. J. C. ) de geus
- Edoardo Conticini
- Edward J. Hollox
- Edward Laane
- Eimear E. Kenny
- Elena Andreucci
- Elena Bargagli
- Elena Desanctis
- Elena Jimenez-Xarrie
- Elena Muino
- Eliecer Coto
- Elisa Arribas
- Elisa Benetti
- Elisa Frullanti
- Elisabetta Menatti
- Elisabetta Schiaroli
- Elizabeth G. Atkinson
- Elizabeth W. Karlson
- Eman Barhoush
- Emanuele Catena
- Emanuele Di Angelantonio
- Emma F. Perez
- Emma L. Adams
- Ene Reimann
- Enrico Martinelli
- Eric E. Schadt
- Erik Solligard
- Erwin Schurr
- Esteban Lopera
- Esther Gonzalez-Villa
- Eugenia Quiros-Roldan
- Eurie L. Hong
- F. Kyle Satterstrom
- Fabio Lena
- Faisal Almalki
- Fatimah Alqubaishi
- Fawz Al Harthi
- Federica Gaia Miraglia
- Federico Anedda
- Federico Franchi
- Ferdinando Giannattasio
- FHoGID RegCOVID
- Filippo Aucella
- Filippo Biscarini
- FinnGen
- Floriana Valentino
- Francesca Andretta
- Francesca Fava
- Francesca Gatti
- Francesca Mari
- Francesca Montagnani
- Francesco Castelli
- Francesco Paciosi
- Francesco Paciosi
- Francesco Raimondi
- Francesco Vladimiro Segala
- Francisca Ruiz-Jaen
- Francisco Lozano
- Franco Maggiolo
- Frazer
- Frederic Frippiat
- G. Mark Lathrop
- Gabriella Coiro
- Gabriella Doddato
- Gabriella Maria Squeo
- Gavin Band
- Geetha Chittoor
- Gemma Castano-Vinyals
- Gemma Serrano-Heras
- Genes &
- Genevieve Roberts
- Genni Spargi
- Georgia Chan
- Giada Beligni
- Gian Piero Caldarelli
- Gianfranco Parati
- Gilles Darcis
- Gillian M. Belbin
- Gina Peloso
- Giordano Botta`
- Girish N. Nadkarni
- Gita A. Pathak
- Gita A. Pathak
- Giulianini Franco
- Giuseppe Fiorentino
- Giuseppe Merla
- Giusy Tiseo
- Gloria Pessina
- Goncalo R. Abecasis
- Gopal Sarma
- Guillaume Butler-Laporte
- Guillaume ButlerLaporte
- Guillermo M. Albaiceta
- Hadeel AlBardis
- Hakon Hakonarson
- Hakon Hakonarson
- Hamed Abdollahi
- Hani Al-Afghani
- Hannah Polikowski
- Hanteera S. Moahmed
- Harendra Guturu
- Health Research Team
- Helene Alavere
- Hengameh Ansari Tadi
- Hilary C. Martin
- Hilary Finucane
- Howard D. Sesso
- Hugo Zeberg
- Hung-Hsin Chen
- Huy Nguyen
- Ilaria Meloni
- Ilaria Rancan
- Iman Almohammed
- Immacolata Andolfo
- Inge Ringmets
- Irene Salib
- Irene van Blokland
- Isabella Zanella
- Israel Fernandez-Cadenas
- Ivan Galvan-Femenia
- J. Brent Richards
- J. Brent Richards
- J. Michael Gaziano
- Jaana Pesukova
- Jack A. Kosmicki
- Jacob Armstrong
- Jacqueline I. Goldstein
- Jahad Alghamdi
- Jaime Masjuan
- James B. Meigs
- James F. Wilson
- Jara Carcel-Marquez
- Jean-Baptiste Giot
- Jehad K. Albakri
- Jehan J. El-Jawhari
- Jekaterina Tabri
- Jennifer Below
- Jennifer E. Huffman
- Jennifer R. Harris
- Jessica Jacques
- Jiannis Ragoussis
- Jing Hua Zhao
- Jiongming Wang
- Joan Marti-Fabregas
- Joan Montaner Villalonga
- JoAnn E. Manson
- Joel Starkopf
- John Danesh
- John Wright
- Jonathan Afilalo
- Jonathan Grip
- Jonathan Shortt
- Jonathon LeFaive
- Jordan W. Smoller
- Jordi Perez-Tur
- Josep L. Bedini
- Josep Maria Mercader
- Josep Mercader
- Joseph B. Leader
- Joseph B. McCormick
- Joseph D. Buxbaum
- Joseph R. Glessner
- Joseph T. Glessner
- Jouke Jan Hottenga
- Juan Gomez
- Judith Garcia-Aymerich
- Judith. M. Vonk
- Judy H. Cho
- Juha Karjalainen
- Julie E. Buring
- Julie E. Horowitz
- Julien Guiot
- Julien Guntz
- Junghyun Jung
- Justine K. Rudkin
- Kai Kisand
- Kamal Okasha
- Karen A. Hunt
- Kari North
- Karolina Chwialkowska
- Katherine Keller
- Kathleen C. Barnes
- Kathrin Aprile von Hohenstaufen
- Kati Donner
- Kati Hensen
- Kati Kristiansson
- Katia Capitani
- Katja Kivinen
- Keith Noto
- Kelly A
- Kelly Cho
- Kenton D’Mellow
- Kevin W. Li
- Konrad J. Karczewski
- Kristi Lall
- Kristi Niblo
- Kristian Hveem
- Kristin Rand
- Kristin Tsuo
- Kristina Zguro
- Kristjan Metsalu
- Kristy Crooks
- Kumar Veerapen
- Kumardeep Chaudhary
- Kyle Gettler
- Laetitia Laurent
- Laia Llucia-Carol
- Laila Al-Awdah
- Lara Lloret Iglesias
- Lara Tang
- Laura Bergantini
- Laura D. Venn
- Laura Di Sarno
- Laura G. Sloofman
- Laura M. Huckins
- Lauro Sumoy
- Leen Abu Safieh
- Leonardo Croci
- Leonardo Marquez
- Lia Crotti
- Liam L. Hiester
- Lili Milani
- Lill-Iren S. Trogstad
- Lindo Nkambul
- Lindokuhle Nkambul
- Lindokuhle Nkambul
- Lindokuhle Nkambule
- Lindokuhle Nkambule
- Lorenzo Salerni
- Louis Petitjean
- Louise V. Wain
- Loukas Moutsianas
- Luca Cantarini
- Luca Guidelli
- Luca Masucci
- Lude Franke Marike Boezen
- Luisa Tavecchia
- Luong Ruiz
- M. Arfan Ikram
- Maarja Lepamets
- Madeleine Durand
- Madonna M. Eltoukhy
- Maha Albeladi
- Mahmoud Abdel-Aziz
- Mairo Puusepp
- Malak Abedalthagafi
- Manal Alaamery
- Manolis Kogevinas
- Mansour Almutairi
- Manuel A. R. Ferreira
- Marc Afilalo
- Marcela Morris
- Marco Castori
- Marco Falcone
- Marco Feri
- Marco Gori
- Marco Mandala`
- Marco Rizzi
- Marco Tanfoni
- Marco Vecchia
- Margherita Baldassarri
- Mari E. K. Niemi
- Mari E. K. Niemi
- Mari E. K. Niemi
- Mari E. K. Niemi
- Mari E. K. Niemi
- Mari Kaunisto
- Maria Antonietta Mazzei
- Maria Antonietta Mencarelli
- Maria Bandini
- Maria J. Arranz
- Maria Lorubbio
- Maria Palmieri
- Maria Teresa La Rovere
- Marie Coignet
- Marie Thys
- Mario Capasso
- Mario Tumbarello
- Mario Umberto Mondelli
- Marissa Zyndorf.
- Mark Daly
- Mark J. Caulfield
- Markus Perola
- Marta Corridi
- Marta Garcıa-Clemente
- Marta GuindoMartinez
- Marta L. DeDiego
- Martin D. Tobin
- Marwa H. Elnagdy
- Mary Ann Belli
- Mary K. Balaconis
- Marylyn D. Ritchie
- Masahiro Kanai
- Masahiro Kanai
- Masahiro Kanai
- Massimiliano Fabbiani
- Massimo Carella
- Massimo Di Pietro
- Massimo Girardis
- Massimo Mangino
- Massimo Vaghi
- Mathieu Quinodoz
- Matsui Hiroko
- Matteo Bassetti
- Matteo Della Monica
- Matteo Siano
- Matthew C. Gass
- Matthew Solomonson
- Matthew Solomonson
- Matti Pirinen
- Mattia Cordioli
- Mattia Cordioli
- Mattia Cordioli
- Mattia Cordioli
- Mattia Cordioli
- Mattia Cordioli
- Mattia Cordioli
- Mattia Cordioli
- Maureen Oliveira
- Maurizio Bussotti
- Maurizio Sanarico
- Maurizio Sanguinetti
- May Alrashed
- Meike Bartels
- Melania Degli Antoni
- Menachem Zlatopolsky
- Meriem Bouab
- Miao Zhang
- Michael Gaddis
- Michael Hultstro¨ m
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- Michael Peruggia
- Michael Preuss
- Michae¨ l Chasse´
- Michel (M. G. ) Nivard
- Michel Georges
- Michel Moutschen
- Michelle Daya
- Mihael H. Polymeropoulos
- Miklos Lipcsey
- Milos Pavlovic
- Mirella Bruttini
- Miriam Lucia Carriero
- Miriana D’Alessandro
- Mirjam Lista
- Mohamed A. F. Hegazy
- Mohamed R. El-shanshory
- Mohamed S. Abd Elghafar
- Mohamed S. Torky
- Mohammad S. Fawzy
- Mohammed A. Eid
- Mona Sawaji
- Moneera Alswailm
- Monica Poscente
- Monnat Pongpanich
- Monpat Chamnanphon
- Morteza Saeedi
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- Nathalie Brassard
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- Nathan Cheng
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- Nguyen Jennifer P
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- Nick Shrine
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- Noemie Suh
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- Olav Rooyackers
- Olivier Malaise
- Olumide Adeleye
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- Per Magnus
- Pere Soler
- Petty E. Lauren
- Phil Tsao
- Philippe Le´ onard
- Pier Giorgio Scotton
- Pierpaolo Parravicini
- Pierre Lepage
- Pierre-Yves Bochud
- Pietro Pinoli
- Pimpayao Sodsai
- Pintip Suchartlikitwong
- Prabhu Arumugam
- Qin Qin Huang
- Rachel G. Liao
- Rafael de Cid
- Raffaele Bruno
- Raffaele Scala
- Raghavendran Partha
- Rahul Gupta
- Raili Allos
- Rana Hasanato
- Rasoul Aliannejad
- Ravaglia Sabrina
- Raymond K. Walters
- Reedik Magi
- Renato Polimanti
- Renzo Scaggiante
- Riccardo Colombo
- Richard C. Trembath
- Richard H. Scott
- Richard J. Packer
- Rita Perna
- Roaa T. Halawani
- Robert C. Free
- Robert C. Green
- Robert Frithiof
- Robert P. Sebra
- Robert Warmerdam
- Roberta Russo
- Roger Colobran
- Ron Do
- Rosangela Artuso
- Rossella Tita
- Rui Li
- Ruth J. F. Loos
- Ryan C. Thompson
- Sabine Claassen
- Sabino Scolletta
- Sabrina Ravaglia
- Saeideh Ahmadi
- Salam Massadeh
- Saleh Alqahtani
- Sam Bryant
- Sam Bryant
- Sam Choi
- Sameer Chavan
- Sameera AlJohani
- Sami Koskelainen
- Samira Azarzar
- Samuli Ripatti
- Sandra P. Smieszek
- Sandro Mancarella
- Sandro Panese
- Sanni Ruotsalainen
- Sara Alotaibi
- Sara Amitrano
- Sara Pigazzini
- Sara Pigazzini
- Sara Pigazzini
- Sara Pigazzini
- Sarah Alkwai
- Sarah Finer
- Sarah G. Earle
- Sauro Luchi
- Saverio Giuseppe Parisi
- Scott T. Weiss
- Sebastian Garcıa Madrona
- Semira Gonseth Nussle
- Serafina Valente
- Serena Ludovisi
- Serghei Mangul
- Sergio Daga
- Seyed Behrooz Mohseni Moghaddam
- Shang-Kuan Lin
- Shannon McCurdy
- Shawn N. Murphy
- Shawneequa Callier
- Shea J. Andrews
- Shea J. Andrews
- Shea J. Andrews
- Shefali S. Verma
- Shona M. Kerr
- Silvia Baroni
- Silvia Cappelli
- Silvia Rojo
- Simona Dei
- Simona Marcantonio
- Simona Sarzi-Braga
- Simone Furini
- Slayton J. Underwood
- Sophie Venturelli
- Souad Rahmouni
- Spencer Knight
- Stefania Mantovani
- Stefano Baratti
- Stefano Busani
- Stefano Ceri
- Stefano Rusconi
- Stephanie Bibert
- Stephen J. Wicks
- Steven Ascolillo
- Ste´ phanie Gofflot
- Stuart C. Sealfon
- Susan Walker
- Susanna Croci
- Susanna Guerrini
- Tala Abdullah
- Tamer A. Elhadidy
- Tess Levy
- Thanyawee Puthanakit
- Thitima B. Suttichet
- Tim D. Spector
- Tiziana Bachetti
- Tom Fowler
- Tomas Segura
- Tomislav Maricic
- Tomoko Nakanishi
- Tomoko Nakanishi
- Tonu Esko
- Tooraj Mirshahi
- Tormod Rogne
- Triin Laisk
- Tullio Trotta
- Valentina Anemoli
- Vasilios Polymeropoulos
- Veronica Rico
- Veronica Robles
- Ve´ronique Erard
- Victor Moreno
- Vincent Mooser
- Vincenzo Forgetta
- Vincenzo Forgetta
- Voraphoj Nilaratanakul
- Vorasuk Shotelersuk
- Walaa A. Felemban
- Walaa M. El-Lawaty
- Walid T. Khafaga
- Wanna Chetruengchai
- Watsamon Jantarabenjakul
- Wei Zhou
- Wei Zhou
- Wenhan Lu
- Werner Albrich
- Xavier Farre
- Xiao Chang
- Xiao Chang
- Xiaoqing Xue
- Xueyang Wang
- Yan V. Sun
- Yaseen M. Arabi
- Yasmine Belhaj
- Yasser M. El-Sherbiny
- Yen-Chen Anne Feng
- Yuk-Lam Ho
- Yuki Bradford
- Yunsung Lee
- Yuval Itan
- Yves Beguin
- Zaman Afrasiabi
- Zeinab Naderpour
- Zhu Wanying
- Ziab Z. Alahmadey
- Øyvind Helgeland
- Publication venue
- 'Elsevier BV'
- Publication date
- 01/01/2022
- Field of study
Variability in SARS-CoV-2 susceptibility and COVID-19 disease severity between individuals is partly due to
genetic factors. Here, we identify 4 genomic loci with suggestive associations for SARS-CoV-2 susceptibility
and 19 for COVID-19 disease severity. Four of these 23 loci likely have an ethnicity-specific component.
Genome-wide association study (GWAS) signals in 11 loci colocalize with expression quantitative trait loci
(eQTLs) associated with the expression of 20 genes in 62 tissues/cell types (range: 1:43 tissues/gene),
including lung, brain, heart, muscle, and skin as well as the digestive system and immune system. We perform
genetic fine mapping to compute 99% credible SNP sets, which identify 10 GWAS loci that have eight or fewer
SNPs in the credible set, including three loci with one single likely causal SNP. Our study suggests that the
diverse symptoms and disease severity of COVID-19 observed between individuals is associated with variants across the genome, affecting gene expression levels in a wide variety of tissue types
The impact of surgical delay on resectability of colorectal cancer: An international prospective cohort study
- Author
- Abadia M
- Abassy J
- Abate E
- Abbott Tom EF
- Abdelaal Samir A
- Abdeldayem H
- Abdelkabir M
- Abdelsamed A
- Abdulwahed E
- Abiyere H
- Abou Chaar MK
- Abukhalaf SA
- Abukhalaf Sadi
- Adamina Michel
- Ademuyiwa Adesoji
- Ademuyiwa Adesoji O
- Adeyeye A
- Adisa Adewale
- Afzal MF
- Agarwal Arnav
- Aggarwal M
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- Agostini C
- Agrawal A
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- Aguiar Junior S
- Ahmed A
- Ahmed K
- Ahmed Nafees R
- Ahmed Z
- Ahn JH
- Aime A
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- Akkulak Murat
- Akrivou D
- Al Abdallah M
- Al Riyami S
- Al Sayed M
- Al-Masri M
- Al-Najjar H
- Al-Slaibi I
- Alaa S
- Alakaloko Felix
- Alameer Ehab
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- Alawneh F
- Albertsmeier M
- Albertsmeier Markus
- Alderson Derek
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- Alkadiki Ghadah Z
- Almaadany Faraj S
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- Alser Osaid
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- Alvarez MR
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- Publication venue
- 'Royal College of Obstetricians & Gynaecologists (RCOG)'
- Publication date
- 01/06/2022
- Field of study
AIM: The SARS-CoV-2 pandemic has provided a unique opportunity to explore the impact of surgical delays on cancer resectability. This study aimed to compare resectability for colorectal cancer patients undergoing delayed versus non-delayed surgery. METHODS: This was an international prospective cohort study of consecutive colorectal cancer patients with a decision for curative surgery (January-April 2020). Surgical delay was defined as an operation taking place more than 4 weeks after treatment decision, in a patient who did not receive neoadjuvant therapy. A subgroup analysis explored the effects of delay in elective patients only. The impact of longer delays was explored in a sensitivity analysis. The primary outcome was complete resection, defined as curative resection with an R0 margin. RESULTS: Overall, 5453 patients from 304 hospitals in 47 countries were included, of whom 6.6% (358/5453) did not receive their planned operation. Of the 4304 operated patients without neoadjuvant therapy, 40.5% (1744/4304) were delayed beyond 4 weeks. Delayed patients were more likely to be older, men, more comorbid, have higher body mass index and have rectal cancer and early stage disease. Delayed patients had higher unadjusted rates of complete resection (93.7% vs. 91.9%, P = 0.032) and lower rates of emergency surgery (4.5% vs. 22.5%, P < 0.001). After adjustment, delay was not associated with a lower rate of complete resection (OR 1.18, 95% CI 0.90-1.55, P = 0.224), which was consistent in elective patients only (OR 0.94, 95% CI 0.69-1.27, P = 0.672). Longer delays were not associated with poorer outcomes. CONCLUSION: One in 15 colorectal cancer patients did not receive their planned operation during the first wave of COVID-19. Surgical delay did not appear to compromise resectability, raising the hypothesis that any reduction in long-term survival attributable to delays is likely to be due to micro-metastatic disease
Effects of hospital facilities on patient outcomes after cancer surgery: an international, prospective, observational study
- Author
- A Yacoub M.
- A. Adam M.
- A. Nassar M.
- A. Nemer A.
- Aahlin E. K.
- Ab Rahim M. F.
- Abad Gurumeta A.
- Abad-Motos A.
- Abang Jamari D. Z. H.
- Abantanga F.
- Abarca S.
- Abazid E.
- Abbas A.
- Abbas K.
- Abbas M. M.
- Abbasy J.
- Abbosh A.
- Abd B.
- Abd Karim M. F. S.
- Abd Wahab H. H.
- Abdalei A.
- Abdalla Ahmed Elkamel A.
- Abdallah A.
- AbdAllah M. S. M.
- Abdel Malik A. B.
- Abdelhady Mousa H.
- Abdelhady S.
- Abdelhakim A.
- Abdelkader M.
- Abdelkawy S.
- Abdelkhalek M.
- Abdellatif E.
- Abdelmaksoud Tawakel N.
- Abdelmohsen N.
- Abdelmotaleb I.
- Abdelrazek A.
- Abdelsalam I.
- Abdelshakour M.
- Abdelwahed A. M.
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- Abdou A. O.
- Abdou H.
- Abdul Aziz M. R.
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- Yuksel O.
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- Yusuf B.
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- Zahra B.
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- Zakaria Z.
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- Zammit M.
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- Zattoni D.
- Zavala G.
- Zawahrah H.
- Zeiton A.
- Zeko A.
- Zeng Z.
- Zeromskas P.
- Zhang G.
- Zhivkov E.
- Zid E.
- Zidan A. M.
- Zielasek C.
- Zilinskas J.
- Zimmermann B.
- Ziprin P.
- Zizzo M.
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- Zoikas A.
- Zorrilla Matilla L. P.
- Zoulamoglou M.
- Zreeg D.
- Zub-Pokrowiecka A.
- Zubiaurre V.
- Zuhdy M.
- Zuikyte D.
- Zuloaga Fernandez del Valle C. J.
- Zulu S.
- Zumbakys
- Zupan D.
- Publication venue
- 'Elsevier BV'
- Publication date
- 01/01/2022
- Field of study
Background Early death after cancer surgery is higher in low-income and middle-income countries (LMICs) compared with in high-income countries, yet the impact of facility characteristics on early postoperative outcomes is unknown. The aim of this study was to examine the association between hospital infrastructure, resource availability, and processes on early outcomes after cancer surgery worldwide.Methods A multimethods analysis was performed as part of the GlobalSurg 3 study-a multicentre, international, prospective cohort study of patients who had surgery for breast, colorectal, or gastric cancer. The primary outcomes were 30-day mortality and 30-day major complication rates. Potentially beneficial hospital facilities were identified by variable selection to select those associated with 30-day mortality. Adjusted outcomes were determined using generalised estimating equations to account for patient characteristics and country-income group, with population stratification by hospital.Findings Between April 1, 2018, and April 23, 2019, facility-level data were collected for 9685 patients across 238 hospitals in 66 countries (91 hospitals in 20 high-income countries; 57 hospitals in 19 upper-middle-income countries; and 90 hospitals in 27 low-income to lower-middle-income countries). The availability of five hospital facilities was inversely associated with mortality: ultrasound, CT scanner, critical care unit, opioid analgesia, and oncologist. After adjustment for case-mix and country income group, hospitals with three or fewer of these facilities (62 hospitals, 1294 patients) had higher mortality compared with those with four or five (adjusted odds ratio [OR] 3.85 [95% CI 2.58-5.75]; p<0.0001), with excess mortality predominantly explained by a limited capacity to rescue following the development of major complications (63.0% vs 82.7%; OR 0.35 [0.23-0.53]; p<0.0001). Across LMICs, improvements in hospital facilities would prevent one to three deaths for every 100 patients undergoing surgery for cancer.Interpretation Hospitals with higher levels of infrastructure and resources have better outcomes after cancer surgery, independent of country income. Without urgent strengthening of hospital infrastructure and resources, the reductions in cancer-associated mortality associated with improved access will not be realised
Albiglutide and cardiovascular outcomes in patients with type 2 diabetes and cardiovascular disease (Harmony Outcomes): a double-blind, randomised placebo-controlled trial
- Author
- Abbas Jalal
- Abraham Sybil
- Ackert Jessica
- Adams Patricia
- Aggarwala Gaurav
- Aher Nutan
- Ahlqvist Jørn
- Ahn Chul Woo
- Akers Teresa
- Akhras Ronald
- Akhter Faiq
- Aksentyev Sergey
- Al Kawas Firas
- Alexander Karen
- Althouse Denise
- Altobelli Desma
- Alvarisqueta Andres
- Ambrosy Andrew
- Andersen James
- Andersen Ulla
- Anderson Michelle
- Anglade Moise
- Arbañil Hugo
- Arciszewska Malgorzata
- Argoud Georges
- Ariani Mehrdad
- Ashdji Reswan
- Avogaro Angelo
- Avramidis Iakovos
- Axthelm Christoph
- Aye Myint
- Babi Charleen
- Bachus Erasmus
- Baik Sei-Hyun
- Bailey Matt
- Bakhtari Ladan
- Baksi Arun
- Balasubramani Mathangi
- Baldovino Jorge
- Banach Marek
- Banerjee Subhash
- Bartlett Andrew
- Bartone Susan
- Baum Howard
- Bays Harold
- Bazhan Larysa
- Beasley Richard
- Beaudry Yves
- Beaulieu Gail
- Beboso Ronnie
- Bedard Jacques
- Beijerbacht Hugo Peter
- Belfort de Aguiar Renata
- Benjamin Sabrina
- Berger Dirk
- Berlingieri Joseph
- Berndtsson Blom Katarina
- Besada Diego
- Bethel M Angelyn
- Bhagwat Ravi
- Bhargava Anuj
- Bhosale Archana
- Bieler Tasso
- Bijata-Bronisz Renata
- Birkeland Kare
- Birkenfeld Andreas
- Blagden Mark
- Bloomfield Gerald
- Bode Bruce
- Boemi Massimo
- Bonadonna Riccardo
- Bondar Irina
- Bott Jochen
- Bousboulas Stavros
- Boye Alain
- Bratcher Christina
- Breneman Jody
- Briskin Toby
- Bristianou Magdalini
- Brockmyre Andrew
- Broughton Raymond
- Brown Judith
- Brown Kim
- Brychta Tomas
- Brønnum-Schou Jens
- Budhraja Madhusudan
- Bull Georgina
- Bundy Charles
- Burgess Lesley
- Busch Klaus
- Caca Karel
- Cadinot Didier
- Calderon Jorge
- Calella Pedro
- Califf Robert M
- Calvo Gómez Carlos
- Camacho Luis
- Cannon Kevin
- Cano Rodríguez Isidoro
- Cantero Maria Cecilia
- Carr Jewell
- Casson Ed
- Castaño Patricia
- Castro Conde Almudena
- Cathcart Harold
- Cavale Arvind
- Cech Vladimir
- Cequier Fillat Angel
- Cervantes-Escárcega Jose-Luis
- Cha Bong-Soo
- Chau Tuan
- Chaykin Louis
- Chehayeb Raja
- Chen David
- Chen Jung-Fu
- Chertkoff Alejandro
- Cheung Deanna
- Cheung Stephen
- Chevts Julia
- Chiang Chern-En
- Childress Richard
- Christian Tamra
- Chung Choon-Hee
- Coetzee Kathleen
- Cohen Allan
- Coker Rebecca
- Cole Joanna
- Collier Jeannie
- Condit Jonathan
- Consoli Agostino
- Conway James
- Cooksey Erin
- Cookson Tobias
- Cooper John
- Cooper Lauren
- Copland Allan
- Cornel Jan
- Cornett George Mitchell
- Crenier Laurent
- Cuadrado Jesus
- Cuatrecasas Cambra Guillem
- Cusson Jean
- D'Agostino Ralph B
- D'Agostino Ralph B.
- Daga Shruti
- Damyanova Velichka
- Dauber Ira
- Davila William
- Dawood Saleem
- De Armas Luis
- De Cosmo Salvatore
- De Loredo Luis
- De Teresa Parreño Luis
- de Álvaro Moreno Fernando
- Dean Julius
- Debroye Corinne
- Del Prato Stefano
- Del Prato Stefano
- Delgado Lista Javier
- Della Siega Anthony
- DeMets David
- Demidova Irina
- Derezinski Tadeusz
- Deshpande Sameer
- Detweiler Robert
- Devore Adam
- Di Bartolo Paolo
- Di Giovanna Michael
- Diaz Ernesto
- Dimitriadis Georgios
- Dimitrov Stefan
- Distiller Larry
- Dombrowski Keith
- Dominguez Andrea
- Domínguez Escribano José Ramón
- Donaldson Jill
- Donaubauer Torsten
- Dor Isaac
- Dotta Francesco
- Dreval Alexander
- Drummond Waymon
- Dumas Richard
- Dumbre Snehal
- Dungan Kathleen
- Durán García Santiago
- Duyck Francis
- Dvorakova Eva
- Dzongowski Peter
- Eagerton Donald
- Eapen Zubin
- Earl John
- Eaton Charles
- Ebo Geraldine
- Edelsberger Tomas
- Eliasson Bjorn
- Eliasson Ken
- Elisaf Moses
- Ellison Howard
- Elvira González Javier
- Emslie-Smith Alistair
- Endsley Patricia
- Enns Robert
- Erlinger Rudolf
- Ershova Olga
- Español Maria Vanesa
- Espinoza Augusto Dextre
- Farris Neil
- Ferguson Murdo
- Fernandez-Salazar Eva
- Fernández Rodríguez José María
- Fiel Thomas
- Finkelstein Hernan
- Firek Anthony
- First Brian
- Fleming John
- Flota-Cervera Luis Fernando
- Forgosh Les
- Frechtel Gustavo
- French William
- Fretes Jose
- Friedman Daniel
- Frontoni Simona
- Funke Klaus
- Fushtey Ivan
- Gadzinski Waldemar
- Gajek Jacek
- Galatius Søren
- Galetta Marianna
- Galstyan Gagik
- Gambineri Alessandra
- Gandy Winston
- Garcia Ronald
- Garganeeva Alla
- Garrido Santos Natalia
- Garrido Elizabeth
- Garvey Louisa
- Gaudet Daniel
- Gazzaruso Carmine
- Gentry Tracy
- Giaccari Andrea
- Gill Santosh
- Giorgino Francesco
- Goday Arno Alberto
- Godse Rupali
- Gomez Huelgas Ricardo
- Gonzales Rolando Vargas
- Gonzalez Joaquin
- González Juanatey José Ramón
- González-González José Gerardo
- Goodman Shaun
- Gordon Murray
- Gouet Didier
- Grachova Mariya
- Granger Christopher B
- Granger Christopher B.
- Green Fiona
- Green Jennifer B
- Green Jennifer B
- Greene Deb
- Greene Stephen
- Grondin Francois
- Grosskopf Josef
- Groutars Reginald G.E.J.
- Guerci Bruno
- Guice Michael
- Guimaraes Patricia
- Gulseth Hanne
- Gummadi Siva
- Gunstone Anthony
- Gupta Anil
- Gupta Milan
- Gupta Nikita
- Guttormsen Gaute
- Ha JuYoung
- Hackenyos Jonathan
- Haddock Trevorlyn
- Hagenow Andreas
- Hairston Kristen
- Hajdú Csaba
- Halciakova Katarina
- Halperin Frank
- Haluzik Martin
- Hamann Monika
- Hanson Lenita
- Haque Ghazala
- Harcsa Eleonóra
- Harris Tara
- Harrison Lindsay
- Harrison Rob
- Hartard Manfred
- Hartman Israel
- Heitner John
- Hejeebu Srini
- Henry Patrick
- Hereghty Belinda
- Hermany Paul
- Hernandez Mijares Antonio
- Hernandez Adrian F
- Hernandez Adrian F.
- Hernandez-Cassis Carlos
- Heymer Peter
- Hidalgo Horacio
- Higgins Alexander
- Hoek Boudewijn A
- Holman Rury
- Hoogslag Pieter A.M.
- Houle Pierre-Alain
- Hove Jens
- Howell Christina
- Hramiak Irene
- Huppertz Wolfgang
- Hutayanon Pisit
- Ibrahim Hassan
- Illies Gabriele
- Issa Basil
- Izmozherova Nadezhda
- Jackson-Voyzey Ewart
- Jacob Stephan
- Jacobs Shahram
- James Kourtnei
- James Rachel
- Jang Hak Chul
- Janmohamed Salim
- Janmohamed Salim
- Jarosz Marie
- Jenkins Wendy
- Jensen Jan Skov
- Jerjes-Díaz Carlos Sánchez
- Jiménez Díaz Víctor Alfonso
- Jintapakorn Woravut
- Jodar Gimeno Esteban
- Johnson Andrew
- Johnson David
- Johnson Megan
- Jones Michael
- Jones Nigel P
- Jones Nigel P
- Jordan Dedrick
- Joshi Parag
- Jung Thomas
- Kadgaonkar Neha
- Kahrmann Gerd
- Karetnikova Victoria
- Karka Mounika
- Karmalkar Anisha
- Kast Petra
- Kaster Steven
- Katerenchuk Vitaliy
- Kellerer Monika
- Kellum Daniel
- Kelly Aoife
- Kempe Hans-Peter
- Kessler Laurence
- Khandelwal Chaitali
- Kharakhulakh Marina
- Khariouzov Andrei
- Khokhlov Aleksandr
- Kim Chong-Jin
- Kim Christopher
- Kim Ellen
- Kim Hye Soon
- Kim In Joo
- Kirby William
- Klausmann Gerhard
- Klein Christiane
- Kleinecke-Pohl Uwe
- Kleinertz Klaus
- Klodawska Katarzyna
- Knouse Albert
- Kobalava Zhanna
- Kober Lars
- Koch Thorsten
- Kocsis Gyozo
- Kolls Brad
- Kong David
- Konyves Laszlo
- Kooy Adriaan
- Korpachev Vadym
- Kosch Christine
- Koshelskaya Olga
- Kosiborod Mikhail
- Koskinen Pekka
- Kosmacheva Elena
- Kostin Vladimir
- Kotsa Kalliopi
- Kouz Simon
- Kovacheva Snezhina
- Kovacs Christopher
- Koziolova Natalia
- Kragten Johannes A.
- Kravchun Nonna
- Kristiansen Ole Peter
- Krizova Jarmila
- Krzyzagorska Ewa
- Kulback Steven
- Kulkarni Mangesh
- Kumar Mariananda
- Kumar Rakesh
- Kumar Somesh
- Kumari Aditi
- Kuruvanka Tulsidas
- Kuzin Anatoly
- Labroo Ajay
- Lalau Jean-Daniel
- Landry Daniel
- Larin Oleksandr
- Larnefeldt Hans
- Lasswell William
- Lastuvka Jiri
- Lauder Steven
- Lauro Davide
- Lee Eun Young
- Lee Hyoung Woo
- Lee Kwan-Woo
- Lee Moon Kyu
- Leiter Lawrence A
- Leiter Lawrence A.
- Lentz John
- Lenzmeier Thomas
- Lesnov Victor
- Lewis David
- Li Wenyan
- Li Zhaoping
- Lieverse Aloysius G.
- Lif-Tiberg Cornelia
- Lillestol Michael
- Linderfalk Carina
- Lindsay Alistair
- Little Raymond
- Litvak Marcos
- Llamas Edmundo-Alfredo Bayram
- Lokhngina Yuliya
- Lombard Landman
- Longley Troy
- Lonn Eva
- Lopes Renato
- Lopez-Sendon Jose
- Lorimer Jamie
- Lorra Babette
- Lorraine Richard
- Loureyro Juan
- Lozanov Lachezar
- Lucas Morante Tomás
- Luedemann Joerg
- Luna Alejandro
- Lund Gustav
- Lund Per
- Lundman Pia
- Luttermann Matthias
- Lysenko Tatyana
- Maclean Malcolm
- Madej Andrzej
- Maffei Laura
- Makotoko Ellen
- Maldonado Natacha
- Mandal Trisha
- Mandawat Aditya
- Mankovsky Boris
- Manrique Helard
- Marazuela Monica
- Margaritov Viktor
- Markov Valentin
- Marquess Marsha
- Martell Claros Nieves
- Mathews Robin
- Mathieu Chantal
- Mauricio Puente Didac
- Maxeiner Stephan
- Mayorov Alexander
- McGuire Darren
- McKeown-Biagas Cecilia
- McKnight John
- McLaughlin Patricia
- McMurray John J.V.
- McMurray John J.V.
- McNeill Robert
- Mehta Anand
- Mehta Rajendra
- Melchior Thomas
- Melidonis Andreas
- Melloni Chiara
- Mena Ribas Elena
- Merino Torres Juan Francisco
- Mezquita Raya Pedro
- Mhambrey Ankita
- Miekus Pawel
- Migdalis Ilias
- Mihaylova-Shumkova Rositsa
- Milek Karsten
- Miller Alan
- Miller Diane
- Mitrakou Asimina
- Moelle Andrea
- Mohr Gasparini Diego
- Moiseev Sergey
- Moodley Rajendran
- Moon Keon-Woong
- Morales-Palomares Ellen
- Moran Joseph
- Morawski Emily
- Moris Linda
- Mucsi János
- Murphy Karen
- Muzulu Solomon
- Muñoz Ernesto German Cardona
- Myasoedova Svetlana
- Mykhalchyshyn Galyna
- Myshanych Halyna
- Nadar Madhumitha
- Nadar Venkatesh
- Naicker Pallavi
- Namgung June
- Nauck Michael
- Neumann Gerhard
- Nikolaeva Antoaneta
- Nischik Ruth
- Noronha Drusilla
- Nubiola Calonge Andreu
- Nyvad Ole
- O'Connell Ian
- O'Connor Thomas
- O'Mahony William
- Odio Alberto
- Oehrig-Pohl Edith
- Oleksyk Olga
- Olesinska-Mader Martyna
- Olsson Åke
- Oosthuysen Wessels
- Opiela Jaroslaw
- Ordoñez Sánchez Xavier
- Orio Silvia
- Orlenko Valeriia
- Orsi Emanuela
- Overton Robert
- Oyesile Babatunde
- Ozaki Risa
- Pagkalos Emmanouil
- Paolisso Giuseppe
- Papanas Nikolaos
- Pappas Angelos
- Park Kyong Soo
- Parker Reginald
- Pascoe-Gonzalez Sara
- Pascual Izuel Jose Maria
- Pashkovska Nataliia
- Patel Chetan
- Patel Prashant
- Patel Rajesh
- Patel Rajivkumar
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- Patil Suradnya
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- Pauker Zsolt
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- Perez Soto Isabel
- Perez Kathleen
- Perriello Gabriele
- Pertseva Nataliia
- Pesarchick Jean
- Peterson Sean
- Petit Catherine
- Petrosyan Olena
- Petró Gizella
- Petunina Nina
- Philip Sam
- Phillips Lawrence
- Phrommintikul Arintaya
- Piatti Piermarco
- Pinto Miguel
- Piperek Martin
- Plassmann Georg
- Plés Zsolt
- Pohlmeier Lars
- Pontiroli Antonio
- Ponzani Paola
- Pope Connie
- Potnis Omkar
- Povsic Thomas
- Prakash Rahul
- Price Lauren
- Price-Olsen Emma
- Proepper Felix
- Prymkova Vera
- Pérez Pérez Antonio
- Quesada Charneco Miguel
- Quesada Simón Angustias
- Raad George
- Raclavska Lea
- Rahman Aref
- Raikhel Marina
- Raisinghani Ajit
- Rajan Raj
- Ramirez-Diaz Santiago-Paulino
- Raorane Amruta
- Rasouli Neda
- Rauzi Frank
- Rebrov Andrey
- Redón Mas Josep
- Regner Stefan
- Rego Iraeta Antonia
- Reich Dennis
- Rethaford Renee
- Revesz Katalin
- Revoredo Frederick Massucco
- Rich Jenny
- Richards Jackie
- Riddle Matthew
- Rieker Werner
- Rincon Luis Zapata
- Rivellese Angela Albarosa
- Rodriguez Alvarez Maria
- Rodriguez Papini Nelson
- Rodríguez Rodríguez Irene
- Roe Matthew
- Rohr Kathryn
- Romanczuk Piotr
- Rose Ludger
- Roseman Hal
- Rosenberg Anne
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- Roush Jennifer
- Rovner Sergio
- Russell Rachael
- Ruyatkina Ludmila
- Saba Fadi
- Sabol Mary Beth
- Sabán Ruiz José
- Sachson Richard
- Sahu Shruti
- Sala Jorgelina
- Saldana-Mendoza Arturo
- Salmonsson Staffan
- Samer Holger
- Samoylova Julia
- Sampanis Christos
- Sandhu Chamandeep
- Sanmartin Berglund Johan
- Sansanayudh Nakarin
- Sarvan Mohamed
- Saswadkar Aarti
- Sauter Joachim
- Sazonova Olga
- Schabauer Alex
- Schaper Frank
- Scheen André
- Schiffer Clemens
- Schleiden Debra
- Schmidt Juergen
- Schneider Ricky
- Scholz Bernd-M.
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- Schubert Jessica
- Schuchard Timothy
- Schultheis Ron
- Schulze Joerg
- Schuyler Jones William
- Schygiel Pablo
- Sedani Sangeeta
- Segner Alexander
- Sensenbrenner John
- Sesti Giorgio
- Seufert Jochen
- Shaik Fayaz
- Shannon Jennifer
- Sharma Abhinav
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- Shavadia Jay
- Shestakova Marina
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- Shinde Rakesh
- Shitut Aditi
- Shlesinger Yshay
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- Singh Narendra
- Sivalingam Kanagaratnam
- Sjöberg Folke
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- Smirnov Ivan
- Smith Paul
- Smith Peter
- Soffer Joseph
- Sokolova Nadezhda
- Solanki Sheetal
- Somerville Matthew
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- Soto González Alfonso
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- Sposetti Georgina
- Srimahachota Suphot
- St-Maurice Francois
- Stankiewicz Andrzej
- Stasinska Teresa
- Stead Janet
- Steindorf Joerg
- Stewart Murray
- Stockhausen Juergen
- Stone Allegra
- Stonesifer Larry
- Storey Daniel
- Stoyanova Zhasmina
- Stuebler Petra
- Suh David
- Sukumaran Usha
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- Sándor Vangel
- Söderberg Stefan
- Taeschner Heidrun
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- Tahir Mohammed
- Tan Anjanette
- Tan Choon Beng Kathryn
- Tan Marilyn
- Taylon Alain
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- Thakkar Maitreya
- Thomas Betsy
- Thorpe Karl
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- Thuan Jean-Francois
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- Tinahones Madueno Francisco
- Tirador Louie
- Tonolo Giancarlo
- Torres-Colores Jose Juan
- Torstensson Ingemar
- Trescoli Serrano Carlos
- Trevisan Roberto
- Tricoci Pierluigi
- Tripathy Devjit
- Trznadel-Morawska Iwona
- Tsapas Apostolos
- Tschoepe Diethelm
- Tseng Shih-Ting
- Tu Shih-Te
- Tugwell Barna
- Tzatzagou Glykeria
- Ulied Armiñana Angels
- Ulla Maria
- Urbanek Robin
- Uwaifo Gabriel
- Van Gaal Luc
- Vandyne Beth
- Vaphare Ashok
- Vasilevskaya Olga
- Vass Viktor
- Vedere Amarnath
- Vemulapalli Sreekanth
- Venugopal Chandra
- Verbovaya Nelli
- Vercammen Chris
- Verra Fernando
- Vidrio-Velázquez Maricela
- Viergever Eric P.
- Villagordoa-Mesa Juan
- Vishneva Elena
- Vizel Saul
- Vlasenko Maryna
- Vo Anthony
- Voinot Christel
- Vorobyev Sergey
- Vorokhobina Natalya
- Vouillarmet Julien
- Vrkoc Jan
- Wang Chih-Yuan
- Wang Ji-Hung
- Watson Anthony
- Watson David
- Welch Michelle
- Welker James
- White Alexander
- Wilhelm Karl
- Willis John
- Wilson Matt
- Wilson Tim
- Witek Robert
- Wium Cecilie
- Womer Terese
- Woo Vincent
- Wraight Ella
- Wynne Alan
- Xing Weibing
- Yamwong Sukit
- Yazdani Shahram
- Ye June
- Yoo Soon Jib
- Yordanov Victor
- Yu Jaemyung
- Zabalua Silvina
- Zaidman Cesar
- Zang Eddie
- Zanozina Olga
- Zeller-Stefan Helga
- Zhdanova Elena
- Zlova Tetiana
- Zubiate Carlos
- Zykova Tatyana
- Publication venue
- 'Elsevier BV'
- Publication date
- 01/01/2018
- Field of study
Background:
Glucagon-like peptide 1 receptor agonists differ in chemical structure, duration of action, and in their effects on clinical outcomes. The cardiovascular effects of once-weekly albiglutide in type 2 diabetes are unknown. We aimed to determine the safety and efficacy of albiglutide in preventing cardiovascular death, myocardial infarction, or stroke.
Methods:
We did a double-blind, randomised, placebo-controlled trial in 610 sites across 28 countries. We randomly assigned patients aged 40 years and older with type 2 diabetes and cardiovascular disease (at a 1:1 ratio) to groups that either received a subcutaneous injection of albiglutide (30–50 mg, based on glycaemic response and tolerability) or of a matched volume of placebo once a week, in addition to their standard care. Investigators used an interactive voice or web response system to obtain treatment assignment, and patients and all study investigators were masked to their treatment allocation. We hypothesised that albiglutide would be non-inferior to placebo for the primary outcome of the first occurrence of cardiovascular death, myocardial infarction, or stroke, which was assessed in the intention-to-treat population. If non-inferiority was confirmed by an upper limit of the 95% CI for a hazard ratio of less than 1·30, closed testing for superiority was prespecified. This study is registered with ClinicalTrials.gov, number NCT02465515.
Findings:
Patients were screened between July 1, 2015, and Nov 24, 2016. 10 793 patients were screened and 9463 participants were enrolled and randomly assigned to groups: 4731 patients were assigned to receive albiglutide and 4732 patients to receive placebo. On Nov 8, 2017, it was determined that 611 primary endpoints and a median follow-up of at least 1·5 years had accrued, and participants returned for a final visit and discontinuation from study treatment; the last patient visit was on March 12, 2018. These 9463 patients, the intention-to-treat population, were evaluated for a median duration of 1·6 years and were assessed for the primary outcome. The primary composite outcome occurred in 338 (7%) of 4731 patients at an incidence rate of 4·6 events per 100 person-years in the albiglutide group and in 428 (9%) of 4732 patients at an incidence rate of 5·9 events per 100 person-years in the placebo group (hazard ratio 0·78, 95% CI 0·68–0·90), which indicated that albiglutide was superior to placebo (p<0·0001 for non-inferiority; p=0·0006 for superiority). The incidence of acute pancreatitis (ten patients in the albiglutide group and seven patients in the placebo group), pancreatic cancer (six patients in the albiglutide group and five patients in the placebo group), medullary thyroid carcinoma (zero patients in both groups), and other serious adverse events did not differ between the two groups. There were three (<1%) deaths in the placebo group that were assessed by investigators, who were masked to study drug assignment, to be treatment-related and two (<1%) deaths in the albiglutide group.
Interpretation:
In patients with type 2 diabetes and cardiovascular disease, albiglutide was superior to placebo with respect to major adverse cardiovascular events. Evidence-based glucagon-like peptide 1 receptor agonists should therefore be considered as part of a comprehensive strategy to reduce the risk of cardiovascular events in patients with type 2 diabetes.
Funding:
GlaxoSmithKline
Intraperitoneal drain placement and outcomes after elective colorectal surgery: international matched, prospective, cohort study
- Author
- Aba M
- Abdellatif M
- Abdelmahmoud S
- Abu Hassan F
- Acil C
- Adarkwah P
- Adarraga J
- Adderley O
- Adefolaju A
- Afzal A
- Afzal Z
- Agarwal H
- Agnes A
- Agostinelli L
- Ahari D
- Ahmad H
- Ahmad R
- Ahmad S
- Ahmed N
- Ahmed N
- Ahmed WUR
- Ahmed WUR
- Akhbari M
- Akintunde A
- Akkaya YM
- Akram J
- Aktas MK
- Aktas MK
- Aktas MK
- Aktaş A
- Akula Y
- Al Nassrallah M
- Al-Habsi R
- Alam F
- Albino V
- Alfadhel S
- Ali T
- Alicata F
- Aljić A
- Allison W
- Almeida T
- Alonso Batanero E
- Alonso Batanero E
- Alsaif A
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- Altaf R
- Altay L
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- Altomare DF
- Altomare DF
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- Alvarez-Gallego M
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- Čustović S
- Štefanová H
- Ευσταθίου Η
- Publication venue
- 'Oxford University Press (OUP)'
- Publication date
- 01/01/2022
- Field of study
Despite current guidelines, intraperitoneal drain placement after elective colorectal surgery remains widespread. Drains were not associated with earlier detection of intraperitoneal collections, but were associated with prolonged hospital stay and increased risk of surgical-site infections.Background Many surgeons routinely place intraperitoneal drains after elective colorectal surgery. However, enhanced recovery after surgery guidelines recommend against their routine use owing to a lack of clear clinical benefit. This study aimed to describe international variation in intraperitoneal drain placement and the safety of this practice. Methods COMPASS (COMPlicAted intra-abdominal collectionS after colorectal Surgery) was a prospective, international, cohort study which enrolled consecutive adults undergoing elective colorectal surgery (February to March 2020). The primary outcome was the rate of intraperitoneal drain placement. Secondary outcomes included: rate and time to diagnosis of postoperative intraperitoneal collections; rate of surgical site infections (SSIs); time to discharge; and 30-day major postoperative complications (Clavien-Dindo grade at least III). After propensity score matching, multivariable logistic regression and Cox proportional hazards regression were used to estimate the independent association of the secondary outcomes with drain placement. Results Overall, 1805 patients from 22 countries were included (798 women, 44.2 per cent; median age 67.0 years). The drain insertion rate was 51.9 per cent (937 patients). After matching, drains were not associated with reduced rates (odds ratio (OR) 1.33, 95 per cent c.i. 0.79 to 2.23; P = 0.287) or earlier detection (hazard ratio (HR) 0.87, 0.33 to 2.31; P = 0.780) of collections. Although not associated with worse major postoperative complications (OR 1.09, 0.68 to 1.75; P = 0.709), drains were associated with delayed hospital discharge (HR 0.58, 0.52 to 0.66; P < 0.001) and an increased risk of SSIs (OR 2.47, 1.50 to 4.05; P < 0.001). Conclusion Intraperitoneal drain placement after elective colorectal surgery is not associated with earlier detection of postoperative collections, but prolongs hospital stay and increases SSI risk
Effect of sitagliptin on cardiovascular outcomes in type 2 diabetes
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- Stein PP
- Stern N
- Stetsyuk O
- Stich M
- Strand J
- Strandberg T
- Strandberg T
- Stranks S
- Stranks S
- Strickler J
- Strotmann HJ
- Stuchlik G
- Stürmer W
- Sulskiene M
- Sundström U
- Suryaprakash G
- Suryawanshi S
- Suryawanshi S
- Sweeney ME
- Szczeh L
- Tai E
- Tajjar A
- Taller A
- Tambascia M
- Tan RS
- Tan Y
- Tang XL
- Tankova T
- Tankova T
- Tarkun I
- Tay L
- Temelkova-Kurktschiev T
- Teterovska D
- Thinesse-Mallwitz M
- Thomas H
- Tillman H
- Tinahones Madueño F
- Tolsma D
- Tomlinson B
- Topliss D
- Torstensson I
- Toserova E
- Townes O
- Tranche S
- Travert F
- Travert F
- Trescolí Serrano C
- Tretyakova T
- Tricoci P
- Trinder Y
- Tritto I
- Trollinger K
- Truffa A
- Tsang CC
- Tsao J
- Tsur A
- Turcinek R
- Turner W
- Turova E
- Tykarski A
- Tykarski A
- Tytko A
- Ukinc K
- Ukwade P
- Ulla MR
- Urbanaviciene L
- Urbancova K
- Urina Triana MA
- Usman M
- Valeeva F
- Valenzuela Rincon A
- Valius L
- Valle T
- Van de Werf F
- Van de Werf F
- Van den Bruel A
- Van der Heijden R
- Van Der Merwe A
- Van Gaal L
- Van Hessen M
- van Kempen W
- Van Zyl L
- Varanauskiene E
- Vejvodova J
- Velichka D
- Velickiene D
- Veresiu IA
- Veresiu IA
- Vico ML
- Vides H
- Viitas L
- Viljoen M
- Vishlitzky V
- Viswanath D
- Vizel S
- Vo A
- Vogel C
- Voitec M
- Vondrakova M
- Voors-Pette C
- Vora P
- Voyce S
- Vélez Pelaez S
- Wainstein J
- Wainstein J
- Waites J
- Waitman JN
- Wang SY
- Weaver J
- Weber Silva DM
- Weintraub H
- Weisnagel S
- Wendisch U
- Wenying Y
- Westendorp I
- Westerberg Maldonado BH
- White H
- White J
- Wilder J
- Wilding J
- Wiles P
- Wilhase A
- Williams M
- Wilson M
- Wolfley A
- Woo V
- Wood M
- Wu P
- Wurziger J
- Wysham C
- Yakov A
- Yale JF
- Yang T
- Yang WY
- Yared K
- Yeung VT
- Yilmaz M
- Yoo SJ
- Yupanqui Lozno H
- Zachoval R
- Zadionchenko V
- Zak R
- Zavaroni DZ
- Zheng SX
- Ziegler O
- Zimanova J
- Zimmerman R
- Zinman B
- Śmiałowski A
- Publication venue
- 'Massachusetts Medical Society'
- Publication date
- 01/01/2015
- Field of study
BACKGROUND: Data are lacking on the long-term effect on cardiovascular events of adding sitagliptin, a dipeptidyl peptidase 4 inhibitor, to usual care in patients with type 2 diabetes and cardiovascular disease. METHODS: In this randomized, double-blind study, we assigned 14,671 patients to add either sitagliptin or placebo to their existing therapy. Open-label use of antihyperglycemic therapy was encouraged as required, aimed at reaching individually appropriate glycemic targets in all patients. To determine whether sitagliptin was noninferior to placebo, we used a relative risk of 1.3 as the marginal upper boundary. The primary cardiovascular outcome was a composite of cardiovascular death, nonfatal myocardial infarction, nonfatal stroke, or hospitalization for unstable angina. RESULTS: During a median follow-up of 3.0 years, there was a small difference in glycated hemoglobin levels (least-squares mean difference for sitagliptin vs. placebo, -0.29 percentage points; 95% confidence interval [CI], -0.32 to -0.27). Overall, the primary outcome occurred in 839 patients in the sitagliptin group (11.4%; 4.06 per 100 person-years) and 851 patients in the placebo group (11.6%; 4.17 per 100 person-years). Sitagliptin was noninferior to placebo for the primary composite cardiovascular outcome (hazard ratio, 0.98; 95% CI, 0.88 to 1.09; P<0.001). Rates of hospitalization for heart failure did not differ between the two groups (hazard ratio, 1.00; 95% CI, 0.83 to 1.20; P = 0.98). There were no significant between-group differences in rates of acute pancreatitis (P = 0.07) or pancreatic cancer (P = 0.32). CONCLUSIONS: Among patients with type 2 diabetes and established cardiovascular disease, adding sitagliptin to usual care did not appear to increase the risk of major adverse cardiovascular events, hospitalization for heart failure, or other adverse events
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