10 research outputs found
An analysis of the FIR/RADIO Continuum Correlation in the Small Magellanic Cloud
The local correlation between far-infrared (FIR) emission and radio-continuum
(RC) emission for the Small Magellanic Cloud (SMC) is investigated over scales
from 3 kpc to 0.01 kpc. Here, we report good FIR/RC correlation down to ~15 pc.
The reciprocal slope of the FIR/RC emission correlation (RC/FIR) in the SMC is
shown to be greatest in the most active star forming regions with a power law
slope of ~1.14 indicating that the RC emission increases faster than the FIR
emission. The slope of the other regions and the SMC are much flatter and in
the range of 0.63-0.85. The slopes tend to follow the thermal fractions of the
regions which range from 0.5 to 0.95. The thermal fraction of the RC emission
alone can provide the expected FIR/RC correlation. The results are consistent
with a common source for ultraviolet (UV) photons heating dust and Cosmic Ray
electrons (CRe-s) diffusing away from the star forming regions. Since the CRe-s
appear to escape the SMC so readily, the results here may not provide support
for coupling between the local gas density and the magnetic field intensity.Comment: 19 pages, 7 Figure
Temperature Shocks and Welfare Costs
This paper examines the welfare implications of rising temperatures. Using a standard VAR, we empirically show that a temperature shock has a sizable, negative and statistically significant impact on TFP, output, and labor productivity. We rationalize these findings within a production economy featuring long-run temperature risk. In the model, macro-aggregates drop in response to a temperature shock, consistent with the novel evidence in the data. Such adverse effects are long-lasting. Over a 50-year horizon, a one-standard deviation temperature shock lowers both cumulative output and labor productivity growth by 1.4 percentage points. Based on the model, we also show that temperature risk is associated with non-negligible welfare costs which amount to 18.4% of the agent's lifetime utility and grow exponentially with the size of the impact of temperature on TFP. Finally, we show that faster adaptation to temperature shocks results in lower welfare costs. These welfare benefits become substantially higher in the presence of permanent improvements in the speed of adaptation
Photothermal response of hollow gold nanoshell to laser irradiation: Continuous wave, short and ultrashort pulse
Maximizing microalgae productivity by shading outdoor cultures * *This work was supported by the CONICYT doctoral grant (Carlos Martínez), and by the Phycover (ANR-14-CE04-0011) and Purple Sun (ANR-13-BIME-0004) projects. F. Mairet is grateful to “FMJH Program Gaspard Monge in optimization and operation research”
Non-natural macrocyclic inhibitors of histone deacetylases: design, synthesis, and activity
Nonpeptidic chiral macrocycles were designed on the basis of an analogue of suberoylanilide hydroxamic acid (2) (SAHA, vorinostat) and evaluated against 11 histone deacetylase (HDAC) isoforms. The identification of critical amino acid residues highly conserved in the cap region of HDACs guided the design of the suberoyl-based macrocycles, which were expected to bear a maximum common substructure required to target the whole HDAC panel. A nanomolar HDAC inhibitory profile was observed for several compounds, which was comparable, if not superior, to that of 2. A promising cytotoxic activity was found for selected macrocycles against lung and colon cancer cell lines. Further elaboration of selected candidates led to compounds with an improved selectivity against HDAC6 over the other isozymes. Pair-fitting analysis was used to compare one of the best candidates with the natural tetrapeptide apicidin, in an effort to define a general pharmacophore that might be useful in the design of surrogates of peptidic macrocycles as potent and isoform-selective inhibitors