The Evolution of Transition Region Loops Using IRIS and AIA

Over the past 50 years, the model for the structure of the solar transition region has evolved from a simple transition layer between the cooler chromosphere to the hotter corona to a complex and diverse region that is dominated by complete loops that never reach coronal temperatures. The IRIS slitjaw images show many complete transition region loops. Several of the "coronal" channels in the SDO AIA instrument include contributions from weak transition region lines. In this work, we combine slitjaw images from IRIS with these channels to determine the evolution of the loops. We develop a simple model for the temperature and density evolution of the loops that can explain the simultaneous observations. Finally, we estimate the percentage of AIA emission that originates in the transition region

Loss of Endocan tumorigenic properties after alternative splicing of exon 2

<p>Abstract</p> <p>Background</p> <p>Endocan was originally described as a dermatan sulfate proteoglycan found freely circulating in the blood. Endocan expression confers tumorigenic properties to epithelial cell lines or accelerate the growth of already tumorigenic cells. This molecule is the product of a single gene composed of 3 exons. Previous data showed that endocan mRNA is subject to alternative splicing with possible generation of two protein products. In the present study we identified, and functionally characterized, the alternative spliced product of the endocan gene: the exon 2-deleted endocan, called endocanΔ2.</p> <p>Methods</p> <p>Stable, endocanΔ2-overexpressing cell lines were generated to investigate the biological activities of this new alternatively spliced product of endocan gene. Tumorigenesis was studied by inoculating endocan and endocanΔ2 expressing cell lines subcutaneously in SCID mice. Biochemical properties of endocan and endocanΔ2 were studied after production of recombinant proteins in various cell lines of human and murine origin.</p> <p>Results</p> <p>Our results showed that the exon 2 deletion impairs synthesis of the glycan chain, known to be involved in the pro-tumoral effect of endocan. EndocanΔ2 did not promote tumor formation by 293 cells implanted in the skin of severe combined immunodeficient (SCID) mice.</p> <p>Conclusion</p> <p>Our results emphasize the key role of the polypeptide sequence encoded by the exon 2 of endocan gene in tumorigenesis, and suggest that this sequence could be a target for future therapies against cancer.</p

A turbulence-driven model for heating and acceleration of the fast wind in coronal holes

A model is presented for generation of fast solar wind in coronal holes, relying on heating that is dominated by turbulent dissipation of MHD fluctuations transported upwards in the solar atmosphere. Scale-separated transport equations include large-scale fields, transverse Alfvenic fluctuations, and a small compressive dissipation due to parallel shears near the transition region. The model accounts for proton temperature, density, wind speed, and fluctuation amplitude as observed in remote sensing and in situ satellite data.Comment: accepted for publication in ApJ

Signatures of impulsive localized heating in the temperature distribution of multi-stranded coronal loops

We study the signatures of different coronal heating regimes on the differential emission measure (DEM) of multi-stranded coronal loops by means of hydrodynamic simulations. We consider heating either uniformly distributed along the loops or localized close to the chromospheric footpoints, in both steady and impulsive conditions. Our simulations show that condensation at the top of the loop forms when the localized heating is impulsive with a pulse cadence time shorter than the plasma cooling time, and the pulse energy is below a certain threshold. A condensation does not produce observable signatures in the global DEM structure. Conversely, the DEM coronal peak is found sensitive to the pulse cadence time. Our simulations can also give an explanation of the warm overdense and hot underdense loops observed by TRACE, SOHO and Yohkoh. However, they are unable to reproduce both the transition region and the coronal DEM structure with a unique set of parameters, which outlines the need for a more realistic description of the transition region.Comment: 31 pages, 7 figure

The Evolution of Transition Region Loops Using IRIS and AIA

No abstract availabl

Sounding Rocket Instrument Development at UAHuntsville/NASA MSFC

We present an overview of solar sounding rocket instruments developed jointly by NASA Marshall Space Flight Center and the University of Alabama in Huntsville. The High Resolution Coronal Imager (Hi-C) is an EUV (19.3 nm) imaging telescope which was flown successfully in July 2012. The Chromospheric Lyman-Alpha SpectroPolarimeter (CLASP) is a Lyman Alpha (121.6 nm) spectropolarimeter developed jointly with the National Astronomical Observatory of Japan and scheduled for launch in 2015. The Marshall Grazing Incidence X-ray Spectrograph is a soft X-ray (0.5-1.2 keV) stigmatic spectrograph designed to achieve 5 arcsecond spatial resolution along the slit

Testing the theory of immune selection in cancers that break the rules of transplantation

Modification of cancer cells likely to reduce their immunogenicity, including loss or down-regulation of MHC molecules, is now well documented and has become the main support for the concept of immune surveillance. The evidence that these modifications, in fact, result from selection by the immune system is less clear, since the possibility that they may result from reorganized metabolism associated with proliferation or from cell de-differentiation remains. Here, we (a) survey old and new transplantation experiments that test the possibility of selection and (b) survey how transmissible tumours of dogs and Tasmanian devils provide naturally evolved tests of immune surveillance

Coronal Loop Evolution Observed with AIA and Hi-C

Despite much progress toward understanding the dynamics of the solar corona, the physical properties of coronal loops are not yet fully understood. Recent investigations and observations from different instruments have yielded contradictory results about the true physical properties of coronal loops. In the past, the evolution of loops has been used to infer the loop substructure. With the recent launch of High Resolution Coronal Imager (Hi-C), this inference can be validated. In this poster we discuss the first results of loop analysis comparing AIA and Hi-C data. We find signatures of cooling in a pixel selected along a loop structure in the AIA multi-filter observations. However, unlike previous studies, we find that the cooling time is much longer than the draining time. This is inconsistent with previous cooling models

Fc-γ receptor-mediated crosslinking co-defines the immunostimulatory activity of anti-human CD96 antibodies.

New strategies that augment T-cell responses are required to broaden the therapeutic arsenal against cancer. CD96, TIGIT and CD226 are receptors that bind to a communal ligand, CD155, and transduce either inhibitory or activating signals. Whereas the function of TIGIT and CD226 is established, the role of CD96 remains ambiguous. Using a panel of engineered antibodies, we discovered that the T-cell stimulatory activity of anti-CD96 antibodies requires antibody crosslinking and is potentiated by Fc-gamma receptors. Thus, soluble 'Fc silent' anti-CD96 antibodies failed to stimulate human T cells, whereas the same antibodies were stimulatory after coating onto plastic surfaces. Remarkably, the activity of soluble anti-CD96 antibodies was reinstated by engineering the Fc domain to a human IgG1 isotype and was dependent on antibody trans-crosslinking by Fc-γRI. In contrast, neither human IgG2 nor variants with increased Fc-γ receptor IIB binding possessed stimulatory activity. Anti-CD96 antibodies acted directly on T cells and augmented gene expression networks associated with T-cell activation, leading to proliferation, cytokine secretion and resistance to regulatory T-cell suppression. Furthermore, CD96 expression correlated with survival in HPV+ head and neck squamous cell carcinoma and its crosslinking activated tumor-infiltrating T cells, thus highlighting the potential of anti-CD96 antibodies in cancer immunotherapy.