25 research outputs found
Brachial artery reactivity in patients with severe sepsis: an observational study
- Author
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2012
- Field of study
Neutralization of Botulinum Neurotoxin by a Human Monoclonal Antibody Specific for the Catalytic Light Chain
- Author
- A Fischer
- A Nowakowski
- A Razai
- AT Brunger
- B. P. Kapadnis
- C Verderio
- Denise M. Ancharski
- E Ravichandran
- Fetweh H. Al-Saleem
- G Krautz-Peterson
- G Schiavo
- GE Boldt
- J Blasi
- JA Coronella
- Jacques Zimmer
- JD Marks
- JE Keller
- K Bagramyan
- L Xie
- Lance L. Simpson
- LL Simpson
- LM Eubanks
- LM Wein
- M Dong
- M Urashima
- Michael J. Root
- MJ Campbell
- MP Lefranc
- MR Baldwin
- R Levy
- R. Mark Jones
- RJ Darling
- S Mahrhold
- Scott K. Dessain
- Sharad P. Adekar
- SK Dessain
- SP Adekar
- SP Adekar
- SS Arnon
- SS Arnon
- TJ Smith
- Tsuyoshi Takahashi
- Publication venue
- Public Library of Science
- Publication date
- 01/01/2008
- Field of study
Background: Botulinum neurotoxins (BoNT) are a family of category A select bioterror agents and the most potent biological toxins known. Cloned antibody therapeutics hold considerable promise as BoNT therapeutics, but the therapeutic utility of antibodies that bind the BoNT light chain domain (LC), a metalloprotease that functions in the cytosol of cholinergic neurons, has not been thoroughly explored. Methods and Findings: We used an optimized hybridoma method to clone a fully human antibody specific for the LC of serotype A BoNT (BoNT/A). The 4LCA antibody demonstrated potent in vivo neutralization when administered alone and collaborated with an antibody specific for the HC. In Neuro-2a neuroblastoma cells, the 4LCA antibody prevented the cleavage of the BoNT/A proteolytic target, SNAP-25. Unlike an antibody specific for the HC, the 4LCA antibody did not block entry of BoNT/A into cultured cells. Instead, it was taken up into synaptic vesicles along with BoNT/A. The 4LCA antibody also directly inhibited BoNT/A catalytic activity in vitro. Conclusions: An antibody specific for the BoNT/A LC can potently inhibit BoNT/A in vivo and in vitro, using mechanisms not previously associated with BoNT-neutralizing antibodies. Antibodies specific for BoNT LC may be valuable components o
A proposed new bacteriophage subfamily: “Jerseyvirinae”
- Author
- A Fokine
- A Joshi
- A Krogh
- A Moreno Switt
- AE Darling
- AI Moreno Switt
- AIM Switt
- Andrea I. Moreno Switt
- Andrew M. Kropinski
- BR Tiwari
- C Alonso
- CV Byl
- D Mollov
- D Schwarzer
- D Turner
- Dann Turner
- Darren M. Reynolds
- Denise Tremblay
- EB Gilcrease
- EJ Summer
- EW Myers
- F Rohwer
- FB Perler
- G Lima-Mendez
- G Lima-Mendez
- GV Carey-Smith
- H Anany
- H-W Ackermann
- H-W Kang
- Hans-Wolfgang Ackermann
- Hany Anany
- HW Ackermann
- HW Ackermann
- J Denyes
- J Grant
- J Söding
- J Söding
- J Xu
- J Xu
- J Xu
- JG Lawrence
- JH Grose
- JJ Bull
- John H. E. Nash
- JS Fraser
- KM Westover
- L Li
- LY Brovko
- M McClelland
- MA Larkin
- Mansel W. Griffiths
- Martin Wiedmann
- MM Susskind
- N Lappe De
- N Papanikolaou
- N Zafar
- Niall De Lappe
- P Jones
- R Lavigne
- R Lavigne
- R Young
- RD Finn
- S Barbirz
- S Chibani-Chennoufi
- S Gajewski
- S Hagens
- S Hong
- S Spinelli
- S-H Kim
- SE Winter
- SJ Labrie
- SPT Hooton
- Sylvain Moineau
- W Demczuk
- YD Niu
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 08/02/2015
- Field of study
© 2015, Springer-Verlag Wien. Based on morphology and comparative nucleotide and protein sequence analysis, a new subfamily of the family Siphoviridae is proposed, named “Jerseyvirinae” and consisting of three genera, “Jerseylikevirus”, “Sp3unalikevirus” and “K1glikevirus”. To date, this subfamily consists of 18 phages for which the genomes have been sequenced. Salmonella phages Jersey, vB_SenS_AG11, vB_SenS-Ent1, vB_SenS-Ent2, vB_SenS-Ent3, FSL SP-101, SETP3, SETP7, SETP13, SE2, SS3e and wksl3 form the proposed genus “Jerseylikevirus”. The proposed genus “K1glikevirus” consists of Escherichia phages K1G, K1H, K1ind1, K1ind2 and K1ind3. The proposed genus “Sp3unalikevirus” contains one member so far. Jersey-like phages appear to be widely distributed, as the above phages were isolated in the UK, Canada, the USA and South Korea between 1970 and the present day. The distinguishing features of this subfamily include a distinct siphovirus morphotype, genomes of 40.7-43.6kb (49.6-51.4mol% G+C), a syntenic genome organisation, and a high degree of nucleotide sequence identity and shared proteins. All known members of the proposed subfamily are strictly lytic
Integrated genomic characterization of oesophageal carcinoma
- Author
- Abeshouse Adam
- Ajani Jaffer A.
- Akbani Rehan
- Ally Adrian
- Appelbaum Elizabeth L.
- Armenia Joshua
- Arora Arshi
- Balasundaram Miruna
- Bartlett John
- Bass Adam J.
- Baylin Stephen B.
- Beer David G.
- Behera Madhusmitara
- Bennett Joseph
- Bernard Brady
- Beroukhim Rameen
- Berrios Mario
- Bootwalla Moiz S.
- Boussioutas Alex
- Bowen Jay
- Bowlby Reanne
- Bristow Christopher A.
- Brooks Denise
- Bullman Susan
- Button Michael
- Camargo M. Constanza
- Carey Frank
- Carlotti Carlos Gilberto
- Carlsen Rebecca
- Carvalho Andre L.
- Chakravarty Debyani
- Chalmers Sally
- Cheong Jae-Ho
- Cherniack Andrew D.
- Chetty Runjan
- Chin Lynda
- Cho Juok
- Chuah Eric
- Cibulskis Carrie
- Cibulskis Kristian
- Cordes Matthew G.
- Crain Daniel
- Curley Erin
- Curtis Christina
- Da Cunha Tirapelli Daniela Pretti
- Darling Gail
- De Oliveira Antonio Talvane
- Defrietas Timothy
- Demchok John
- Demchok John A.
- Den Berg David J. Van
- Derks Sarah
- Dhalla Noreen
- Dhankani Varsha
- Dhir Rajiv
- DIng Li
- DInjens Winand
- Dos Santos Jose Sebastiaõ
- Dubina Michael
- Dunford Andrew
- El-Zimaity Haila
- Eschbacher Jennifer
- Felau Ina
- Ferguson Martin L.
- Ferrer-Torres Daysha
- Force Seth
- Frazer Scott
- Frick Jessica
- Fronick Catrina C.
- Fulidou Victoria
- Fulton Lucinda A.
- Fulton Robert S.
- Gabriel Stacey B.
- Gao Jianjiong
- Gardner Johanna
- Garman Katherine
- Gastier-Foster Julie M.
- Gehlenborg Nils
- Gerken Mark
- Getz Gad
- Godwin Andrew
- Gulley Margaret L.
- Hadjipanayis Angela
- Hegde Apruva
- Heiman David I.
- Hinoue Toshinori
- Hoadley Katherine A.
- Holbrook Andrea
- Holt Robert A.
- Huelsenbeck-DIll Lori
- Hutter Carolyn M.
- Hwang Jun-Eul
- Iacocca Mary
- IanForgie Dundee
- Iype Lisa
- Jang Hee-Jin
- Janjigian Yelena
- Jones Steven J. M.
- Juhl Hartmut
- Kasaian Katayoon
- Kelsen David P.
- Kemp Rafael
- Khuri Fadio
- Kim Goyang Hark Kyun
- Kim Jaegil
- Kim Jihun
- Knox Jennifer
- Kucherlap Melanie
- Kucherlapati Raju
- Kundra Ritika
- Kwon Sun Young
- Ladanyi Marc
- Lai Phillip H.
- Laird Peter W.
- Lander Eric
- Lawrence Michael
- Lawrence Michael S.
- Le Xuan
- Lee Jae-Hyuck
- Lee Ju-Seog
- Lee Semin
- Lehmann Kjong-Van
- Leraas Kristen
- Leraas Kristen M.
- Li Haiyan I.
- Lichtenberg Tara M.
- Lin Pei
- Liu Geoffrey
- Liu Jai
- Liu Ouida
- Liu Wenbin
- Lolla Laxmi
- Lu Yiling
- Lucchesi Fabiano
- Luketich James D.
- Ma Yussanne
- Madan Rashna
- Mahadeshwar Harshad S.
- Mallery David
- Mardis Elaine R.
- Marra Marco A.
- Matsushita Marcus Medeiros
- Mayo Michael
- McCall Shannon J.
- McLellan Michael
- McLellan Michael D.
- Meier Samuel R.
- Meyerson Matthew
- Miller Christopher A.
- Miller Michael
- Mills Gordon B.
- MillsShaw Kenna R.
- Moore Richard A.
- Morris Scott
- Mozgovoy Eugene
- Mungall Andrew J.
- Mungall Karen L.
- Murray Bradley A.
- Naima Zaid
- Naresh Rashi
- Nistelrooij Anna Van
- Noble Michael S.
- Noushmehr Houtan
- Odze Robert D.
- Ojesina Akinyemi I.
- Owonikoko Taofeek
- Paklina Oxana
- Pantazi Angeliki
- Parfenov Michael
- Parfitt Jeremy
- Park Do Young
- Park Peter J.
- Park Young Soo
- Paulauskis Joseph
- Pedamallu Chandra Sekhar
- Pennathur Arjun
- Penny Robert
- Piazuelo M. Blanca
- Pickens Allan
- Pihl Todd
- Polak Paz
- Potapova Cureline Olga
- Protopopov Alexei
- Rabkin Charles S.
- Radenbaugh Cruz Amie
- Ramalingam Suresh
- Ramirez Nilsa C.
- Raphae Benjamin J.
- Raphael
- Rathme W. Kimryn
- Reid Brian J.
- Reilly Colleen
- Reis Rui Manuel
- Ren Xiaojia
- Reynolds Sheila M.
- Robertson A. Gordon
- Saggioro Fabiano Pinto
- Sakai Ku Leuven Ryo
- Saksena Gordon
- Saller Charles
- Sander Chris
- Sandusky George
- Sankarankutty Ajith Kumar
- Schein Jacqueline E.
- Schmidt Heather K.
- Schneider Barbara G.
- Schultz Nikolaus
- Schumacher Steven E.
- Seoane Jose A.
- Setdikova Galiya
- Seth Sahil
- Sharp Alexis
- Shelton Candace
- Shelton Troy
- Shen Hui
- Shen Ronglai
- Sheth Margi
- Shih Juliann
- Shmulevich Ilya
- Sica Gabriel
- Sipahimalani Payal
- Sofia Heidi J.
- Sohn Bo Hwa
- Song Xingzhi
- Stepa Serghei
- Stewart Chip
- Sun Qiang
- Sánchez-Vega Francisco
- Tam Angela
- Tang Jiabin
- Tang Laura
- Tarnuzzer Roy
- Tarvin Katherine
- Taylor-Weiner Amaro
- Thiessen Nina
- Thorsson Vésteinn
- Trevisan Felipe Amstalden
- Vinco Michele
- Voet Doug
- Voronina Olga
- Wan Yunhu
- Wang Kenneth
- Wang Zhining
- Weinhold Nils
- Weinstein John N.
- Weisenberger Daniel J.
- Wijnhoven Bas
- Willis Joseph E.
- Wilson Richard K.
- Wise Lisa
- Wiznerowicz MacIej
- Wong Alexandra M.
- Wong Rebecca
- Wong Tina
- Wu Hsin-Ta
- Wu Ye
- Yang Liming
- Yang Lixing
- Zenklusen Jean Claude
- Zhang Hailei
- Zhang Hongxin
- Zhang Jiashan
- Zhang Julia
- Zhang Wei
- Zhangw Jianhua
- Zhou Zhongren
- Zmuda Erik
- Zornig Hamburg Carsten
- Publication venue
- Publication date
- 01/01/2017
- Field of study
Oesophageal cancers are prominent worldwide; however, there are few targeted therapies and survival rates for these cancers remain dismal. Here we performed a comprehensive molecular analysis of 164 carcinomas of the oesophagus derived from Western and Eastern populations. Beyond known histopathological and epidemiologic distinctions, molecular features differentiated oesophageal squamous cell carcinomas from oesophageal adenocarcinomas. Oesophageal squamous cell carcinomas resembled squamous carcinomas of other organs more than they did oesophageal adenocarcinomas. Our analyses identified three molecular subclasses of oesophageal squamous cell carcinomas, but none showed evidence for an aetiological role of human papillomavirus. Squamous cell carcinomas showed frequent genomic amplifications of CCND1 and SOX2 and/or TP63, whereas ERBB2, VEGFA and GATA4 and GATA6 were more commonly amplified in adenocarcinomas. Oesophageal adenocarcinomas strongly resembled the chromosomally unstable variant of gastric adenocarcinoma, suggesting that these cancers could be considered a single disease entity. However, some molecular features, including DNA hypermethylation, occurred disproportionally in oesophageal adenocarcinomas. These data provide a framework to facilitate more rational categorization of these tumours and a foundation for new therapies
A case-only study to identify genetic modifiers of breast cancer risk for BRCA1/BRCA2 mutation carriers
- Author
- Aalfs C.M. (Cora)
- Adamo P. (Pio) d'
- Adank M.A. (Muriel)
- Adenis C. (Claude)
- Adlard J.W. (Julian)
- Agata S. (Simona)
- Ahearn T. (Thomas)
- Aittomäki K. (Kristiina)
- Andrieu N. (Nadine)
- Andrulis I.L. (Irene L.)
- Anton-Culver H. (Hoda)
- Antoniou A.C. (Antonis C.)
- Arndt V. (Volker)
- Arnold N. (Norbert)
- Aronson K.J. (Kristan J.)
- Arun B.K. (Banu)
- Augustinsson A. (Annelie)
- Ausems M.G.E.M. (Margreet)
- Azzollini J.
- Barjhoux L. (Laure)
- Barnes D. (Daniel)
- Barouk-Simonet E. (Emmanuelle)
- Barrowdale D. (Daniel)
- Barwell J. (Julian)
- Baurand A. (Amandine)
- Baxter R. (Robert)
- Baynes C. (Caroline)
- Becher H. (Heko)
- Beesley J. (Jonathan)
- Belotti M. (Muriel)
- Bermisheva M. (Marina)
- Bernstein L. (Leslie)
- Berthet P. (Pascaline)
- Bertolone G. (Geoffrey)
- Bertrand O. (Ophélie)
- Białkowska K. (Katarzyna)
- Bignon Y.-J. (Yves-Jean)
- Birot A.-M. (Anne-Marie)
- Blok M.J. (Marinus J.)
- Blomqvist C. (Carl)
- Bock G.H. (Geertruida) de
- Bojesen S.E. (Stig)
- Bolla M.K. (Manjeet K.)
- Bonadona V. (Valérie)
- Bonnani B. (Bernardo)
- Bonnet F. (Françoise)
- Borg Å. (Åke)
- Bourdon V. (Violaine)
- Boutry-Kryza N. (N.)
- Bowtell D. (David)
- Brady A. (A.)
- Brauch H. (Hiltrud)
- Brenner H. (Hermann)
- Bressac-de Paillerets B. (Brigitte)
- Brewer C. (Carole)
- Bronner M. (Myriam)
- Bubien V. (Virginie)
- Buecher B. (Bruno)
- Burwinkel B. (Barbara)
- Buys S.S. (Saundra S.)
- Bézieau S. (Stéphane)
- Caldes T. (Trinidad)
- Calender A. (Alain)
- Caligo M.A. (Maria A.)
- Campa D. (Daniele)
- Campbell I. (Ian)
- Caputo S. (Sandrine)
- Caron O. (Olivier)
- Carpenter T.A. (Adrian)
- Carter B.D. (Brian D.)
- Castelao J.E. (Jose )
- Castera L. (Laurent)
- Chang-Claude J. (Jenny)
- Chanock S.J. (Stephen J.)
- Chenevix-Trench G. (Georgia)
- Chiesa J. (Jean)
- Chung W.K. (Wendy K.)
- Claes K.B.M. (Kathleen B. M.)
- Clarke C. (Christine)
- Clarke C.L. (Christine L.)
- Coignard J. (Juliette)
- Colas C. (Chrystelle)
- Collonge-Rame M.-A.
- Collée J.M. (J. Margriet)
- Collée J.M. (J. Margriet)
- Conroy D.M. (Don M.)
- Cook J. (Jackie)
- Coron F. (Fanny)
- Couch F.J. (Fergus)
- Coulet F. (Florence)
- Coupier I. (Isabelle)
- Cronenburg T.C.T.E.F. van
- Czene K. (Kamila)
- Daly M.B. (Mary B.)
- Damette A. (Alexandre)
- Damiola F. (Francesca)
- Davidson R. (Rosemarie)
- Davis A. (Alison)
- De Fazio A. (Anna)
- de Pauw A. (Antoine)
- Deb S. (Sid)
- Delnatte C. (Capucine)
- Dennis J. (Joe)
- Deurzen C.H.M. (Carolien) van
- Devilee P. (Peter)
- Diez O. (Orland)
- Ding Y.C. (Yuan Chun)
- Domchek S.M. (Susan)
- Donaldson A. (Alan)
- Dreyfus H. (Hélène)
- Dumont A. (Aurélie)
- Dunning A.M. (Alison M.)
- Dupré A. (Anaïs)
- Dwek M. (Miriam)
- Dörk T. (Thilo)
- Eason J. (Jacqueline)
- Eccles D. (Diana)
- Eccles D.M. (Diana M.)
- Eeles R. (Rosalind)
- Eliassen A.H. (A. Heather)
- Engel C. (Christoph)
- Eriksson M. (Mikael)
- Evans D.G. (D. Gareth)
- Faivre L. (Laurence)
- Fasching P.A. (Peter)
- Feillel V. (Viviane)
- Ferrer S.F.
- Floris O.A.M.
- Flyger H. (Henrik)
- Foo C. (Claire)
- Fostira F. (Florentia)
- Fourme E. (Emmanuelle)
- Fox S.B. (Stephen)
- Friedman E. (Eitan)
- Fritschi L. (Lin)
- Frost D. (Debra)
- Gago-Dominguez M. (Manuela)
- Gapstur S.M. (Susan M.)
- Garber J. (Judy)
- Garcia-Barberan V. (Vanesa)
- García-Closas M. (Montserrat)
- García-Sáenz J.A. (José A.)
- Gaudet M.M. (Mia M.)
- Gauthier-Villars M. (Marion)
- Gayther S.A. (Simon)
- Gehrig A. (Andrea)
- Georgoulias V. (Vassilios)
- Gesta P. (Paul)
- Giles G.G. (Graham G.)
- Gille J.J.P. (J. J.P.)
- Giraud S. (Sophie)
- Gladieff L. (Laurence)
- Godwin A.K. (Andrew K.)
- Goldberg M.S. (Mark)
- Golmard L. (Lisa)
- González-Neira A. (Anna)
- Graham D. (Dinny)
- Greene M.H. (Mark H.)
- Gregory H. (Helen)
- Guillaud-Bataille M. (Marine)
- Guimbaud R. (Rosine)
- Guénel P. (Pascal)
- Gómez Garcia E.B. (Encarna B.)
- Haeberle L. (Lothar)
- Hahnen E. (Eric)
- Haiman C.A. (Christopher)
- Hall P. (Per)
- Hamann U. (Ute)
- Harrington P.A. (Patricia A.)
- Hart S.N. (Steven N.)
- He W. (Wei)
- Henderson A. (Alex)
- Hogervorst F.B.L. (Frans B. L.)
- Hollestelle A. (Antoinette)
- Hooning M.J. (Maartje)
- Hopper J.L. (John)
- Horcasitas D.J. (Darling J.)
- Houdayer C. (Claude)
- Hout A.H. (Annemarie) van der
- Hulick P.J. (Peter J.)
- Hunter D.J. (David J.)
- Håkansson N. (Niclas)
- Imyanitov E.N. (Evgeny)
- Ingster O. (Olivier)
- Izatt L. (Louise)
- Jacquot C. (Caroline)
- Jager A. (Agnes)
- Jakubowska A. (Anna)
- James M. (Margaret)
- Jensen U.B. (Uffe Birk)
- John E.M. (Esther)
- Jones M.E. (Michael E.)
- Joseph V. (Vijai)
- Kaaks R. (Rudolf)
- Kapoor P.M. (Pooja Middha)
- Karlan B.Y. (Beth)
- Keeman R. (Renske)
- Kennedy M.J. (M. John)
- Kets C.M. (Marleen)
- Khusnutdinova E.K. (Elza)
- Kientz C. (Caroline)
- Kiiski J.I. (Johanna I.)
- Kirk J. (Judy)
- Ko Y.-D. (Yon-Dschun)
- Kolk L.E. (Lizet) van der
- Kosma V.-M. (Veli-Matti)
- Kraft P. (Peter)
- Kurian A.W. (Allison W.)
- Laitman Y. (Yael)
- Lallaoui H. (Hakima)
- Lalloo F. (Fiona)
- Lambrechts D. (Diether)
- Lange J.L. (J.) de
- Lasset C. (Christine)
- Le Marchand L. (Loic)
- Le Mentec M. (Marine)
- Lebrun M. (Marine)
- Leeuwen F.E. (Flora) van
- Leroux D. (Dominique)
- Leslie G. (Goska)
- Lester J. (Jenny)
- Lesueur F. (Fabienne)
- Lindeman G.J. (Geoffrey)
- Lindstrom T. (Tricia)
- Lizard S. (Sarab)
- Longy M. (Michel)
- Lopez-Fernández A. (Adria)
- Loud J.T. (Jennifer T.)
- Luccarini C. (Craig)
- Lush M. (Michael)
- Léone M. (Mélanie)
- Mannermaa A. (Arto)
- Manoukian S. (Siranoush)
- Margolin S. (Sara)
- Mari V. (Véronique)
- Marsh D. (Deborah)
- Martens J.W.M. (John)
- Mazoyer S. (Sylvie)
- McCann E. (Emma)
- McGuffog L. (Lesley)
- Mebirouk N. (Noura)
- Meijers-Heijboer E.J. (Hanne)
- Meindl A. (Alfons)
- Mensenkamp A.R. (Arjen R.)
- Miedzybrodzka Z. (Zosia)
- Miller A. (Austin)
- Milne R.L. (Roger L.)
- Milne R.L. (Roger)
- Molina-Gomes D. (Denise)
- Moncoutier V. (Virginie)
- Montagna M. (Marco)
- Morrison P.J. (Patrick J.)
- Mortemousque I. (Isabelle)
- Mourits M.J. (Marjan)
- Muller D.W. (Danièle)
- Murray A. (Alexandra)
- Nathanson K.L. (Katherine)
- Nevanlinna H. (Heli)
- Nielsen F.C. (Finn C.)
- Noguchi T. (Tetsuro)
- Noguchi T. (Tetsuro)
- Nogues C. (Catherine)
- Obdeijn A.I.M. (Inge-Marie)
- Offit K. (Kenneth)
- Olopade O.I. (Olofunmilayo)
- Olson J.E. (Janet)
- Olsson H. (Håkan)
- Ong K.-R. (Kai-ren)
- Oosterwijk J.C. (Jan)
- Osorio A. (Ana)
- Ottini L. (Laura)
- Ouweland A.M.W. (Ans) van den
- Overbeek L.I.H. (Lucy)
- O’Brien K.M. (Katie M.)
- O’Mara T.A. (Tracy A.)
- Park S.K. (Sue K.)
- Park-Simon T.-W. (Tjoung-Won)
- Parsons M. (Marilyn)
- Pathmanathan N. (Nirmala)
- Pedersen I.S. (Inge Sokilde)
- Peshkin B. (Beth)
- Peterlongo P. (Paolo)
- Peto J. (Julian)
- Peysselon M. (Magalie)
- Pharoah P.D.P. (Paul)
- Phillips K.-A. (Kelly-Anne)
- Pol C. (Carmen) van der
- Polley E.C. (Eric C.)
- Popovici C. (Cornel)
- Poppe B. (Bruce)
- Porteous M.E. (Mary)
- Presneau N. (Nadege)
- Price M. (Melanie)
- Prieur F. (Fabienne)
- Pujana M.A. (Miquel Angel)
- Pujol P. (Pascal)
- Punie K. (Kevin)
- Radice P. (Paolo)
- Radice P. (Paolo)
- Rantala J. (Johanna)
- Rashid M.U. (Muhammad)
- Rebischung C. (Christine)
- Remenieras A. (Audrey)
- Rennert G. (Gad)
- Rennert H.S. (Hedy S.)
- Robson M. (Mark)
- Rogers M.T. (Mark)
- Romero A. (Atocha)
- Rookus M.A. (Matti)
- Rossing M. (Maria)
- Russell N.S. (Nicola)
- Révillion F. (Françoise)
- Sachchithananthan M. (Mythily)
- Saloustros E. (Emmanouil)
- Sandler D.P. (Dale P.)
- Santella R.M. (Regina)
- Santos Silva I. (Isabel) dos
- Saule C. (Claire)
- Scheuner M.T. (Maren T.)
- Schmidt G. (Gunnar)
- Schmidt M.K. (Marjanka K.)
- Schmutzler R.K. (Rita)
- Scott C. (Christopher)
- Scott R.J. (Rodney)
- Sevenet N. (Nicolas)
- Seynaeve C.M. (Caroline)
- Sharma P. (Priyanka)
- Side L.E. (Lucy E.)
- Siesling S. (Sabine)
- Simard J. (Jacques)
- Simpson P. (Peter)
- Sinilnikova O. (Olga)
- Snape K. (Katie)
- Sobol H. (Hagay)
- Sokolowska J. (Johanna)
- Soubrier F. (Florent)
- Soucy P. (Penny)
- Southey M.C. (Melissa C.)
- Southey M.C. (Melissa)
- Spinelli J.J. (John J.)
- Spurdle A. (Amanda)
- Steinsnyder Z. (Zoe)
- Stone J. (Jennifer)
- Stoppa-Lyonnet D. (Dominique)
- Swerdlow A.J. (Anthony )
- Tamimi R. (Rulla)
- Tapper W.J. (William J.)
- Tassell M. (Margaret)
- Taylor J.A. (Jack A.)
- Terry M.B. (Mary Beth)
- Teulé A. (Alex)
- Thomassen M. (Mads)
- Thull D.L. (Darcy L.)
- Tischkowitz M. (Marc)
- Toland A.E. (Amanda)
- Torres D. (Diana)
- Toulas C. (Christine)
- Trainer A.H. (Alison H.)
- Truong T. (Thérèse)
- Tung N. (Nadine)
- Tyrer J.P. (Jonathan P.)
- Uhrhammer N. (Nancy)
- Vachon C. (Celine)
- van Asperen C.J. (Christi J.)
- van der Luijt R.B. (Rob B.)
- Vaur D. (Dominique)
- Vega A. (Ana)
- Verny-Pierre C. (Carole)
- Vénat-Bouvet L. (Laurence)
- Walker L. (Lisa)
- Wang Q. (Qin)
- Wappenschmidt B. (Barbara)
- Warcoin M. (Mathilde)
- Webb P. (Penny)
- Weinberg C.R. (Clarice R.)
- Weitzel J.N. (Jeffrey)
- Wendt C. (Camilla)
- Wijnands R. (R.)
- Wijnen J.T. (Juul)
- Wolk K. (Kerstin)
- Yadav S. (Siddhartha)
- Yang X.R. (Xiaohong R.)
- Yannoukakos D. (Drakoulis)
- Yip D. (Desmond)
- Zheng W. (Wei)
- Ziogas A. (Argyrios)
- Zorn K.K. (Kristin K.)
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 17/02/2021
- Field of study
Breast cancer (BC) risk for BRCA1 and BRCA2 mutation carriers varies by genetic and familial factors. About 50 common variants have been shown to modify BC risk for mutation carriers. All but three, were identified in general population studies. Other mutation carrier-specific susceptibility variants may exist but studies of mutation carriers have so far been underpowered. We conduct a novel case-only genome-wide association study comparing genotype frequencies between 60,212 general population BC cases and 13,007 cases with BRCA1 or BRCA2 mutations. We identify robust novel associations for 2 variants with BC for BRCA1 and 3 for BRCA2 mutation carriers, P < 10−8, at 5 loci, which are not associated with risk in the general population. They include rs60882887 at 11p11.2 where MADD, SP11 and EIF1, genes previously implicated in BC biology, are predicted as potential targets. These findings will contribute towards customising BC polygenic risk scores for BRCA1 and BRCA2 mutation carriers
A case-only study to identify genetic modifiers of breast cancer risk for BRCA1/BRCA2 mutation carriers
- Author
- Aalfs Cora M.
- Adank Muriel A.
- Adank Muriel A.
- Adenis Claude
- Adlard Julian
- Agata Simona
- Ahearn Thomas
- Aittomäki Kristiina
- Andrieu Nadine
- Andrulis Irene L.
- Anton-Culver Hoda
- Antoniou Antonis C.
- Arndt Volker
- Arnold Norbert
- Aronson Kristan J.
- Arun Banu K.
- Augustinsson Annelie
- Ausems Margreet G. E. M.
- Azzollini Jacopo
- Barjhoux Laure
- Barnes Daniel R.
- Barouk-Simonet Emmanuelle
- Barrowdale Daniel
- Barwell Julian
- Baurand Amandine
- Baxter Robert
- Baynes Caroline
- Becher Heko
- Beesley Jonathan
- Belotti Muriel
- Bermisheva Marina
- Bernstein Leslie
- Berthet Pascaline
- Bertolone Geoffrey
- Bertrand Ophélie
- Białkowska Katarzyna
- Bignon Yves- Jean
- Birot Anne-Marie
- Blok Marinus J.
- Blomqvist Carl
- Bojesen Stig E.
- Bolla Manjeet K.
- Bonadona Valérie
- Bonanni Bernardo
- Bonnet Françoise
- Borg Ake
- Bourdon Violaine
- Boutry-Kryza Nadia
- Bowtell David
- Brady Angela
- Brauch Hiltrud
- Brenner Hermann
- Bressac-de-Paillerets Brigitte
- Brewer Carole
- Bronner Myriam
- Bubien Virginie
- Buecher Bruno
- Burwinkel Barbara
- Buys Saundra S.
- Bézieau Stéphane
- Caldés Trinidad
- Calender Alain
- Caligo Maria A.
- Campa Daniele
- Campbell Ian
- Caputo Sandrine
- Caron Olivier
- Carpenter Jane
- Carter Brian D.
- Castelao Jose E.
- Castera Laurent
- Chang-Claude Jenny
- Chanock Stephen J.
- Chenevix-Trench Georgia
- Chiesa Jean
- Chung Wendy K.
- Claes Kathleen B. M.
- Clarke Christine
- Clarke Christine L.
- Coignard Juliette
- Colas Chrystelle
- Collonge-Rame Marie-Agnès
- Collée J. Margriet
- Collée J. Margriet
- Conroy Don M.
- Cook Jackie
- Coron Fanny
- Couch Fergus J.
- Coulet Florence
- Coupier Isabelle
- Czene Kamila
- Daly Mary B.
- Damette Alexandre
- Damiola Francesca
- Davidson Rosemarie
- Davis Alison
- de Bock G. H.
- de Fazio Anna
- de Lange Judith L.
- de Pauw Antoine
- Deb Sid
- Delnatte Capucine
- Dennis Joe
- Devilee Peter
- Diez Orland
- Ding Yuan Chun
- Domchek Susan M.
- Donaldson Alan
- dos-Santos-Silva Isabel
- Dreyfus H. lène
- Dumont Aurélie
- Dunning Alison M.
- Dupré Anaïs
- Dwek Miriam
- Dörk Thilo
- Eason Jacqueline
- Easton Douglas F.
- Eccles Diana
- Eccles Diana M.
- Eeles Rosalind A.
- Eliassen A. Heather
- Engel Christoph
- Eriksson Mikael
- Evans D. Gareth
- Faivre Laurence
- Fasching Peter A.
- Feillel Viviane
- Ferrer Sandra Fert
- Flyger Henrik
- Foo Claire
- Fostira Florentia
- Fourme Emmanuelle
- Fox Stephen
- Friedman Eitan
- Fritschi Lin
- Frost Debra
- Gago-Dominguez Manuela
- Gapstur Susan M.
- Garber Judy
- Garcia-Barberan Vanesa
- García-Closas Montserrat
- García-Sáenz José A.
- Gaudet Mia M.
- Gauthier-Villars Marion
- Gayther Simon A.
- Gehrig Andrea
- Georgoulias Vassilios
- Gesta Paul
- Giles Graham G.
- Gille J. J. P.
- Giraud Sophie
- Gladieff Laurence
- Godwin Andrew K.
- Goldberg Mark S.
- Goldgar David E.
- Golmard Lisa
- González-Neira Anna
- Graham Dinny
- Greene Mark H.
- Gregory Helen
- Guillaud-Bataille Marine
- Guimbaud Rosine
- Guénel Pascal
- Gómez Garcia Encarna B.
- Haeberle Lothar
- Hahnen Eric
- Haiman Christopher A.
- Hall Per
- Hamann Ute
- Harrington Patricia A.
- Hart Steven N.
- He Wei
- Henderson Alex
- Hogervorst Frans B. L.
- Hollestelle Antoinette
- Hooning Maartje J.
- Hopper John L.
- Horcasitas Darling J.
- Houdayer Claude
- Hulick Peter J.
- Hunter David J.
- Håkansson Niclas
- Imyanitov Evgeny N.
- Ingster Olivier
- Izatt Louise
- Jacquot Caroline
- Jager Agnes
- Jakubowska Anna
- James Paul A.
- Jensen Uffe Birk
- John Esther M.
- Jones Michael E.
- Kaaks Rudolf
- Kapoor Pooja Middha
- Karlan Beth Y.
- Keeman Renske
- Kennedy M. John
- Kets Carolien M.
- Khusnutdinova Elza
- Kientz Caroline
- Kiiski Johanna I.
- Kirk Judy
- Ko Yon-Dschun
- Kosma Veli-Matti
- Kraft Peter
- Kurian Allison W.
- Laitman Yael
- Lallaoui Hakima
- Lalloo Fiona
- Lambrechts Diether
- Lasset Christine
- le Marchand Loic
- le Mentec Marine
- Lebrun Marine
- Leroux Dominique
- Leslie Goska
- Lester Jenny
- Lesueur Fabienne
- Lindeman Geoff
- Lindstrom Tricia
- Lizard Sarab
- Longy Michel
- Lopez-Fernández Adria
- Loud Jennifer T.
- Luccarini Craig
- Lush Michael
- Léone M. lanie
- Mannermaa Arto
- Manoukian Siranoush
- Margolin Sara
- Mari V. ronique
- Marsh Deborah
- Martens John W. M.
- Mazoyer Sylvie
- McCann Emma
- McGuffog Lesley
- Mebirouk Noura
- Meijers-Heijboer Hanne E. J.
- Meindl Alfons
- Mensenkamp Arjen R.
- Miedzybrodzka Zosia
- Miller Austin
- Milne Roger
- Milne Roger L.
- Molina-Gomes Denise
- Moncoutier Virginie
- Montagna Marco
- Morrison Patrick J.
- Mortemousque Isabelle
- Mourits Marian J. E.
- Muller Danièle
- Murray Alex
- Nathanson Katherine L.
- Neuhausen Susan L.
- Nevanlinna Heli
- Nielsen Finn C.
- Noguchi Tetsuro
- Noguchi Tetsuro
- Noguès Catherine
- Obdeijn Inge M.
- Offit Kenneth
- Olopade Olufunmilayo I.
- Olson Janet E.
- Olsson H. kan
- Ong Kai-ren
- Oosterwijk Jan C.
- Osorio Ana
- Ottini Laura
- Overbeek Lucy
- O’Brien Katie M.
- O’Mara Tracy A.
- Park Sue K.
- Park-Simon Tjoung-Won
- Parsons Michael T.
- Pathmanathan Nirmala
- Pedersen Inge Sokilde
- Peshkin Beth
- Peterlongo Paolo
- Peto Julian
- Peysselon Magalie
- Pharoah Paul D. P.
- Phillips Kelly-Anne
- Polley Eric C.
- Popovici Cornel
- Poppe Bruce
- Porteous Mary E.
- Presneau Nadege
- Price Melanie
- Prieur Fabienne
- Pujana Miquel Angel
- Pujol Pascal
- Punie Kevin
- Radice Paolo
- Rantala Johanna
- Rashid Muhammad U.
- Rebischung Christine
- Remenieras Audrey
- Rennert Gad
- Rennert Hedy S.
- Robson Mark
- Rogers Mark T.
- Romero Atocha
- Rookus Matti A.
- Rossing Maria
- Russell Nicola S.
- Révillion Françoise
- Sachchithananthan Mythily
- Saloustros Emmanouil
- Sandler Dale P.
- Santella Regina
- Saule Claire
- Scheuner Maren T.
- Schmidt Gunnar
- Schmidt Marjanka K.
- Schmutzler Rita K.
- Scott Christopher
- Scott Rodney
- Sevenet Nicolas
- Seynaeve Caroline
- Sharma Priyanka
- Side Lucy E.
- Siesling Sabine
- Simard Jacques
- Simpson Peter
- Sinilnikova Olga
- Snape Katie
- Sobol Hagay
- Sokolowska Johanna
- Soubrier Florent
- Soucy Penny
- Southey Melissa
- Southey Melissa C.
- Spinelli John J.
- Spurdle Amanda
- Steinsnyder Zoe
- Stone Jennifer
- Stoppa-Lyonnet Dominique
- Swerdlow Anthony
- Tamimi Rulla M.
- Tapper William J.
- Tassell Margaret
- Taylor Jack A.
- Terry Mary Beth
- Teulé Alex
- Thomassen Mads
- Thull Darcy L.
- Tischkowitz Marc
- Toland Amanda E.
- Torres Diana
- Toulas Christine
- Trainer Alison H.
- Truong Thérèse
- Tung Nadine
- Tyrer Jonathan P.
- Uhrhammer Nancy
- Vachon Celine M.
- van Asperen Christi J.
- van Cronenburg T. C. T. E. F.
- van den Ouweland Ans M. W.
- van der Hout Annemieke H.
- van der Kolk Lizet E.
- van der Luijt Rob B.
- van der Pol Carmen C.
- van Deurzen Carolien H. M.
- van Leeuwen Flora E.
- Vaur Dominique
- Vega Ana
- Verny-Pierre Carole
- Vijai Joseph
- Vénat-Bouvet Laurence
- Walker Lisa
- Wang Qin
- Wappenschmidt Barbara
- Warcoin Mathilde
- Webb Penny
- Weinberg Clarice R.
- Weitzel Jeffrey N.
- Wendt Camilla
- Wijnands R.
- Wijnen Juul T.
- Wolk Alicja
- Yadav Siddhartha
- Yang Xiaohong R.
- Yannoukakos Drakoulis
- Yip Desmond
- Zheng Wei
- Ziogas Argyrios
- Zorn Kristin K.
- Publication venue
- Nature Communications
- Publication date
- 01/02/2021
- Field of study
Abstract: Breast cancer (BC) risk for BRCA1 and BRCA2 mutation carriers varies by genetic and familial factors. About 50 common variants have been shown to modify BC risk for mutation carriers. All but three, were identified in general population studies. Other mutation carrier-specific susceptibility variants may exist but studies of mutation carriers have so far been underpowered. We conduct a novel case-only genome-wide association study comparing genotype frequencies between 60,212 general population BC cases and 13,007 cases with BRCA1 or BRCA2 mutations. We identify robust novel associations for 2 variants with BC for BRCA1 and 3 for BRCA2 mutation carriers, P < 10−8, at 5 loci, which are not associated with risk in the general population. They include rs60882887 at 11p11.2 where MADD, SP11 and EIF1, genes previously implicated in BC biology, are predicted as potential targets. These findings will contribute towards customising BC polygenic risk scores for BRCA1 and BRCA2 mutation carriers
Multiancestry analysis of the HLA locus in Alzheimer’s and Parkinson’s diseases uncovers a shared adaptive immune response mediated by HLA-DRB1*04 subtypes
- Author
- Aarsland Dag
- Aarsland Dag
- Abdelnour Carla
- Abraham Richard
- Abraham Richard
- Adarmes-Gómez A.D.
- Adarmes-Gómez Ad
- Aguilera N.
- Aguilera Nuria
- Ahmad Shahzad
- Al-Chalabi Ammar
- Al-Chalabi Ammar
- Alarcon E.
- Alarcón-Martín E.
- Alarcón-Martín Emilio
- Alcolea Daniel
- Alegret M.
- Alegret Montserrat
- Alonso M.D.
- Alvarez Ignacio
- Alvarez Victoria
- Ambati Aditya
- Amer-Ferrer G.
- Amin Najaf
- Amouyel Philippe
- Amouyel Philippe
- Amouyel Phillippe
- Anastasiou Anna
- Anastasiou Costas
- Andrade Victor
- Andreassen Ole A.
- Andreassen Ole A.
- Andreassen Ole A.
- Andreoni Simona
- Annuar Azlina Ahmad
- Antequera M.
- Anthoula Tsolaki
- Antikainen Riitta
- Antonell Anna
- Antúnez C.
- Appollonio Ildebrando
- Arcaro Marina
- Archetti Silvana
- Arfan Ikram M.
- Arias Pastor Alfonso
- Ariel Prestia Federico
- Armstrong Nicola J.
- Arosio Beatrice
- Arosio Beatrice
- Assogna Francesca
- Athanasiu Lavinia
- Athanasiu Lavinia
- Au Wing-Lok
- Bahrami Shahram
- Bailly Henri
- Banaj Nerisa
- Baquero M.
- Baquero Miquel
- Bass Nicholas J.
- Bass Nick
- Bastiani Patrizia
- Bayer Anthony
- Becker Tim
- Belezhanska Diyana
- Bellenguez Céline
- Bellenguez Céline
- Bellenguez Céline
- Belloy Michael E.
- Belén Pastor Ana
- Ben-Shlomo Yoav
- Benussi Alberto
- Benussi Luisa
- Benussi Luisa
- Bergh Sverre
- Bernal M.
- Bernardo-Harrington Mateus
- Berr Claudine
- Berr Claudine
- Besse Céline
- Bessi Valentina
- Binetti Giuliano
- Bizarro Alessandra
- Bjerke Maria
- Blennow Kaj
- Blesa R.
- Blesa Rafael
- Boada M.
- Boada M.
- Boada Mercè
- Boada Mercè
- Boecker Henning
- Boland Anne
- Boland Anne
- Borroni Barbara
- Borroni Barbara
- Boschi Silvia
- Bosnes Ingunn
- Bossù Paola
- Brayne Carol
- Brayne Carol
- Bresner Catherine
- Brice Alexis
- Brodaty Henry
- Brookes Keeley J.
- Brown Kristelle
- Brown Kristelle S.
- Bråthen Geir
- Bråthen Geir
- Buendia M.
- Buendia Mar
- Buiza-Rueda D.
- Buiza-Rueda Dolores
- Bullido M.J.
- Bullido María J.
- Bullido María J.
- Burguera J.A.
- Burholt Vanessa
- BÛrger Katharina
- Caffarra Paolo
- Calero M.
- Calero Miguel
- campion Dominique
- Campos-Martin Rafael
- Cano A.
- Carracedo A.
- Carracedo Ángel
- Carrillo F.
- Carrillo F.
- Carrion-Claro M.
- Carrión-Claro M.
- Casajeros M.J.
- Castaño Eduardo M.
- Castillo Morales Atahualpa
- Cañabate P.
- Cañabate Pilar
- Cecchetti Roberta
- Cervera-Carles Laura
- Chan Anne Y.Y.
- Chao Yinxia
- Chapuis Julien
- Charbonnier Camille
- Chen Ling
- Chen Yongping
- Chene Geneviève
- Chew Elaine Guo Yan
- Chillotti Caterina
- Chipi Elena
- Chung Sun Ju
- Ciccone Simona
- Ciullo Valentina
- Claassen Jurgen A.H.R.
- Clarimon Jordi
- Clarimon Jordi
- Clarimon Jordi
- Clarimón J.
- Clark Christopher
- Clarke Robert
- Collinge John
- Collinge John
- Conti Elisa
- Corbatón-Anchuelo A.
- Cores Valeria
- Corma-Gómez Anaïs
- Costa Marcos R
- Costantini Emanuele
- Craig David
- Craig David
- Cruz-Gamero J.M.
- Cuesta Carolina
- Custodero Carlo
- Daian Delphine
- Dalmasso Maria Carolina
- Damotte Vincent
- Damotte Vincent
- Daniele Antonio
- Daniele Antonio
- Dardiotis Efthimios
- Darling Daniel
- Dartigues Jean-Francois
- Dartigues Jean-François
- David Smith A.
- David Smith A.
- Davies Chloe
- de Deyn Peter Paul
- de Mendonça Alexandre
- de Mendonça Alexandre
- de Munain Adolfo Lopez
- de Pancorbo M.M.
- De Roeck Ellen
- de Rojas I.
- de Rojas I.
- de Rojas Itziar
- de Rojas Itziar
- Debette Stéphanie
- Debette Stéphanie
- Deckert Jürgen
- del Ser T.
- del Ser Teodoro
- Del Zompo Maria
- Deleuze Jean-François
- Deleuze Jean-François
- Deloukas Panagiotis
- Deloukas Pangiotis
- den Bussche Hendrik
- Denning Nicola
- Denning Nicola
- Deramecourt Vincent
- Dermecourt Vincent
- Dichgans Martin
- Dichgans Martin
- Dichgans Martin
- Diego S.
- Diego Susana
- Diehl-Schmid Janine
- Diez-Fairen M.
- Diez-Fairen Mónica
- Dionigi Rossi Paolo
- Djurovic Srdjan
- Djurovic Srdjan
- Dolores Alonso María
- Dowzell Kimberley
- Drichel Dmitriy
- Dubois Bruno
- Dufouil Carole
- Dufouil Carole
- Dufouil Carole
- During Emmanuel
- Duron Emmanuelle
- Düzel Emrah
- Düzel Emrah
- Engelborghs Sebastiaan
- Epelbaum Jacques
- Escott-Price Valentina
- Escott-Price Valentina
- Escuela R.
- Escuela R.
- Espinosa A.
- Espinosa Ana
- Etchepareborda Ignacio
- Eugenia Sáez María
- Ewers Michael
- Fabrizio Tagliavini
- Fallgaard Nielsen Sune
- Farotti Lucia
- Fenoglio Chiara
- Fernández-Fuertes Marta
- Ferrarese Carlo
- Ferreira Catarina B
- Ferri Evelyn
- Feulner Thomas
- Fievet Nathalie
- Fievet Nathalie
- Fin Bertrand
- Fischer Peter
- Fisher Elizabeth
- Fladby Tormod
- Fladby Tormod
- Fließbach Klaus
- Foo Jia Nee
- Foo Jia Nee
- Forsell Charlotte
- Fortea J.
- Fortea Juan
- Fostinelli Silvia
- Fox Nick
- Fox Nick C.
- Fox Nick C.
- Franco E.
- Franco-Macías Emlio
- Frank-García A.
- Frank-García Ana
- Frikke-Schmidt Ruth
- Frikke-Schmidt Ruth
- Froelich Lutz
- Frölich Lutz
- Gailhajenet A.
- Gailhajenet Anna
- Galeano Pablo
- Galimberti Daniela
- Galimberti Daniela
- Gan-Or Ziv
- Garcia Madrona S.
- Garcia-Gonzalez Pablo
- Garcia-Madrona Sebastian
- Garcia-Ribas G.
- Garcia-Ribas Guillermo
- Garcia-Ribas Guillermo
- García-Alberca J.M.
- García-Alberca José María
- García-González P.
- García-González Pablo
- García-González Pablo
- Garrote-Espina L.
- Garrote-Espina L.
- Germani Sandra
- Gerrish Amy
- Gerrish Amy
- Ghanbari Mohsen
- Ghidoni Roberta
- Giedraitis Vilmantas
- Giedraitis Vilmantas
- Giegling Ina
- Giegling Ina
- Gill Michael
- Gill Michael
- Gill Michael
- Gim Jungsoo
- Giorgio Giaccone
- Goldhardt Oliver
- Goldhardt Oliver
- González-Péerez A.
- González-Pérez Antonio
- Graff Caroline
- Graff Caroline
- Grande Giulia
- Green Emma
- Greicius Michael D.
- Grenier-Boley Benjamin
- Grenier-Boley Benjamin
- Grenier-Boley Benjamin
- Grimmer Timo
- Grünblatt Edna
- Grünblatt Edna
- Gu Wei
- Guerreiro Rita
- Guetta-Baranes Tamar
- Guitart M.
- Guitart Marina
- Gurling Hugh
- Gwilliam Rhian
- Gwilliam Rhian
- Gómez-Garre P.
- Gómez-Garre P.
- Haapasalo Annakaisa
- Hadjigeorgiou Georgios
- Hampel Harald
- Hampel Harald
- Hannequin Didier
- Hanon Olivier
- Hanon Olivier
- Hanon Olivier
- Hardy John
- Hardy John
- Hardy John
- Harold Denise
- Harold Denise
- Hartmann Annette M.
- Hartmann Annette M.
- Harwood Janet
- Hausner Lucrezia
- Hausner Lucrezia
- He Zihuai
- Heilmann-Heimbach Stefanie
- Heilmann-Heimbach Stefanie
- Helisalmi Seppo
- Heneka Michael T.
- Hernández Isabel
- Herold Christine
- Herrmann Martin J.
- Heun Reinhard
- Heuser Isabella
- Hevilla S.
- Hiltunen Mikko
- Hiltunen Mikko
- Hodges Angela
- Hoffmann Per
- Hoffmann Per
- Hollingworth Paul
- Hollingworth Paul
- Holmans Peter
- Holmans Peter A.
- Holmes Clive
- Holmes Clive
- Holstege Henne
- Holstege Henne
- Hooper Nigel M.
- Hort Jakub
- Hort Jakub
- Huerto Vilas Raquel
- Hulsman Marc
- Hüll Michael
- Ibarria M.
- Ibarria Marta
- Ignacio Bacha Juan
- Ignacio Brusco Luis
- Ikeuchi Takeshi
- Ingelsson Martin
- Ingelsson Martin
- Ingino Carlos
- Jan Biessels Geert
- Janowitz Daniel
- Jansen Iris
- Jansen Iris
- Jeon Beom S.
- Jessen Frank
- Jessen Frank
- Jessen Frank
- Jesús S.
- Jesús S.
- Jiang Lulu
- Johansson Charlotte
- Johnston Janet A.
- Johnston Jarret A.
- Jones Lesley
- Jones Lesley
- Jung Yoo Jin
- Jöckel Karl-Heinz
- Jürgen Deckert
- Kauwe John
- Kehoe Patrick
- Kehoe Patrick G.
- Kehoe Patrick G.
- Kern Silke
- Khor Chiea Chuen
- Kilander Lena
- Kinhult Ståhlbom Anne
- Kivipelto Miia
- Kleineidam Luca
- Klopp Norman
- Kochen Silvia
- Koh Woon-Puay
- Kohler Eduardo
- Kohler Matias
- Koivisto Anne
- Kornhuber Johannes
- Kornhuber Johannes
- Kosmidis Mary H.
- Kuulasmaa Teemu
- Kuulasmaa Teemu
- Kölsch Heike
- Küçükali Fahri
- Küçükali Fahri
- Laatikainen Tiina
- Labrador Espinosa M.A.
- Labrador Ma
- Lacidogna Giordano
- Lacour ndré
- Laczo Jan
- Lafuente A.
- Lafuente Asunción
- Lage C.
- Lage Carmen
- Lage Carmen
- Lambert Jean-Charles
- Lambert Jean-Charles
- Lambert Jean-Charles
- Laske Christoph
- Laukka Erika J
- Lauria Alessandra
- Lawlor Brian
- Lawlor Brian
- Le Guen Yann
- Lee Kun Ho
- Legaz A.
- Lehtisalo Jenni
- Lerch Ondrej
- Lian Michelle M.
- Lian Michelle Mulan
- Lim Jia Lun
- Lim Shen-Yang
- Lin Juei-Jueng
- Lin Ling
- Lindström Jaana
- Lis Palacio Dana
- Lisso Julieta
- Liu Chunfeng
- Liu Jianjun
- Livingston Gill
- Livingston Gill
- Lleó Alberto
- Lleóo A.
- Lord Jenny
- Love Seth
- Love Seth
- Lovestone Simon
- Lovestone Simon
- Luckcuck Lauren
- Luckcuck Lauren
- Luis Royo Jose
- Luo Guo
- Lupton Michelle
- Lupton Michelle
- Luís Royo Jose
- Lynch Aoibhinn
- Lynch Aoibhinn
- Lóopez de Munáin A.
- López-García S.
- López-García Sara
- Löwemark Malin
- Macias J.
- Macias-García D.
- Macias-García D.
- MacLeod Catherine A.
- Macías Juan
- Magda Tsolaki
- Maier Wolfgang
- Maier Wolfgang
- Malik Rainer
- Mangialasche Francesca
- Mangone Carlos
- Mann David
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- Manzanares S.
- Mao Chengjie
- Marco Spallazzi
- Maria García-Alberca Jose
- Maroñas O.
- Marquié M.
- Marquié M.
- Marquié Marta
- Marshall Rachel
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- Marín M.
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- Masullo Carlo
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- Mata Ignacio
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- McGuinness Bernadette
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- McQuillin Andrew
- McQuillin Andrew
- Mead Simon
- Mead Simon
- Meah Wee-Yang
- Mecocci Patrizia
- Mecocci Patrizia
- Medel Nancy
- Medina M.
- Medina Miguel
- Meggy Alun
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- Mehrabian Shima
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- Mendioroz Iriarte M.
- Mendoza Silvia
- Menéndez-González M.
- Menéndez-González Manuel
- Mignot Emmanuel
- Mir P.
- Mir Pablo
- Mir Pablo
- Miyashita Akinori
- Moebus Susanne
- Moebus Susanne
- Moebus Susanne
- Mok Shi Qi
- Mok Vincent
- Mol Merel
- Molina-Porcel Laura
- Montrreal L.
- Montrreal L.
- Montrreal Laura
- Morelli Laura
- Moreno Fermin
- Moreno Fermin
- Moreno M.
- Moreno Mariona
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- Moreno-Grau Sonia
- Morgan Kevin
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- Morizono Takashi
- Morris John
- Muchnik Carolina
- Mummery Catherine
- Möthen Markus M
- Nacmias Benedetta
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- Naito Tatsuhiko
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- Ng Ebonne Y.
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- Niida Shumpei
- Nordestgaard Børge G.
- Nordestgaard Børge G.
- Novack Gisela
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- O'Donovan Michael
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- Okada Yukinori
- Olaso Robert
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- Orellana A.
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- Orellana Adelina
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- Ortega G.
- Ortega Gemma
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- Owen Michael
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- Pastor Pau
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- Peters Oliver
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- Pinchler Sabrina
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- Pineda Juan A.
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- Popp Julius
- Popp Julius
- Porcel Laura Molina
- Posthuma Danielle
- Powell John
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- Prakash Kumar-M.
- Preckler S.
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- Ramirez Alfredo
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- Real Luis M.
- Reinders Marcel J.T.
- Reyes Toso Carlos
- Riedel-Heller Steffi
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- Riedel-Heller Steffi
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- Rosende-Roca M.
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- Ryan Nathalie
- Ráabano A.
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- Sanabria A.
- Sanabria Ángela
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- Sando Sigrid B.
- Sastre Merlín Isabel
- Sastre I.
- Satake Wataru
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- Scarmeas Nikolaos
- Scarmeas Nikolaos
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- Scherbaum Norbert
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- Schmid Matthias
- Schneider Anja
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- Schott Jonathan M.
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- Sevillano Zulma
- Shadrin Alexey A.
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- Shang Hui-Fang
- Shaw Christopher E.
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- Shi Chang-He
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- Singleton Andrew B.
- Skoog Ingmar
- Skrobot Olivia
- Sleegers Kristel
- Sleegers Kristel
- Soininen Hilkka
- Solfrizzi Vincenzo
- Solfrizzi Vincenzo
- Solis Patricia
- Solomon Alina
- Song Kyuyoung
- Sorbi Sandro
- Sotolongo-Grau O.
- Sotolongo-Grau O.
- Sotolongo-Grau Oscar
- Spalletta Gianfranco
- Spalletta Gianfranco
- Spottke Annika
- Squassina Alessio
- Squassina Alessio
- Stordal Eystein
- Stordal Eystein
- Strandberg Timo
- Sussams Rebecca
- Sáez M.E.
- Sánchez Juan Pascual
- Sánchez-Arjona María Bernal
- Sánchez-Juan P.
- Sánchez-Juan Pascual
- Sánchez-Valle Raquel
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- Takalo Mari
- Talyansky Seth D.
- Tan Ai Huey
- Tan Eng-King
- Tan Eng-King
- Tan Louis C.S.
- Tandiono Moses
- Tegos Thomas
- Teipel Stefan
- Teresa Martínez-Larrad María
- Tesí Niccolo
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- Thalamuthu Anbupalam
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- Thomas Tegos
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- Todd Stephen
- Traykov Latchezar
- Tremolizzo Lucio
- Tremolizzo Lucio
- Tsolaki Magda
- Tsolaki Magda
- Tuomilehto Jaakko
- Turton James
- Tybjærg-Hansen Anne
- Tzourio Christophe
- Táarraga L.
- Tárraga Lluís
- Uitterlinden Andre
- Ullgren Abbe
- Ulstein Ingun
- Ulstein Ingun
- Uphill James
- Vacca Alessandro
- Valero S.
- Valero S.
- Valero Sergi
- Van Broeckhoven Christine
- van der Flier Wiesje
- van der Flier Wiesje M.
- van der Lee Sven J.
- van der Lugt Aad
- Van Dongen Jasper
- van Duijn Cornelia M.
- Van Duin Cornelia
- van Rooij Jeroen
- van Swieten John
- van Swieten John
- Vandenberghe Rik
- Vardy Emma
- Vargas L.
- Vargas Liliana
- Verhey Frans
- Verhey Frans
- Vicente M.P.
- Vidal Jean-Sébastien
- Vigo-Ortega R.
- Vigo-Ortega R.
- Vivancos L.
- Vogelgsang Jonathan
- Vyhnalek Martin
- Vyhnalek Martin
- Waern Margda
- Wagner Michael
- Wallon David
- Wallon David
- Warden Donald
- Warner Nick
- Warren Jason D.
- Weber Heike
- Weinhold Leonie
- Wichmann H-Erich
- Wilcock Gordon
- Williams Amy
- Williams Julie
- Williams Julie
- Williams Julie
- Wiltfang Jens
- Wiltfang Jens
- Wiltfang Jens
- Windle Gill
- Woods Bob
- Wu Yih-Ru
- Xu Renshi
- Xu Yu-ming
- Yan Yaping
- Yang Jing
- Yannakoulia Mary
- Yaqub Amber
- Yogeshwar Selina Maria
- Yonkova Mihova Kalina
- Yu Eric
- Zetterberg Henrik
- Zettergren Anna
- Zhang Jing
- Zulaica Miren
- Álvarez I.
- Álvarez V.
- Álvarez Victoria
- Publication venue
- National Academy of Sciences
- Publication date
- 29/08/2023
- Field of study
Across multiancestry groups, we analyzed Human Leukocyte Antigen (HLA) associations in over 176,000 individuals with Parkinson’s disease (PD) and Alzheimer’s disease (AD) versus controls. We demonstrate that the two diseases share the same protective association at the HLA locus. HLA-specific fine-mapping showed that hierarchical protective effects of HLA-DRB1*04 subtypes best accounted for the association, strongest with HLA-DRB1*04:04 and HLA-DRB1*04:07, and intermediary with HLA-DRB1*04:01 and HLA-DRB1*04:03. The same signal was associated with decreased neurofibrillary tangles in postmortem brains and was associated with reduced tau levels in cerebrospinal fluid and to a lower extent with increased Aβ42. Protective HLA-DRB1*04 subtypes strongly bound the aggregation-prone tau PHF6 sequence, however only when acetylated at a lysine (K311), a common posttranslational modification central to tau aggregation. An HLA-DRB1*04-mediated adaptive immune response decreases PD and AD risks, potentially by acting against tau, offering the possibility of therapeutic avenues
Reducing the environmental impact of surgery on a global scale: systematic review and co-prioritization with healthcare workers in 132 countries
- Author
- Abad-Motos Ane
- Abbas Ahmed M.
- Abbas Mostafa
- Abbasi Mujeeb
- Abbott Tom
- Abd Karim Muhammad Fairuz Shah
- Abdalaal Ibrahim
- Abdel-Galil Khalid
- Abdelemam Rania
- Abdelgawad Abdalrahman
- Abdelkarim Maryam
- Abdelkhalek Mohamed
- Abdelmageed Abdelfatah
- Abdelmawgoud Sherif
- Abdelmohsen Sarah
- Abdelrahman Ahmed Saber
- Abdelrahman Mostafa
- Abdelwahab Khaled
- Abdou Hossam
- Abdulai Darling Ramatu
- Abdulkhaleq Marwa
- Abdullah Bahiyah
- Abdulsalam Khalifa
- Abdulsalam Shuaib
- Abdur-Rahman Lukman
- Abdus-Salam Rukiyat
- Abdussalam Hameedat Opeyemi
- Abebrese John Tabiri
- Abeldaño Ariel
- Abou-Khalil Jad
- Abou-Taleb Hisham
- Abozid Anwaar
- Abozied Hesham
- Abrate Alberto
- Abu-Zaid Ahmed
- Abubakar Mohammed Kabir
- Abud Burçin
- Abuzaid Mohammed
- Adam Albushra Altayeb
- Adamina Michel
- Adamou Harissou
- Adamu Auwal
- Adamu Kabir Musa
- Adanu Kekeli
- Adebara Idowu
- Adebola Oluwaseyi
- Ademuyiwa Adesoji
- Adeniran Abiodun
- Adepiti Akinfolarin
- Aderogba Adeleke Akeem
- Adesunkanmi Abdulhafiz
- Adeyeye Ademola
- Adisa Adewale
- Adjeso Theophilus Justus Kofi
- Ads Adel Mohamed
- Ads Alaa Mohamed
- Adu-Aryee Nii Armah
- Adumah Collins
- Afzal Irrum
- Agapov Mikhail
- Agarwal Gaurav
- Agarwal Ravi
- Agbeko Anita Eseenam
- Agbeno Evans Kofi
- Agbonrofo Peter
- Agboola Oluseyi
- Aggarwal Gaurav
- Aghadi Ifeanyi
- Aghtarafi Natasha
- Agrawal Amit
- Agresta Ferdinando
- Aguado Héctor J.
- Aguilera-Arevalo Maria-Lorena
- Aherne Thomas
- Ahmad Aline
- Ahmad Maleeha
- Ahmad Misbahu
- Ahmad Sarwat
- Ahmad Shahzaib
- Ahmad Shoaib
- Ahmed Hayat Tarig Abdelhafiz
- Ahmed Khalid
- Ahmed Sharwany
- Ahmed Shima
- Ahmed Usama
- Aisuodionoe-Shadrach Oseremen
- Aitken Sarah
- Ajenifuja Kayode
- Ajiya Abdulrazak
- Akeel Nouf
- Akin Emrah
- Akinajo Opeyemi
- Akinyemi Tosin
- Akrida Ioanna
- Aktokmakyan Talar Vartanoglu
- Akwaisah Ayoub
- Al Bettar Osama
- Al-Badawi Ismail A.
- Al-Juaifari Maytham
- Al-Khyatt Waleed
- Al-Mallah Abdullah
- Al-Nusairi Ahmed
- Al-Saadi Nina
- Al-Sayaghi Khaled
- Al-Shaiji Tariq
- Al-Shehari Mohammed
- Al-Touny Aiman
- Al-Touny Shimaa A.
- Aladawi Omar
- Aladna Abdallah
- Alali Mahmoud
- Alam Mahmood
- Alam Mohammed Shadrul
- Alarabi Rehab
- Alawneh Yazan
- Alayande Barnabas
- Albanese Erminia
- Albayadi Eslam
- Albdour Maram
- Alconchel Felipe
- Alderazi Amer
- Alegbeleye Bamidele
- Alekberli Tural
- Alemu Misganaw Alemu Adimass
- Alexander Philip
- Alfieri Alex
- Algahtany Khaled
- Algarni Kamal
- Alhamad Ameen
- Alhamid Mohammad
- Alharmi Rawan A. Rahman
- Alharthi Mohammed
- Alhazmi Barrag
- Ali Mohamed Shafi Mahboob
- Ali Stephen
- Alibrahim Hidar
- Aljaaly Hattan
- Aljaiuossi Anas
- Aljanadi Firas
- Aljiffry Murad
- Aljirdabi Noof
- Alkahlan Mohammed
- Alkhalifa Elmustafa
- Alkhatib Sondos
- Alkhatieb Maram
- Allan Anna
- Almarshad Felwa
- Almgla Naser
- Almhimid Ali
- Almiqlash Bushray
- Almoshantaf Mohammad Badr
- Almutairi Abdulmjeed
- Alnsour Abed Alfattah Mahmoud
- Alobied Majd
- Alomar Osama
- Alonso Jesús Aarón Martínez
- Alonso Manuel Diez
- Alonso Nestor Fabian Pedraza
- Alonso Veronica
- Alqallaf Abdullah
- Alqaseer Asma
- Alrayes Bourhan
- Alsefri Maryam
- Alser Osaid
- Alsharif Mohammed
- Alsori Mohamed
- Altaf Abdulmalik
- Altinel Yuksel
- Altiner Saygin
- Altouny Ahmad
- Altun Demet
- Alvarez Natalia
- Alvarez-Lozada Luis Adrian
- Alvi Abdul
- Alwael Athari
- Alwash Mohammed
- Alyami Ziyad
- Alyousef Mohammed
- Alzahrani Saud
- Alzerwi Nasser
- Amin Shivang
- Amir Mohammed
- Ammar Ahmed Siddique
- Ammendola Michele
- Amores Remedios Revilla
- Amrayev Sultan
- Anastasiadou Sofia
- Ancans Guntis
- Anderson Caroline
- Andreani Lorenzo
- Andreotti Dario
- Andreuccetti Jacopo
- Andrianakis Alexandros
- Andro Christophe
- Anesi Alexandre
- Angamuthu Stephen
- Angeles Martina Aida
- Angelico Roberta
- Angelis Fragkiskos
- Angelou Dimitrios
- Angelou Kyveli
- Angulo Victor Pinto
- Anjum Arfa
- Anjum Muhammad Ayyub
- Annicchiarico Alfredo
- Anoldo Pietro
- Ansaloni Luca
- Anthoulakis Christos
- Antonelli Amedeo
- Anwar Mohamed
- Anwar Sumadi Lukman
- Anwer Mariyah
- Anyanwu Lofty-John
- Apostolou Christos
- Apostolou Konstantinos
- Appiah-Kubi Adu
- Aprea Giovanni
- Arbab Hana
- Archer James
- Ardura Francisco
- Aremu Muyiwa
- Arif Tahera
- Arkani Samara
- Armatura Giulia
- Armijos Daniel
- Arnaout Ali
- Arnaoutoglou Eleni
- Arnaud Alexis P.
- Arneja Jugpal
- Arrangoiz Rodrigo
- Arshad Muhammad
- Arthur Joshua
- Ashcroft James
- Ashford Bruce
- Ashraf Fariha
- Asiimwe Daniel
- Asirifi Samuel Amoako
- Asla Amir
- Aslam Ramisha
- Aspide Raffaele
- Ataya Karim
- Ateca Ibabe Villalabeitia
- Atici Semra Demirli
- Atis Gokhan
- Atkins William
- Atkinson Kate
- Attwood Joseph
- Auerkari Aino
- Augestad Knut Magne
- Augustin Goran
- Aujayeb Avinash
- Avella Pasquale
- Awad Ahmed K.
- Awad Hadeel
- Awad Rabih
- Awad Selmy
- Ayad Kusay
- Ayana Birhanu
- Aydin Yener
- Ayeni Funbi
- Aytac Erman
- Azab Ahmed
- Azami Rizwan
- Azize Diallo Abdoul
- Azzam Ahmed Y.
- Azzis Olivier
- Baba Yabasin Iddrisu
- Babis George
- Bacalbasa Nicolae
- Badiani Sarit
- Badran Saif
- Baduell Albert
- Baeesa Saleh
- Baertschiger Reto
- Bafaquh Mohammed
- Bahassan Omar Mohammed
- Bahrami-Hessari Michael
- Baia Marco
- Baidoo Ebikela Ivie
- Bailey Karen
- Baili Efstratia
- Bains Lovenish
- Baiocchi Gian Luca
- Baiocchi Glauco
- Baiyewu Lateef Ayodele
- Bajaj Ankur
- Bajunaid Khalid
- Balagobi Balasingam
- Balasubramanian Ishwarya
- Balduzzi Alberto
- Baldwin Alexander
- Balla Andrea
- Balogh Zsolt J.
- Balogun James A.
- Balogun Simon
- Baloyiannis Ioannis
- Ban Vin Shen
- Bandyopadhyay Samik Kumar
- Bandyopadhyay Soham
- Banerjee Sumit
- Banipal Gurpreet Singh
- Banky Balazs
- Bannone Elisa
- Bansal Sujesh
- Barberis Andrea
- Barbosa-Breda Joao
- Bareka Metaxia
- Barišić Tatjana
- Barlas Aziz Mutlu
- Barlow Ciaran
- Barmayehvar Behrad
- Baroffio Paolo
- Barone Mirko
- Barra Fabio
- Barranquero Alberto G.
- Barugola Giuliano
- Basendowah Mohammed
- Bashir Mahmod
- Basnayake Oshan
- Bass Gary Alan
- Basu Somprakas
- Bateman Antony
- Bateman Kellie
- Batista Sylvia
- Batstone Martin
- Bauer Marlies
- Bauset Juan Carlos Catalá
- Bawa Ashvind
- Bawa Sayesha
- Bayhan Hüseyin
- Bayo Heura Llaquet
- Bazzi Nagham
- Beamish Andrew
- Beasley Nigel
- Beatty Jasmine Winter
- Becerra Angel
- Bedada Alemayehu Ginbo
- Bedzhanyan Arkady
- Begum Farzana
- Beisenov Bekzat
- Bellio Gabriele
- Bello Usman Mohammed
- Bellés Ana Ciscar
- Belzile Etienne
- Benamar Safia
- Bence Matthew
- Benshetrit Guy
- Bensoltane Khadidja
- Bergkvist David Julià
- Beristain-Hernandez Jose-Luis
- Bernante Paolo
- Bernardi Daniele
- Beron Reinaldo Isaacs
- Berselli Bruno
- Berselli Mattia
- Bertelli Giacomo
- Bertoglio Pietro
- Bertolaccini Luca
- Beswick Daniel
- Bette Birgit
- Bezirci Rifat
- Bhangu Aneel
- Bharathan Rasiah
- Bhat Vivek
- Bhatti Khalid
- Bianchi Valentina
- Bianco Francesco
- Bianco Giuseppe
- Bijou Walid
- Bilfaqirah Majed
- Biloslavo Alan
- Bin Alhassan Baba Alhaji
- Binnawara Muhannud
- Bissacco Daniele
- BİŞGİN TAYFUN
- Blair James
- Blanco Jose
- Blencowe Natalie
- Bloemers Frank
- Board Timothy
- Bobak Peter
- Boccalatte Luis
- Boedo Maria Jesus Maroño
- Bohmer Rob
- Boira Mar Achalandabaso
- Boisson Matthieu
- Boligo Sofia
- Bolton William
- Bombardini Cristina
- Bonavina Luigi
- Bonci Eduard-Alexandru
- Bondurri Andrea
- Bonilla Antonio Ramos
- Bonsaana Gilbert Batieka
- Booth L.
- Borg Elaine
- Borges Miguel Fróis
- Borges Nuno
- Bork Ulrich
- Borselle Dominika
- Bortul Marina
- Botelho Pedro
- Bottari Andrea
- Bouchagier Konstantinos
- Bouliaris Konstantinos
- Bowan Antoinette Bediako
- Bowen Joel
- Bozbiyik Osman
- Bracale Umberto
- Brachini Gioia
- Bramis Konstantinos
- Branagan Graham
- Branzan Daniela
- Brasset Camille
- Bratus Dejan
- Bravo Ana Maria Minaya
- Bravo Sybil Lizanne
- Bright Tim
- Brisinda Giuseppe
- Brodkin Edgar
- Broglia Alessandro
- Brolese Alberto
- Browning Rebecca
- Bruzzaniti Placido
- Brzeszczyński Filip
- Bsisu Isam
- Bua Emmanuel
- Budd Gabrielle
- Bukhari Syed Imran
- Bulian Dirk Rolf
- Bumbasirevic Uros
- Bumber Boris
- Burgos-Blasco Barbara
- Burlov Nikita
- Bussu Francesco
- Bàmbina Fabrizio
- Börner Nikolaus
- Böttcher Arne
- Cabeza Leticia
- Cabrera Marino
- Cais Simon
- Cakmak Guldeniz Karadeniz
- Calabretto Francesca
- Calabrò Marcello
- Calavia Pablo
- Calculli Federica
- Calini Giacomo
- Callan Rory
- Callcut Rachael
- Calu Valentin
- Calvache Jose Andres
- Calvache Nieto
- Calvo Francisco Javier Redondo
- Cama Jitoko
- Camacho Barbosa
- Camarena Ana Isabel Avellaneda
- Camargo-Parra Katherin
- Cammarata Emanuele
- Cammarata Francesco
- Cammarata Roberto
- Campagnaro Tommaso
- Campanelli Michela
- Campennì Paola
- Campisi Giuseppina
- Campo Flaminia
- Campuzano Nicolas
- Cano-Trigueros Emiliano
- Capella Stefano
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- Kapetanakis Emmanouil
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- Katorkin Sergey
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- Katsura Morihiro
- Kauppila Joonas H
- Kaur Amanjot
- Kausar Nabila
- Kavalakat Alfie
- Kavanagh Marcel Marjanović
- Kazan Ozgur
- Kealey Joshua
- Kebede Ephrem
- Kedwany Ahmed
- Kelly Michael
- Ken-Amoah Sebastian
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- Kennerton A.S.
- Kent Alistair J
- Keramati Mohammad Reza
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- Lohmann Tibor Karl
- Lohse Helmut Alfredo Segovia
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- Loubani Mahmoud
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- Lule Herman
- Lumenta David Benjamin
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- Lyra Humberto Fenner
- Mabood Waleed
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- Maguire Patrick J.
- Mahečić Tina Tomić
- Mahmood Fahad
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- Mallmann Christoph
- Mallmann Michael R.
- Mambrilla Sara
- Manangi Mallikarjuna
- Manesh Hassan Fatemi
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- Martins Ana
- Martins Claudia Pinto
- Martins Paulo N.
- Martínez Daniel Fernández
- Martínez Eunate Ganuza
- Martínez Verónica Martín
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- Matthews Emily
- Mauriello Claudio
- Maurus Christine
- Mayer Horacio F.
- Mayo-Yáñez Miguel
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- Meara John G.
- Meead Adullah
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- Shoukrie Shoukrie I. M.
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- Wong Benjamin Ngie Xiong
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- Yigit Banu
- Yildirim Asif
- Yim Guang
- Yiu Andrew
- Yonekura Hiroshi
- Yotsov Tsanko
- Younis Muhammad Umar
- Yunus Alif
- Yusefi Hossein
- Zabaleta Jon
- Zabkiewicz Catheriner
- Zaccaria Giulia
- Zacharia Bincy
- Zafar Syed Nabeel
- Zago Mauro
- Zaheen Zakia
- Zahid Zahra
- Zaimis Tilemachos
- Zakaria Andee Dzulkarnaen
- Zambon Martina
- Zamora Lindsey
- Zampogna Biagio
- Zancana Giuseppa
- Zani Augusto
- Zanin Luca
- Zanini Nicola
- Zapardiel Ignacio
- Zapata Carlos Shiraishi
- Zarif Pierre
- Zaránd Attila
- Zehnder Philipp
- Zenger Serkan
- Zenha Horácio
- Zhu Michael Z. L.
- Ziemann Sebastian
- Zimak Danijela Mrazovac
- Zimak Zoran
- Zivkovic Dragana
- Zizzo Maurizio
- Zucker Benjamin
- Zwain Yasir
- Zyskowski Michael
- Ávila Clara Castro
- Älgå Andreas
- Çakici Mehmet Çaǧlar
- Çelik Enes
- Çelik Meryem Nur
- Özçay Necdet
- Şevik Hüsnü
- Šantak Goran
- Šimko Kristián
- Žatecký Jan
- Publication venue
- 'Oxford University Press (OUP)'
- Publication date
- 01/01/2023
- Field of study
Abstract
Background
Healthcare cannot achieve net-zero carbon without addressing operating theatres. The aim of this study was to prioritize feasible interventions to reduce the environmental impact of operating theatres.
Methods
This study adopted a four-phase Delphi consensus co-prioritization methodology. In phase 1, a systematic review of published interventions and global consultation of perioperative healthcare professionals were used to longlist interventions. In phase 2, iterative thematic analysis consolidated comparable interventions into a shortlist. In phase 3, the shortlist was co-prioritized based on patient and clinician views on acceptability, feasibility, and safety. In phase 4, ranked lists of interventions were presented by their relevance to high-income countries and low–middle-income countries.
Results
In phase 1, 43 interventions were identified, which had low uptake in practice according to 3042 professionals globally. In phase 2, a shortlist of 15 intervention domains was generated. In phase 3, interventions were deemed acceptable for more than 90 per cent of patients except for reducing general anaesthesia (84 per cent) and re-sterilization of ‘single-use’ consumables (86 per cent). In phase 4, the top three shortlisted interventions for high-income countries were: introducing recycling; reducing use of anaesthetic gases; and appropriate clinical waste processing. In phase 4, the top three shortlisted interventions for low–middle-income countries were: introducing reusable surgical devices; reducing use of consumables; and reducing the use of general anaesthesia.
Conclusion
This is a step toward environmentally sustainable operating environments with actionable interventions applicable to both high– and low–middle–income countries
Analyzing educators’ online interactions: a framework of online learning support roles
- Author
- Publication venue
- 'Informa UK Limited'
- Publication date
- Field of study
Dietary Glycomacropeptide Supports Growth and Reduces the Concentrations of Phenylalanine in Plasma and Brain in a Murine Model of Phenylketonuria
- Author
- Angela K. Hull
- AOAC
- Bell
- Boehm
- Bruck
- Castagne
- Darling
- Darling
- Denise M. Ney
- Donlon
- Etzel
- Harding
- Harper
- Hidalgo
- IOM
- Koch
- Lim
- Mark R. Etzel
- Matalon
- McDonald
- National Institutes of Health Consensus Development Conference Statement
- NRC
- Pardridge
- Paxinos
- Pedersen
- Peters
- Pietz
- Reeves
- Rogers
- Sandra C. van Calcar
- Sanjurjo
- Schindeler
- Slocum
- Smith
- Spencer
- Tovar
- Weglage
- Xiaowen Liu
- Zhao
- Publication venue
- 'Oxford University Press (OUP)'
- Publication date
- Field of study