Computational temporal ghost imaging

Ghost imaging is a fascinating process, where light interacting with an object is recorded without resolution, but the shape of the object is nevertheless retrieved, thanks to quantum or classical correlations of this interacting light with either a computed or detected random signal. Recently, ghost imaging has been extended to a time object, by using several thousands copies of this periodic object. Here, we present a very simple device, inspired by computational ghost imaging, that allows the retrieval of a single non-reproducible, periodic or non-periodic, temporal signal. The reconstruction is performed by a single shot, spatially multiplexed, measurement of the spatial intensity correlations between computer-generated random images and the images, modulated by a temporal signal, recorded and summed on a chip CMOS camera used with no temporal resolution. Our device allows the reconstruction of either a single temporal signal with monochrome images or wavelength-multiplexed signals with color images

Preference for a prefilled syringe or an auto-injection device for delivering golimumab in patients with moderate-to-severe ulcerative colitis: a randomized crossover study.

Purpose: Simponi((R)) (golimumab, MSD) is a fully human monoclonal antibody against tumor necrosis factor alpha administered subcutaneously using an autoinjector or a prefilled syringe. This study examined preference for administration of golimumab by autoinjector or prefilled syringe in patients with moderate-to-severe ulcerative colitis (UC). Patients and methods: This was a multicenter, open-label, randomized crossover trial (EudraCT no 2014-000656-29). Patients with moderate-to-severe UC were randomized 1:1 to receive 2 subcutaneous injections of 50 mg golimumab with the autoinjector followed by 2 injections of 50 mg with the prefilled syringe or the same 4 injections administered in the opposite order. Patients assessed preference, ease of use, and discomfort immediately after the injections and 2 weeks later. Results: Ninety-one patients were included (median age=42.7 years [range, 19.7-93.7]; 58% male). The autoinjector was preferred by 76.9% of patients immediately after injections and by 71.4% 2 weeks later. The autoinjector was more often considered extremely easy or easy to use (94.5%) than the prefilled syringe (73.6%). Moderate discomfort or worse was reported by more patients when using the prefilled syringe (20.9%) than when using the autoinjector (5.5%), and severe discomfort or discomfort preventing injection of future doses was reported by 8.8% for the pre-filled syringe but not at all when using the autoinjector. A favorable or extremely favorable overall impression was reported by 89.0% for the autoinjector and 72.5% for the prefilled syringe. Conclusion: Most patients with moderate-to-severe UC preferred to self-administer golimumab with the autoinjector over a prefilled syringe

Extracorporeal Membrane Oxygenation for Severe Acute Respiratory Distress Syndrome associated with COVID-19: An Emulated Target Trial Analysis.

RATIONALE: Whether COVID patients may benefit from extracorporeal membrane oxygenation (ECMO) compared with conventional invasive mechanical ventilation (IMV) remains unknown. OBJECTIVES: To estimate the effect of ECMO on 90-Day mortality vs IMV only Methods: Among 4,244 critically ill adult patients with COVID-19 included in a multicenter cohort study, we emulated a target trial comparing the treatment strategies of initiating ECMO vs. no ECMO within 7 days of IMV in patients with severe acute respiratory distress syndrome (PaO2/FiO2 <80 or PaCO2 ≥60 mmHg). We controlled for confounding using a multivariable Cox model based on predefined variables. MAIN RESULTS: 1,235 patients met the full eligibility criteria for the emulated trial, among whom 164 patients initiated ECMO. The ECMO strategy had a higher survival probability at Day-7 from the onset of eligibility criteria (87% vs 83%, risk difference: 4%, 95% CI 0;9%) which decreased during follow-up (survival at Day-90: 63% vs 65%, risk difference: -2%, 95% CI -10;5%). However, ECMO was associated with higher survival when performed in high-volume ECMO centers or in regions where a specific ECMO network organization was set up to handle high demand, and when initiated within the first 4 days of MV and in profoundly hypoxemic patients. CONCLUSIONS: In an emulated trial based on a nationwide COVID-19 cohort, we found differential survival over time of an ECMO compared with a no-ECMO strategy. However, ECMO was consistently associated with better outcomes when performed in high-volume centers and in regions with ECMO capacities specifically organized to handle high demand. This article is open access and distributed under the terms of the Creative Commons Attribution Non-Commercial No Derivatives License 4.0 (http://creativecommons.org/licenses/by-nc-nd/4.0/)

Discutindo a educação ambiental no cotidiano escolar: desenvolvimento de projetos na escola formação inicial e continuada de professores

A presente pesquisa buscou discutir como a Educação Ambiental (EA) vem sendo trabalhada, no Ensino Fundamental e como os docentes desta escola compreendem e vem inserindo a EA no cotidiano escolar., em uma escola estadual do município de Tangará da Serra/MT, Brasil. Para tanto, realizou-se entrevistas com os professores que fazem parte de um projeto interdisciplinar de EA na escola pesquisada. Verificou-se que o projeto da escola não vem conseguindo alcançar os objetivos propostos por: desconhecimento do mesmo, pelos professores; formação deficiente dos professores, não entendimento da EA como processo de ensino-aprendizagem, falta de recursos didáticos, planejamento inadequado das atividades. A partir dessa constatação, procurou-se debater a impossibilidade de tratar do tema fora do trabalho interdisciplinar, bem como, e principalmente, a importância de um estudo mais aprofundado de EA, vinculando teoria e prática, tanto na formação docente, como em projetos escolares, a fim de fugir do tradicional vínculo “EA e ecologia, lixo e horta”.Facultad de Humanidades y Ciencias de la Educació

Imagerie fantôme d'un signal temporel non périodique : méthodes classiques et quantiques

National audience&nbsp

Détection d'un signal temporel fantôme unique par multiplexage spatial de la mesure

National audienceNous présentons un dispositif expérimental très simple d’imagerie fantôme permettant la détection d’un signal temporel avec un détecteur ne présentant pas de résolution temporelle. La reconstruction du signal fantôme est assurée par la mesure unique et spatialement multiplexée de corrélations d’intensité entre une base d’images aléatoires et indépendantes et les mêmes images modulées par le signal temporel et intégrées dans le temps par une caméra sans résolution temporelle

Cryopreservation of yam germplasm in Guadeloupe (FWI)

International audienceCryopreservation is the only technique ensuring the safe, long-term and cost-effective conservation of germplasm of vegetatively propagated species. Its applicability is currently being evaluated in Guadeloupe for the long-term storage of the yam germplansm collection maintained by INRA. The first preliminary positive results have been obtained with Dioscorea cayenensis-rotundata shoot tips frozen using the droplet-vitrification technique. Additional experiments are under way to improve the results, to test other cryopreservation techniques and to apply them to different Dioscorea species. Indexation of regenerated material, to evaluate the efficiency of virus elimination through cryopreservation, will be performed when recovery after freezing in liquid nitrogen is consistently achieved

Application de l'intrication spatiale à l'imagerie fantôme temporelle

National audienceNous avons mis en place une expérience d’imagerie fantôme temporelle utilisant les propriétés de faisceaux corrélés spatialement. Cette expérience montre qu’il est possible de reconstruire un signal temporel unique et non périodique, acquis au moyen d’une caméra intégrant entièrement le signal, c’est-à-dire sans résolution temporelle

Paradoxe de Einstein-Podolsky-Rosen dans des images uniques

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