Electrostatic Field Classifier for Deficient Data

This paper investigates the suitability of recently developed models based on the physical field phenomena for classification problems with incomplete datasets. An original approach to exploiting incomplete training data with missing features and labels, involving extensive use of electrostatic charge analogy, has been proposed. Classification of incomplete patterns has been investigated using a local dimensionality reduction technique, which aims at exploiting all available information rather than trying to estimate the missing values. The performance of all proposed methods has been tested on a number of benchmark datasets for a wide range of missing data scenarios and compared to the performance of some standard techniques. Several modifications of the original electrostatic field classifier aiming at improving speed and robustness in higher dimensional spaces are also discussed

Generic, disease-specific and individualised approaches to measuring health-related quality of life among people with heart disease - a comparative analysis

Increasing emphasis is being placed on the evaluation of health-related quality of life. However, there is no consensus on the definition of this concept and as a result there are a plethora of existing measurement instruments. Head-to-head comparisons of the psychometric properties of existing instruments are necessary to facilitate evidence-based decisions about which instrument should be chosen for routine use. Therefore, an individualised instrument (the modified Patient Generated Index), a generic instrument (the Short Form 36) and a disease-specific instrument (the Quality of Life after Myocardial Infarction questionnaire) were administered to patients with ischaemic heart disease (n=117) and the evidence for the validity, reliability and sensitivity of each instrument was examined and compared. The modified Patient Generated Index compared favourably with the other instruments but none of the instruments examined provided sound evidence for sensitivity to change. Therefore, any recommendation for the use of the individualised approach in the routine collection of health-related quality of life data in clinical practice must be conditional upon the submission of further evidence to support the sensitivity of such instruments

Understanding degenerate ground states of a protected quantum circuit in the presence of disorder

A recent theoretical proposal suggests that a simple circuit utilizing two superinductors may produce a qubit with ground state degeneracy [P. Brooks et al., Phys. Rev. A 87, 052306 (2013)]. We perform a full circuit analysis along with exact diagonalization of the circuit Hamiltonian to elucidate the nature of the spectrum and low-lying wave functions of this $0-\pi$ device. We show that the ground state degeneracy is robust to disorder in charge, flux and critical current as well as insensitive to modest variations in the circuit parameters. Our treatment is non-perturbative, provides access to excited states and matrix elements, and is immediately applicable also to intermediate parameter regimes of experimental interest.Comment: 9 pages, 8 figure

SACOC: A spectral-based ACO clustering algorithm

The application of ACO-based algorithms in data mining is growing over the last few years and several supervised and unsupervised learning algorithms have been developed using this bio-inspired approach. Most recent works concerning unsupervised learning have been focused on clustering, where ACO-based techniques have showed a great potential. At the same time, new clustering techniques that seek the continuity of data, specially focused on spectral-based approaches in opposition to classical centroid-based approaches, have attracted an increasing research interest–an area still under study by ACO clustering techniques. This work presents a hybrid spectral-based ACO clustering algorithm inspired by the ACO Clustering (ACOC) algorithm. The proposed approach combines ACOC with the spectral Laplacian to generate a new search space for the algorithm in order to obtain more promising solutions. The new algorithm, called SACOC, has been compared against well-known algorithms (K-means and Spectral Clustering) and with ACOC. The experiments measure the accuracy of the algorithm for both synthetic datasets and real-world datasets extracted from the UCI Machine Learning Repository

X-ray Lighthouses of the High-Redshift Universe. II. Further Snapshot Observations of the Most Luminous z>4 Quasars with Chandra

We report on Chandra observations of a sample of 11 optically luminous (Mb<-28.5) quasars at z=3.96-4.55 selected from the Palomar Digital Sky Survey and the Automatic Plate Measuring Facility Survey. These are among the most luminous z>4 quasars known and hence represent ideal witnesses of the end of the "dark age ''. Nine quasars are detected by Chandra, with ~2-57 counts in the observed 0.5-8 keV band. These detections increase the number of X-ray detected AGN at z>4 to ~90; overall, Chandra has detected ~85% of the high-redshift quasars observed with snapshot (few kilosecond) observations. PSS 1506+5220, one of the two X-ray undetected quasars, displays a number of notable features in its rest-frame ultraviolet spectrum, the most prominent being broad, deep SiIV and CIV absorption lines. The average optical-to-X-ray spectral index for the present sample (=-1.88+/-0.05) is steeper than that typically found for z>4 quasars but consistent with the expected value from the known dependence of this spectral index on quasar luminosity. We present joint X-ray spectral fitting for a sample of 48 radio-quiet quasars in the redshift range 3.99-6.28 for which Chandra observations are available. The X-ray spectrum (~870 counts) is well parameterized by a power law with Gamma=1.93+0.10/-0.09 in the rest-frame ~2-40 keV band, and a tight upper limit of N_H~5x10^21 cm^-2 is obtained on any average intrinsic X-ray absorption. There is no indication of any significant evolution in the X-ray properties of quasars between redshifts zero and six, suggesting that the physical processes of accretion onto massive black holes have not changed over the bulk of cosmic time.Comment: 15 pages, 7 figures, accepted for publication in A

C1 inhibitor deficiency: 2014 United Kingdom consensus document

C1 inhibitor deficiency is a rare disorder manifesting with recurrent attacks of disabling and potentially life-threatening angioedema. Here we present an updated 2014 United Kingdom consensus document for the management of C1 inhibitor-deficient patients, representing a joint venture between the United Kingdom Primary Immunodeficiency Network and Hereditary Angioedema UK. To develop the consensus, we assembled a multi-disciplinary steering group of clinicians, nurses and a patient representative. This steering group first met in 2012, developing a total of 48 recommendations across 11 themes. The statements were distributed to relevant clinicians and a representative group of patients to be scored for agreement on a Likert scale. All 48 statements achieved a high degree of consensus, indicating strong alignment of opinion. The recommendations have evolved significantly since the 2005 document, with particularly notable developments including an improved evidence base to guide dosing and indications for acute treatment, greater emphasis on home therapy for acute attacks and a strong focus on service organisation. This article is protected by copyright. All rights reserved

Fluid pressure penetration for advanced FEA of metal-to-metal seals

This numerical study investigates the behaviour of the contact faces in the metal-to-metal seal of a typical pressure relief valve in the commercial FE-package ANSYS. The valve geometry is simplified to an axisymmetric problem, which comprises a simple representative geometry consisting of only three components. A cylindrical nozzle, which has a valve seat on top, contacts with a disk, which is preloaded by a compressed linear spring. Analysis considerations include the effects of the Fluid Pressure Penetration (FPP) across the valve seat which exists at two different scales. In-service observations show that there is certain limited fluid leakage through the valve seat at operational pressures about 90% of the set pressure, which is caused by the fluid penetrating into surface asperities at the microscale. At the macroscale, non-linear FE-analysis using the FPP technique available in ANSYS revealed that there is also a limited amount of fluid penetrating into gap, which is caused primarily by the global plastic deformation of the valve seat. Accurate prediction of the fluid pressure profile over the valve seat is addressed in this study by considering the FPP interaction on both scales. The shape of this pressure profile introduces an additional component of the spring force, which needs to be considered to provide a reliable sealing

Reconstruction of photon statistics using low performance photon counters

The output of a photodetector consists of a current pulse whose charge has the statistical distribution of the actual photon numbers convolved with a Bernoulli distribution. Photodetectors are characterized by a nonunit quantum efficiency, i.e. not all the photons lead to a charge, and by a finite resolution, i.e. a different number of detected photons leads to a discriminable values of the charge only up to a maximum value. We present a detailed comparison, based on Monte Carlo simulated experiments and real data, among the performances of detectors with different upper limits of counting capability. In our scheme the inversion of Bernoulli convolution is performed by maximum-likelihood methods assisted by measurements taken at different quantum efficiencies. We show that detectors that are only able to discriminate between zero, one and more than one detected photons are generally enough to provide a reliable reconstruction of the photon statistics for single-peaked distributions, while detectors with higher resolution limits do not lead to further improvements. In addition, we demonstrate that, for semiclassical states, even on/off detectors are enough to provide a good reconstruction. Finally, we show that a reliable reconstruction of multi-peaked distributions requires either higher quantum efficiency or better capability in discriminating high number of detected photons.Comment: 8 pages, 3 figure

Artificial water points facilitate the spread of an invasive vertebrate in arid Australia

Summary: The spread of invasive species after their initial introduction is often facilitated by human actions. In some cases, invaders only become established in habitats where dominant native species have been displaced as a result of human actions or where humans inadvertently provide essential resources such as food, water or shelter. We investigated if dams that provide water for livestock have facilitated the cane toad's (Rhinella marina) invasion of a hot semi-arid landscape by providing toads with a resource subsidy and hence refuge from extreme heat and aridity. To determine the relationship between the presence of surface water and habitat occupancy by toads, we surveyed natural and artificial water features for cane toads during the annual dry season. We used radiotracking and acoustic tags to determine whether movement patterns and shelter use of cane toads were focussed around dams. To determine whether dams provide toads with refuge from extreme heat and aridity, we deployed plaster models with internal thermometers to estimate ambient temperatures and toad desiccation rates in shelter sites. To determine whether dams alleviate the stress experienced by toads, we measured plasma corticosterone levels of toads that sheltered in and away from dams. Toads were present in sites with standing water and absent from waterless sites. Most radiotracked toads sheltered within 1 m of water. Toad movements were focussed around water. Toads tracked with passive acoustic telemetry over a 6-month dry season were highly resident at dams. Plaster models placed in toad shelter sites away from the water lost 27% more mass and experienced higher temperatures than models placed near the water's edge. Toads that sheltered in terrestrial shelters exhibited higher plasma corticosterone levels compared to toads that sheltered near dams. Dams provide toads with refuge habitats where they are less at risk from overheating and dehydration. Synthesis and applications. Artificial water points can facilitate biological invasions in arid regions by providing a resource subsidy for water-dependent invasive species. Our study suggests that there is scope to control populations of water-dependent invasive vertebrates in arid regions by restricting their access to artificial water points. © 2014 British Ecological Society

Biased tomography schemes: an objective approach

We report on an intrinsic relationship between the maximum-likelihood quantum-state estimation and the representation of the signal. A quantum analogy of the transfer function determines the space where the reconstruction should be done without the need for any ad hoc truncations of the Hilbert space. An illustration of this method is provided by a simple yet practically important tomography of an optical signal registered by realistic binary detectors.Comment: 4 pages, 3 figures, accepted in PR