The modified post-earthquake damage assessment methodology for TCIP (TCIP-DAM-2020)

Chapter 5Post-Earthquake damage assessment has always been one of the major challenges that both engineers and authorities face after disastrous earthquakes all around the world. Considering the number of buildings in need of inspection and the insufficient number of qualified inspectors, the availability of a thorough, quantitative and rapidly applicable damage assessment methodology is vitally important after such events. At the beginning of the new millennia, an assessment system satisfying these needs was developed for the Turkish Catastrophe Insurance Pool (TCIP, known as DASK in Turkey) to evaluate the damages in reinforced concrete (RC) and masonry structures. Since its enforcement, this assessment method has been successfully used after several earthquakes that took place in Turkey, such as 2011 Van Earthquake, 2011 Kutahya Earthquake, 2019 Istanbul Earthquake and 2020 Elazig Earthquake to decide the future of damaged structures to be either ‘repaired’ or ‘demolished’.Scopus - Affiliation ID: 6010507

New Records For the Turkish Freshwater Algal Flora in Twenty Five River Basins of Turkey, Part Vi: Charophyta

DergiPark: 875740trkjnatAlthough planktonic algae are a basic component of freshwater ecosystems, studies on their diversity and species distribution are still not in satisfactory numbers. This study aims to contribute to Turkish freshwater algal flora particularly with the new records reported. A total of 158 Charophyta taxa were determined in the study conducted from 2017 to 2019 in 25 river basins of Turkey. In this study, while the highest Charophyta taxon was found in Sakarya and Batı Akdeniz basins with 50 and 42 taxa, respectively, Burdur basin was the only basin where we did not find the Charophyta species. The highest Charophyta diversity was observed in Girdev Lake (Batı Akdeniz basin) and Işık Dağı Karagöl Lake (Sakarya basin) among the lakes of Turkey’s 25 river basins. Thirty-one of these Charophyta taxa represent new records for the freshwater algal flora of Turkey. Of these, 13 species are commonly distributed, while 18 species have rare distribution areas. Morphology, ecology, and distribution of each taxon were also discussed in details.Planktonik algler tatlı su ekosistemlerinin temel bir bileşeni olmasına rağmen, onların çeşitliliği ve tür dağılımları konusundaki çalışmalar hala tatmin edici sayılarda değildir. Bu çalışma, özellikle raporlanan yeni kayıtlarla Türkiye tatlı su alg florasına katkıda bulunmayı amaçlamaktadır. 2017-2019 yılları arasında Türkiye'nin 25 nehir havzasında yapılan bu çalışmada toplam 158 Charophyta taksonu tespit edilmiştir. Bu çalışmada, en yüksek Charophyta taksonuna sırasıyla 50 ve 42 takson sayısıyla Sakarya ve Batı Akdeniz havzalarında rastlanırken, Charophyta türüne rastlamadığımız tek havza Burdur olmuştur. Türkiye'nin 25 akarsu havzasındaki göller arasında en fazla Charophyta çeşitliliği Girdev Gölü (Batı Akdeniz havzası) ve Işık Dağı Karagöl (Sakarya havzası)’de görülmüştür. Tespit edilen bu Charophyta taksonlarının 31’i Türkiye'deki tatlısu alg florası için yeni kayıt niteliğindedir. Bunlardan 13 tür yayılış alanı olarak yaygın iken, 18 tür nadir yayılış alanına sahiptir. Her bir taksonun morfolojisi, ekolojisi ve dağılımı da ayrıntılı olarak verilmiştir

The orientation of non-governmental organization executives towards sports events: A quantitative research

Bu araştırmada, gençlik ve spor alanında faaliyet gösteren sivil toplum kuruluşları yürütücülerinin spor etkinliklerine yönelim durumlarının incelenmesi amaçlanmıştır. Araştırmanın örneklem grubu, Türkiye’de faaliyet gösteren sivil toplum kuruluşlarında görev yapan 167 katılımcıdan oluşmaktadır. Betimleyici olarak tasarlanan bu araştırmada veri toplama aracı olarak anket tekniği kullanılmıştır. Araştırmada yer alan katılımcıların demografik durumlarının tespit edilmesi için frekans analizi; verilen normal dağılım durumunu saptamak adına basıklık ve çarpıklık testi uygulanmıştır. Yapılan analizler sonucunda, gençlik ve spor alanında faaliyet gösteren sivil toplum kuruluşları yürütücülerinin spor etkinliklerine yönelim durumlarının cinsiyet değişkenine göre, erkek katılımcıların ölçek puan ortalamalarının kadın katılımcıların toplam puan ortalamalarından anlamlı düzeyde ve ölçek alt boyutlarından duygu arama, bilgi arama boyutlarında erkek katılımcılar lehine anlamlı farklılık görülmüştür. Gençlik ve spor alanında faaliyet gösteren sivil toplum kuruluşları yürütücülerinin spor etkinliklerine yönelimlerinin düzenli spor yapma ve yapmama değişkenine göre, ‘duygu arama, bilgi arama’ alt boyutları ve toplam puanlarda düzenli spor yapanlar lehine anlamlı farklılaştığı tespit edilmiştir. Gençlik ve spor alanında faaliyet gösteren sivil toplum kuruluşları yürütücülerinin spor etkinliklerine yönelimlerinin yaşanılan bölge değişkenine göre, Marmara Bölgesi’nde yaşayan katılımcıların, Güneydoğu Anadolu Bölgesi’nde yaşayan katılımcılara göre anlamlı oranda farklılaştığı gözlenmiştir. Gençlik ve spor alanında faaliyet gösteren sivil toplum kuruluşları yürütücülerinin spor etkinliklerine yönelimlerinin yaş ve eğitim değişkenlerine göre anlamlı bir farklılığın olmadığı görülmüştür.In this research, it is aimed to examine the orientation of the non-governmental organizations active in the field of youth and sports to sports activities. The sample group of the research consists of 167 participants working in non-governmental organizations operating in Turkey. Questionnaire technique was used as a data collection tool in this research, which was designed as descriptive. Frequency analysis to determine the demographic status of the participants in the research; In order to determine the given normal distribution, the kurtosis and skewness tests were applied. As a result of the analyzes made, according to the gender variable of the orientation of the non-governmental organizations active in the field of youth and sports, the scale score averages of the male participants were significantly different from the total score averages of the female participants, and there was a significant difference in favor of the male participants in the sub-dimensions of emotion seeking and information seeking. It has been determined that the orientation of the executives of non-governmental organizations operating in the field of youth and sports to sports activities differs significantly in favor of those who regularly do sports in the sub-dimensions of "searching for emotions, seeking information" and total scores, according to the variable of doing or not doing sports regularly. It has been observed that the orientation of the executives of non-governmental organizations operating in the field of youth and sports to sports activities differs significantly between the participants living in the Marmara Region and the participants living in the Southeastern Anatolia Region, according to the region of residence. It has been observed that there is no significant difference in the orientation of the executives of non-governmental organizations operating in the field of youth and sports to sports activities according to age and education variables

Structural assessment of the 13th century great mosque and hospital of Divrigi: A world heritage listed structure

. The Great Mosque and Hospital of Divrigi is located in the central eastern part of Turkey, in Divrigi, Sivas. The historical facility consists of a monumental mosque and a two-story hospital, which are adjacent to each other. The structure dates back to 13th century Mengujekids period and has been listed by the UNESCO as a World Heritage since 1985. Great Mosque and Hospital of Divrigi is particularly notable for its monumental stone portals that are decorated with three-dimensional ornaments carved from stone. The structural system of the monument consists of multi-leaf stone masonry walls and stone piers that support the roof structure which consists of stone and brick arches and vaults. The structure is located about 90 km away from the North Anatolian Fault Line, that has been causing several destructive earthquakes. Consequently, the structure is prone to destructive seismic activities. In this study, after a brief introduction on the structural system and current condition of the structure, the structural performance of the Great Mosque and Hospital of Divrigi is investigated through site observations and structural analyses. For this purpose, linear and nonlinear 3D finite element models of the structure are developed and the structure is examined under the effects of vertical loads and seismic actions. In the light of the analyses results, recommendations for potential interventions are outlined for further preservation of the structure

Long-Term Follow-Up of Two-Phase Orthodontic Treatment of Class II Malocclusions

Aim:The aim of the study was to investigate the stability of dentoskeletal changes 8 years after treatment with the activator appliance, followed by an edgewise appliance.Subjects and Methods:The study comprised 18 children (10 boys and 8 girls at 12.2±1.4 years of age) with a skeletal Class II pattern and a Class II molar relationship. Pre-treatment (T1) their ANB angles were greater than 4 degrees and overjets greater than 7 mm. Standardized lateral cephalograms were taken in centric occlusion at the start of treatment (T1), at the end of activator treatment (T2), at the end of fixed appliance therapy (T3) and 6.2 years after the removal of the fixed appliances (T4). Ten angular and nine linear cephalometric measurements were determined. A paired-sample t-test was used to evaluate the treatment changes.Results:At the end of active treatment period (T3) the skeletal relationship was improved and there were significant (p=0.000) increases in maxillary and mandibular length (Co-A and Co-Gn) and SNB. The upper incisors were significantly (p=0.023) uprighted and retruded (U1-NA). SNA and ANB angles were significantly (p=0.012, p=0.000 respectively) decreased whereas IMPA and mandibular plane angle (Go-Gn-SN) remained stable. At (T4) the changes were generally in agreement with those T3 at except for a slight return to the original values for SNA and A to N -I FH (mm) measurements.Conclusion:The anteroposterior dentoskeletal changes obtained with the activator appliance followed by fixed edgewise appliances were demonstrated to be stable over 6.2 years

Effect of taxifolin on acrylamide-induced oxidative and proinflammatory lung injury in rats: Biochemical and histopathological studies

Purpose: To examine the probable beneficial effects of taxifolin against acrylamide damage in lung tissue.Methods: 18 male albino Wistar rats were divided into healthy (HG), acrylamide (AG) and taxifolin + acrylamide (TAG) groups. Once a day for 30 days, acrylamide was orally administered to the AG group (50 mg/kg), while ACL (50 mg/kg) and TAX (20 mg/kg) were orally administered to TAG group. Protein concentration, malondialdehyde (MDA), and total glutathione (tGSH) levels as well as oxidant and antioxidant molecules concentrations of the rat lung tissues were measured. In addition, degree of mononuclear (MN) cell infiltration and bronchial-associated lymphoid tissue (BALT) hyperplasia was evaluated by the degree of hyperplasia (absent, mild, moderate, severe). The histopathological andbiochemical data the groups were compared.Results: When compared in terms of MDA levels, it was found that the AG group had high MDA levels, and the TAG group had low MDA levels. (p < 0.001). TAG group was found to have a higher tGSH level than the AG group (p < 0.001). Compared to the AG group, lower TOS and higher TAS levels were obtained in the TAG group (p < 0.001). In addition, when TOS levels of TAG and HG groups were compared, the TOS levels between the two groups were statistically insignificant (p = 0.213). It has been observed that TAX administration prevents the increase in NF-ƘB level. When the NF-ƘB levels of the AG and TAG groups were compared with each other, there was a statistically significant difference (p = 0.001). In the AG group, severe MN cell hyperplasia and BALT hyperplasia were observed histopathologically. It was determined that these findings were alleviated in the TAG group. A histopathologically significant difference was found between AG and TAG groups (p < 0.05).Conclusion: Taxifolin has beneficial effects against lung injury caused by acrylamide, a healthdamaging environmental factor. Regular use of taxifolin can be recommended, especially in people who are known to have intense contact with acrylamide. There is a need for research studies on this subject

Comparison of the real-life clinical outcomes of warfarin with effective time in therapeutic range and NOACs: Insight from AFTER-2 Trial

BACKGROUND: We aimed to compare the long-term follow-up results of patients with atrial fibrillation (AF) who use vitamin K antagonist (VKA) with effective time in therapeutic range (TTR) and non-vitamin K antagonist oral anticoagulants (NOACs). METHODS: A total of 1140 patients were followed at 35 different centers for five years. During the follow-up period, the INR values were studied at least 4 times a year and the TTR values were calculated according to the Roosendaal method. The effective TTR level was accepted as >60% as recommended by the guidelines. There were 254 patients in the effective TTR group and 886 patients in the NOACs group. Ischemic cerebrovascular disease/ transient ischemic attack (CVD/TIA), hemorrhagic CVD, and mortality were considered primary endpoints based on one-year and five-year follow-ups. RESULTS: Ischemic CVD/TIA (3.9% vs. 6.2%; P = 0.17) and hemorrhagic CVD (0.4% vs. 0.5%, P = 0.69), the one-year mortality rate (7.1% vs. 8.1%; P = 0.59), five-year mortality rates (24% vs. 26.3%; P = 0.46) were not different between the effective TTR and NOACs groups during the follow-up respectively. The CHA2DS2-VASC score was similar between warfarin with the effective TTR group and NOACs group (3 [2–4] vs. 3 [2–4]; P = 0.17, respectively]. Additionally, survival free-time did not differ between the warfarin with effective TTR group and each NOAC in the Kaplan-Meier analysis (dabigatran, P = 0.59; rivaroxaban, P = 0.34; apixaban, P = 0.26; and edoxaban, P = 0.14). CONCLUSION: There was no significant difference in primary outcomes between the effective TTR and NOAC groups in AF patients

Mevcut binalar için güçlendirme yöntemleri geliştirilmesi

TÜBİTAK MAG01.05.2005Bugün ülkemizde ve diğer ülkelerde yaygın olarak uygulanan "sistem iyileştirmesi" yöntemi, dayanımı ve rijitliği yetersiz çerçevelerin bazı gözlerinin betonarme dolgu ile doldurularak yeni bir yatay yük taşıyıcı sistemi olmuşturulması olarak tanımlanabilir. Ülkemizde bugün karşılaşılan en önemli sorunlardan biri de hasar görmemiş ve kullanılmakta olan çok sayıda zayıf binanın depreme dayanıklı duruma getirilmesidir. Bu binaların güçlendirilmesinde, "sistem iyileştirmesi" yönteminin kullanılması elbette mümkündür. Ancak sözü edilen yöntemde dolgu duvarların oluşturulmasında beton kullanılacağından, binaların boşaltılması gerekmektedir. Çok sayıda binanın boşaltılması ve binada yaşayanların eşyaları ile birlikte başka bir konuta yerleştirilmesi pratik bir çözüm değildir. Bu proje kapsamında, depreme dayanıklı olmayan ve halen kullanılmakta olan binaların boşaltılmadan güçlendirilmesini sağlayacak yöntemler geliştirilmiş ve bunların gerekli dayanım ve rijitliği sağladığı deneysel ve analitik olarak kanıtlanmıştır.In the system behavior improvement technique, the general philosophy is to introduce a new lateral load resisting system, which will increase the lateral strength and the lateral stiffness of the existing system, which is generally a non-ductile frame with inadequate lateral stiffness. Various techniques based on this principle have been developed and applied in the past. Among them, the most widely used technique is the formation of new stiff walls through infilling some bays of the existing frame with reinforced concrete infills. Use of infilled frames as a method of seismic behavior improvement for existing structures is presently a very common application in Turkey. All these techniques are applicable at the cost of a certain discomfort to the occupants and, the application of these techniques in the rehabilitation of undamaged buildings may not very practical. With this project, the development of new strengthening techniques was achieved. Experimental and anaylical studies have been done to proove the effectiveness of newly developed strengthening techniques. In this study, rapid and yet reliable rehabilitation methodologies for Turkey have be developed

Efficacy of subsequent treatments in patients with hormone-positive advanced breast cancer who had disease progression under CDK 4/6 inhibitor therapy

Background: There is no standard treatment recommended at category 1 level in international guidelines for subsequent therapy after cyclin-dependent kinase 4/6 inhibitor (CDK4/6) based therapy. We aimed to evaluate which subsequent treatment oncologists prefer in patients with disease progression under CDKi. In addition, we aimed to show the effectiveness of systemic treatments after CDKi and whether there is a survival difference between hormonal treatments (monotherapy vs. mTOR-based). Methods: A total of 609 patients from 53 centers were included in the study. Progression-free-survivals (PFS) of subsequent treatments (chemotherapy (CT, n:434) or endocrine therapy (ET, n:175)) after CDKi were calculated. Patients were evaluated in three groups as those who received CDKi in first-line (group A, n:202), second-line (group B, n: 153) and ≥ 3rd-line (group C, n: 254). PFS was compared according to the use of ET and CT. In addition, ET was compared as monotherapy versus everolimus-based combination therapy. Results: The median duration of CDKi in the ET arms of Group A, B, and C was 17.0, 11.0, and 8.5 months in respectively; it was 9.0, 7.0, and 5.0 months in the CT arm. Median PFS after CDKi was 9.5 (5.0–14.0) months in the ET arm of group A, and 5.3 (3.9–6.8) months in the CT arm (p = 0.073). It was 6.7 (5.8–7.7) months in the ET arm of group B, and 5.7 (4.6–6.7) months in the CT arm (p = 0.311). It was 5.3 (2.5–8.0) months in the ET arm of group C and 4.0 (3.5–4.6) months in the CT arm (p = 0.434). Patients who received ET after CDKi were compared as those who received everolimus-based combination therapy versus those who received monotherapy ET: the median PFS in group A, B, and C was 11.0 vs. 5.9 (p = 0.047), 6.7 vs. 5.0 (p = 0.164), 6.7 vs. 3.9 (p = 0.763) months. Conclusion: Physicians preferred CT rather than ET in patients with early progression under CDKi. It has been shown that subsequent ET after CDKi can be as effective as CT. It was also observed that better PFS could be achieved with the subsequent everolimus-based treatments after first-line CDKi compared to monotherapy ET.Breast Cancer Consortiu